ライフサイエンスコーパス: total body

1 T genotype and T allele carriers had greater total body (4.8% and 4.1%) and total appendicular lean m

2 this question, we tested FGF21 in mice with total body ablation of KLB (KLBKO) and found no detectab

3 entrated in the tumor (10.5% +/- 1.3% of the total-body activity; average concentration, 30.1% +/- 4.

4 In PEDF knockout (KO) mice, total body adiposity was increased by >50% compared with

5 t in women, this relation was independent of total body adiposity.

6 We examined the associations of total body and abdominal fat measures with respiratory r

7 Increased total body and fat mass, as well as obesity-associated m

8 Total body and hip BMC and BMD decreased over time (P </

9 ent from a markedly lower weight gain, lower total body and liver fat accumulation, better glucose to

10 Intrasubject differences in the total body and subcompartmental volumes (ST, fat, lung,

11 and quality, overall physical function, and total body and thigh compositions.

12 The absorbed doses to total body and tumors obtained when including these late

13 A ratio was associated with higher childhood total-body and abdominal fat mass.

14 Total-body and focused in vivo tumor SPECT was performed

15 tom analysis protocols were used to quantify total body area and spontaneous activity in live embryos

16 Outcomes were self-reported SSE of the total body as well as easy-to-see and difficult-to-see r

17 erin deficiency may allow for an increase in total body BH4 content.

18 regnancy was associated with lower offspring total body BMC (beta = -0.10 SD/SD; 95% CI: -0.19, -0.02

19 late pregnancy were associated with greater total body BMC (beta = 0.12 SD/SD; 95% CI: 0.02, 0.21; P

20 ently higher" trajectory had 3.2-3.4% higher total body BMC and BMD than those who were in the "consi

21 17, and 20 y was positively associated with total-body BMC and BMD at age 20 y [covariate-adjusted i

22 alcin at 12 months correlated with change in total body BMD (r = 0.35, P = .02).

23 e was a greater increase in femoral neck and total body BMD and bone mineral content (BMC) in the WM

24 Ovariectomy (ovx) reduced the total body BMD and the trabecular bone mass to the same

25 BMD (total body BMD as well as subtotal BMD and BMD of the ex

26 ect on total hip (TH), femoral neck (FN), or total body BMD or bone biomarkers.

27 not significantly associated with lumbar and total-body BMD.

28 We measured childhood total body bone mass by using dual-energy X-ray absorpti

29 Offspring total body bone mineral density (BMD), bone mineral cont

30 Obl-Wnt16 mice displayed increased total body bone mineral density (BMD), surprisingly caus

31 supplementation resulted in greater gains in total-body bone mass than did placebo.

32 The total-body bone mineral content (TBBMC), total-body bone

33 me measures assessed every 6 mo included the total-body bone mineral content and density, cortical an

34 The total-body bone mineral content (TBBMC), total-body bone mineral density (TBBMD), spine bone mine

35 Thus, diet accounted for nearly all of the total body burden of Cs in these animals.

36 ccumulation of lipophilic POPs will increase total body burden.

37 ut this accounted for only 1.2-2.5% of their total body burden.

38 A similar effect was seen in total-body CD36-knockout mice.

39 pha, scap, and cck) concomitantly decreasing total body cholesterol and triglyceride content and incr

40 nt Half-life (11.7 +/- 4.2 hours), estimated total body clearance (0.39 +/- 0.27 L/h), or fluctuation

41 Polymyxin B total body clearance did not show any relationship with

42 Estimated total body clearance normalized by dose and weight was l

43 Even with very diverse demographics, the total body clearance of polymyxin B when scaled by total

44 Although the total body content is low ( approximately 100 mg), dysfu

45 The mean total-body dose was 0.011 +/- 0.011 mGy/MBq, and the eff

46 ea, and BMC were estimated with the use of a total body dual-energy X-ray absorptiometry scan at 20 y

47 LBM was measured by total-body dual-energy x-ray absorptiometry at study bas

48 tion in AHI correlated with the reduction in total body ECFV (r = 0.567; P = 0.027) and was associate

49 able; it consumes an outstanding 20% of the total body energy budget despite representing only 2% of

50 EFA uptake per BAT volume and an increase in total body energy expenditure did not differ in patients

51 Total-body examination yielded a higher absolute number

52 Accidental or therapeutic total body exposure to ionizing radiation has profound p

53 ht polysomnography along with measurement of total body extracellular fluid volume (ECFV), and ECFV o

54 ed vs nonexposed subjects exhibited a higher total body fat (by approximately 1.7 kg; P = .009) and f

55 cents with NAFLD also had a higher amount of total body fat (p < 0.001) and subcutaneous fat (p < 0.0

56 chronically obese sheep demonstrated greater total body fat (p < 0.001); LA volume (p < 0.001); LA pr

57 x-ray absorptiometry scans for estimation of total body fat (TBF) and lean body mass (LBM) (n = 10,52

58 with significant attenuation of the rate of total body fat accumulation, along with a decrease in he

59 Total body fat and regional fat mass percentages of the

60 c, resistance, and combined training reduced total body fat and waist circumference in obese adolesce

61 hropometric measurements, blood pressure and total body fat distribution] of these adolescents were c

62 neurodevelopment, and limit the increase in total body fat during the first 6 mo.

63 n NOER mice) and effects on liver weight and total body fat mass being essentially independent of mER

64 ring euglycemic clamp was increased, whereas total body fat mass, VAT, SSAT, and hemoglobin A1c were

65 = 1.58, 95%CI: 1.31-1.91; Ptrend < 0.0001), total body fat percentage (HR = 1.27, 95%CI: 1.06-1.53;

66 aist-to-hip ratio) and body fat composition (total body fat percentage and trunk fat percentage) meas

67 After 6 mo, total body fat, interleukin IL-6, and hepcidin were sign

68 Total body fat, measured from dual energy x-ray absorpti

69 /m(2) was 26% sensitive and 97% specific for total body fat-defined obesity.

70 Total body fat-free mass (175 +/- 96 vs 84 +/- 71, P < 0

71 ary sample, is independently associated with total body fat.

72 fter additional adjustments for visceral and total body fat.

73 acid, were associated with a lower childhood total-body fat percentage and a lower android:gynoid fat

74 cid, were associated with a higher childhood total-body fat percentage, android:gynoid fat mass ratio

75 arly with intrinsic body-level noise via the total body-goal sensitivity, a new derived quantity that

76 BMDs for total body, hip, and spine were measured at baseline and

77 In the Total Body Hypothermia for Neonatal Encephalopathy Trial

78 Total Body hypothermia plus Xenon (TOBY-Xe) was a proof-

79 can be increased by a factor of about 40 for total-body imaging or a factor of about 4-5 for imaging

80 Total body iron (TBI) that is calculated from ferritin a

81 n), soluble transferrin receptor (sTfR), and total body iron (TBI) were summarized in relation to inf

82 ron status assessment in NHANES has used the total body iron stores (TBI) model, in which the log rat

83 e transferrin receptor (sTfR), and estimated total body iron.After treatment, both the iron-supplemen

84 Serum ferritin and total-body iron decreased more after RYGBP than after SG

85 Total-body iron stores (TBI), which are calculated from

86 ludarabine and targeted busulfan (n = 25) or total body irradiation (>/=12 Gy; n = 18).

87 Eight recipient dogs received total body irradiation (4.5 cGy), hematopoietic cell tra

88 Cyclophosphamide combined with total body irradiation (Cy/TBI) or busulfan (BuCy) are t

89 nditioning regimens of cyclophosphamide plus total body irradiation (CY/TBI), busulfan plus cyclophos

90 D154 (MR1) and rapamycin (Rapa) plus 100 cGy total body irradiation (MR1/Rapa/100 cGy) and transplant

91 male sexual function domains declined after total body irradiation (P < .05).

92 ence indicates that the addition of low-dose total body irradiation (TBI) (2-4 Gy) to reduced intensi

93 ed: (1) myeloablative conditioning (MA) with total body irradiation (TBI) + PBSCs, (2) MA + TBI + BM,

94 re we use bone marrow transplantation (BMT), total body irradiation (TBI) and abdominal irradiation (

95 Lymphodepletion using total body irradiation (TBI) and administering high-dose

96 man urine data sets from patients undergoing total body irradiation (TBI) and from a colorectal cance

97 ) cell recovery in rhesus macaques following total body irradiation (TBI) and reinfusion of vector-tr

98 onmyeloablative chemotherapy with or without total body irradiation (TBI) before adoptive T-cell tran

99 anti-CD45 radioimmunotherapy (RIT) replacing total body irradiation (TBI) before haploidentical HCT i

100 Total body irradiation (TBI) damages hematopoietic cells

101 BMT, rats were treated with varying doses of total body irradiation (TBI) followed by transplantation

102 not been compared with cyclophosphamide plus total body irradiation (TBI) in adults with advanced ref

103 rs of 2 articles have compared busulfan with total body irradiation (TBI) in preparative regimens for

104 ood, Shao et al report that a side effect of total body irradiation (TBI) is long-term bone marrow in

105 Fractionated, high-dose total body irradiation (TBI) is used therapeutically to

106 inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to mori

107 Addition and intensification of total body irradiation (TBI) to the preparative lymphode

108 e NSG host environment using preconditioning total body irradiation (TBI) was indispensable for effic

109 of fludarabine, anti-thymocyte globulin, and total body irradiation (TBI) would enable reduction of t

110 eived cyclophosphamide (CY), single fraction total body irradiation (TBI), and antithymocyte globulin

111 ty conditioning (RIC) consisting of low-dose total body irradiation (TBI), cyclophosphamide, and flud

112 is upregulated during lymphopenia induced by total body irradiation (TBI), cyclophosphamide, or Thy1

113 f the endosteal osteoblastic HSC niche after total body irradiation (TBI), defined as relocalization

114 ive intravenous busulfan (IV-BU) vs ablative total body irradiation (TBI)-based regimens in myeloid m

115 way as a new mechanism for the mitigation of total body irradiation (TBI)-induced mortality.

116 sphamide of 60 mg/kg per day for 2 days, and total body irradiation (TBI).

117 recovery in the blood and bone marrow after total body irradiation (TBI).

118 Our results show that total body irradiation alters intracellular signaling an

119 ient Tregs after a conditioning regimen with total body irradiation and led to a TGF-beta-dependent i

120 of pretransplant T cell depletion, low-dose total body irradiation and posttransplant (donor) bone m

121 Total body irradiation and radiation proctitis were moni

122 r nonmyeloablative (3 Gy) and minimal (1 Gy) total body irradiation and treatment with costimulation

123 e marrow (BM) cells or through myeloablative total body irradiation conditioning and reconstitution w

124 ll transplantation with cyclophosphamide and total body irradiation develop wide-spectrum manifestati

125 erance, significantly decreasing the minimum total body irradiation dose required.

126 ry of young BM ECs along with HSCs following total body irradiation improved HSC engraftment and enha

127 experimental and clinical scenarios in which total body irradiation is involved.

128 yclophosphamide associated with fractionated total body irradiation or busulfan.

129 sk for osteoporosis and bone fractures after total body irradiation preconditioning.

130 depletion with CD3-immunotoxin, and 100 cGy total body irradiation prior to hematopoietic cell trans

131 Total body irradiation reduced numbers of proliferating

132 r without T-cell lymphodepletion reduced the total body irradiation requirement to 100 cGy for establ

133 Mice subjected to total body irradiation showed alterations in glucose met

134 or-bearing mice with DMA 2 hours before 8 Gy total body irradiation showed an impressive rescue of ra

135 le protected rodents against lethal doses of total body irradiation up to 13 Gy, whether DIM dosing w

136 demia (RR = 3.2, P < .01); conditioning with total body irradiation was associated with an increased

137 e-unit transplantation in patients receiving total body irradiation without antithymocyte globulin (A

138 We found that total body irradiation, a conditioning regimen required

139 ere hypoplastic and more apoptotic 24 h post-total body irradiation, a time when stem cell survival i

140 smoking history, conditioning with high-dose total body irradiation, and an absolute lymphocyte count

141 receptor and anti-CD8 monoclonal antibodies, total body irradiation, cyclosporine A and mycophenolate

142 Upon total body irradiation, medullary complexity was partial

143 nti-FVIII immune response, and together with total body irradiation, suppresses anti-FVIII immune res

144 th severe thrombocytopenia induced by 6.5 Gy total body irradiation, thereby markedly abridging the d

145 eted PBSC grafts following conditioning with total body irradiation, thiotepa, and fludarabine.

146 s the antileukemic benefits of myeloablative total body irradiation-based conditioning and unrelated

147 cantly higher rate of DC was associated with total body irradiation-based conditioning and with acute

148 blastic leukemia 10) were conditioned with a total body irradiation-based regimen.

149 Total body irradiation-containing preparative regimen wa

150 iation-induced gastrointestinal syndrome and total body irradiation-induced hematopoietic failure.

151 ft and a conditioning regimen with > 450 cGy total body irradiation.

152 autologous bone marrow transplantation after total body irradiation.

153 depletion-based conditioning with 1 or 3 Gy total body irradiation.

154 increases survival of mice exposed to lethal total body irradiation.

155 and hematopoietic radioprotection following total body irradiation.

156 re enriched early after TLI/ATS + BMT versus total body irradiation/ATS + BMT.

157 X compared with TLI/ATS, lethal or sublethal total body irradiation/ATS/CTX, or CTX/ATS conditioning.

158 reert2)/Met(+/+)/LacZ) were exposed to 10 Gy total body irradiation; intestinal tissues were collecte

159 g of alemtuzumab (1 mg/kg in divided doses), total-body irradiation (300 cGy), sirolimus, and infusio

160 T was seen only in patients conditioned with total-body irradiation (HR, 3.9 [95% CI, 2.6-6.8]).

161 Recipient dogs were given 2-Gy total-body irradiation (TBI) before and a short course o

162 Impact of total-body irradiation (TBI) in conditioning regimen on

163 to show that temporarily blocking p53 during total-body irradiation (TBI) not only ameliorates acute

164 Cyclophosphamide (Cy) combined with total-body irradiation (TBI) or with busulfan (Bu) are c

165 ool and 100% survival after a lethal dose of total-body irradiation (TBI).

166 with age and after genotoxic stress, such as total-body irradiation (TBI).

167 unotherapy targeting CD45 may substitute for total-body irradiation in hematopoietic cell transplanta

168 simulated weightlessness and space-relevant total-body irradiation on vascular responsiveness in mic

169 Total-body irradiation was a major determinant for BCC.

170 Rats were subjected to 15 Gy of total-body irradiation with x-rays.

171 al and gonadal white adipose tissues of ESR1 total body knockout female mice compared to wild type mi

172 lead level does not necessarily reflect the total body lead burden.

173 olleagues perform bivariate GWAS analyses of total body lean mass and bone mass density in children,

174 performed a bivariate GWAS meta-analysis of total-body lean mass (TB-LM) and total-body less head bo

175 Total body length of the species is estimated to have re

176 l serum 25(OH)D concentrations and offspring total body less head (TBLH) and spinal BMC were assessed

177 analysis of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH-BMD) reg

178 e RT+Meat group experienced greater gains in total body LTM (0.45 kg; 95% CI: 0.07, 0.84 kg), leg LTM

179 (BA), and bone mineral density (BMD) at the total body, lumbar spine, and hip (total and femoral nec

180 ools able to sensitively detect and quantify total body M. tuberculosis burden might well be transfor

181 Genes near loci regulating total body mass are enriched for expression in the CNS,

182 y minimal loss (<10%) or positive changes in total body mass by midcentury; we attribute this respons

183 yers) who are most reliant on LM rather than total body mass for success, compared to other rugby ath

184 and women who later developed HF had higher total body mass when compared with those versus those wh

185 lone in flying insects comprise up to 65% of total body mass.

186 sociated with a significantly higher BMD for total body (mean 3-y change: 0.003 g/cm(2); 95% CI: 0.00

187 emic blood flow while conducting only 39% of total body metabolism.

188 ed plasma methylglyoxal (-37%, P < 0.05) and total body methylglyoxal-protein glycation (-14%, P < 0.

189 -effectiveness analysis, the average cost of total-body moisturization using 7 common moisturizers fr

190 otransporter (NCC) is a major determinant of total body Na(+) and BP.

191 hy human skin DNA methylomes associated with total body nevi count, incorporating genetic and transcr

192 Total body or HSC-specific p62 ablation potentiates HSCs

193 We also assessed total body overhydration (bioimpedance spectroscopy), 24

194 sodium content correlated more strongly than total body overhydration did with left ventricular mass

195 Skin sodium content, but not total body overhydration, correlated with systolic BP (r

196 left ventricular mass, unaffected by BP and total body overhydration.

197 m, and its plasma concentration reflects the total body parasite burden.

198 ase is, in part, a result of a high level of total-body parasite sequestration.

199 The primary outcome established a priori was total-body percentage fat (TBPF) measured by dual-energy

200 nner, discuss selected application areas for total-body PET, and project the impact of further improv

201 When combined with total-body PET, this could produce overall sensitivity g

202 The world's first total-body PET/CT scanner is currently under constructio

203 be our efforts to develop a first-generation total-body PET/CT scanner, discuss selected application

204 Proposed standards for specific-use cases in total body photography, teledermatology, and dermoscopy

205 sequential digital dermoscopy in addition to total-body photography.

206 Labeled tritium dilution and total-body potassium were used to estimate total-body wa

207 [4-compartment Lohman method for analysis of total body protein (4CL-TBPro)] and another that used fa

208 The change in total body protein (TBP) measured by neutron activation

209 Initial reductions were seen in body weight, total body protein and fat, and muscle mass.

210 A simple method to measure total body protein by using a DXA system and BIA unit wa

211 sought to derive a simple method to measure total body protein by using dual-energy X-ray absorptiom

212 ot a clinically accessible method to measure total body protein, which is the functional mass of musc

213 etabolites in the urine from mice exposed to total body radiation (TBI) would predict for the presenc

214 d survival when administered after nonlethal total body radiation (TBI).

215 produced a greater than 25-fold reduction in total body radiation exposure relative to (89)Zr-desferr

216 acy for discriminating patients who received total body radiation.

217 ement of patients exposed to lethal doses of total-body radiotherapy, but not doses high enough to le

218 the change of BMD, BMC, or bone area for the total-body radius, lumbar spine, and total hip were obse

219 in the metrics for image acquisition at the total body, regional, close-up, and dermoscopic levels i

220 in the metrics for image acquisition at the total body, regional, close-up, and dermoscopic levels i

221 The study sought to determine changes in total body reserves (TBRs) of vitamin A with consumption

222 appropriate death mechanism, and whether the total body residue is a proper dose metric for toxic eff

223 In addition to the assessment of total-body retinol stores (TBSs) by using RID, tests inc

224 These systems are able to perform fast total-body scans by shifting the animal bed through the

225 nts, and the spine is easily included in the total body screening performed in patients with severe b

226 We developed a method to capture total-body simian immunodeficiency virus (SIV) replicati

227 ram improved body composition (lean mass and total body skeletal muscle mass), weight, and walking ca

228 Results: All participants (1668 total-body skin examination [TBSE] and 248 lesion-direct

229 All participants (1668 total-body skin examination [TBSE] and 248 lesion-direct

230 d transplant dermatology center and baseline total-body skin examination should be part of posttransp

231 ified in the literature review who underwent total-body skin examinations (TBSE) were found to have M

232 owing compartmental volumes were calculated: total body, soft tissue (ST), fat, lung, and intermediat

233 ritically injured, as demonstrated by mean % total body surface area (TBSA) (41.2 +/- 18.3 for adults

234 s were included in the analysis, with a mean total body surface area (TBSA) burn of 7.2% and a mean a

235 red cell transfusion strategy in 20% or more total body surface area (TBSA) burn patients.

236 ly burned adult patients with burns over 20% total body surface area (TBSA) burn were prospectively r

237 severity, even after adjusting for age and % total body surface area (TBSA) burn.

238 he subjects is 42.5 +/- 16.0 years, the mean total body surface area (TBSA) burned is 18.5 +/- 16.4%,

239 patients with burns of at least 30% of their total body surface area (TBSA).

240 als with burns covering more than 20% of the total body surface area and required at least one surgic

241 hin 96 hours after injury, and more than 20% total body surface area burn requiring at least 1 surgic

242 d from 12 male pediatric burn patients (>30% total body surface area burn) and 12 young, healthy male

243 valuated the varying effects of patient age, total body surface area burn, and inhalation injury on t

244 cet showed that a burn size of more than 60% total body surface area burned (an increase from 40% a d

245 dern burn care setting, adults with over 40% total body surface area burned and children with over 60

246 rface area burned and children with over 60% total body surface area burned are at high risk for morb

247 study of 612 burned children [52% +/- 1% of total body surface area burned, ages 0.5-14 years (boys)

248 syndrome after controlling for age, gender, total body surface area burned, and inhalation injury (h

249 Age, total body surface area burned, and inhalation injury we

250 ts, 44 +/- 15 years old and with 38% +/- 14% total body surface area burned, underwent an oral glucos

251 ese outcomes was lower, at approximately 40% total body surface area burned.

252 multiple organ failure was approximately 60% total body surface area burned.

253 younger than 18 years or with more than 20% total body surface area burns (TBSA) burns were excluded

254 patients (>/=16 years old) with 20% or more total body surface area burns recruited from 6 US burn c

255 hin 96 hours after injury, and more than 20% total body surface area burns requiring at least one sur

256 We describe a 22-year-old soldier with 19% total body surface area burns, polytrauma, and sequence-

257 /kg) before receiving an approximately 12.5% total body surface area full thickness burn.

258 Fifty-four patients with burns to total body surface area of greater than or equal to 15%,

259 raftment confirmed and then subjected to 30% total body surface area steam burn injury.

260 The animals were exposed to 40% total body surface area third degree skin flame burn and

261 The total body surface area was 33% (22%-52%).

262 jury in 63 patients with major burns (>/=15% total body surface area).

263 c alterations as patients with larger burns (total body surface area, >/= 30%).

264 of 147 burn patients (mean age, 26.9 years; total body surface area, 16.1%) received 415 laser sessi

265 Patients with lower burn severity (total body surface area, 20-30%) express similar metabol

266 Total body surface area, age, and inhalation injury had

267 155 patients, including 1476 with burns >20% total body surface area, by presence of AKI.

268 ned burn and smoke inhalation injury (40% of total body surface area, third-degree flame burn; 4 x 12

269 re subjected to a full-thickness burn of 30% total body surface area.

270 was admitted with burns covering 52% of his total body surface area.

271 gmental vitiligo that involved 15% to 50% of total body surface area.

272 f a dorsal scald burn injury covering 30% of total body surface area.

273 an-diagnosed AD involving at least 5% of the total body surface area.

274 ned children with burns exceeding 30% of the total body surface, requiring at least 1 surgical proced

275 As a consequence, the total-body time-activity curve had a tail, which was not

276 and respiratory kinetics in mouse models of total body (TKO) and skeletal muscle-specific (TXNIP(SKM

277 Liver and total-body vitamin A were highly correlated with intake

278 Total body volume (TBV), with the exclusion of internal

279 volumes were summed to derive body mass and total body volume.

280 a 3-compartment model based on body weight, total body water (deuterium dilution), and body volume.

281 1) for the estimation of free water (FW) and total body water (TBW) losses and systematically evaluat

282 when compared with gold-standard measures of total body water by using stable isotope dilution (deute

283 predictions of fat-free mass, fat mass, and total body water matched actual measurements within 1 kg

284 rs of water balance, an excess or deficit of total body water relative to body electrolyte content, a

285 , body density, bioelectrical impedance, and total body water, and 4-component fat and fat-free masse

286 doubly labeled water method, measurement of total body water, and measurement of insulin resistance

287 tively measures stable heavy water levels in total body water.

288 d total-body potassium were used to estimate total-body water (TBW) and intracellular water (ICW), re

289 )), visceral fat mass (1350-1650 cm(3)), and total body weight (11-12 kg).

290 body clearance of polymyxin B when scaled by total body weight (population mean, 0.0276 L/hour/kg) sh

291 The different effects of total body weight (TBW), fat-free mass (FFM), and fat ma

292 A significant difference in total body weight due to the reduction of subcutaneous a

293 ng, paw flutters, head shakes, diarrhea, and total body weight loss), but did not elicit any cannabim

294 rated mice, energy expenditure corrected for total body weight was significantly increased by about 2

295 otal body weight), or high-dose (>/=10 mg/kg total body weight) daptomycin for VRE-BSI.

296 patients treated with standard-dose (6 mg/kg total body weight), medium-dose (8 mg/kg total body weig

297 /kg total body weight), medium-dose (8 mg/kg total body weight), or high-dose (>/=10 mg/kg total body

298 f intravenous polymyxin B are best scaled by total body weight.

299 ed dose per gram of tissue and normalized to total body weight.

300 5 years, corresponding to 27.7% reduction in total body weight.