ライフサイエンスコーパス: torpor

1 genous torpor-producing signals and initiate torpor.

2 t would appear to preclude multiday bouts of torpor.

3 ys important roles in the timing of bouts of torpor.

4 apid reperfusion upon periodic arousals from torpor.

5 lized or that transcription continues during torpor.

6 icating that translation is depressed during torpor.

7 e and leptin in the regulation of entry into torpor.

8 all-sized species that can more easily enter torpor.

9 ower, similarly to that occurring in natural torpor.

10 ndition of regulated hypometabolism known as torpor.

11 important role in adaptive thermogenesis and torpor.

12 ction in metabolic regulation for entry into torpor.

13 nown, although the CNS is a key regulator of torpor.

14 se torpor, inducing a state called synthetic torpor.

15 por was similar to spontaneous entrance into torpor.

16 ophylline reversed spontaneous entrance into torpor.

17 MSX-3 failed to reverse spontaneous onset of torpor.

18 n and core body temperature as indicators of torpor.

19 ed regulation of metabolism and sleep during torpor.

20 nsitizes mice to a hibernation-like state of torpor.

21 al nervous system remains active during deep torpor.

22 asticity in the ground squirrel brain during torpor.

23 such as leptin, influence the expression of torpor [4-7].

24 Torpor, a controlled rapid drop in metabolic rate and bo

25 izer, the suprachiasmatic nucleus, abolishes torpor, a hibernation-like state, implicating the circad

26 thetic nervous system (SNS) in mediating the torpor adaptation to fasting by telemetrically monitorin

27 tivity at beta3-AR-containing tissues in the torpor adaptation to limited energy availability and coo

28 dily reduced serum leptin levels and entered torpor after a fast in a cool environment.

29 ostaglandin D2 synthase declined during late torpor and arousal but returned to a high level on retur

30 During hibernation, animals cycle between torpor and arousal.

31 (TLS; S. tridecemlineatus) during prolonged torpor and in squirrels that did not hibernate or had no

32 Synthetic 5'-AMP induced torpor and mClps expression in LD animals.

33 ipid oxidation nearly exclusively fuels deep torpor and most of the rewarming process.

34 c-Jun, but not junD, commencing during late torpor and peaking during the arousal phase of individua

35 Despite cerebral ischemia during torpor and rapid reperfusion during arousal, hibernator

36 Incidences of torpor and reduced body temperature were observed in the

37 s identify hypothalamic circuits involved in torpor and reveal GPR50 to be a novel component of adapt

38 etermine the synaptic changes that accompany torpor and to investigate the mechanisms behind these ch

39 significantly reduced following arousal from torpor and undetectable in mRNA obtained from summer gro

40 ut and early and late following arousal from torpor) and from active ground squirrels sacrificed in t

41 Both hibernation, also called multiday torpor, and daily torpor are common among mammals and oc

42 d animation-like states such as hibernation, torpor, and estivation.

43 ds can affect the depth and duration of deep torpor, and saturated fatty acids may be preferentially

44 A(3)AR agonist 2-Cl-IB MECA failed to induce torpor, and the A(2a)R antagonist MSX-3 failed to revers

45 tion, also called multiday torpor, and daily torpor are common among mammals and occur in at least 11

46 ughout the hibernation season, bouts of deep torpor are punctuated by periodic arousals in which brow

47 Hibernation and short daily torpor are states of energy conservation with reduced me

48 Our results demonstrate that altered torpor-arousal cycles underlie mortality from WNS and pr

49 reorganization on return to euthermy during torpor-arousal cycles.

50 varied metabolic activity across annual and torpor-arousal cycles.

51 control squirrels were more likely to enter torpor at night and to arouse during the day in the pres

52 ostructure from animals at several stages of torpor at two different ambient temperatures, and during

53 hibernation states (early and late during a torpor bout and early and late following arousal from to

54 During torpor bouts in which T(b) rhythms were unaffected by T(

55 In this latter bat, we documented 5 torpor bouts that lasted >/=16 days and a flightless per

56 ontrol squirrels; the duration of individual torpor bouts was 2 days shorter and far more variable in

57 showing the interruption of low-temperature torpor bouts with periodic interbout arousals (IBAs).

58 son and the temporal structure of individual torpor bouts.

59 heterothermy - wherein they exploit episodic torpor bouts.

60 res and food restriction induce hypothermic (torpor) bouts and characteristic metabolic and sleep cha

61 rine concentrating ability diminished during torpor but returned during IBA.

62 ystem is robust in animals that show shallow torpor, but its activity in hibernators is at least damp

63 n lesser bushbaby, which is capable of daily torpor, but uses it only under extremely adverse conditi

64 se Tissue (BAT) drives periodic arousal from torpor by generating essential heat.

65 During torpor, c-fos expression in the cortex was suppressed wh

66 ating ground squirrels retract on entry into torpor, change little over the course of several days, a

67 Some SCNx squirrels cycled through bouts of torpor continuously for nearly 2 years.

68 es of animals can drop during hibernation or torpor covering a large range of temperatures.

69 to replacement of gene products lost during torpor due to degradation of mRNA.

70 e increase in the frequency of arousals from torpor during hibernation, and were emaciated after 3-4

71 esis is that they spend too much time out of torpor during hibernation, depleting vital fat reserves

72 , naturally undergoing photoperiod-dependent torpor during winter-like photoperiods.

73 patic inflammation, increased mortality, and torpor, findings which were attributed to impaired PPARa

74 d squirrel, endure severe hypothermia during torpor followed by periodic rewarming (REW) during inter

75 irrel (GS) cycles through repeated CI during torpor, followed by warm ischemia/reperfusion (WI) durin

76 ateral septum also distinguished 2DG-induced torpor from other 2DG-induced behaviors.

77 ere is a peculiar situation, because to date torpor has been almost exclusively reported for Malagasy

78 However, the impact that prolonged torpor has on cognitive function is poorly understood.

79 To date, signaling pathways required for torpor have not been identified.

80 neither leptin nor thyroid hormone prevented torpor in A-ZIP/F-1 mice.

81 ol oxalate] severely blunted fasting-induced torpor in control mice, whereas other AR antagonists wer

82 Torpor in hibernating mammals defines the nadir in mamma

83 chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice.

84 here are at least two signals for entry into torpor in mice, a low leptin level and another signal th

85 ild-type mice, Gpr50(-/-) mice readily enter torpor in response to fasting and 2-deoxyglucose adminis

86 urnal rhythms of entry into and arousal from torpor in SCNx animals held under a light/dark cycle, an

87 onist N(6)-cyclohexyladenosine (CHA) induced torpor in six of six AGSs tested during the mid-hibernat

88 uced responses was absent during 2DG-induced torpor in the present experiment.

89 s), a species that naturally undergoes daily torpor in which Tb decreases by as much as 15-20 degrees

90 uspended animation state, resembling natural torpor, in a nonhibernator.

91 Torpor induced by metabolic stress was associated with e

92 enditure in species that do not normally use torpor, inducing a state called synthetic torpor.

93 eep deprivation, however, show that the post-torpor intense sleep is not homeostatically regulated, b

94 Torpor is a short-term hibernation-like state that allow

95 The hypometabolic state of torpor is a widely utilized and well-orchestrated respon

96 Long-term torpor is an adaptive strategy that allows animals to su

97 The view that torpor is an evolutionary extension of sleep is supporte

98 Entry into torpor is associated with a 50-65% loss of synapses, as

99 p immediately following torpor suggests that torpor is functionally a period of sleep deprivation.

100 otein clustering occurring during entry into torpor is not attributable to protein loss.

101 e primary determinants of arousal state, and torpor is the most extreme state change that occurs in m

102 orthern Vietnam during winter indeed undergo torpor lasting up to 63 h, that is, hibernation.

103 2-deoxy-d-glucose (2DG) produces pronounced torpor-like hypothermia (not< approximately 15 degrees C

104 tructures activated during the initiation of torpor-like hypothermia induced by 2DG treatment.

105 dings demonstrate that a deeply hypothermic, torpor-like state can be pharmacologically induced in a

106 cyclohexyladenosine to induce a hypothermic, torpor-like state in the (nonhibernating) rat.

107 erature, central A1AR stimulation produced a torpor-like state similar to that in hibernating species

108 ally suppress energy expenditure and enter a torpor-like state; this behavior is markedly enhanced in

109 ng rodent torpor provides insight into human torpor-like states such as near drowning in cold water a

110 sts that the processes involved in prolonged torpor may have a fundamentally different impact on memo

111 cle, these SCNx squirrels expressed bouts of torpor nearly continuously throughout 2.5 yr of cold exp

112 Neither the incidence of torpor nor its depth or duration was related to NPY dose

113 k cycle, whereas entry into and arousal from torpor occurred at random clock times in both SCNx and c

114 as the arctic ground squirrel (AGS), display torpor only during the winter, hibernation season.

115 sults show that metabolic suppression during torpor onset is regulated within the CNS via A(1)AR acti

116 he mechanism of metabolic suppression during torpor onset is unknown, although the CNS is a key regul

117 ed in a programmed manner by undergoing deep torpor or hibernation during which the hypothalamic setp

118 A cohort of transcripts increased during torpor, paradoxical because transcription effectively ce

119 rnators are defined by body temperature, not torpor per se.

120 During torpor, physiological processes such as respiration, car

121 c systems that normally integrate endogenous torpor-producing signals and initiate torpor.

122 Studying rodent torpor provides insight into human torpor-like states su

123 t differences in extent of retraction during torpor, recovery reaches the same final values of cell b

124 We show torpor-related alterations in synaptic protein localizat

125 These findings suggest that torpor-related changes in synapses stem from dissociatio

126 sed, yet the neural mechanisms that regulate torpor remain unclear [3].

127 lowered serum leptin levels and rescued the torpor response.

128 e of the CNS in the induction of hibernation/torpor, since CNS-driven changes in organ physiology hav

129 Recent studies that employ post-torpor sleep deprivation, however, show that the post-to

130 nimals from the fall; these fall animals use torpor sporadically with body temperatures mirroring amb

131 no decline in total RNA or total mRNA during torpor; such a decline had been previously hypothesized.

132 Poly(A) tail lengths were not altered during torpor, suggesting either that mRNA is stabilized or tha

133 Deep sleep immediately following torpor suggests that torpor is functionally a period of

134 sufficient to reach the criterion for daily torpor (Tb < 32 degrees C for at least 30 min).

135 Throughout torpor the suprachiasmatic nucleus ('biological clock')

136 erated in the animals reaching criterion for torpor; the decrease in food intake was positively corre

137 mmalian hibernators periodically rewarm from torpor to high, euthermic body temperatures for brief in

138 me mammals employ bouts of deep hypothermia (torpor) to cope with reduced food supply and harsh clima

139 s that influence the expression of sleep and torpor uncover significant differences.

140 mice failed to reduce serum leptin and enter torpor under fasting conditions, whereas restoration of

141 o record sub-hourly patterns of activity and torpor use, in one case over a period of 224 days that s

142 Interestingly, during torpor very strong c-fos activation was seen in the epit

143 In ob/ob mice, fasting-induced torpor was completely reversed by leptin treatment.

144 Torpor was expressed in fasted Dbh-/- mice immediately a

145 CHA-induced torpor was similar to spontaneous entrance into torpor.

146 During entrance into torpor, we detected activation of the ventrolateral subd

147 mals, some low-amplitude T(b) rhythms during torpor were driven by small (<0.1 degrees C) diurnal cha

148 -ZIP/F-1 (but not control) mice entered deep torpor, with a minimum core body temperature of 24 degre

149 exhibit a dramatic form of plasticity during torpor, with dendritic arbors retracting as body tempera

150 CHA-induced torpor within the hibernation season was specific to A(1

151 After the induction of arousal from torpor, within 2 h, the apical dendritic lengths, branch

152 suspended animation state similar to natural torpor would be greatly beneficial in medical science, s