ライフサイエンスコーパス: toward

1 rength") rises profoundly as loop gain rises toward 1.

2 mescales and provide a candidate entry point toward a better understanding of cognitive architectures

3 atile organic compounds (VOCs) from a source toward a building is limited by diffusion through the so

4 t-independent activation of lung macrophages toward a conserved hypoxia program, with the development

5 These collective findings point toward a deformed B cell repertoire as a fundamental com

6 male and female) were instructed to saccade toward a face or a house that, on different trials, rema

7 asein kinase 2, shifted the whole population toward a faster speed and lower contractility state.

8 accumulated evidence from literature points toward a future UWM that offers significant potential be

9 ecessitates a paradigm shift in conservation toward a holistic approach that incentivizes protection

10 t by adult mice engaging in social behaviors toward a juvenile mouse, compared with time spent in non

11 eatment resulted in the polarization of glia toward a prohealing phenotype associated with reduced NF

12 on of mouse peritoneal and human macrophages toward a proinflammatory M1 phenotype.

13 e related to steroid treatment shows a trend toward a protective effect (odds ratio, 0.16; 95% CI, 0.

14 obtained but also creates a predictive tool toward a quantitative approach.

15 mines (pi-electrophiles), but are unreactive toward a range of other electrophiles.

16 a bowel protocol was associated with a trend toward a reduction in constipation (risk ratio, 0.50 [95

17 g-DC skewed CD4(+) naive T cell polarization toward a regulatory phenotype and impaired CD8(+) T cell

18 f Hsp70 inactivation by AMPylation and point toward a role for protein AMPylation in the regulation o

19 omes, but the majority of DSBs are processed toward a safer alternative, namely noncrossovers (NCOs),

20 to apply a strong level of scientific rigor toward a well-planned, step-wise sequence of preclinical

21 Moving our society towards a bioeconomy requires efficient and sustainable

22 from the extended, partially unfolded state towards a compact, pre-organized conformation that resem

23 e relative abundance of each segment evolves towards a constant ratio.

24 to move (chemotaxis) or grow (chemotropism) towards a favorable environment.

25 This constitutes a first step towards a fully integrated system for rapid label-free s

26 cellent yield, and represents the first step towards a general transition metal catalysed synthesis o

27 pening inflammatory cytokines, thus pointing towards a new direction of immunomodulation for SCI repa

28 logy approach - moving free-living nematodes towards a parasitic lifestyle - will be our ultimate tes

29 tion can influence implicit attitudes (e.g., towards a race).

30 hole-dope the system away from half-filling, towards a regime in which complex many-body states are e

31 ce of non-canonical pairs, an important step towards accurate prediction of the full tertiary structu

32 Working towards achieving 120 x 20 is crucial for ultimately ach

33 mechanosensitive ICAM-1 downstream signaling toward activation of the PI3K, and recruitment of F-acti

34 t and eventually for designing new molecules toward AD therapeutic drugs.

35 Canver et al. have now taken the first steps towards addressing these issues by increasing screening

36 n shown that EDCs can predispose individuals toward adiposity by affecting developmental processes, l

37 P, and to strategically target interventions toward adolescents and rural poor women.

38 sensors in wearable electronics systems, and toward advanced bionic skin applications.

39 ing the treatment-free phase, no progression toward advanced phase CML occurred, and all relapsing pa

40 ion of oncogenic drivers are essential steps toward advancing cancer precision medicine.

41 ad-on-trunk position, but the phases shifted towards alignment with the head.

42 9b, and exert strongly suppressive functions toward allergic responses induced by naive and in vivo-p

43 ll conjugates, the ligand binding competence toward alphaVbeta3 (using both isolated receptors and al

44 mediated by deficient microglia polarization toward amyloid deposits, resulting in ineffective plaque

45 This paper proposes a first step toward an alternative computational framework in which n

46 will soon allow measurable clinical advances toward an HIV cure.

47 A trend toward an increased bleeding rate at presentation was ob

48 LVD switched cardiac MSCs toward an inflammatory phenotype, with increased secreti

49 granule biogenesis and directional migration toward an SDF1alpha gradient, leading to ectopic platele

50 As a next step toward an understanding of the mechanism by which IreB r

51 plication of theoretical mathematical models toward an understanding of the system's regulatory prope

52 tivating protein TPX2 shifts the equilibrium towards an active T-loop conformation whereas addition o

53 o that shortage by shifting antibiotic usage toward antibiotics traditionally known to place patients

54 rmutation (SHM) and affinity-based selection toward antigen in activated germinal center (GC) B cells

55 xyindoles exhibit remarkably high reactivity toward aromatic diazonium ions and this reaction can be

56 onstrating improved electrochemical activity towards ascorbic acid.

57 telligence have designed crucial ingredients towards autonomous learning: curiosity and intrinsic mot

58 xis and phagocytosis; Dictyostelium chemotax toward bacteria and phagocytose them as food sources.

59 es that switching of tetrapyrrole metabolism toward bacteriochlorophyll is coordinated with the produ

60 n of pilocarpine on endogenous M3R is biased toward beta-arrestin.

61 seeds, we assayed chemotaxis of S. meliloti towards betonicine, choline, glycine betaine, stachydrin

62 of standardized assays for novel biomarkers toward better defining hepatitis B virus cure should occ

63 chypodium can be exploited as a model system towards better understanding of F. pseudograminearum-whe

64 f drugs due to the remarkable ability of CB7 toward binding input molecules in water with high affini

65 P cells) and the kinase inhibitory activity (toward both isolated kinases and EPCs) remained almost u

66 for rare V2-bNAb precursors, and drive them toward breadth.

67 ons, and represent a significant advancement toward broader practical delivery of monoclonal antibody

68 on of nanomaterials could be a fruitful path towards building composites combining unique mechanical

69 the ability to operate as Delta6 desaturases towards C24 PUFA enabling them to synthesise DHA through

70 1000-fold and reduces the toxicity of Taxol towards cancer cell lines by over 200-fold.

71 tentiate the activity of innate immune cells towards cancer.

72 owth are found to be the optimized parameter toward capacity, Coulombic efficiency, stability, and ra

73 ytic activity with lower oxidation potential towards CC than SPCE modified with GR-CMF composite.

74 npoints the residues that confer specificity towards CC/TC motifs.

75 tently induces multiple myeloma PC migration toward CCL3 while abrogating the multiple myeloma PC mig

76 steady-state output of protein-coding genes toward circular RNAs.

77 pport future work to move CNGB1-RP therapies toward clinical trials.

78 creased the chemical stability of the capsid toward ClO2.

79 rodes with unprecedented catalytic stability toward CO2 reduction.

80 re shaped by evolution to bias transcription toward coding versus non-coding RNAs.

81 gainst a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietary antigens

82 Electrolysis is participating in the trend toward continuous flow synthesis, and this has led to a

83 Enormous progress has been made toward controlling the interactions of longitudinal mode

84 Despite enormous progress toward controlling the shapes and surface chemistry of c

85 f medicinal chemists to stabilize candidates toward cytochrome P450 activity, which increases the ris

86 balancing conflicting behavioral tendencies toward danger and reward, enabling adaptive responding u

87 e study of cell types is a powerful approach toward deciphering animal evolution.

88 somal markers thus reflects their rapid flux towards degradation rather than specific targeting to a

89 Bioelectronics moves toward designing nanoscale electronic platforms that all

90 give clues as to gecko behaviour, as well as towards designing synthetic adhesive mimics.

91 As countries move towards detecting the 3 million tuberculosis cases estim

92 invasiveness, thereby providing implications toward developing an effective therapy for TNBC.

93 nd thus a major focus of the oil industry is toward developing new technologies to increase recovery.

94 ults show that this strategy is a first step towards developing "activator drugs" for a large number

95 ture review of the current progress underway towards developing a vaccine to prevent cryptococcosis.

96 me naturally occurring compounds and efforts toward development of small molecules and biologics that

97 ) can increase the electrode sensing current toward different analytes.

98 Recognition behavior of FONs towards different metal ions was investigated with fluor

99 This pattern of results points toward DNAm as a potentially important biological mechan

100 omprehensive review of the synthetic efforts toward each member of the natural product family, includ

101 density) between antagonist strains swarming toward each other.

102 from early symptom-related causes, attitudes toward early palliative care integration, and patient-pa

103 c nanobiosensor paves a fascinating platform towards early detection of cancer tumour and is anticipa

104 the effects of shifting the immune response toward either M1 or M2 macrophages in vivo, wild-type mi

105 -RNA-guided Cas9 endonuclease and first step towards eliminating the ribose dependency of Cas9 to dev

106 lanie Taylor and colleagues discuss progress towards eliminating vertical transmission of HIV and syp

107 opportunities are needed to monitor progress toward elimination of mother-to-child HIV transmission.

108 foundation, the goal is now to drive malaria towards elimination.

109 While great strides have been made toward elucidating the cytoplasmic components of MAPK si

110 Toward elucidating the response of this modular protein

111 , as well as avoiding canopy gaps and moving toward emergent crowns.

112 there was very little agonist action of I942 towards EPAC2 or protein kinase A (PKA).

113 y findings of our study is the overall shift toward excitation in liver-related hypothalamic neurons

114 tion is of crucial importance to all efforts towards extending the species range of the technology as

115 t did not lead to O-O cleavage or reactivity toward external substrates.

116 these cells conveyed orally acquired prions toward FDC within Peyer's patches was not known.

117 sparse; the present study is a contribution towards filling this gap.

118 c cells to facilitate their initial delivery toward follicular dendritic cells to establish host infe

119 are shifting from simple control of symptoms toward full control of these diseases (clinical and endo

120 king activities, and that introducing a bias toward GDP tubulin has little impact on the observed MT

121 radiative lifetime limit, which is promising towards generation of transform-limited single photons.

122 hanism for the formation of doping-gradients toward grain boundaries, potentially explaining the exte

123 -aggregate porosity and a simultaneous shift toward greater accumulation of pore space in larger aggr

124 o performed surgical operations, the efforts toward group organization provided a means to promote th

125 nsitivity and selectivity of the array AgNRs toward H2S.

126 These strategies present a critical step towards harnessing the myriad of potential applications

127 r, social skills development programs geared toward having a balanced social skill must be implemente

128 e simultaneously inducing high levels of Abs toward hemagglutinin.

129 Recent years have seen strong tendencies toward high-protein diets.

130 taining structural stability is the key step towards high-voltage operation of layered-cathode materi

131 This shift towards higher frequencies was also reflected in the vis

132 his strategy elicits potent T cell responses toward highly conserved internal Ags while simultaneousl

133 y on bacterial growth with very low toxicity towards host macrophages.

134 FKBP22, and FKBP65 showed increased activity toward hydroxyproline-containing peptide substrates.

135 odulation may provide additional information toward identifying individuals potentially at risk for c

136 dentification of the linkage is a first step toward identifying the linking enzyme and potential inhi

137 the immunosuppressive tumor microenvironment toward immunostimulation and improves drug delivery and

138 These data are important first steps toward implementation of precision head and neck oncolog

139 To expedite progress towards improved quantitative tools, we have developed c

140 in threat response would be a valuable step towards improving our understanding of anxiety disorder

141 a, eczema, and allergy in childhood pointing toward in utero immune programming of the child.

142 reased the propensity of some human proteins towards inactivation due to disease-associated mutations

143 perienced a shortage and also showed a shift toward increased use of high-risk antibiotics was 1.30 (

144 idence for a shift in vector species complex towards increased zoophilic behavior in recent years.

145 mponents using optics alone promises a route towards increasingly dynamic systems, where the geometry

146 turn recruited circulating CCR2(+) monocytes toward infection.

147 r removal by immune cells and may contribute toward infusion-related adverse effects such as allergic

148 hese features results in a broad specificity toward Ins(1,2,4,5,6)P5 These features are main-chain co

149 f phage display to identify novel activities toward insects from distant taxonomic Orders and establi

150 sprayed on plants has been a major challenge towards its practical application.

151 the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p.

152 sponse against HA exhibited an inherent bias toward lambda L chain usage.

153 ift of Hmox1(-/-) myofiber size distribution toward larger one.

154 stant receptive fields and preclude any bias toward local light-intensity fluctuations.

155 There was a nonsignificant trend toward lower rates of GUSTO-defined severe/life-threaten

156 and fitness, there has been a genetic change towards lower body mass.

157 , and fat depot-specific cellular remodeling toward lowered energy storage capacity and browning of w

158 w numbers of cells underwent differentiation toward macrophages.

159 e the contributions of the Cas10-Csm complex toward maturation and explore roles of non-Cas nucleases

160 The ability to respond toward mechanical stimuli is a fundamental property of b

161 hope is that this could accelerate progress toward meeting this "grand challenge."

162 ity of the non-digested and digested samples towards metabolic syndrome-associated enzymes (alpha-amy

163 ics organelles, vesicles, and macromolecules toward microtubule minus ends.

164 Moreover, our findings point toward monitoring pathobiont-induced changes in microbio

165 he balance of bivalent histone modifications toward more active forms and induced KSHV reactivation i

166 rom expression of innate defensive responses toward more adaptive behavioral responses to threatening

167 , suggesting that Hmox1(-/-) SCs are shifted toward more differentiated myogenic population.

168 , and with more direct response trajectories toward negative ratings (i.e., less response competition

169 s the regulatory influence of new insertions toward neighboring chromosomal DNA.

170 led their dynamic and prolonged polarization toward neighboring NK cells without degranulation.

171 rrent experiments are taking the first steps toward noise-resilient logical qubits.

172 nsor showed high selectivity and sensitivity towards NSE, produced a linear response in the concentra

173 tal structure reveals that binding is biased toward occupation of the adenine subpocket of the AcCoA

174 induction; and 3) residual biocompatibility toward osteoblasts.

175 Response time of the immunosensor toward OTA was in the range of 500-800s.

176 sferase 1 (POMGNT1) catalyzes the first step toward other various glycan structures present on alpha-

177 udies of helminth infection have contributed toward our expanding cellular and molecular understandin

178 ves the redox shift from originally reducing toward oxidizing environments, when nitrate input has co

179 formance and cost-effective electrocatalysts toward oxygen evolution and hydrogen evolution reactions

180 of these, SbCCR2, displayed greater activity toward p-coumaroyl-CoA than did SbCCR1, which could impl

181 lted in increased injury tolls due to shifts toward participation in competitive sports at earlier ag

182 take kinetics and great sorption selectivity toward PFOS are observed.

183 ant BAR and PAT exhibit substrate preference toward phosphinothricin over the 20 proteinogenic amino

184 athrin and dynamin, show a strong preference towards positive membrane curvatures with a radius <200

185 rs to target financial support interventions toward potential donors at higher risk of perceiving don

186 Although the first steps toward potential therapies have been taken, there are su

187 h a few exceptions, the estimates are biased toward predicting saturation vapor pressures that are to

188 he response of human dermal fibroblast cells toward pristine titania nanotubes fabricated by anodic o

189 Rosa species demonstrated inhibition potency towards production of some monitored eicosanoids in cycl

190 en synthesized and its recognition abilities toward pyridinium guests have been investigated and comp

191 nificance of the pellet-based sensing system towards realizing a reusable, point-of-care sensor that

192 polymer electrodes with kinetic selectivity toward redox active species and help guide synthetic app

193 AVA was reduced and a trend toward reduced IVNV was seen in UPI/OIR compared to cont

194 racer [(11)C]DPA-713 revealed a strong trend towards reduced TSPO binding in the middle frontal gyrus

195 Moreover, they maintained good activity also toward resistant strains, and they were selective over o

196 und healing is a biological process directed towards restoration of tissue that has suffered an injur

197 Risk preferences changed substantially toward risk aversion as reward accumulated within a cont

198 various types of aggression, their attitudes towards seclusion and restraint, and their emotions.

199 er exhibits a very high level of selectivity towards small substrates including the natural indole-3-

200 Under dry conditions, the reactivity towards SO2 uptake was highest on delta-MnO2 but lowest

201 ner and colleagues describe a promising step toward solving this problem by identifying and describin

202 vantageous or obtrusive to function directed toward speech and language at a given moment.

203 nescent properties of ZnO QDs and is applied towards substrate-free Schottky photodetector applicatio

204 ted PDI variants with a slowed reaction rate toward substrates.

205 e able to shift substrate specificity of MCD toward succinyl-CoA through active-site mutagenesis.

206 ailable a maximum envelope of US $45 million toward supporting countries not eligible for Gavi fundin

207 cterized, and their electrochemical behavior towards SY was investigated.

208 for bSC dendritogenesis: orienting dendrites toward TCAs, adding de novo dendritic segments, and elon

209 co-activators (NCOA1, -2 and -3, and CREBBP) towards term is a shared derived feature of eutherians.

210 ved substrates, similar trends in reactivity toward tertiary and benzylic C-H bonds are observed.

211 t" at long time where its response now tends toward that of a hemicylinder of equal radius.

212 of 17alpha-hydroxypregnenolone to DHEA than toward the 17alpha-hydroxylation of pregnenolone.

213 Conversely, the imbalance toward the 4R isoform promoted a retrograde bias by a si

214 It was found that the dopant migration toward the alloyed interface of core/shell QDs is a ther

215 When humans moved from Asia toward the Americas over 18,000 y ago and eventually peo

216 e NIMS sensitivity of these various surfaces toward the analysis of diverse analytes.

217 ults highlighted that KuQs are highly active toward the analyzed cell lines and almost nontoxic for h

218 uring along the filopodial shaft and surfing toward the cell body, the most common mode of capture; (

219 of super-enhancers in DIPG provides insights toward the cell of origin, highlighting oligodendroglial

220 The growing microtubule plus ends extend toward the cell's apex and base with a region of antipar

221 step decision dynamics were initially biased toward the choice representing the highest sum/mean befo

222 the highest sum/mean before being redirected toward the choice representing the maximal reward (i.e.,

223 l when the conformational equilibrium shifts toward the conductive state.

224 S)-Orteronel was three times more inhibitory toward the conversion of 17alpha-hydroxypregnenolone to

225 croFIPs represent a significant step forward toward the development of implantable drug-delivery syst

226 rdized care on outcomes has yielded progress toward the development of novel therapeutic strategies a

227 gation this methodology provides a blueprint toward the development of photoredox catalysis as a gene

228 other diseases and represents an advancement toward the development of small molecule activators of t

229 These data, however, have spurred efforts toward the discovery and development of improved or nove

230 We demonstrate its potential use toward the electrochemical detection of nitroaromatic co

231 Our "ex-cell" approach toward the electrosynthesis of benzoxazoles is compatibl

232 ear HS11 freshwater signal, which attenuated toward the eMed, and also that last interglacial surface

233 Toward the end of each phase, we measured arterial blood

234 hus, upregulation of EBI2 drives the B cells toward the extrafollicular area, whereas downregulation

235 al maps and robust remapping of place fields toward the goal location.

236 ve and the supramolecular helicity is biased toward the helical preference of the sergeant.

237 e Synechococcus with less phycouribilin fell toward the HLO end of the continuum.

238 Major efforts toward the identification of chemical modulators of the

239 o control centrosome and Golgi reorientation toward the leading edge, a hallmark of cell polarization

240 phycouribilin: phycoerythrobilin ratios fell toward the LLO end of the continuum, while sub-cluster 5

241 spectively, suggesting that release of the Q toward the membrane is coupled to an energy transduction

242 hat the 4'-OMe imparts a conformational bias toward the North-East sugar pucker, due to intramolecula

243 ate that MAPK1 exhibits preferential binding toward the open conformation of vinculin, suggesting tha

244 A unified synthetic strategy toward the oridamycin and xiamycin families of natural p

245 otential that directs the rotating lever arm toward the poststroke conformation is almost flat, imply

246 lioma cells, shunting tryptophan degradation toward the production of neurotoxic quinolinic acid.

247 full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emiss

248 As genome editing rapidly progresses toward the realization of its clinical promise, assessin

249 response, and high electrocatalytic activity toward the reduction of paraoxon.

250 The BiO-SPEs were evaluated toward the sensing of APAP and INH in human serum, urine

251 te pathway, and a redirection of carbon flux toward the shikimate-derived aromatic amino acids tyrosi

252 cilitates the trafficking of axonal retromer toward the soma and thus enhances protease transport to

253 ve predominantly in the retrograde direction toward the soma, where mature lysosomes are mainly locat

254 and caused defects in axon projection of DRG toward the spinal cord in vivo Furthermore, live-cell im

255 s is a reversible process, generally shifted toward the sulfoxide.

256 IV)-oxo species by channeling these oxidants toward the synthesis of a functionally equivalent binucl

257 ions of these geometrically defined enamides toward the synthesis of cis vicinal amino alcohols and t

258 ready very versatile Suzuki-Miyaura reaction toward the synthesis of very electron-poor products, mak

259 rms a strong basis for using humanized IL-27 toward the treatment of post-menopausal osteoporosis.

260 a probe for PSMA-targeted RGS and also hint toward the unexpected potential of (99m)Tc-PSMA-I&S as a

261 chnological efforts are currently being made towards the development of neural prostheses.

262 driven by an increase in home range overlap towards the end of the dry season.

263 e that individual susceptibility predisposes towards the expression of different behavioural subtypes

264 oxide complex exhibited superior performance towards the generation of syn 2,5-disubstituted pyrrolid

265 n energy for eta changes little with cooling towards the glass transition temperature, Tg.

266 g and other tropisms, leading us yet further towards the Holy Grail of plant growth.

267 rrelation with the behavioral changes of IJs towards the infected hosts.

268 increasing concentration of fluorescent PTM towards the lens centre in accord with the increased opt

269 of driving processes of iceberg degradation towards the open ocean.

270 MG is explored as a significant biomarker towards the prediction of diabetic complications.

271 nd successive harvesting may be useful tools towards the production of high quality end-product with

272 nical architecture affords a promising route towards the realization of topological nano-mechanospint

273 necessary for its ubiquitin ligase activity towards the substrate and also the self-ubiquitylation.

274 he specific and selective biosensor response towards the target protein.

275 ammals, thalamic axons are guided internally toward their neocortical target by corridor (Co) neurons

276 romising siRNA carriers for in vivo purposes towards therapeutic applications.

277 Toward this end, embedding electronic-spin-based qubits

278 Toward this end, the availability of DNA sequence data f

279 Toward this end, we have synthesized a platinum complex

280 rticle will describe the past decade of work toward this goal and articulate both the promise that no

281 Here, Davanco et al. stride toward this goal by hybrid on-chip integration of Si3N4

282 Toward this goal, we developed a software pipeline named

283 Towards this aim, we have designed a holographic on-chip

284 etic engineering show considerable potential towards this goal.

285 and is 4 orders of magnitude more selective towards thrombin than to the other serine proteases of t

286 reatic cancer research community as it moves toward to the goal of extending patient survival.

287 he motif's enrichment or biased distribution towards transcription start sites in the promoters of co

288 ess whether a change in access site practice toward transradial access nationally has led to worse ou

289 both KCl and NaCl act as salting-out agents towards trehalose, as seen in the elevated activity coef

290 significant attenuation, hindering progress toward understanding determinants of transmission and pa

291 cannabis dependence is among the first steps toward understanding the biological contributions to the

292 These results move us towards understanding how the PAG might be intricately i

293 an interaction-relaxation model is developed towards understanding the microscopic mechanism of the p

294 on from lower-than-average rates before 1990 toward unprecedented high rates in recent decades.

295 Global health systems are shifting toward value-based care in an effort to drive better out

296 The SDT predicts unilinear change toward very low fertility and a diversity of union and f

297 hich exhibit excellent sorption capabilities toward water and fluorocarbon R134a.

298 d surface suitable for membrane interaction, toward which the kinase active sites are oriented.

299 The synthetic strategies toward YSNs are divided into four categories, including

300 pproximately 50% of serum immunoreactivities toward ZnT8 were mapped to its transmembrane domain that