1 the use of cyclic ketones ring expansion in
total synthesis.
2 ssive efficiency, which are of high value in
total synthesis.
3 resulted in the development of a seven-step
total synthesis.
4 cal cations under nonoxidative conditions in
total synthesis.
5 nine a challenging and attractive target for
total synthesis.
6 nt methods and strategies utilized for their
total synthesis.
7 igned to (+)-subincanadine E on the basis of
total synthesis.
8 en, its main application has been its use in
total synthesis.
9 step routes afforded to organic chemistry by
total synthesis.
10 iled in this manuscript constitutes a formal
total synthesis (
12 steps each) of these [2.2.2]diazabic
11 supply, we report a highly stereocontrolled
total synthesis (
3.2% yield) based on a convergent seque
12 A straightforward enantioselective
total synthesis algorithm for the preparation of 8 out o
13 nd chemical transformations developed in the
total synthesis allowed the elucidation of previously un
14 alin analogs, synthesized utilizing diverted
total synthesis,
allowed the identification of the struc
15 To generate inhibitors of CD38 by
total synthesis,
analogues based on the cyclic inosine 5
16 Herein, we report the diverted
total synthesis and biological evaluation of a rationall
17 scades using this method constitute a formal
total synthesis and demonstrate the utility of this meth
18 search areas, including medicinal chemistry,
total synthesis and materials science, a general, select
19 Since the pioneering days of
total synthesis and retrosynthetic analysis, the communi
20 ith loss of the furanyl acetate, has enabled
total synthesis and stereochemical elucidation of the ma
21 Here we disclose the first
total synthesis and structural confirmation of isoplocam
22 The
total synthesis and structural revision of (+)-cryptocon
23 The
total synthesis and structural revision of antibiotic CJ
24 n of d-sarmentosyl donors enabling the first
total synthesis and structure validation of cardenolide
25 n efficient solid-phase method for the first
total synthesis and the full structural assignment of th
26 parallel with collective synthesis, diverted
total synthesis and the preparation of truncated natural
27 we describe the first isolation, solid-phase
total synthesis,
and full structural assignment of a new
28 Utilizing a
total synthesis approach, the first 8-heterocyclyltetrac
29 in drug diversification and natural product
total synthesis are described.
30 ct modifications and were introduced through
total synthesis but are also remarkable in that they are
31 ules of this complexity be prepared today by
total synthesis but such efforts can be extended to the
32 to highlight modern achievements in alkaloid
total synthesis,
but also demonstrate how the molecular
33 Herein, we report its
total synthesis by a highly convergent Ser ligation appr
34 The continuous development of
total synthesis chemistry has allowed many organic and b
35 Total synthesis combined with click chemistry was used t
36 The success in
total synthesis,
designed with a novel convergent strate
37 we synthesized 16 analogs utilizing diverted
total synthesis (
DTS).
38 applications of gold catalysed reactions in
total synthesis during the years since our last article
39 plex scaffold, okaramines have inspired many
total synthesis efforts, but the enzymology of the okara
40 Herein we report the concise, high-yielding
total synthesis (
eight steps, 35% yield) of promysalin,
41 The
total synthesis features the first application of the tr
42 of inspiration for chemists in the field of
total synthesis for the development of innovative method
43 III (3), have succumbed to enantioselective
total synthesis for the first time in only 18 steps from
44 e decades ago (1984), and in natural product
total synthesis has been conducted.
45 A direct and efficient
total synthesis has been developed for telmisartan, a wi
46 intriguing structures of these compounds by
total synthesis have also inspired novel strategies, thu
47 The expedient
total synthesis involves a one-pot sequential Zr-mediate
48 AdoRbl was prepared by de novo
total synthesis involving both biological and chemical s
49 ctives for the use of this transformation in
total synthesis is also included.
50 s nucleophilic and electrophilic partners in
total synthesis is elegantly demonstrated.
51 This
total synthesis is highly convergent and modular, thus o
52 The
total synthesis leverages an MNBA (Shiina's reagent)-med
53 An asymmetric
total synthesis of (+)-6-hydroxythiobinupharidine (1b) a
54 The asymmetric (er > 99:1)
total synthesis of (+)-anti- and (-)-syn-mefloquine hydr
55 A concise asymmetric (>99:1 e.r.)
total synthesis of (+)-anti- and (-)-syn-mefloquine hydr
56 The
total synthesis of (+)-cavicularin is described.
57 The
total synthesis of (+)-cryptocaryol A was achieved in 20
58 odology is eventually employed in the formal
total synthesis of (+)-folicanthine (1b).
59 Studies describe the
total synthesis of (+)-ileabethoxazole (1) using a Still
60 A
total synthesis of (+)-patulolide C has been accomplishe
61 A gram-scale enantioselective
total synthesis of (+)-peganumine A was accomplished in
62 This first
total synthesis of (+)-pestalazine A also allowed us to
63 ynthesis strategy to achieve enantiospecific
total synthesis of (+)-phorbol in only 19 steps from the
64 y of this method is highlighted in the first
total synthesis of (+)-sibirinine.
65 The formation of 7p represents a
total synthesis of (+)-trans-whisky lactone.
66 We report the enantiospecific
total synthesis of (+)-tubingensin A.
67 by the protecting groups and applied to the
total synthesis of (+)-varitriol and of two diastereoiso
68 A short, 5-step
total synthesis of (+/-)-3-demethoxyerythratidinone from
69 The
total synthesis of (+/-)-aspergilline A (1) is described
70 tion of analogues, a flexible and convergent
total synthesis of (+/-)-aureothin is presented.
71 e ylide 1,3-dipolar cycloaddition toward the
total synthesis of (+/-)-caldaphnidine C is presented.
72 The methodology was used for the
total synthesis of (+/-)-chelonin A.
73 the thermic ring contraction applied to the
total synthesis of (+/-)-Gelsemoxonine.
74 The first
total synthesis of (+/-)-gelsenicine is reported.
75 to furnish the final E ring and complete the
total synthesis of (+/-)-minfiensine (2).
76 Here we report a
total synthesis of (+/-)-morphine that employs two key s
77 In this work, the first
total synthesis of (+/-)-phaeosphaeride B (1d) and the u
78 Total synthesis of (+/-)-taiwaniaquinol F (1a) has been
79 product classes and also enabled a nine-step
total synthesis of (-)-6-epi-ophiobolin N, a member of t
80 Described herein is a catalytic asymmetric
total synthesis of (-)-actinophyllic acid, with the key
81 Herein we report a concise
total synthesis of (-)-albocycline in 14 steps from comm
82 The
total synthesis of (-)-amphidinolide K (1) based on asym
83 an application in the first enantioselective
total synthesis of (-)-aspewentins A, B, and C is demons
84 The first biomimetic enantioselective
total synthesis of (-)-communesin F based on a late-stag
85 The first enantioselective
total synthesis of (-)-cycloclavine was accomplished in
86 The first enantioselective
total synthesis of (-)-deoxoapodine is described.
87 The first catalytic enantioselective
total synthesis of (-)-goniomitine, along with divergent
88 The enantioselective
total synthesis of (-)-hodgkinsine, (-)-calycosidine, (-
89 The first
total synthesis of (-)-marinisporolide C is described, w
90 rifluoromethanesulfonate completed the first
total synthesis of (-)-methylenebismehranine.
91 A convergent
total synthesis of (-)-nahuoic acid Ci(Bii) (3), a novel
92 e key step of the first catalytic asymmetric
total synthesis of (-)-rocaglamide (natural) and (+)-roc
93 Herein, we report an efficient
total synthesis of (-)-spinosyn A with 15 steps in the l
94 n in natural product synthesis and the first
total synthesis of (2S)-hydroxy-3,4-dehydroneomajucin, t
95 The catalytic enantioselective
total synthesis of 1 was accomplished in 7 steps and 38%
96 The first
total synthesis of 1 was successfully established via 31
97 ly efficient strategy enabled the asymmetric
total synthesis of 15 antifeedant leucosceptroid natural
98 osylations were employed as key steps in the
total synthesis of a branched pentasaccharide from a sap
99 The first
total synthesis of a chromodorolide diterpenoid is descr
100 The
total synthesis of a dimeric thymol derivative (thymarni
101 exchange, isotopic labeling experiments, and
total synthesis of a focused collection of peptide candi
102 ably, this synthesis is the first gram-scale
total synthesis of a guaianolide natural product.
103 Key to the first reported
total synthesis of a kopsifoline that is detailed herein
104 and has been exploited by application to the
total synthesis of a natural occurring benzodioxole and
105 have also been employed as key steps in the
total synthesis of a number of natural products.
106 trategies and tactics that culminated in the
total synthesis of ajudazol B, the most potent and least
107 Described herein is a short
total synthesis of alkaloid (-)-205B (1) by means of an
108 he new synthetic route was effective for the
total synthesis of all members in the homohalichondrin s
109 tion of this synthetic route resulted in the
total synthesis of all three known 10-oxygenated Lycopod
110 ion of macrolactone 33a we describe a formal
total synthesis of amphidinolide Q.
111 starting material and its application to the
total synthesis of an antiepileptic drug (R)-lacosamide
112 An improved and enantioselective
total synthesis of antibiotic CJ-16,264 through a practi
113 A convergent diastereo- and enantioselective
total synthesis of anticancer and antifungal macrocyclic
114 The
total synthesis of antroquinonol has been accomplished t
115 A concise
total synthesis of artalbic acid has been enabled by a s
116 Moreover, the first enantioselective
total synthesis of aspidophylline A is described.
117 Herein we report the first
total synthesis of berkeleyone A, a potential gateway co
118 s for the protecting group-free or minimized
total synthesis of biaryl-type phytoalexins.
119 The first
total synthesis of bifidenone, a novel natural tubulin p
120 Also presented is an enantioselective
total synthesis of both (-)-mitragynine and its unnatura
121 The
total synthesis of both side chain epimers of the origin
122 The formal
total synthesis of both the enantiomers of cyclophellito
123 Here, we report a
total synthesis of bryostatin 1 that proceeds in 29 tota
124 ein we describe synthetic efforts toward the
total synthesis of calyciphylline B-type alkaloids.
125 crossover reaction, a highly stereoselective
total synthesis of cephalosporolide E (which is typicall
126 thermore, using the same strategy, the first
total synthesis of chatenaytrienin-4, the proposed unsat
127 The result is a highly convergent
total synthesis of chivosazole F through the orchestrati
128 Strategies for the
total synthesis of complex natural products that contain
129 a highly efficient, scalable approach to the
total synthesis of conformationally unrestricted, electr
130 We identify a short
total synthesis of congeners in the reverse-prenylated i
131 Herein, we describe the first
total synthesis of cystobactamid 919-2 from three fragme
132 and convergent route for the stereoselective
total synthesis of cytotoxic macrolides pestalotioprolid
133 The
total synthesis of cytotoxic polyketides myceliothermoph
134 r variants of the method were applied to the
total synthesis of danaidal and suffrutine A from the re
135 Synthetic studies toward the
total synthesis of dehaloperophoramidine have led to the
136 lkaloid C13 position, as demonstrated by the
total synthesis of dehydrocorydaline.
137 The
total synthesis of dehydromicrosclerodermin B and micros
138 We report a concise
total synthesis of dictyodendrin F and the first total s
139 The
total synthesis of enantiomerically pure (+)-mesembrine
140 a convenient and efficient strategy for the
total synthesis of enantiomerically pure 1 is described,
141 is one-pot process was demonstrated with the
total synthesis of four oxybenzo[c]phenanthridine alkalo
142 A novel
total synthesis of fully protected idraparinux has been
143 of this method as it enabled the convergent
total synthesis of G-CSF aglycone.
144 The first
total synthesis of galanal A and B has been achieved fro
145 l account of our studies directed toward the
total synthesis of gelsemoxonine that relies on a concep
146 The first
total synthesis of Gliomasolide C, the short synthesis o
147 Here we report the
total synthesis of glucosepane, enabled by the developme
148 Herein, we describe a divergent
total synthesis of glycinocins A-C, which differ in the
149 An efficient
total synthesis of goadsporin is reported in which the k
150 The first enantioselective
total synthesis of griseusin A, griseusin C, 4'-deacetyl
151 Here, we report the first
total synthesis of hybrubin A, a bipyrrole tetramic acid
152 A formal
total synthesis of ivorenolide A has been accomplished e
153 We have devised a highly selective
total synthesis of ladderane lipid tails and a full phos
154 ltimately allowed us to go on and complete a
total synthesis of lasonolide A.
155 We report the first
total synthesis of laspartomycin C as well as a series o
156 ntifungal agents leupyrrin A1 and B1 and the
total synthesis of leupyrrin A1 are reported.
157 An efficient and highly convergent
total synthesis of Leustroducsin B was achieved in 17 lo
158 The asymmetric
total synthesis of loline alkaloids is reported and exte
159 The
total synthesis of lundurines A-C has been accomplished
160 The
total synthesis of lycoricidine and narciclasine is enab
161 Efforts directed toward the
total synthesis of macrosalhine chloride (5) are also re
162 f a program directed at the enantioselective
total synthesis of maoecrystal V, a highly modified ent-
163 An enantioselective
total synthesis of martinellic acid is described.
164 with enamine 3 as the key step of a concise
total synthesis of methoxatin is described.
165 ersion of palladium complexes results in the
total synthesis of MK 7607, cyathiformine B type, strept
166 The same strategy is applied to a formal
total synthesis of morphinan alkaloids.
167 NMR data, and complete the enantioselective
total synthesis of muironolide A.
168 A stereocontrolled first
total synthesis of muraymycin D1 (1) has been achieved.
169 A streamlined
total synthesis of N(14)-desacetoxytubulysin H (Tb1) bas
170 etone rearrangement was applied in a concise
total synthesis of naphthomevalin, a prominent member of
171 The
total synthesis of narciclasine is accomplished by the l
172 n of first-row metal-mediated methods to the
total synthesis of natural products is discussed.
173 t become suitable starting materials for the
total synthesis of natural products, ingredients, and in
174 on reactions have found broad application in
total synthesis of natural products.
175 Enantioselective first
total synthesis of naturally occurring cytotoxic (+)-sub
176 s which has been successfully applied to the
total synthesis of naturally occurring pyrolidine alkalo
177 is provides access to many natural products,
total synthesis of numerous complex molecules is not eco
178 h were successfully overcome to complete the
total synthesis of picrinine.
179 The
total synthesis of plantazolicin A and its biosynthetic
180 sed on a C-H activation strategy and a short
total synthesis of pretubulysin D (PTb-D43) are describe
181 ise and convergent route for stereoselective
total synthesis of promising anticancer natural lipid my
182 The first
total synthesis of psychrophilin E, a potent antiprolife
183 A biomimetic
total synthesis of racemic homodimericin A was achieved
184 Completion of the first
total synthesis of resolvin D4 established the absolute
185 The first
total synthesis of resorcyclic acid lactone spiroketal c
186 mediated by Mn(OAc)3 as a key operation, the
total synthesis of retrojusticidin B, justicidin E, and
187 ded an efficient means to complete the first
total synthesis of rifsaliniketal and salinisporamycin.
188 The first
total synthesis of rottlerin is described.
189 ach has been applied to the enantioselective
total synthesis of rumphellaone A.
190 yl cross-coupling reaction was probed in the
total synthesis of salmochelins (siderophores) and comme
191 of numerous tandem processes, as well as the
total synthesis of several natural products.
192 no substituted ketones is exemplified in the
total synthesis of sphingolipid HPA-12 and the sedamine
193 Here we report the
total synthesis of stolonidiol starting from (R)-(+)-lim
194 Although
total synthesis of such terpenes is widely studied, synt
195 This work lays a foundation for an eventual
total synthesis of Taxol capable of delivering not only
196 e laboratory is reported, culminating in the
total synthesis of taxuyunnanine D, itself a natural pro
197 The transformation was applied to a concise
total synthesis of the 14-membered macrolactone, Sch 725
198 rmediate associated with a recently reported
total synthesis of the alkaloid kopsihainanine A (1).
199 erial O-glycans, as exemplified by the first
total synthesis of the amino linker-attached, conjugatio
200 The methodology has been used for the
total synthesis of the antidepressant agent (+/-)-5-phen
201 ted alpha-amino acids including an expedient
total synthesis of the antiepileptic drug levetiracetam.
202 pment of a strategy culminating in the first
total synthesis of the architecturally complex daphniphy
203 The
total synthesis of the architecturally complex Daphniphy
204 A convergent
total synthesis of the architecturally complex indole di
205 A highly convergent, stereocontrolled
total synthesis of the architecturally complex marine sp
206 a mild formamide reduction enabled the first
total synthesis of the Aspidosperma alkaloids (-)-mehran
207 A seven-step
total synthesis of the axially chiral, dimeric tetrahydr
208 ated by completing a highly enantioselective
total synthesis of the beta3-adrenergic receptor agonist
209 We report the first
total synthesis of the complex akuammiline alkaloid picr
210 The first enantioselective
total synthesis of the complex tricarbocyclic sesquiterp
211 Described is the
total synthesis of the cyanotoxin microcystin-LF (MC-LF,
212 A formal
total synthesis of the cytotoxic macrolide amphidinolide
213 The first enantioselective
total synthesis of the cytotoxic natural product (+)-psi
214 A highly stereoselective
total synthesis of the diacetonide derivative of the ant
215 A
total synthesis of the diastereoisomeric pair of compoun
216 The first
total synthesis of the dimeric berberine alkaloid ilicif
217 We report the concise, biomimetic
total synthesis of the dimeric, Diels-Alder natural prod
218 synthesis of tubocurine represents a formal
total synthesis of the famous arrow poison alkaloid tubo
219 A 13-step
total synthesis of the fungal meroterpenoid berkeleyone
220 on tactic, was successfully employed for the
total synthesis of the highly cytotoxic marine macrolide
221 Total synthesis of the highly functionalized cyclic pept
222 A stereocontrolled
total synthesis of the indole diterpenoid natural produc
223 subsequent elaboration to complete the first
total synthesis of the juvenimicin, M-4365, and rosamici
224 his methodology has also been applied to the
total synthesis of the lignan natural product (-)-burseh
225 We report the first
total synthesis of the limonoid andirolide N using a 12-
226 The first
total synthesis of the marine natural product avrainvill
227 Herein, we describe the
total synthesis of the most common pseudaminic acid, 5,7
228 Based on these findings, a concise
total synthesis of the natural product (+)-varitriol and
229 A new
total synthesis of the natural product (-)-depudecin, a
230 odular biosynthetic enzymes, we describe the
total synthesis of the natural product aeruginosamide B
231 e was used as the key building block for the
total synthesis of the natural product phorbin A.
232 CPA), has enabled the first enantioselective
total synthesis of the natural product piperarborenine B
233 re now accessible because of advances in the
total synthesis of the natural product.
234 n an original convergent and stereoselective
total synthesis of the natural product.
235 ow accessible as a result of advances in the
total synthesis of the natural product.
236 A streamlined
total synthesis of the naturally occurring antitumor age
237 s are reported, which culminated in a formal
total synthesis of the neurotrophic agent (-)-jiadifenol
238 An asymmetric
total synthesis of the nootropic alkaloid (-)-huperzine
239 An enantioselective
total synthesis of the norditerpenoid alkaloid nigelladi
240 The first
total synthesis of the novel cyclohexylethanoid natural
241 be the isolation, structure elucidation, and
total synthesis of the novel marine natural product rifs
242 A short
total synthesis of the novel unnatural parthenolide dias
243 An enantioselective
total synthesis of the polycyclic diterpene (+)-chatanci
244 A 10-step
total synthesis of the polycyclic polyprenylated acylphl
245 A catalytic asymmetric
total synthesis of the potent and selective antileukemic
246 The development of a practical asymmetric
total synthesis of the potent HIV-1 integrase inhibitor
247 A convergent and stereoselective
total synthesis of the previously assigned structure of
248 A
total synthesis of the proposed structure of nhatrangin
249 hod has been applied in the enantioselective
total synthesis of the purported structure of pulveraven
250 The first asymmetric
total synthesis of the putative structure of diplopyrone
251 lpha,beta-unsaturation is exemplified in the
total synthesis of the quinolizidine alkaloid natural pr
252 A
total synthesis of the racemic modification, (+/-)-2, of
253 The
total synthesis of the rare but extremely potent antitum
254 The first
total synthesis of the reported structure of 13a-hydroxy
255 nd flexible strategy for the stereoselective
total synthesis of the reported structure of baulamycin
256 The method was further applied to the
total synthesis of the sesquiterpene natural products (+
257 The
total synthesis of the spliceosome inhibitor thailanstat
258 The methodology was used in the
total synthesis of the Stemona alkaloid (-)-stemaphyllin
259 arine natural product rifsaliniketal and the
total synthesis of the structurally related variants sal
260 A
total synthesis of the structure, 1, assigned to the rec
261 The
total synthesis of the Strychnos alkaloid (+/-)-minfiens
262 Herein we report the
total synthesis of the substance with the assigned struc
263 veloped that culminated in a stereoselective
total synthesis of the tetracyclic antimalarial Myrioneu
264 The first
total synthesis of the tetracyclic antimalarial Myrioneu
265 Here we report the
total synthesis of the three largest circular bacterioci
266 Herein we report the
total synthesis of the trans-fused 8,12-guaianolide (+)-
267 t-controlled enantio- and diastereoselective
total synthesis of the two most likely diastereomeric ca
268 An efficient
total synthesis of the unusual polyketide portentol is r
269 lecules to date have been facilitated by the
total synthesis of the various PP-InsP isomers and by th
270 A stereocontrolled
total synthesis of this densely functionalized natural p
271 Herein, we disclose the first
total synthesis of this highly strained target in 13 ste
272 Two distinct strategies toward the
total synthesis of this interesting target are reported.
273 ard picrinine, which culminates in the first
total synthesis of this long-standing target.
274 inhibitor of rosettes (IOR-1) as well as the
total synthesis of this molecule and all of its stereois
275 he application of these methodologies in the
total synthesis of THP-based natural products.
276 mon precursor to accomplish collective first
total synthesis of titled natural products and proposed
277 The enantioselective
total synthesis of trans-clerodane diterpenoid 1 reporte
278 t-coupling strategy for the enantioselective
total synthesis of trans-clerodane diterpenoids is descr
279 The first
total synthesis of trichoaurantianolides C and D is desc
280 thod was successfully applied to the concise
total synthesis of trichodermamide A (in gram quantities
281 An enantioselective
total synthesis of trioxacarcin DC-45-A2 (1) featuring a
282 design toward a concise and enantiospecific
total synthesis of tubingensin B, which hinges on the st
283 dged bicycle, these efforts have enabled the
total synthesis of tubingensin B.
284 In addition, the
total synthesis of tubocurine represents a formal total
285 w reaction manifold is also showcased in the
total synthesis of two proteins.
286 a streamlined and practical enantioselective
total synthesis of uncialamycin that is amenable to the
287 described synthetic strategy resulted in the
total synthesis of viridicatumtoxin B (1), which, in tur
288 is general methodology was successful in the
total synthesis of Xyridin A, an important natural produ
289 Here we report the first
total synthesis of YM-254890 and FR900359, as well as of
290 te the prominence of pericyclic reactions in
total synthesis,
only three naturally existing enzymatic
291 ine ring have been highlighted to accomplish
total synthesis or to obtain bioactive compounds, one of
292 ernative to the highly complex approaches of
total synthesis recently reported to the same aim.
293 This
total synthesis revealed that the reported structure of
294 available to the organic chemist engaged in
total synthesis,
the Diels-Alder reaction is among the m
295 This
total synthesis unambiguously proves the correct stereoc
296 The design and evolution of our succinct
total synthesis underscores the utility of long-avoided
297 A four-step colloidal
total synthesis was developed, where the key step in the
298 l combination of computational chemistry and
total synthesis was explored to tentatively elucidate th
299 tructure has been confirmed by an asymmetric
total synthesis,
which also established its absolute con
300 e been obtained either formally or by direct
total synthesis,
with efforts toward one of these-the co