ライフサイエンスコーパス: topotecan

1 etween cancer cell 'A549_LUNG' and compound 'Topotecan'.

2 roved camptothecin analogues (irinotecan and topotecan).

3 observed in patients receiving ABT-888 with topotecan.

4 n, and 26 patients were randomly assigned to topotecan.

5 ads to a greater proportion of intracellular topotecan.

6 stoma, as a single agent or with concomitant topotecan.

7 ed camptothecin (CPT) analogs irinotecan and topotecan.

8 chemotherapy including cyclophosphamide and topotecan.

9 f random assignment was 13% on BSC and 7% on topotecan.

10 s analog 7-cyanoquinocarcinol (DX-52-1), and topotecan.

11 e cytotoxic effect of the DNA-damaging agent Topotecan.

12 ) I in response to topo I inhibitors such as topotecan.

13 tion with cytarabine (ara-C), idarubicin, or topotecan.

14 gistic chemosensitisation to doxorubicin and topotecan.

15 The MTD was established as topotecan 0.6 mg/m(2)/d and ABT-888 10 mg BID on days on

16 weeks (CPT); cisplatin 50 mg/m(2) day 1 plus topotecan 0.75 mg/m(2) days 1 to 3 every 3 weeks (CT); o

17 IV cyclophosphamide 250 mg/m(2) followed by topotecan 0.75 mg/m(2) each day for 5 days every 21 days

18 on for SSOAI received melphalan (3-6 mg) and topotecan (0.5-1 mg; doses calculated by age and weight)

19 assigned window therapy (weeks 0 to 6) with topotecan (0.75 mg/m(2) daily x 5 every 21 days) immedia

20 clitaxel (175 mg/m(2) over 3 h on day 1) and topotecan (0.75 mg/m(2) for 30 min on days 1-3) with or

21 xel (135 mg/m(2) or 175 mg/m(2) on day 1) or topotecan (0.75 mg/m(2) on days 1-3) plus paclitaxel (17

22 y 5-day topotecan (2 mg/m(2)) or combination topotecan (0.75 mg/m(2)) and cyclophosphamide (250 mg/m(

23 ) by 5 minute IV infusion on days 1 to 3, or topotecan 1.0 mg/m(2) as an continuous IV infusion on da

24 scalation to the highest planned dose level (topotecan 1.25 mg/m(2), days 1 to 5; M6620 210 mg/m(2),

25 mg/m(2) intravenously (IV) on days 1 to 3 or topotecan 1.5 mg/m(2) IV on days 1 to 5.

26 otecan 2.3 mg/m2/d on days 1 through 5 or IV topotecan 1.5 mg/m2/d on days 1 through 5 every 21 days.

27 tients were randomly assigned to either oral topotecan 1.7 mg/m2/d x 5 with IV cisplatin 60 mg/m2 on

28 5, or 7.5 mg) in every case, with additional topotecan (1 mg) and/or carboplatin (30 or 50 mg) as nec

29 the study was reopened using lower doses of topotecan (1.0 mg/m(2) or 0.8 mg/m(2) for patients with

30 nfusion, days 1 through 3, every 21 days) or topotecan (1.5 mg/m(2)/d in a 30-minute IV infusion, day

31 Oral topotecan (1.8 mg/m(2)/d) on a qd x 5 x 2 schedule is we

32 at affect the HIF-1alpha pathways, including topotecan, 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazol

33 as 33.0 weeks for oral and 35.0 weeks for IV topotecan; 1- and 2-year survival rates were 32.6% and 1

34 The antitumor efficacy of topotecan, (131)I-MIBG, and (131)I-MIBG/topotecan combin

35 ors by convection-enhanced delivery (CED) of topotecan (136 mumol/L) for 1, 4, or 7 days, and then ch

36 9.1% had received liposomal doxorubicin, 25% topotecan, 15.9% both agents, and 47.7% had received thr

37 14 to 21 days; the next 33 patients received topotecan 2 mg/m(2)/d for 5 days IV every 21 days; a thi

38 were assigned to treatment with either oral topotecan 2.3 mg/m2/d on days 1 through 5 or IV topoteca

39 gimen) were randomly assigned to daily 5-day topotecan (2 mg/m(2)) or combination topotecan (0.75 mg/

40 al structures of norindenoisoquinoline 5 and topotecan (2) bound in the topoisomerase I-DNA covalent

41 s 13.9 weeks (95% CI, 11.1 to 18.6) and with topotecan, 25.9 weeks (95% CI, 18.3 to 31.6).

42 tory and randomly assigned to receive weekly topotecan 4 mg/m(2) intravenously (IV) with or without z

43 -deficient mice after an intravenous dose of topotecan (4 mg/kg).

44 resulted in a significantly higher ORR than topotecan (44% v 15%; P = .021).

45 e documented in 67% of children who received topotecan, 76% after topo-cyclo, and 25% after paclitaxe

46 Tdp1-/- mice treated with topotecan, a drug that increases levels of Top1-DNA comp

47 sorption and decreased systemic clearance of topotecan, a model substrate, indicating that additional

48 ATR inhibitor M6620 (previously VX-970) and topotecan, a selective TOP1 inhibitor, would be tolerabl

49 Topotecan, a soluble analog of CPT and FDA-approved anti

50 53 knockout counterpart after treatment with topotecan, a specific topoisomerase I inhibitor.

51 al extracellular fluid (ECF) accumulation of topotecan, a substrate of the ATP-binding cassette (ABC)

52 Here we find that topotecan, a topoisomerase 1 (TOP1) inhibitor, dose-depe

53 We have previously shown that topotecan, a topoisomerase I poison, inhibits hypoxia-in

54 arib), a PARP inhibitor, in combination with topotecan, a topoisomerase I-targeted agent, was carried

55 Topotecan, a topoisomerase inhibitor, killed both hair c

56 osage of NSC 19630 and the chemotherapy drug topotecan acted synergistically to inhibit cell prolifer

57 le of Ube3a in neurons, but the mechanism of topotecan action on the PWS/AS locus is unknown.

58 lly binding to the enzyme-substrate complex, Topotecan acts as an uncompetitive inhibitor.

59 sults demonstrate that the AS candidate drug topotecan acts predominantly through stabilizing R loops

60 Three treatment schedules were evaluated: topotecan administered 24 h before, 24 h after, or simul

61 Topotecan administered on a protracted schedule is activ

62 Concomitant topotecan administration did not influence melphalan pha

63 s no effect of the sequence of melphalan and topotecan administration in plasma pharmacokinetics.

64 Topotecan after cyclophosphamide is a combination that i

65 as higher with combination therapy than with topotecan alone in patients who had platinum-sensitive d

66 l lung cancer, which tends not to respond to topotecan alone.

67 dvantage compared with subjects treated with topotecan alone.

68 uality of life; however, only cisplatin plus topotecan also improved overall survival.

69 nation of zoledronic acid + cyclophosphamide/topotecan also significantly improved survival (P < 0.00

70 Topotecan also suppressed spontaneous network activity w

71 However, whether topotecan alters synaptic protein levels and synapse fun

72 dies also demonstrate promise for the use of topotecan and 2-deoxy-D-glucose in children.

73 cytotoxicity of the topoisomerase I poisons topotecan and camptothecin (CPT).

74 ingle-agent topotecan (TOPO) and combination topotecan and cyclophosphamide (TOPO/CTX) were compared

75 ABCG2 function was determined by measuring topotecan and doxorubicin efflux using flow cytometry, i

76 eloma cell lines increased after exposure to topotecan and doxorubicin, and was greater in logphase c

77 Topotecan and irinotecan are already in widespread use i

78 Topotecan and irinotecan are two CPTs that are approved

79 ced by anticancer camptothecins (CPTs) (e.g. topotecan and irinotecan) as well as structurally pertur

80 on induced by anticancer camptothecins (e.g. topotecan and irinotecan) as well as structurally pertur

81 Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (

82 tothecin (CPT) and its clinical derivatives, topotecan and irinotecan.

83 nalogues that are used clinically, including topotecan and irinotecan.

84 s are more sensitive to the topo I inhibitor topotecan and other anticancer agents such as VM-26 and

85 n vitro, only simultaneous administration of topotecan and PJ34 or PJ34 and (131)I-MIBG induced supra

86 tently reverses ABCG2-mediated resistance to topotecan and SN-38 and significantly increases accumula

87 rsing resistance to camptothecin derivatives topotecan and SN-38.

88 Combinations of topotecan and the PARP-1 inhibitor PJ34 were assessed fo

89 Topotecan and topo-cyclo are active in children with NB,

90 and protein expression after treatment with topotecan, and at relapse.

91 eated with VAC alternating with vincristine, topotecan, and cyclophosphamide (VAC/VTC).

92 C alone or VAC alternating with vincristine, topotecan, and cyclophosphamide.

93 In contrast, while cisplatin, topotecan, and gemcitabine each activated Chk1, RNAi-med

94 itors, such as the camptothecin derivatives, topotecan, and irinotecan, which are used to treat human

95 no effect on cell sensitivity to cisplatin, topotecan, and methotrexate.

96 drugs such as mitoxantrone, anthracyclines, topotecan, and SN-38.

97 ant to other Top1 inhibitors, including CPT, topotecan, and the indenoisoquinolines MJ-III-65 (NSC 70

98 ology Group conducted a study of paclitaxel, topotecan, and topotecan-cyclophosphamide (topo-cyclo) i

99 sensitize BRCA1-depleted cells to cisplatin, topotecan, and veliparib beyond the potent sensitization

100 Topotecan- and paclitaxel-resistant prostate cancer line

101 therapeutics derived from it, irinotecan and topotecan, are highly specific inhibitors of human nucle

102 deaths occurred in four patients (6%) in the topotecan arm.

103 emergent adverse events in the amrubicin and topotecan arms were: neutropenia (41% v 54%; P = .004),

104 Herein we describe the identification of topotecan as a novel inhibitor of global SUMOylation.

105 orresponding to the anatomic distribution of topotecan as predicted by MRI of a surrogate tracer.

106 the safety and efficacy of amrubicin versus topotecan as second-line treatment for SCLC.

107 n ORR of 44% compared with an ORR of 15% for topotecan as second-line treatment in patients with SCLC

108 a dose of 135 or 175 mg per square meter or topotecan at a dose of 0.75 mg per square meter on days

109 r low (0.1 microM)- and high (1 microM)-dose topotecan at multiple time points within the first 6 h o

110 e presence of camptothecin or its derivative topotecan, ATP (at up to 2 mM) inhibited PARP-1/NAD-faci

111 Target topotecan AUCs were achieved in 92 (72%) of the 127 meas

112 Purpose To evaluate topotecan-based therapy for advanced intraocular retinob

113 Topotecan blocked the IGF-I-stimulated increase in HIF-1

114 Gefitinib increased topotecan brain ECF penetration but decreased the ventri

115 In conclusion, topotecan brain ECF penetration was lower compared with

116 Eight patients received topotecan capsules during course 2 only.

117 l active transport of topotecan lactone over topotecan carboxylate was shown in vivo by vCSF lactone-

118 Concomitant with HIF-1alpha inhibition, topotecan caused a significant tumor growth inhibition a

119 To study the effect of gefitinib on topotecan CNS penetration, 200 mg/kg gefitinib was admin

120 lood-cerebrospinal fluid barriers to enhance topotecan CNS penetration.

121 The PJ34 and (131)I-MIBG/topotecan combination treatment induced G(2) arrest in a

122 y of topotecan, (131)I-MIBG, and (131)I-MIBG/topotecan combination treatment was increased by PARP-1

123 ash, and mucositis on the troxacitabine plus topotecan combination.

124 Conclusion Topotecan combined with vincristine, carboplatin, and ag

125 as similar with combined ziv-aflibercept and topotecan compared with topotecan in both strata.

126 ntiated neurons and show a reduced effect of topotecan compared with wild-type neurons.

127 ht, new injection site location, addition of topotecan, concomitant focal treatment, and time interva

128 Topotecan concomitantly downregulated expression of the

129 rebrospinal fluid barrier, resulting in high topotecan CSF penetration.

130 Mucositis rarely occurred after topotecan cycles (9.7%) in contrast to 30% after MSKCC c

131 ducted a study of paclitaxel, topotecan, and topotecan-cyclophosphamide (topo-cyclo) in newly diagnos

132 the efficacy and toxicity of carboplatin +/- topotecan delivered by ophthalmic artery chemosurgery wh

133 Oral topotecan demonstrates activity and tolerability similar

134 we report that in primary cortical neurons, topotecan depleted synaptic proteins that are encoded by

135 Topotecan did not alter the pharmacokinetics of ABT-888.

136 on topotecan tECF penetration and intratumor topotecan distribution.

137 The median topotecan dosage required to achieve the target AUC was

138 3 status) and the treatment effect (i.e., of topotecan dose and time of exposure).

139 ysis, neither increasing maximum carboplatin/topotecan dose nor cumulative carboplatin/topotecan dose

140 in/topotecan dose nor cumulative carboplatin/topotecan dose was associated with statistically signifi

141 Pharmacokinetically guided topotecan dosing (target systemic exposure with area und

142 ograft models in comparison with irinotecan, topotecan, doxorubicin, 5-FU, gemcitabine, docetaxel, ox

143 and in vivo, to further enhance (131)I-MIBG/topotecan efficacy.

144 h platinum and a taxane; these drugs include topotecan, etoposide, pegylated liposomal doxorubicin, e

145 The desired CSF topotecan exposure was achieved in seven of eight pharma

146 At equivalent plasma topotecan exposures, we found that P(tumor) after gefiti

147 A regimen combining melphalan and topotecan for SSOAI treatment of retinoblastoma is activ

148 ic inhibitors in combination with cisplatin, topotecan, gemcitabine, and the PARP inhibitor veliparib

149 ase I trial of the injectable formulation of topotecan given orally once daily for 5 days for 2 conse

150 val (primary end point) was prolonged in the topotecan group (log-rank P = .0104).

151 ocytopenia seemed to be more frequent in the topotecan group as compared with the amrubicin group (78

152 orse neutropenia and thrombocytopenia in the topotecan group as compared with the amrubicin group.

153 Myeloma patients treated with topotecan had an increase in ABCG2 mRNA and protein expr

154 Patients on topotecan had slower quality of life deterioration and g

155 DX-52-1 and topotecan have been previously established as HIF-1 inhi

156 months with amrubicin versus 7.8 months with topotecan (hazard ratio [HR], 0.880; P = .170); in refra

157 .1 months with amrubicin and 3.5 months with topotecan (HR, 0.802; P = .018).

158 esolution) in ternary complexes with DNA and topotecan (Hycamtin), a camptothecin analogue currently

159 microg in 0.04 mL of diluent) combined with topotecan hydrochloride (8-20 microg in 0.04 mL of balan

160 A well-known chemotherapeutic drug, topotecan hydrochloride, was used to investigate the eff

161 as administered orally 1 hour before 4 mg/kg topotecan i.v.

162 After 4 and 8 mg/kg topotecan i.v., the brain ECF to plasma AUC ratio of unb

163 I study tested the combination of M6620 and topotecan in 3-week cycles using 3 + 3 dose escalation.

164 werful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines.

165 ziv-aflibercept and topotecan compared with topotecan in both strata.

166 nhanced accumulation of the anticancer agent topotecan in brain tissue and cerebrospinal fluid (CSF).

167 ates activity and tolerability similar to IV topotecan in chemotherapy-sensitive SCLC patients and of

168 A phase II trial of IT topotecan in children with neoplastic meningitis is in p

169 s provide a compelling rationale for testing topotecan in clinical trials to target HIF-1 in cancer p

170 Varying schedules and doses of intravenous topotecan in combination with ABT-888 (10 mg) administer

171 ts received 66 cycles of SSOAI melphalan and topotecan in combination.

172 ation of combined intravitreal melphalan and topotecan in eyes not subsequently enucleated appears to

173 Inclusion of topotecan in front-line clinical trials for patients wit

174 ased the cell cycle and cytotoxic effects of topotecan in multiple cell line models.

175 The MTD and recommended phase II dose of IT topotecan in patients who are 3 years or older is 0.4 mg

176 omized, phase III study compared oral and IV topotecan in patients with SCLC sensitive to initial che

177 nd efficacy of single-agent amrubicin versus topotecan in patients with small-cell lung cancer (SCLC)

178 ucted to evaluate the activity and safety of topotecan in pediatric patients with recurrent Wilms' tu

179 ed superior levels of activity compared with topotecan in preclinical models.

180 ts were up- or down-regulated in response to topotecan in the p53+/+ cells, whereas only 1% of the tr

181 did not improve survival when compared with topotecan in the second-line treatment of patients with

182 odel, and compared favorably with CPT-11 and topotecan in the SKNEP anaplastic Wilms' tumor model.

183 rmined the volume of distribution of unbound topotecan in tumor (V(u,tumor)) and found that it was si

184 rugs (eg, pegylated liposomal doxorubicin or topotecan) in platinum-resistant ovarian cancer.

185 Both paclitaxel and topotecan, in combination with cisplatin, yielded superi

186 , ABT-888, with a topoisomerase I inhibitor, topotecan, in PBMCs, tumor, and CTCs.

187 31)I-MIBG with the topoisomerase I inhibitor topotecan induced long-term DNA damage and supraadditive

188 heduled combinations of PJ34 and (131)I-MIBG/topotecan induced supraadditive toxicity and increased D

189 plexes, phospho-H2AX and Rad51 suggests that topotecan-induced DNA double-strand breaks occur at site

190 Topotecan-induced topo I-DNA complexes peak at 15-30 min

191 57 carboplatin +/- topotecan infusions (of 111 total) were performed in 31

192 Carboplatin +/- topotecan infusions are effective for ophthalmic artery

193 Topotecan inhibited HIF-1 activity only at cytotoxic con

194 Here, we report that daily administration of topotecan inhibits HIF-1alpha protein expression in U251

195 esults suggest that Bcrp1 and P-gp transport topotecan into vCSF and out of brain parenchyma through

196 d, multicenter phase III study compared oral topotecan/intravenous cisplatin (TC) with intravenous (I

197 These drugs included topotecan, irinotecan, etoposide and dexrazoxane (ICRF-1

198 e combination of Nutlin-3a(OC) with systemic topotecan is a significantly better treatment for retino

199 Topotecan is a substrate of the ATP-binding cassette tra

200 Topotecan is a topoisomerase 1 (TOP1) inhibitor that is

201 Topotecan is active against neuroblastoma when it is adm

202 Topotecan is an active agent for the treatment of advanc

203 Topotecan is an effective agent against pediatric medull

204 Single-agent intravenous (IV) topotecan is an effective treatment for small-cell lung

205 Chemotherapy with oral topotecan is associated with prolongation of survival an

206 e evidence that inhibition of SUMOylation by topotecan is associated with reduced levels of CDK6 and

207 s were individualized to attain a single-day topotecan lactone area under the plasma concentration-ti

208 studies were conducted on day 1 to attain a topotecan lactone area under the plasma concentration-ti

209 nder the plasma concentration-time curve for topotecan lactone at this dosage was 20.9 +/- 8.4 ng/mL.

210 The brain ECF to plasma AUC ratio of unbound topotecan lactone increased by 1.6-fold to 0.35 +/- 0.04

211 Preferential active transport of topotecan lactone over topotecan carboxylate was shown i

212 the brain ECF to plasma AUC ratio of unbound topotecan lactone was 0.21 +/- 0.04 and 0.61 +/- 0.16, r

213 Topotecan lactone was below detectable limits in the ECF

214 vCSF penetration of unbound topotecan lactone was measured as the ratio of vCSF-to-p

215 These agents include gemcitabine, topotecan, liposomal doxorubicin, and prolonged oral eto

216 h oral topotecan (n = 153) and 21.9% with IV topotecan (n = 151), with a difference (oral -IV) of -3.

217 nalysis, response rates were 18.3% with oral topotecan (n = 153) and 21.9% with IV topotecan (n = 151

218 coadminister ABT-888 with standard doses of topotecan, necessitating dose reductions.

219 BCRP substrates include numerous drugs (topotecan, nitrofurantoin, cimetidine) as well as food c

220 ORR was 31.1% with amrubicin and 16.9% with topotecan (odds ratio, 2.223; P < .001).

221 e tested the effects of locally administered topotecan on a rat model of glioblastoma that is induced

222 and significantly increases accumulation of topotecan only in cells expressing functional ABCG2.

223 stoma patients whom received carboplatin +/- topotecan ophthalmic artery chemosurgery.

224 during, or within 3 months of discontinuing, topotecan or liposomal doxorubicin.

225 eloped grade 3 to 4 marrow suppression after topotecan or topo-cyclo.

226 toma receiving 630 intravitreous (melphalan, topotecan) or topotecan periocular injections.

227 oisomerase (Topo) I inhibitor (camptothecin, topotecan, or SN-38) and tumor necrosis factor-related a

228 h to characterize the effect of gefitinib on topotecan P(tumor).

229 mbining bevacizumab/A4.6.1 with doxorubicin, topotecan, paclitaxel, docetaxel, or radiotherapy result

230 Topotecan-paclitaxel was not superior to cisplatin-pacli

231 liposomal doxorubicin, weekly paclitaxel, or topotecan), patients were randomly assigned to single-ag

232 We found that topotecan penetration (P(tumor)) of U87 was 0.96 +/- 0.2

233 e effect of modulating these transporters on topotecan penetration in gliomas has not been thoroughly

234 This study focused on topotecan penetration into the brain extracellular fluid

235 To define the role of these transporters in topotecan penetration into the ventricular cerebrospinal

236 630 intravitreous (melphalan, topotecan) or topotecan periocular injections.

237 en of eight pharmacokinetic studies when the topotecan plasma AUC was within target range.

238 ments in progression-free survival, but only topotecan plus cisplatin has demonstrated an improvement

239 astine, doxorubicin, and cisplatin (MVAC) or topotecan plus cisplatin in advanced cervix cancer, we u

240 The maximum dose of topotecan plus M6620 is tolerable.

241 onths) received chemotherapy: two courses of topotecan plus vincristine followed by three alternating

242 boplatin and vincristine for two courses and topotecan plus vincristine for one course, with optional

243 al administration of melphalan combined with topotecan produced complete control of vitreous seeds in

244 ntiate responses to the clinically used drug topotecan, producing a more than 9-fold suppression of c

245 nt to enhance antiproliferative responses to topotecan, producing a significant survival advantage co

246 nrolled and received a total of 94 cycles of topotecan (range, one to six cycles).

247 We recently found that topotecan reduces the expression of multiple long genes,

248 DDR evoked by the topoisomerase I poison topotecan remained unaffected by lovastatin.

249 The topotecan resistance of cells overexpressing Mrp4 and th

250 survival rates were 32.6% and 12.4% for oral topotecan, respectively, and 29.2% and 7.1% for IV topot

251 amrubicin and 3.3 months and 7.6 months with topotecan, respectively.

252 can, respectively, and 29.2% and 7.1% for IV topotecan, respectively.

253 somerase, DNA, and the chemotherapeutic drug topotecan show important differences in the mechanisms f

254 neous administration of PJ34 and (131)I-MIBG/topotecan significantly delayed the growth of SK-N-BE(2c

255 vealed that two of the six, flubendazole and topotecan, significantly suppress hair cell regeneration

256 Topotecan strongly suppressed inhibitory neurotransmissi

257 On the basis of topotecan systemic clearance, doses were individualized

258 Targeted topotecan systemic exposure was achieved in 26 (84%) of

259 ) penetration and the effect of gefitinib on topotecan tECF penetration and intratumor topotecan dist

260 perienced disease progression during initial topotecan therapy.

261 (P = .002 and P = .018, respectively) after topotecan therapy.

262 VW/NAT xenografts, compared with (131)I-MIBG/topotecan therapy.

263 nsporting the 9-dimethylaminomethyl group of topotecan to the 10-position of the norindenoisoquinolin

264 tential strategy to increase the efficacy of topotecan to treat central nervous system (CNS) malignan

265 Single-agent topotecan (TOPO) and combination topotecan and cyclophos

266 mal release kinetics of the anticancer agent topotecan (TPT) in physiological fluids and subsequently

267 Topotecan (TPT) is a topoisomerase I inhibitor that unde

268 We demonstrate that in addition to topotecan (TPT), a known inhibitor of HIF-1alpha, UVC, b

269 wn previously that the camptothecin analogue topotecan (TPT), a topoisomerase I (Top 1) poison, inhib

270 h ISG15 expression that is comparable to the topotecan (TPT)-sensitive NSCLC cell lines was found in

271 eveloped a method to efficiently encapsulate topotecan (TPT, 1), an important cytotoxic drug, in biod

272 r resistance protein 1 (Bcrp1), an efficient topotecan transporter, was detected at the apical aspect

273 Topotecan treatment reduced GFP(+) cells about 10-fold a

274 Here, we demonstrate that topotecan treatment stabilizes the formation of RNA:DNA

275 ons for at least 12 weeks after cessation of topotecan treatment, indicating that transient topoisome

276 th was observed with combination miR-34a and topotecan treatment.

277 c human gliomas (U87 and MT330) and assessed topotecan tumor ECF (tECF) penetration and the effect of

278 When administered in vivo, topotecan unsilenced the paternal Ube3a allele in severa

279 These results indicate that topotecan unsilences Ube3a in cis by reducing transcript

280 At nanomolar concentrations, topotecan upregulated catalytically active UBE3A in neur

281 , vincristine, and etoposide with or without topotecan, vincristine, and doxorubicin) and achieved an

282 Response to topotecan was 7% partial and 44% stable disease.

283 says, ABCG2-mediated resistance to SN-38 and topotecan was abrogated in ABCG2-transfected HEK-293 cel

284 Topotecan was administered at 1.5 mg/m(2) (or 1.2 mg/m(2

285 In this prospective phase II trial, topotecan was administered intravenously daily for 5 day

286 Topotecan was administered intravenously over 30 minutes

287 Further studies demonstrated that topotecan was an Mrp4 substrate and that cells overexpre

288 oxicity in patients who received oral and IV topotecan was as follows: neutropenia in 47% and 64%, th

289 A phase I trial of intrathecal (IT) topotecan was performed to determine the optimal dose, t

290 ater-mediated contact between the enzyme and topotecan, we were surprised to find that a well-ordered

291 n of the chemotherapy backbone (single-agent topotecan, weekly paclitaxel, or gemcitabine), patients

292 and (131)I-MIBG and of PJ34 and (131)I-MIBG/topotecan were also assessed using similar scheduling.

293 ry properties of miR-34a in combination with topotecan were determined by cell growth assay.

294 Principal toxicities with topotecan were hematological: grade 4 neutropenia, 33%;

295 substrates of ABCG2 such as mitoxantrone or topotecan were not identified, we characterized three no

296 stingly, topoisomerase inhibitors, including topotecan, were recently identified in an unbiased drug

297 The topotecan window consisted of two cycles, administered i

298 Comparing topotecan with BSC, infection grade 2 was 14% versus 12%

299 Oral topotecan with cisplatin provides similar efficacy and t

300 cribe a randomized, phase II trial of weekly topotecan with or without ziv-aflibercept (VEGF-trap) in