ライフサイエンスコーパス: topogenic

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1 e-tagged full-length proteins, we found that topogenic activities of two C-trans (type II) signal anc

2 e findings suggest a correlation between the topogenic and transforming activities of TLS and EWS N-t

3 ctural features contributing to this unusual topogenic behavior included 1) a short, flexible peptide

4 tional and sequential manner, while multiple topogenic determinants appear to be required for the int

5 g of sequential translocation events, native topogenic determinants are capable of generating two alt

6 neously integrates information from multiple topogenic determinants as they are presented in rapid su

7 t tunnel can influence the timing with which topogenic determinants contact, enter, and pass through

8 ation efficiencies, indicating that multiple topogenic determinants cooperate during Kv1.3 topogenesi

9 extraction assays, we have characterized the topogenic determinants encoded by Kv1.3 segments that me

10 locyte lysate system, we have identified two topogenic determinants encoded within the first (TM1) an

11 Here we characterize 12 topogenic determinants in the cystic fibrosis transmembr

12 Topogenic determinants that direct protein topology at t

13 The other three, H6-H8, did not have topogenic function in the native context and were transl

14 H9, indicating that here only H5 and H9 have topogenic function.

15 This topogenic importance of plakoglobin is now directly show

16 Cox2p C terminus by a mechanism dependent on topogenic information at least partially contained withi

17 This novel arrangement of topogenic information provides an alternative to convent

18 genous neuropeptides, viral fusion proteins, topogenic peptides, and amyloids.

19 In vitro analysis of the topogenic potential of the five remaining TM domains rev

20 We studied the topogenic properties of five hydrophobic segments (H5-H9

21 We conclude that the unique topogenic properties of TM8 direct the generation of mul

22 Here we examined the topogenic sequence requirements and mechanism of inserti

23 Topogenic sequences direct the membrane topology of prot

24 ssembly and suggest that a complex series of topogenic sequences directs this process.

25 polytopic membrane proteins is determined by topogenic sequences in the protein, protein-translocon i

26 explain the general behavior of hydrophobic topogenic sequences.

27 PTS2 nonapeptide and demonstrated that this topogenic signal is capable of directing heteromultimeri

28 ignal that is consistent with the degenerate topogenic signal targeting proteins to the glycosome, a

29 slated on free ribosomes, and mRNAs encoding topogenic signal-bearing proteins are translated on ER-b

30 Unexpectedly, the topogenic signal-encoding mRNA transcriptome was observe

31 distribution of cytosolic/nucleoplasmic and topogenic signal-encoding mRNAs, with mRNAs of both coho

32 associated mRNAs encoding both cytosolic and topogenic signal-encoding proteins display similar ribos

33 hierarchical system of intrinsic and encoded topogenic signals and identify mRNA cohort-restricted mo

34 anges correct for mismatches in the membrane topogenic signals between E. coli and eukaryotic cells g

35 topology either directly by interacting with topogenic signals of newly inserted proteins or indirect

36 ng are governed by structural principles and topogenic signals that are recognized and decoded by the

37 curring upon translation of proteins lacking topogenic signals.

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