ライフサイエンスコーパス: towards

1 hift away from the antibiotic napyradiomycin towards 8-amino-flaviolin, an intermediate in the napyra

2 Moving our society towards a bioeconomy requires efficient and sustainable

3 red of white adipose tissue origin can shift towards a brown/beige adipocyte phenotype.

4 from the extended, partially unfolded state towards a compact, pre-organized conformation that resem

5 f the bound nucleotide AMPylation biases BiP towards a conformation normally attained by the ATP-boun

6 e relative abundance of each segment evolves towards a constant ratio.

7 sition (EMT)-related molecules further point towards a contribution of the modulation of EMT.

8 Taken together, the findings indicate towards a crucial role played by the tissue-specific alt

9 t the vicinity of the disordering transition towards a defective fluorite structure translates into a

10 to move (chemotaxis) or grow (chemotropism) towards a favorable environment.

11 This constitutes a first step towards a fully integrated system for rapid label-free s

12 These results pave the way towards a gene replacement approach for OPMD treatment.

13 cellent yield, and represents the first step towards a general transition metal catalysed synthesis o

14 DBS shifts global brain dynamics of patients towards a Healthy regime.

15 rapies that will redirect the gut microbiome towards a healthy state and maintain remission in IBD.

16 analyzing cell viability has been developed towards a high throughput drug screening.

17 interleukin (IL)-4 in polarizing these cells towards a M1 or M2 phenotype, respectively.

18 rodent models of helminth infection, points towards a multitude of interactions occurring between pa

19 pening inflammatory cytokines, thus pointing towards a new direction of immunomodulation for SCI repa

20 This constitutes a significant step towards a new generation of stem cell-based treatment fo

21 logy approach - moving free-living nematodes towards a parasitic lifestyle - will be our ultimate tes

22 ed to enhance females' affiliative behaviour towards a partner.

23 a tumor associated macrophages (TAMs) shift towards a pro-tumoral M2 phenotype.

24 hol consumption may activate endothelial EVs towards a pro-vascularization phenotype, which could hav

25 tion can influence implicit attitudes (e.g., towards a race).

26 hole-dope the system away from half-filling, towards a regime in which complex many-body states are e

27 ion and that Th2 cells modulate Th1 cultures towards a self-regulatory phenotype, contributing to the

28 Our results therefore pave the way towards a statistical description of heterogeneous calci

29 by mutations in the Shine-Dalgarno sequence towards a stronger translation initiation signal.

30 king such an undulator a potential candidate towards a table-top FEL.

31 edia, where light is driven out of coherence towards a thermal mixture.

32 gineering of insulin itself and its potency, towards a viable GRI.

33 ce of non-canonical pairs, an important step towards accurate prediction of the full tertiary structu

34 Working towards achieving 120 x 20 is crucial for ultimately ach

35 imensional tunnelled materials, particularly towards achieving high-rate capability.

36 Findings from this study pave the way towards adapting novel QUS-based frameworks for breast c

37 Canver et al. have now taken the first steps towards addressing these issues by increasing screening

38 a concrete, feasible, and promising approach towards advancing health equity and improving population

39 ad-on-trunk position, but the phases shifted towards alignment with the head.

40 components, which cooperate synergistically towards alkaline hydrogen evolution reaction.

41 ariation between sampler and sensor, hinting towards an 'optimization' for efficient chemoreception.

42 tivating protein TPX2 shifts the equilibrium towards an active T-loop conformation whereas addition o

43 ure seabird conservation policies and moving towards an ecosystem-based approach to sustainable fishe

44 sufficient to drive switching of Th17 cells towards an IFN-gamma-producing phenotype.

45 profile of multi-cytokine producing T-cells towards an IFNgamma(+) perforin(+) response, suggesting

46 BAL cytokine skewed towards an M2 profile with increase in CCL22, IL-4, IL-1

47 r which bacteria are developing a resistance towards anyway.

48 nanoparticle ensemble exhibited selectivity towards Arg by showing distinguishable colour change fro

49 idizing bacteria exhibit positive chemotaxis towards As(III), however, the related As(III) chemorecep

50 onstrating improved electrochemical activity towards ascorbic acid.

51 ought that aids LiOH oxidation and is stable towards attack by hydroxyl radicals.

52 telligence have designed crucial ingredients towards autonomous learning: curiosity and intrinsic mot

53 bunit containing GABAA receptors insensitive towards benzodiazepines.

54 seeds, we assayed chemotaxis of S. meliloti towards betonicine, choline, glycine betaine, stachydrin

55 chypodium can be exploited as a model system towards better understanding of F. pseudograminearum-whe

56 4+ (hBM34+) cells into symptomatic G93A mice towards blood-spinal cord barrier (BSCB) repair.

57 mycin, which have high inhibitory activities towards both Hsp70 and Hsp90, exhibit enhanced anti-leuk

58 on of nanomaterials could be a fruitful path towards building composites combining unique mechanical

59 Here, we present our progress towards building such a modulator by demonstrating the o

60 butyrylcholinesterase (BChE) enzyme activity towards butyrylthiocholine with and without exposure to

61 the ability to operate as Delta6 desaturases towards C24 PUFA enabling them to synthesise DHA through

62 1000-fold and reduces the toxicity of Taxol towards cancer cell lines by over 200-fold.

63 explain the observed bias for L1 insertions towards cancer-associated genes.

64 tentiate the activity of innate immune cells towards cancer.

65 found that TTPA also exhibits lytic activity towards capsular exopolysaccharide (EPS) of the multires

66 ycle to increase carbon flux and redirect it towards carbon fixation.

67 The biosensor has high selectivity towards CC in the presence of potentially active biomole

68 ytic activity with lower oxidation potential towards CC than SPCE modified with GR-CMF composite.

69 npoints the residues that confer specificity towards CC/TC motifs.

70 rophils remained fully functional to migrate towards chemical cues and maintained their ability to un

71 gressing these devices through animal models towards clinical products, understanding the mechanical

72 ibited outstanding anti-interference ability towards co-existing molecules with good stability, sensi

73 in other plasmid-host pairs, our work points towards common mechanisms of plasmid stabilization.

74 It can be used to identify the creep towards complete antibiotics resistance in bacteria usin

75 tive evidence that Campi Flegrei is evolving towards conditions more favourable to eruption and ident

76 somal markers thus reflects their rapid flux towards degradation rather than specific targeting to a

77 give clues as to gecko behaviour, as well as towards designing synthetic adhesive mimics.

78 As countries move towards detecting the 3 million tuberculosis cases estim

79 ults show that this strategy is a first step towards developing "activator drugs" for a large number

80 ture review of the current progress underway towards developing a vaccine to prevent cryptococcosis.

81 research and highlight different approaches towards developing crops with enhanced PUE.

82 Our results open a new avenue towards developing novel thermoelectric materials throug

83 nctions of ERG in prostate tumor biology and towards development of early targeted therapeutic strate

84 onfer DmGSTE6-like activity could contribute towards development of phytoremediation strategies to cl

85 Recognition behavior of FONs towards different metal ions was investigated with fluor

86 romagnetic materials and unveils new avenues towards dissipationless topological antiferromagnetic sp

87 spite the inherent challenges, nurses strive towards doing their utmost for patients and families.

88 lms we can significantly improve sensitivity towards dopamine as well as selectively promote cell via

89 c nanobiosensor paves a fascinating platform towards early detection of cancer tumour and is anticipa

90 s recently triggered substantial R&D efforts towards efficient and stable water electrolysis technolo

91 ite also displays high performance catalysis towards electroreduction of H2O2 with a high sensitivity

92 -RNA-guided Cas9 endonuclease and first step towards eliminating the ribose dependency of Cas9 to dev

93 lanie Taylor and colleagues discuss progress towards eliminating vertical transmission of HIV and syp

94 foundation, the goal is now to drive malaria towards elimination.

95 known to result from single-cell chemotaxis towards emitted pulses of cyclic adenosine monophosphate

96 Here, we present a first step towards empirically investigating the probability of tra

97 wledge, attitudes, confidence, and behaviour towards employees with mental health problems, and its e

98 ated single-electron transfer as a mechanism towards enabling site- and chemoselective bioconjugation

99 ase rapidly affects glomeruli and progresses towards end stage renal failure and multiple organ dysfu

100 stinal digestion and the inhibitory activity towards endothelial cell migration.

101 gurations are identified that can be steered towards entities predominantly fused to graphene edges t

102 tide small molecules with agonist properties towards EPAC1.

103 there was very little agonist action of I942 towards EPAC2 or protein kinase A (PKA).

104 th elevated erythropoiesis, an obligate step towards erythroid recovery in response to supplementatio

105 This work provides a step towards establishing a more robust framework for using C

106 The quest towards expansion of the M n+1AX n design space has been

107 tion is of crucial importance to all efforts towards extending the species range of the technology as

108 als continuously gather sensory cues to move towards favourable environments.

109 sparse; the present study is a contribution towards filling this gap.

110 dose-response relationship is a key element towards fulfilling safety assessments and satisfying reg

111 urface with substantially different affinity towards fungal hyphae.

112 lable data (from the past decade) pertaining towards fungal occurrence and level of mycotoxins in var

113 radiative lifetime limit, which is promising towards generation of transform-limited single photons.

114 ss scenario, in which countries' advancement towards global targets is constrained by their health sy

115 ucose sensor favored a very high selectivity towards glucose in the presence of competing and non-com

116 ic enzymes and in turn switches glucose flux towards glycolysis relative to the pentose phosphate pat

117 r KD against GtfC, demonstrating selectivity towards GtfC.

118 ssor exposure, including long-lasting biases towards habit-based responding in a food-reinforced oper

119 These strategies present a critical step towards harnessing the myriad of potential applications

120 The recent surge of interest towards high-band gap absorbers for tandem applications

121 taining structural stability is the key step towards high-voltage operation of layered-cathode materi

122 nature selection for population inhabitation towards higher altitudes on the Qinghai-Tibetan Plateau.

123 This shift towards higher frequencies was also reflected in the vis

124 y on bacterial growth with very low toxicity towards host macrophages.

125 ng the temperature, vesicles can be directed towards hot or cold, forming a highly concentrated regio

126 inib hybrids have weak inhibitory activities towards Hsp70 and Abl, and display lower cytotoxicity ag

127 nt sub-micromolar antiproliferative activity towards human cancer cells and are active in vivo.

128 l putative binding site; is weakly cytotoxic towards human primary blood leukocytes or retinal pigmen

129 ly observed effect was an increased affinity towards hydrophobic probes in the presence of all co-sol

130 To expedite progress towards improved quantitative tools, we have developed c

131 in threat response would be a valuable step towards improving our understanding of anxiety disorder

132 reased the propensity of some human proteins towards inactivation due to disease-associated mutations

133 idence for a shift in vector species complex towards increased zoophilic behavior in recent years.

134 mponents using optics alone promises a route towards increasingly dynamic systems, where the geometry

135 differentiation of T helper 17 (TH17) cells towards induced regulatory T (iTreg) cells, we show that

136 he TNF promoter, thereby tipping the balance towards inflammation rather than resolution.

137 neration derivatives to improve drug potency towards inhibition of their molecular targets.

138 or and sensory nerves from the residual limb towards intact muscles and skin regions.

139 ects important for SHIP2 activity and points towards interesting new possibilities for therapeutic in

140 leading to efficient funnelling of excitons towards isolated strain-tuned quantum emitters that exhi

141 sprayed on plants has been a major challenge towards its practical application.

142 all molecule with around 75-fold selectivity towards KDM2A/7A versus other KDMs, as well as cellular

143 ve shown that humans act more altruistically towards kin.

144 the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p.

145 ed patterns under secondary succession (e.g. towards late-successional short-statured hardwoods in Me

146 nscriptome to facilitate parasite transition towards latency.

147 We show that cells indeed gravitate towards local minima and signal inductions dictate cell

148 and fitness, there has been a genetic change towards lower body mass.

149 livers of DR mice is correspondingly shifted towards lowered triglyceride content and shorter chain l

150 We then review recent efforts towards man-made dissipative assembly of structures and

151 icroneedle patches, will facilitate progress towards measles elimination and eradication.

152 we propose application of mass spectrometry towards measurement of compositional differences among e

153 the later dispersal took place more recently towards Mediterranean Europe during the Neolithic ( 8 th

154 ity of the non-digested and digested samples towards metabolic syndrome-associated enzymes (alpha-amy

155 xpression pattern of Zt6 and potent toxicity towards microorganisms suggest that, although it may con

156 ing organelles, RNAs, proteins, and viruses, towards microtubule minus ends.

157 ged substantially with age, with progression towards more biomarker abnormalities among individuals w

158 ion, they are beginning to advance the field towards more fine-grained approaches that interrogate th

159 MB/MF behaviour but rather displayed a shift towards more MB behavior over the first two blocks that

160 HeLa and HT-29 cell lines, but were inactive towards MRC-5 and MCF7.

161 diisopropylphenyl)imidazol-2-ylidene (IPr)), towards [Na(dioxane)x ][PnCO] (Pn=P, As) is described.

162 h with 66 nonbreakthrough IMIs shows a shift towards non-Aspergillus molds with a significantly incre

163 te or unavailable, biasing existing analysis towards Northern Hemisphere Christian countries.

164 imals can be confounded further by neophobia towards novel test environments and avoidance of test st

165 nsor showed high selectivity and sensitivity towards NSE, produced a linear response in the concentra

166 sus C-terminal carboxylates can be exploited towards obtaining C-terminal functionalization exclusive

167 cost, highly selective along with abilities towards online monitoring and remote sensing of analyte.

168 at the enzymes involved have already evolved towards optimal performance.

169 ooperators channel their help preferentially towards others of similar phenotypes.

170 This decrease sensitizes bacteria towards oxidative stress, reduces colonization and atten

171 nce and cross-reactivity of T-cell responses towards Phl p 12 are comparable to the major allergen Ph

172 athrin and dynamin, show a strong preference towards positive membrane curvatures with a radius <200

173 es the multimodal imaging of biliary anatomy towards precision cholecystectomy.

174 inical and biological complexity and to move towards precision medicine in COPD, we need to integrate

175 ential for in vitro testing of drug efficacy towards prediction of in vivo outcomes and investigation

176 of evolution of species' elevational ranges towards present.

177 on was accompanied by a change in motivation towards problem-solving, expressed in reduced neophobia

178 To date, the attempts towards producing c-BN NDs were mainly performed under e

179 Rosa species demonstrated inhibition potency towards production of some monitored eicosanoids in cycl

180 elayed drainage of corneal edema and a trend towards prolonged corneal opacification.

181 These findings point towards promiscuous spread of the mcr-1 gene by efficien

182 le substantial research efforts are directed towards quantifying projections and uncertainties of fut

183 The extract showed antioxidant activity towards radicals in both environments, aqueous and hydro

184 work therefore provides a promising approach towards rational design of multifunctional, elastic SEIs

185 nificance of the pellet-based sensing system towards realizing a reusable, point-of-care sensor that

186 racer [(11)C]DPA-713 revealed a strong trend towards reduced TSPO binding in the middle frontal gyrus

187 opagated using a dual media approach refined towards regulatory compliance showed expression of marke

188 olve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic cefotaxime in an Es

189 und healing is a biological process directed towards restoration of tissue that has suffered an injur

190 rated biomimetic functions is paving the way towards rudimentary forms of artificial cell-like entiti

191 ble of controlled interactions offers a step towards rudimentary forms of collective behaviour in com

192 a and Pokkali show a high level of tolerance towards salinity stress compared to IR64 variety.

193 icantly higher causal drive in the direction towards SBP and COPr.

194 various types of aggression, their attitudes towards seclusion and restraint, and their emotions.

195 ity contrast of 12 per cent, which increases towards shorter wavelengths.

196 molecular cues that control MK polarization towards sinusoids and limit transendothelial crossing to

197 er exhibits a very high level of selectivity towards small substrates including the natural indole-3-

198 Under dry conditions, the reactivity towards SO2 uptake was highest on delta-MnO2 but lowest

199 ard trend in the measured values and a shift towards soft tissue values was observed with decreasing

200 r to the Holocene ( 11.5 thousand years ago) towards South Asia, while the later dispersal took place

201 Our results open a path towards specialized embedded memory-logic applications a

202 an atomic resolution of 2.3 A, which points towards specific amino acids that may function in cataly

203 nucleosomes, directing remodelling activity towards specific nucleosome substrates according to thei

204 his review describes experimental approaches towards studying endosymbiotic and horizontal gene trans

205 efficaciousness of the biosensor performance towards subcutaneous alcohol monitoring was substantiate

206 s a cheap, sensitive and quantitative method towards substandard and counterfeit drug detection.

207 nescent properties of ZnO QDs and is applied towards substrate-free Schottky photodetector applicatio

208 To take first steps towards such a multifunctional surface we propose mergin

209 fers a guideline for the clinical management towards survival of GITB in transplant patients, complic

210 cterized, and their electrochemical behavior towards SY was investigated.

211 current knowledge on AMF diversity is biased towards temperate ecosystems, whereas little is known ab

212 co-activators (NCOA1, -2 and -3, and CREBBP) towards term is a shared derived feature of eutherians.

213 n, which is essential for fate determination towards TH17 cells.

214 Towards the 19(th) and 20(th) centuries, Q was introgres

215 tion in the methods for determining progress towards the 90-90-90 target.

216 crystal structures using measurements biased towards the active site geometry.

217 the particle sub-pixel positions are biased towards the center of the pixel.

218 impact, and may thereby accelerate progress towards the desired endpoint (e.g., elimination) or incr

219 this work represents an important milestone towards the detection of biomarkers in tissues, which is

220 ased chemical sensor and GOx based biosensor towards the determination of H2O2 and glucose in the rea

221 3) and the sensitivity of 924muAmM(-1)cm(-2) towards the determination of UA.

222 high-resolution crystal structure are a step towards the development of antivirals against ZIKV and o

223 rther applied in UPR-targeted drug discovery towards the development of disease-modifying therapeutic

224 chnological efforts are currently being made towards the development of neural prostheses.

225 at low pressures and increasing in pressure towards the dew point along isotherms.

226 nd the avian fovea is off the retinal center towards the dorso-temporal region of the retina.

227 y the phase-shift in their expression scores towards the early stages of the disease.

228 on of fluorophores decreased as it was moved towards the end of the construct while reprogramming was

229 driven by an increase in home range overlap towards the end of the dry season.

230 e soil, which represents a technical advance towards the establishment of causal relationships betwee

231 e that individual susceptibility predisposes towards the expression of different behavioural subtypes

232 Cracks propagate from the core of the weld towards the free surface along the solidifying grain bou

233 roposed to account for the funnelling of gas towards the galactic centre to feed the black hole.

234 colloidal particles move either away from or towards the gas-liquid interface depending on their surf

235 oxide complex exhibited superior performance towards the generation of syn 2,5-disubstituted pyrrolid

236 n energy for eta changes little with cooling towards the glass transition temperature, Tg.

237 ensitivity of as-formed label-free biosensor towards the GVA-antigens was determined in the range fro

238 ates an unexpectedly high catalytic activity towards the HER (-0.46 V vs. SCE) upon the 1000th cycle,

239 g and other tropisms, leading us yet further towards the Holy Grail of plant growth.

240 We discover that fibrils accumulate towards the hot side of the channel at the temperature r

241 We developed a novel approach towards the identification of active pharmaceutical ingr

242 rrelation with the behavioral changes of IJs towards the infected hosts.

243 fference between the two groups was observed towards the lateral and the posterior sides of prostate.

244 increasing concentration of fluorescent PTM towards the lens centre in accord with the increased opt

245 his approach, we found that the 2nd position towards the N-terminus side of the HA PCS (P2 position)

246 of driving processes of iceberg degradation towards the open ocean.

247 ibited an enhanced electrocatalytic response towards the oxidation of NO as compared to other control

248 Our work constitutes a stepping stone towards the paradigm of self-correcting quantum informat

249 ei showed a softer and more viscous response towards the periphery, suggesting a reduced degree of cr

250 d rank participant's phenotypic contribution towards the PGP.

251 translocation of alphaENaC immunoreactivity towards the plasma membrane.

252 lance, guides the flow and orients extension towards the posterior end.

253 Recent research has been directed towards the potential association of vitamin D concentra

254 MG is explored as a significant biomarker towards the prediction of diabetic complications.

255 , projecting throughout the hypothalamus and towards the preoptic area.

256 ake some recommendations for future research towards the prevention and control of this important dis

257 nd successive harvesting may be useful tools towards the production of high quality end-product with

258 nical architecture affords a promising route towards the realization of topological nano-mechanospint

259 a hybrida, SL transport within the plant and towards the rhizosphere is driven by the ABCG-class prot

260 ons clam-shell drops would move from the tip towards the root on a conical wire.

261 lular alignments, which indicate two streams towards the sites of dorsal amniotic closure and ventral

262 ic aster asymmetry and spindle pole movement towards the subdomain of cortical ER, whereas locally in

263 necessary for its ubiquitin ligase activity towards the substrate and also the self-ubiquitylation.

264 Besides, the biosensor had good selectivity towards the target DNA over the non-specific sequences a

265 he specific and selective biosensor response towards the target protein.

266 nd this provides for an additional mechanism towards the therapeutic utility of these drugs as immuno

267 drophobic binding groove of the SRP M domain towards the translocon.

268 our communities in Zambia to assess progress towards the UNAIDS targets after 1 y of the PopART inter

269 ), although this anomaly may be concentrated towards the very base of the mantle.

270 gradient by crawling under the agarose spots towards their centre.

271 identified the contribution of gene activity towards their construction.

272 romising siRNA carriers for in vivo purposes towards therapeutic applications.

273 Towards this aim, we have designed a holographic on-chip

274 Towards this end, we sought to determine how two SR prot

275 Towards this end, we used CRISPR-Cas9 genome editing to

276 Structure-based methods have contributed towards this goal but they focus on predicting the bindi

277 There has been significant progress towards this goal using electron tomography.

278 As a step towards this goal, we developed a method to examine whet

279 etic engineering show considerable potential towards this goal.

280 Hypervigilance towards threat is one of the defining features of post-t

281 and is 4 orders of magnitude more selective towards thrombin than to the other serine proteases of t

282 he motif's enrichment or biased distribution towards transcription start sites in the promoters of co

283 s a designed deactivation of one nucleophile towards transmetallation.

284 both KCl and NaCl act as salting-out agents towards trehalose, as seen in the elevated activity coef

285 in eudicots the CYP716s evolved specifically towards triterpenoid biosynthesis.

286 Structural modelling points towards two plausible and distinct mechanisms of oestrog

287 quired to reach to either a single target or towards two potential targets while grasping an object.

288 interdigitated electrode arrays (IDE-arrays) towards ultrafast, label-free screening of heart type-FA

289 genes for phenocopy as a critical first step towards understanding disease mechanisms of the candidat

290 These results move us towards understanding how the PAG might be intricately i

291 gen and the need for in-depth investigations towards understanding its pathogenesis, epidemiology and

292 ight the considerable progress made recently towards understanding the diverse roles of the cytoskele

293 an interaction-relaxation model is developed towards understanding the microscopic mechanism of the p

294 ledge of such pathways is a fundamental step towards understanding the neural circuits underpinning e

295 lated outcomes provides invaluable knowledge towards understanding the roles of microbes in the under

296 ght the importance to increase the awareness towards upper airway disorders in the swimming athletes

297 et needs with the intent to enhance progress towards use of these facilities in determining safety an

298 uring ectothermic assemblages facing changes towards warmer and dryer climates.

299 which slow-wave activity might bias synapses towards weakening, while preserving the synaptic connect

300 The negligible activity of AnGDH towards xylose was also explained on the basis of a 3D s