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1 ant after treatment with camptothecin, a DNA topoisomerase I inhibitor.
2  its nonthreading counterparts and was not a topoisomerase I inhibitor.
3 t after treatment with topotecan, a specific topoisomerase I inhibitor.
4 s from apoptosis mediated by camptothecin, a topoisomerase I inhibitor.
5 nsitivity to camptothecin, an antineoplastic topoisomerase I inhibitor.
6 the design of future clinical trials of this topoisomerase I inhibitor.
7                      Moreover, they acted as topoisomerase I inhibitors.
8  myosin VI transcript were decreased only by topoisomerase I inhibitors.
9  as a strategy for enhancing the efficacy of topoisomerase I inhibitors.
10  AGT inhibitors or O6-alkylating agents with topoisomerase I inhibitors.
11  a novel class of cytotoxic non-camptothecin topoisomerase I inhibitors.
12 glucuronidation in de novo resistance to two topoisomerase I inhibitors.
13 checkpoint also enhanced the cytotoxicity of topoisomerase I inhibitors.
14                             We show that the topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1
15 RC stress response was also activated by the topoisomerase I inhibitor 7-ethyl-10-hydroxycamptothecin
16 ed prodrug irinotecan (CPT-11) to the potent topoisomerase I inhibitor 7-ethyl-10-hydroxycamptothecin
17            Time course experiments using the topoisomerase I inhibitor 9-amino-20(S)-camptothecin rev
18 e pancreatic growth factor gastrin), and the topoisomerase I inhibitor 9-nitrocamptothecin.
19 he previously synthesized indenoisoquinoline topoisomerase I inhibitors, a series of compounds lackin
20 circadian toxicity patterns of irinotecan, a topoisomerase I inhibitor active against colorectal canc
21 ]isoquinoline hydrochloride (14) is a strong topoisomerase I inhibitor and also displays very high cy
22 53-independent channel of cross-talk between topoisomerase I inhibitors and Apo2L/TRAIL and suggest t
23 rtical neurons from mice, we identify twelve topoisomerase I inhibitors and four topoisomerase II inh
24 ibitor of topoisomerase II), camptothecin (a topoisomerase I inhibitor), and ultraviolet radiation in
25                                          The topoisomerase I inhibitors are a unique class of chemoth
26                                              Topoisomerase I inhibitors are effective anticancer ther
27 s, which indicates that these two classes of topoisomerase I inhibitors are likely to target the canc
28 olar concentrations of camptothecin (CPT), a topoisomerase I inhibitor, arrest or delay cell cycle pr
29 hydrogen-bonding interactions in determining topoisomerase I inhibitor binding in the ternary cleavag
30 y, markedly enhanced the cytotoxicity of the topoisomerase I inhibitor camptothecin (CPT).
31 atment of HCT116 colon cancer cells with the topoisomerase I inhibitor camptothecin (CPT).
32                                 Although the topoisomerase I inhibitor camptothecin also activated AT
33 nd PRC2 exhibit synthetic sensitivity to the topoisomerase I inhibitor Camptothecin and accumulate ga
34               A selection protocol using the topoisomerase I inhibitor camptothecin facilitated isola
35 acilitate the cytotoxic effectiveness of the topoisomerase I inhibitor camptothecin in the killing of
36  HCT116 human carcinoma cells exposed to the topoisomerase I inhibitor camptothecin, the resulting ga
37 ries, Abbott Park, IL), and the DNA-damaging topoisomerase I inhibitor camptothecin-11 (CPT-11) or SN
38  we examined cells treated with the specific topoisomerase I inhibitor camptothecin.
39 rons undergo apoptosis when treated with the topoisomerase-I inhibitor camptothecin.
40 , we identified DC-stimulatory potentials of topoisomerase I inhibitors (camptothecin derivatives) an
41  various replication inhibitors, including a topoisomerase I inhibitor, camptothecin (CPT).
42 rylated within 1 h after addition of the DNA topoisomerase I inhibitor, camptothecin, and that lamin
43 I inhibitors, etoposide and doxorubicin, and topoisomerase I inhibitor, camptothecin.
44 ensitive PC3 cell line to treatment with the topoisomerase I inhibitor, camptothecin.
45                       When combined with the topoisomerase I inhibitor CPT-11 (irinotecan), Apo2L/TRA
46 osure to SN-38, the active metabolite of the topoisomerase I inhibitor, CPT-11.
47 l studies suggest that prolonged infusion of topoisomerase I inhibitors enhances cell toxicity due to
48                 The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activ
49            CPT-11 (Camptosar, irinotecan), a topoisomerase I inhibitor, has been shown to be highly e
50             Two series of indenoisoquinoline topoisomerase I inhibitors have been prepared to investi
51  to determine the antitumor activity of this topoisomerase I inhibitor in 53 patients with metastatic
52  plays a predominant role in the response to topoisomerase I inhibitors in carcinoma cells and identi
53 optotic factors may increase the efficacy of topoisomerase I inhibitors in the clinical setting if gi
54                        Camptothecin (CPT), a topoisomerase I inhibitor, induced significantly more ap
55  This system contains SN-38-a prodrug of the topoisomerase I inhibitor irinotecan.
56 ders tumor cells relatively resistant to the topoisomerase I inhibitor, irinotecan.
57 he biological activity of indenoisoquinoline topoisomerase I inhibitors is significantly enhanced by
58 a liposomal formulation of the water-soluble topoisomerase I inhibitor lurtotecan (GI147211), which d
59                                 Data for the topoisomerase I inhibitor, luteolin, are presented.
60 eath or apoptosis, we studied campothecin (a topoisomerase I inhibitor)-mediated apoptosis in the hum
61 tically sensitizes glioblastoma cells to DNA topoisomerase I inhibitor-mediated apoptosis.
62 tic effect on how glioblastoma cells process topoisomerase I inhibitor-mediated DNA damage.
63 ne, camptothecin-derived and indolocarbazole topoisomerase I inhibitors, methotrexate, flavopiridol,
64                           In comparison, the topoisomerase I inhibitors nitidine and coralyne exhibit
65 expression changes elicited by camptothecin (topoisomerase I inhibitor) or adriamycin (topoisomerase
66 HER2, a novel enzyme-cleavable linker, and a topoisomerase I inhibitor payload.
67  In vitro data indicate that the addition of topoisomerase I inhibitors shortly after irradiation cau
68                     Here we encapsulated the topoisomerase-I inhibitor SN-38 in polymeric nanoparticl
69 ncer drug, and it is a prodrug of the potent topoisomerase I inhibitor, SN-38 (7-ethyl-10-hydroxycamp
70 s activated by esterases to yield the potent topoisomerase I inhibitor, SN-38.
71 y carboxylesterases (CE) to yield the potent topoisomerase I inhibitor, SN-38.
72                                          The topoisomerase I inhibitor SN38 arrests cell cycle progre
73 t requires the p53 tumor suppressor, yet the topoisomerase I inhibitor SN38 induces p53 after the G(1
74  arrest and enhanced the cytotoxicity of the topoisomerase I inhibitor SN38 only in p53-defective cel
75 p synthesis of a series of clinically active topoisomerase I inhibitors such as NSC 314622, LMP-400,
76 ) mice are hypersensitive to camptothecin, a topoisomerase I inhibitor that causes DNA damage primari
77 anticancer agent camptothecin (CPT) is a DNA topoisomerase I inhibitor that causes fork collapse and
78                         Topotecan (TPT) is a topoisomerase I inhibitor that undergoes reversible, pH-
79 isoquinolines are a class of noncamptothecin topoisomerase I inhibitors that display significant cyto
80 indenoisoquinolines are a class of cytotoxic topoisomerase I inhibitors that offer certain advantages
81          Etirinotecan pegol is a long-acting topoisomerase-I inhibitor that prolongs exposure to, but
82 reported that combining (131)I-MIBG with the topoisomerase I inhibitor topotecan induced long-term DN
83 A damage induced by gamma-irradiation or the topoisomerase I inhibitor topotecan was used to induce G
84 r treatment with gamma-radiation or with the topoisomerase-I inhibitor topotecan.
85 f bcl-2 family members on the ability of the topoisomerase I inhibitor, topotecan (TPT), to induce pr
86 raction of a PARP inhibitor, ABT-888, with a topoisomerase I inhibitor, topotecan, in PBMCs, tumor, a
87 n the present studies, an indenoisoquinoline topoisomerase I inhibitor was conjugated to DUPA via a p
88                                 Topotecan, a topoisomerase I inhibitor, was evaluated in a multicente
89                               Topotecan is a topoisomerase I inhibitor with antitumor activity agains
90 ,2-c]isoquinolines are an important class of topoisomerase I inhibitors with anticancer activity.
91 an pegol (NKTR-102) is a unique, long-acting topoisomerase-I inhibitor with prolonged systemic exposu

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