1 The catalytic enantioselective
total synthesis of 1 was accomplished in 7 steps and 38%
2 The first
total synthesis of 1 was successfully established via 31
3 Total synthesis of 10-membered lactone (+)-seimatopolide
4 ly efficient strategy enabled the asymmetric
total synthesis of 15 antifeedant leucosceptroid natural
5 The evolution of an enantioselective
total synthesis of (+)-
18-epi-latrunculol A, a congener
6 C-19 methyl-substituted alkaloids including
total synthesis of 19(S),20(R)-dihydroperaksine-17-al (1
7 n in natural product synthesis and the first
total synthesis of (
2S)-hydroxy-3,4-dehydroneomajucin, t
8 A short, 5-step
total synthesis of (+/-)-
3-demethoxyerythratidinone from
9 An asymmetric
total synthesis of (+)-
6-hydroxythiobinupharidine (1b) a
10 product classes and also enabled a nine-step
total synthesis of (-)-
6-epi-ophiobolin N, a member of t
11 d systems was exploited to complete a formal
total synthesis of 7'-desmethylkealiiquinone, an analogu
12 osylations were employed as key steps in the
total synthesis of a branched pentasaccharide from a sap
13 The first
total synthesis of a chromodorolide diterpenoid is descr
14 The
total synthesis of a dimeric thymol derivative (thymarni
15 exchange, isotopic labeling experiments, and
total synthesis of a focused collection of peptide candi
16 ably, this synthesis is the first gram-scale
total synthesis of a guaianolide natural product.
17 Key to the first reported
total synthesis of a kopsifoline that is detailed herein
18 and has been exploited by application to the
total synthesis of a natural occurring benzodioxole and
19 have also been employed as key steps in the
total synthesis of a number of natural products.
20 A
total synthesis of (+/-)-
actinophyllic acid has been com
21 Described herein is a catalytic asymmetric
total synthesis of (-)-
actinophyllic acid, with the key
22 trategies and tactics that culminated in the
total synthesis of ajudazol B, the most potent and least
23 Herein we report a concise
total synthesis of (-)-
albocycline in 14 steps from comm
24 en describing the approaches used toward the
total synthesis of aliskiren.
25 Described herein is a short
total synthesis of alkaloid (-)-205B (1) by means of an
26 he new synthetic route was effective for the
total synthesis of all members in the homohalichondrin s
27 tion of this synthetic route resulted in the
total synthesis of all three known 10-oxygenated Lycopod
28 The
total synthesis of amphidinolide C and a second-generati
29 ion of macrolactone 33a we describe a formal
total synthesis of amphidinolide Q.
30 The
total synthesis of (-)-
amphidinolide K (1) based on asym
31 starting material and its application to the
total synthesis of an antiepileptic drug (R)-lacosamide
32 Through rational design and
total synthesis of an apratoxin A/E hybrid, apratoxin S4
33 The asymmetric (er > 99:1)
total synthesis of (+)-
anti- and (-)-syn-mefloquine hydr
34 A concise asymmetric (>99:1 e.r.)
total synthesis of (+)-
anti- and (-)-syn-mefloquine hydr
35 An improved and enantioselective
total synthesis of antibiotic CJ-16,264 through a practi
36 A convergent diastereo- and enantioselective
total synthesis of anticancer and antifungal macrocyclic
37 Total synthesis of anticonvulsant amino acid, lacosamide
38 The
total synthesis of antroquinonol has been accomplished t
39 Total synthesis of (+/-)-
antroquinonol D, which is isola
40 A concise
total synthesis of artalbic acid has been enabled by a s
41 The
total synthesis of (+/-)-
aspergilline A (1) is described
42 an application in the first enantioselective
total synthesis of (-)-
aspewentins A, B, and C is demons
43 Moreover, the first enantioselective
total synthesis of aspidophylline A is described.
44 tion of analogues, a flexible and convergent
total synthesis of (+/-)-
aureothin is presented.
45 Herein we report the first
total synthesis of berkeleyone A, a potential gateway co
46 s for the protecting group-free or minimized
total synthesis of biaryl-type phytoalexins.
47 The first
total synthesis of bifidenone, a novel natural tubulin p
48 A short and convergent stereoselective
total synthesis of biologically potent cytospolide P has
49 Also presented is an enantioselective
total synthesis of both (-)-mitragynine and its unnatura
50 The
total synthesis of both side chain epimers of the origin
51 The formal
total synthesis of both the enantiomers of cyclophellito
52 Here, we report a
total synthesis of bryostatin 1 that proceeds in 29 tota
53 e ylide 1,3-dipolar cycloaddition toward the
total synthesis of (+/-)-
caldaphnidine C is presented.
54 ein we describe synthetic efforts toward the
total synthesis of calyciphylline B-type alkaloids.
55 The
total synthesis of (+)-
cavicularin is described.
56 crossover reaction, a highly stereoselective
total synthesis of cephalosporolide E (which is typicall
57 thermore, using the same strategy, the first
total synthesis of chatenaytrienin-4, the proposed unsat
58 The methodology was used for the
total synthesis of (+/-)-
chelonin A.
59 The result is a highly convergent
total synthesis of chivosazole F through the orchestrati
60 We report a stereodivergent, asymmetric
total synthesis of (-)-
clusianone in six steps from comm
61 The first biomimetic enantioselective
total synthesis of (-)-
communesin F based on a late-stag
62 Strategies for the
total synthesis of complex natural products that contain
63 a highly efficient, scalable approach to the
total synthesis of conformationally unrestricted, electr
64 We identify a short
total synthesis of congeners in the reverse-prenylated i
65 The
total synthesis of (+)-
cryptocaryol A was achieved in 20
66 The first enantioselective
total synthesis of (-)-
cycloclavine was accomplished in
67 Herein, we describe the first
total synthesis of cystobactamid 919-2 from three fragme
68 and convergent route for the stereoselective
total synthesis of cytotoxic macrolides pestalotioprolid
69 The
total synthesis of cytotoxic polyketides myceliothermoph
70 A
total synthesis of D-erythro-sphinganine [(2S,3R)-2-amin
71 r variants of the method were applied to the
total synthesis of danaidal and suffrutine A from the re
72 Synthetic studies toward the
total synthesis of dehaloperophoramidine have led to the
73 lkaloid C13 position, as demonstrated by the
total synthesis of dehydrocorydaline.
74 The
total synthesis of dehydromicrosclerodermin B and micros
75 The first enantioselective
total synthesis of (-)-
deoxoapodine is described.
76 urancarboxylic acid, facile enantioselective
total synthesis of desbromoarborescidines A-C and the fo
77 We report a concise
total synthesis of dictyodendrin F and the first total s
78 was applied as the pivotal step of the first
total synthesis of dixiamycin B.
79 The
total synthesis of enantiomerically pure (+)-mesembrine
80 a convenient and efficient strategy for the
total synthesis of enantiomerically pure 1 is described,
81 In pursuit of these goals, the first
total synthesis of (+)-
fastigiatine (2) was accomplished
82 Recently, we reported the first
total synthesis of flinderoles B and C, structurally uni
83 odology is eventually employed in the formal
total synthesis of (+)-
folicanthine (1b).
84 is one-pot process was demonstrated with the
total synthesis of four oxybenzo[c]phenanthridine alkalo
85 A novel
total synthesis of fully protected idraparinux has been
86 of this method as it enabled the convergent
total synthesis of G-CSF aglycone.
87 The first
total synthesis of galanal A and B has been achieved fro
88 h provided a key intermediate for the formal
total synthesis of (-)-
galanthamine with 97% ee in 97% y
89 l account of our studies directed toward the
total synthesis of gelsemoxonine that relies on a concep
90 the thermic ring contraction applied to the
total synthesis of (+/-)-
Gelsemoxonine.
91 The first
total synthesis of (+/-)-
gelsenicine is reported.
92 decahydroquinoline ring system, enabling the
total synthesis of (-)-
gephyrotoxin in nine steps and 14
93 The first
total synthesis of Gliomasolide C, the short synthesis o
94 Here we report the
total synthesis of glucosepane, enabled by the developme
95 Herein, we describe a divergent
total synthesis of glycinocins A-C, which differ in the
96 We describe herein a convergent
total synthesis of GM-CSF aglycone and two homogeneous g
97 An efficient
total synthesis of goadsporin is reported in which the k
98 The first catalytic enantioselective
total synthesis of (-)-
goniomitine, along with divergent
99 The first enantioselective
total synthesis of griseusin A, griseusin C, 4'-deacetyl
100 A
total synthesis of halichondrin A, the phantom member in
101 The enantioselective
total synthesis of (-)-
hodgkinsine, (-)-calycosidine, (-
102 The
total synthesis of hongoquercin B was carried out in 9 s
103 The
total synthesis of hyacinthacines B3, B4, and B5 and pur
104 Here, we report the first
total synthesis of hybrubin A, a bipyrrole tetramic acid
105 Studies describe the
total synthesis of (+)-
ileabethoxazole (1) using a Still
106 A formal
total synthesis of ivorenolide A has been accomplished e
107 The
total synthesis of kibdelone A has been accomplished via
108 We have devised a highly selective
total synthesis of ladderane lipid tails and a full phos
109 ltimately allowed us to go on and complete a
total synthesis of lasonolide A.
110 We report the first
total synthesis of laspartomycin C as well as a series o
111 ntifungal agents leupyrrin A1 and B1 and the
total synthesis of leupyrrin A1 are reported.
112 An efficient and highly convergent
total synthesis of Leustroducsin B was achieved in 17 lo
113 The asymmetric
total synthesis of loline alkaloids is reported and exte
114 The
total synthesis of lundurines A-C has been accomplished
115 The
total synthesis of lycoricidine and narciclasine is enab
116 Efforts directed toward the
total synthesis of macrosalhine chloride (5) are also re
117 f a program directed at the enantioselective
total synthesis of maoecrystal V, a highly modified ent-
118 The first
total synthesis of (-)-
marinisporolide C is described, w
119 An enantioselective
total synthesis of martinellic acid is described.
120 with enamine 3 as the key step of a concise
total synthesis of methoxatin is described.
121 rifluoromethanesulfonate completed the first
total synthesis of (-)-
methylenebismehranine.
122 to furnish the final E ring and complete the
total synthesis of (+/-)-
minfiensine (2).
123 sed to the nines: The first enantioselective
total synthesis of (-)-
minovincine has been accomplished
124 ersion of palladium complexes results in the
total synthesis of MK 7607, cyathiformine B type, strept
125 The same strategy is applied to a formal
total synthesis of morphinan alkaloids.
126 Here we report a
total synthesis of (+/-)-
morphine that employs two key s
127 NMR data, and complete the enantioselective
total synthesis of muironolide A.
128 A stereocontrolled first
total synthesis of muraymycin D1 (1) has been achieved.
129 A streamlined
total synthesis of N(14)-desacetoxytubulysin H (Tb1) bas
130 The first
total synthesis of N-methylwelwitindolinone B isothiocya
131 A convergent
total synthesis of (-)-
nahuoic acid Ci(Bii) (3), a novel
132 etone rearrangement was applied in a concise
total synthesis of naphthomevalin, a prominent member of
133 The
total synthesis of narciclasine is accomplished by the l
134 n of first-row metal-mediated methods to the
total synthesis of natural products is discussed.
135 rks or serving as key transformations in the
total synthesis of natural products, has expanded rapidl
136 t become suitable starting materials for the
total synthesis of natural products, ingredients, and in
137 the Diels-Alder reaction of quinones in the
total synthesis of natural products.
138 on reactions have found broad application in
total synthesis of natural products.
139 Enantioselective first
total synthesis of naturally occurring cytotoxic (+)-sub
140 indole intermediate, could be applied to the
total synthesis of naturally occurring horsfiline.
141 s which has been successfully applied to the
total synthesis of naturally occurring pyrolidine alkalo
142 tility of this method is demonstrated by the
total synthesis of nortopsentin D.
143 is provides access to many natural products,
total synthesis of numerous complex molecules is not eco
144 A
total synthesis of (+)-
patulolide C has been accomplishe
145 A gram-scale enantioselective
total synthesis of (+)-
peganumine A was accomplished in
146 This first
total synthesis of (+)-
pestalazine A also allowed us to
147 In this work, the first
total synthesis of (+/-)-
phaeosphaeride B (1d) and the u
148 ynthesis strategy to achieve enantiospecific
total synthesis of (+)-
phorbol in only 19 steps from the
149 h were successfully overcome to complete the
total synthesis of picrinine.
150 The
total synthesis of plantazolicin A and its biosynthetic
151 A short
total synthesis of podophyllotoxin, the prototypical ary
152 sed on a C-H activation strategy and a short
total synthesis of pretubulysin D (PTb-D43) are describe
153 ise and convergent route for stereoselective
total synthesis of promising anticancer natural lipid my
154 The first
total synthesis of psychrophilin E, a potent antiprolife
155 A biomimetic
total synthesis of racemic homodimericin A was achieved
156 Completion of the first
total synthesis of resolvin D4 established the absolute
157 The first
total synthesis of resorcyclic acid lactone spiroketal c
158 mediated by Mn(OAc)3 as a key operation, the
total synthesis of retrojusticidin B, justicidin E, and
159 y of the method is demonstrated by the first
total synthesis of rhizochalinin C, the long-chain, "two
160 Here, we report a modular
total synthesis of RIF-1 stereoisomers and structural an
161 ded an efficient means to complete the first
total synthesis of rifsaliniketal and salinisporamycin.
162 e key step of the first catalytic asymmetric
total synthesis of (-)-
rocaglamide (natural) and (+)-roc
163 The first
total synthesis of rottlerin is described.
164 ach has been applied to the enantioselective
total synthesis of rumphellaone A.
165 The first
total synthesis of (
S)-6-(2,9-dihydroxynonyl)-4-hydroxy-
166 yl cross-coupling reaction was probed in the
total synthesis of salmochelins (siderophores) and comme
167 ng and implementation of an enantioselective
total synthesis of (+)-
scholarisine A is presented.
168 The
total synthesis of sculponeatin N, a bioactive polycycli
169 of numerous tandem processes, as well as the
total synthesis of several natural products.
170 y of this method is highlighted in the first
total synthesis of (+)-
sibirinine.
171 Ultimately, the enantioselective
total synthesis of (+)-
sieboldine A was completed by for
172 Total synthesis of sortase A will enable more sophistica
173 no substituted ketones is exemplified in the
total synthesis of sphingolipid HPA-12 and the sedamine
174 Herein, we report an efficient
total synthesis of (-)-
spinosyn A with 15 steps in the l
175 duct synthesis programs to achieve the first
total synthesis of spirodienal A and the preparation of
176 We disclose the first
total synthesis of stachybotrin C, a potent neuroprotect
177 Here we report the
total synthesis of stolonidiol starting from (R)-(+)-lim
178 Although
total synthesis of such terpenes is widely studied, synt
179 Total synthesis of (+/-)-
taiwaniaquinol F (1a) has been
180 intermediate 64 completes an improved formal
total synthesis of talcarpine (26) and provides a starti
181 This work lays a foundation for an eventual
total synthesis of Taxol capable of delivering not only
182 e laboratory is reported, culminating in the
total synthesis of taxuyunnanine D, itself a natural pro
183 This method is illustrated by the
total synthesis of the (-)-isoaltholactone.
184 Here, an enantioselective convergent
total synthesis of the (-)-lasonolide A in 16 longest li
185 The transformation was applied to a concise
total synthesis of the 14-membered macrolactone, Sch 725
186 rmediate associated with a recently reported
total synthesis of the alkaloid kopsihainanine A (1).
187 erial O-glycans, as exemplified by the first
total synthesis of the amino linker-attached, conjugatio
188 The methodology has been used for the
total synthesis of the antidepressant agent (+/-)-5-phen
189 ted alpha-amino acids including an expedient
total synthesis of the antiepileptic drug levetiracetam.
190 pment of a strategy culminating in the first
total synthesis of the architecturally complex daphniphy
191 The
total synthesis of the architecturally complex Daphniphy
192 A convergent
total synthesis of the architecturally complex indole di
193 A highly convergent, stereocontrolled
total synthesis of the architecturally complex marine sp
194 a mild formamide reduction enabled the first
total synthesis of the Aspidosperma alkaloids (-)-mehran
195 A seven-step
total synthesis of the axially chiral, dimeric tetrahydr
196 ated by completing a highly enantioselective
total synthesis of the beta3-adrenergic receptor agonist
197 The first
total synthesis of the C18-norditerpenoid aconitine alka
198 ntin, a member of quassinoid family, and the
total synthesis of the cardioactive terpenoid (+)-cassai
199 We report the first
total synthesis of the complex akuammiline alkaloid picr
200 The first enantioselective
total synthesis of the complex tricarbocyclic sesquiterp
201 Described is the
total synthesis of the cyanotoxin microcystin-LF (MC-LF,
202 A formal
total synthesis of the cytotoxic macrolide amphidinolide
203 The first enantioselective
total synthesis of the cytotoxic natural product (+)-psi
204 A highly stereoselective
total synthesis of the diacetonide derivative of the ant
205 A
total synthesis of the diastereoisomeric pair of compoun
206 The first
total synthesis of the dimeric berberine alkaloid ilicif
207 We report the concise, biomimetic
total synthesis of the dimeric, Diels-Alder natural prod
208 ted by the application of this method to the
total synthesis of the Erythrina alkaloids 3-demethoxyer
209 synthesis of tubocurine represents a formal
total synthesis of the famous arrow poison alkaloid tubo
210 A 13-step
total synthesis of the fungal meroterpenoid berkeleyone
211 on tactic, was successfully employed for the
total synthesis of the highly cytotoxic marine macrolide
212 Total synthesis of the highly functionalized cyclic pept
213 The
total synthesis of the indole alkaloid ervincidine (3) i
214 A stereocontrolled
total synthesis of the indole diterpenoid natural produc
215 subsequent elaboration to complete the first
total synthesis of the juvenimicin, M-4365, and rosamici
216 his methodology has also been applied to the
total synthesis of the lignan natural product (-)-burseh
217 We report the first
total synthesis of the limonoid andirolide N using a 12-
218 The first
total synthesis of the marine natural product avrainvill
219 A five-step
total synthesis of the marine natural product synoxazoli
220 A four-step
total synthesis of the marine pyridoacridine alkaloid de
221 Additionally, the first
total synthesis of the monomeric indole alkaloids (+)-sp
222 Herein, we describe the
total synthesis of the most common pseudaminic acid, 5,7
223 Based on these findings, a concise
total synthesis of the natural product (+)-varitriol and
224 A new
total synthesis of the natural product (-)-depudecin, a
225 odular biosynthetic enzymes, we describe the
total synthesis of the natural product aeruginosamide B
226 n products has been demonstrated through the
total synthesis of the natural product cimiracemate B.
227 e was used as the key building block for the
total synthesis of the natural product phorbin A.
228 CPA), has enabled the first enantioselective
total synthesis of the natural product piperarborenine B
229 re now accessible because of advances in the
total synthesis of the natural product.
230 n an original convergent and stereoselective
total synthesis of the natural product.
231 ow accessible as a result of advances in the
total synthesis of the natural product.
232 A streamlined
total synthesis of the naturally occurring antitumor age
233 s are reported, which culminated in a formal
total synthesis of the neurotrophic agent (-)-jiadifenol
234 An asymmetric
total synthesis of the nootropic alkaloid (-)-huperzine
235 An enantioselective
total synthesis of the norditerpenoid alkaloid nigelladi
236 The first
total synthesis of the novel cyclohexylethanoid natural
237 be the isolation, structure elucidation, and
total synthesis of the novel marine natural product rifs
238 A short
total synthesis of the novel unnatural parthenolide dias
239 An enantioselective
total synthesis of the polycyclic diterpene (+)-chatanci
240 A 10-step
total synthesis of the polycyclic polyprenylated acylphl
241 A catalytic asymmetric
total synthesis of the potent and selective antileukemic
242 The development of a practical asymmetric
total synthesis of the potent HIV-1 integrase inhibitor
243 A convergent and stereoselective
total synthesis of the previously assigned structure of
244 The
total synthesis of the proposed structure for the minor
245 A
total synthesis of the proposed structure of nhatrangin
246 e results were utilized to achieve the first
total synthesis of the protein kinase C inhibitor corall
247 A short
total synthesis of the published structure of racemic tr
248 hod has been applied in the enantioselective
total synthesis of the purported structure of pulveraven
249 The first asymmetric
total synthesis of the putative structure of diplopyrone
250 lpha,beta-unsaturation is exemplified in the
total synthesis of the quinolizidine alkaloid natural pr
251 A
total synthesis of the racemic modification, (+/-)-2, of
252 The
total synthesis of the rare but extremely potent antitum
253 Furthermore, the
total synthesis of the related macrolide (2S)-sanctolide
254 The first
total synthesis of the reported structure of 13a-hydroxy
255 nd flexible strategy for the stereoselective
total synthesis of the reported structure of baulamycin
256 Herein, a
total synthesis of the resveratrol trimer vaticanol A ha
257 The method was further applied to the
total synthesis of the sesquiterpene natural products (+
258 The
total synthesis of the spliceosome inhibitor thailanstat
259 The methodology was used in the
total synthesis of the Stemona alkaloid (-)-stemaphyllin
260 arine natural product rifsaliniketal and the
total synthesis of the structurally related variants sal
261 A
total synthesis of the structure, 1, assigned to the rec
262 The
total synthesis of the Strychnos alkaloid (+/-)-minfiens
263 Herein we report the
total synthesis of the substance with the assigned struc
264 veloped that culminated in a stereoselective
total synthesis of the tetracyclic antimalarial Myrioneu
265 The first
total synthesis of the tetracyclic antimalarial Myrioneu
266 Here we report the
total synthesis of the three largest circular bacterioci
267 Herein we report the
total synthesis of the trans-fused 8,12-guaianolide (+)-
268 t-controlled enantio- and diastereoselective
total synthesis of the two most likely diastereomeric ca
269 An efficient
total synthesis of the unusual polyketide portentol is r
270 lecules to date have been facilitated by the
total synthesis of the various PP-InsP isomers and by th
271 We report herein a
total synthesis of the widely used polyketide insecticid
272 A stereocontrolled
total synthesis of this densely functionalized natural p
273 Herein, we disclose the first
total synthesis of this highly strained target in 13 ste
274 Two distinct strategies toward the
total synthesis of this interesting target are reported.
275 ard picrinine, which culminates in the first
total synthesis of this long-standing target.
276 inhibitor of rosettes (IOR-1) as well as the
total synthesis of this molecule and all of its stereois
277 he application of these methodologies in the
total synthesis of THP-based natural products.
278 The first
total synthesis of three omega-6 dihydroxylated (E,E,Z)-
279 mon precursor to accomplish collective first
total synthesis of titled natural products and proposed
280 The enantioselective
total synthesis of trans-clerodane diterpenoid 1 reporte
281 t-coupling strategy for the enantioselective
total synthesis of trans-clerodane diterpenoids is descr
282 The formation of 7p represents a
total synthesis of (+)-
trans-whisky lactone.
283 The first
total synthesis of trichoaurantianolides C and D is desc
284 thod was successfully applied to the concise
total synthesis of trichodermamide A (in gram quantities
285 An enantioselective
total synthesis of trioxacarcin DC-45-A2 (1) featuring a
286 design toward a concise and enantiospecific
total synthesis of tubingensin B, which hinges on the st
287 dged bicycle, these efforts have enabled the
total synthesis of tubingensin B.
288 We report the enantiospecific
total synthesis of (+)-
tubingensin A.
289 In addition, the
total synthesis of tubocurine represents a formal total
290 The
total synthesis of two key analogues of vancomycin conta
291 w reaction manifold is also showcased in the
total synthesis of two proteins.
292 An enantioselective
total synthesis of two sesquiterpenoids, kopeolin and ko
293 first isolation, structural elucidation and
total synthesis of two totally new polyketides isolated
294 a streamlined and practical enantioselective
total synthesis of uncialamycin that is amenable to the
295 by the protecting groups and applied to the
total synthesis of (+)-
varitriol and of two diastereoiso
296 A full account of the enantioselective
total synthesis of virgatolide B is reported.
297 The details of the
total synthesis of viridicatumtoxin B (1) are described.
298 described synthetic strategy resulted in the
total synthesis of viridicatumtoxin B (1), which, in tur
299 is general methodology was successful in the
total synthesis of Xyridin A, an important natural produ
300 Here we report the first
total synthesis of YM-254890 and FR900359, as well as of