ライフサイエンスコーパス: toxic shock

1 ells, which can result in potentially lethal toxic shock.

2 ice and were also protected from SEB-induced toxic shock.

3 as a leading cause of food-borne disease and toxic shock.

4 including sepsis, necrotizing fasciitis and toxic shock.

5 be key effector cells in the pathogenesis of toxic shock.

6 sociated with severe systemic infections and toxic shock.

7 -induced lymphocyte proliferation and lethal toxic shock.

8 t attempt to associate toxin production with toxic shock.

9 ock and multiorgan failure characteristic of toxic shock.

10 ring on the pathophysiology of streptococcal toxic shock.

11 e for IL-18/IL-18Ralpha in Ehrlichia-induced toxic shock.

12 ering a potential approach in the therapy of toxic shock.

13 ller (NK) and NKT cells in Ehrlichia-induced toxic shock.

14 yndecan-1-null mice undergoing Gram-positive toxic shock.

15 ting inflammatory responses in Gram-positive toxic shock, a systemic disease that is a significant ca

16 oning, is also a superantigen that can cause toxic shock after traumatic or surgical staphylococcal w

17 MyD88(-/-) mice were resistant to SEA or SEB toxic shock and displayed reduced levels of pro-inflamma

18 These enterotoxins, which cause both toxic shock and food poisoning, bind in an identical way

19 Staphylococcal enterotoxin B induces toxic shock and is a major virulence factor of staphyloc

20 inflammation, permanent airway destruction, toxic shock, and mortality.

21 an diseases including pharyngitis, impetigo, toxic shock, and necrotizing fasciitis, as well as the p

22 lethal in two animal models of streptococcal toxic shock, and SpeM was lethal in one model.

23 ar to WT mice, they did not develop signs of toxic shock, as shown by elevated bacterial burdens, low

24 sm that protects the host from Gram-positive toxic shock by inhibiting the dysregulation and amplific

25 in, rescued syndecan-1-null mice from lethal toxic shock by suppressing the production of TNFalpha an

26 ing in myriad disorders, such as dermatitis, toxic shock, cardiovascular disease, acute pelvic and ar

27 hich is known to mediate immunopathology and toxic shock in a murine model of fatal ehrlichiosis.

28 ctivation and cytokine production as well as toxic shock induced by staphylococcal enterotoxin B (SEB

29 omplications characteristic of streptococcal toxic shock-like syndrome (TSLS).

30 infection with IOE resulted in acute, severe toxic shock-like syndrome and severe multifocal hepatic

31 of CD1d-restricted NKT cells in induction of toxic shock-like syndrome caused by gram-negative, lipop

32 otropic Ehrlichia strains results in a fatal toxic shock-like syndrome characterized by a decreased n

33 virulent Ehrlichia strain (IOE) results in a toxic shock-like syndrome characterized by severe liver

34 uis arthroplasty infection and streptococcal toxic shock-like syndrome due to an nonencapsulated sero

35 [IOE]) results in CD8+ T-cell-mediated fatal toxic shock-like syndrome marked by apoptosis of CD4+ T

36 ls mediate Ehrlichia-induced T-cell-mediated toxic shock-like syndrome, most likely via cognate and n

37 HME disease can range from mild to a fatal, toxic shock-like syndrome, yet the mechanisms regulating

38 ng adult respiratory distress syndrome and a toxic shock-like syndrome.

39 racellular bacterium that causes acute fatal toxic shock-like syndrome.

40 ologies as well as severe conditions such as toxic shock-like syndrome.

41 man monocytic ehrlichiosis (HME) that mimics toxic-shock-like syndrome in immunocompetent hosts.

42 oup A Streptococcus, is sufficient to induce toxic-shock-like vascular leakage and tissue injury.

43 role for these cytokines in the treatment of toxic shock merits further investigation.

44 by proinflammatory nucleic acids in an acute toxic shock model in mice.

45 for their therapeutic efficacy in the mouse toxic shock model using different challenge doses of SEB

46 on molecule 1 have a negligible role in this toxic shock model.

47 was 11% but was much higher in patients with toxic shock syndrome (55%) and necrotizing fasciitis (58

48 Menstrual toxic shock syndrome (mTSS) is thought to be associated

49 Streptococcal toxic shock syndrome (strep TSS) with associated necroti

50 Streptococcal toxic shock syndrome (StrepTSS) is an invasive infection

51 tic cases have been defined as streptococcal toxic shock syndrome (StrepTSS).

52 e from severe cases, including streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (N

53 S) isolates from patients with streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (N

54 Streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis ar

55 n A) is highly associated with streptococcal toxic shock syndrome (STSS) and other invasive streptoco

56 s associated with outbreaks of streptococcal toxic shock syndrome (STSS) in the United States and Eur

57 Streptococcal toxic shock syndrome (STSS) is a highly lethal, acute-on

58 nd is strongly associated with streptococcal toxic shock syndrome (STSS), a severe and often fatal il

59 sult in the recently described streptococcal toxic shock syndrome (STSS), which is characterized by r

60 ave been implicated in causing streptococcal toxic shock syndrome (STSS).

61 necrotizing fasciitis (NF) or streptococcal toxic shock syndrome (STSS).

62 e of inflammatory cytokines that can lead to toxic shock syndrome (TSS) and death.

63 Toxic shock syndrome (TSS) and other superantigen-mediat

64 erantigens (PTSAgs) that are associated with toxic shock syndrome (TSS) and staphylococcal food poiso

65 creted virulence factors sufficient to cause toxic shock syndrome (TSS) in the animals.

66 Toxic shock syndrome (TSS) is a clinical consequence of

67 Toxic shock syndrome (TSS) is a multi system disorder re

68 Toxic shock syndrome (TSS) is an acute onset illness cha

69 Toxic shock syndrome (TSS) is caused by staphylococcal a

70 Toxic shock syndrome (TSS) may be mediated by superantig

71 Lethal toxic shock syndrome (TSS) results from the MHC class II

72 uced by concentrations of the staphylococcal toxic shock syndrome (TSS) toxin 1 (TSST-1) and the stre

73 Despite knowledge of the effects of toxic shock syndrome (TSS) toxin 1 (TSST-1) on the adapt

74 During toxic shock syndrome (TSS), bacterial superantigens trig

75 G) is sometimes administered for presumptive toxic shock syndrome (TSS), but its frequency of use and

76 icated in several serious diseases including toxic shock syndrome (TSS), Kawasaki disease, and sepsis

77 Many cases of neonatal toxic shock syndrome (TSS)-like exanthematous disease bu

78 nd compared with isolates from patients with toxic shock syndrome (TSS).

79 egs) might be beneficial in diseases such as toxic shock syndrome (TSS).

80 eins compared to isolates from patients with toxic shock syndrome (TSS).

81 rome toxin-1 (TSST-1), are the main cause of toxic shock syndrome (TSS).

82 olonizer of the nose and is a major cause of toxic shock syndrome (TSS).

83 tening consequences typically encountered in toxic shock syndrome (TSS).

84 of inflammatory molecules and potentially to toxic shock syndrome (TSS).

85 obic, Gram-positive bacterium that can cause toxic shock syndrome after gynecological procedures.

86 nkeys manifested a T cell activation-related toxic shock syndrome and a profound depletion of CD4+ ly

87 xin B (SEB) is a potent toxin that can cause toxic shock syndrome and act as a lethal and incapacitat

88 e of inflammatory cytokines that can lead to toxic shock syndrome and death.

89 ens (SAg) as dangerous toxins that may cause toxic shock syndrome and death.

90 This cascade can ultimately result in toxic shock syndrome and death.

91 d underlying medical conditions; 4 developed toxic shock syndrome and died (case fatality, 57%).

92 SAGs have been implicated in toxic shock syndrome and food poisoning, and they may al

93 important causative agents in staphylococcal toxic shock syndrome and food poisoning.

94 aureus group-III strains are responsible for toxic shock syndrome and have been underestimated in oth

95 auses a variety of human diseases, including toxic shock syndrome and necrotizing fasciitis, which ar

96 e disease in humans, including streptococcal toxic shock syndrome and necrotizing fasciitis.

97 rom pharyngitis to severe infections such as toxic shock syndrome and necrotizing fasciitis.

98 irulence factors and are responsible for the toxic shock syndrome and other superantigen-related dise

99 duce a massive release of cytokines, causing toxic shock syndrome and possibly death.

100 describe four deaths due to endometritis and toxic shock syndrome associated with C. sordellii that o

101 Endometritis and toxic shock syndrome associated with Clostridium sordell

102 e GAS infections, including 11 streptococcal toxic shock syndrome cases and one necrotizing fasciitis

103 he 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise.

104 ylococcus aureus is a causative agent of the toxic shock syndrome disease.

105 ria that cause fatal ehrlichiosis, mimicking toxic shock syndrome in humans and mice.

106 en exotoxins that mediate food poisoning and toxic shock syndrome in humans.

107 The cause of death is a syndrome much like toxic shock syndrome in humans.

108 partial thromboplastin time in streptococcal toxic shock syndrome is associated with activation of th

109 sis of necrotizing soft-tissue infection and toxic shock syndrome resulting from Streptococcus pyogen

110 The epidemic of toxic shock syndrome that occurred in the 1970s was caus

111 s described that specifically promote either toxic shock syndrome toxin (TSST) 1 or staphylococcal en

112 on of staphylococcal enterotoxin A (SEA) and toxic shock syndrome toxin (TSST) in neat milk without s

113 us, staphylococcal enterotoxins (SE) A-E and toxic shock syndrome toxin (TSST)-1, which are associate

114 ncluding the staphylococcal enterotoxins and toxic shock syndrome toxin (TSST).

115 nicity island SaPI1 carries the gene for the toxic shock syndrome toxin (TSST-1) and can be mobilized

116 IPs to S. aureus inhibited the production of toxic shock syndrome toxin (TSST-1) and enterotoxin C3,

117 dose-dependent transcytosis in vitro, while toxic shock syndrome toxin (TSST-1) exhibited increased

118 .g., carriage of the enterotoxin A (sea) and toxic shock syndrome toxin (tst) genes and production of

119 of oxygen is necessary for the production of toxic shock syndrome toxin 1 (TSST-1) by Staphylococcus

120 The production of toxic shock syndrome toxin 1 (TSST-1) by Staphylococcus

121 he effect of O(2) and CO(2) on expression of toxic shock syndrome toxin 1 (TSST-1) by Staphylococcus

122 Toxic shock syndrome toxin 1 (TSST-1) contains a long ce

123 The superantigenic function of toxic shock syndrome toxin 1 (TSST-1) is generally regar

124 s with staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin 1 (TSST-1) resulted in enhanc

125 Administration of the superantigen toxic shock syndrome toxin 1 (TSST-1) results in the spe

126 T2-I-A(b), is very inefficient at presenting toxic shock syndrome toxin 1 (TSST-1) to T cells, sugges

127 ne monoclonal antibodies (MAbs) specific for toxic shock syndrome toxin 1 (TSST-1), a bacterial super

128 there have been reports of the production of toxic shock syndrome toxin 1 (TSST-1), enterotoxin, and

129 Superantigens, such as toxic shock syndrome toxin 1 (TSST-1), have been implica

130 tes production of agr RNAIII, protein A, and toxic shock syndrome toxin 1 (TSST-1), particularly unde

131 r, unlike the classical enterotoxins SEB and toxic shock syndrome toxin 1 (TSST-1), the gene for SEl-

132 ught to be associated with colonization with toxic shock syndrome toxin 1 (TSST-1)-producing Staphylo

133 tigens staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin 1 (TSST-1).

134 tum or pharynx of patients with KD, secretes toxic shock syndrome toxin 1 (TSST-1).

135 g., staphylococcal enterotoxin A [SEA], SEB, toxic shock syndrome toxin 1 [TSST-1]) which act both as

136 ococcal enterotoxin A (SEA), SEB, or SEC3 or toxic shock syndrome toxin 1 and a potentiating dose of

137 study the activity of superantigens such as toxic shock syndrome toxin 1 and also found that despite

138 ant Staphylococcus aureus and genes encoding toxic shock syndrome toxin 1 and Panton-Valentine leukoc

139 ttenuated staphylococcal enterotoxin (SE) or toxic shock syndrome toxin 1 develop protective antibodi

140 mec type II, the enterotoxin A gene, and the toxic shock syndrome toxin 1 gene.

141 taphylococcal clone or structural variant of toxic shock syndrome toxin 1 is associated with Kawasaki

142 replication, and suboptimal stimulation with toxic shock syndrome toxin 1 leads to viral replication

143 staphylococcal enterotoxin B and C negative, toxic shock syndrome toxin 1 positive, and staphylococca

144 nced portions of the regions encoding mature toxic shock syndrome toxin 1 were identical in all six s

145 f staphylococcal enterotoxin A (SEA) to SEH, toxic shock syndrome toxin 1, and Panton-Valentine leuko

146 roliferation in response to the superantigen toxic shock syndrome toxin 1, as well as the proliferati

147 erum) against combinations of superantigens (toxic shock syndrome toxin 1, enterotoxins B and C, and

148 eus toxins (the enterotoxins A and B and the toxic shock syndrome toxin).

149 ere capable of attenuating the production of toxic shock syndrome toxin-1 (also under the control of

150 Responses to toxic shock syndrome toxin-1 (TSST-1) and pokeweed mitog

151 as well as the staphylococcal superantigens toxic shock syndrome toxin-1 (TSST-1) and staphylococcus

152 fine the interface between the bacterial SAG toxic shock syndrome toxin-1 (TSST-1) and the TCR, we pe

153 ee-dimensional structures of five mutants of toxic shock syndrome toxin-1 (TSST-1) have been determin

154 The staphylococcal superantigen toxic shock syndrome toxin-1 (TSST-1) is a causative age

155 superantigens [staphylococcal enterotoxins, toxic shock syndrome toxin-1 (TSST-1), and streptococcal

156 Staphylococcal superantigens (SAgs), such as toxic shock syndrome toxin-1 (TSST-1), are the main caus

157 nical cases of TSS arise due to an exotoxin, toxic shock syndrome toxin-1 (TSST-1), elaborated by tox

158 Tst, the gene for toxic shock syndrome toxin-1 (TSST-1), is part of a 15.2

159 ram quantities of topically applied purified toxic shock syndrome toxin-1 (TSST-1), staphylococcal en

160 A major causative agent of TSS is toxic shock syndrome toxin-1 (TSST-1), which is unique r

161 teins although they elaborate high levels of toxic shock syndrome toxin-1 (TSST-1).

162 EB), staphylococcal enterotoxin C (SEC), and toxic shock syndrome toxin-1 (TSST-1).

163 We investigated whether the superantigen toxic shock syndrome toxin-1 (TSST1) could induce an ant

164 Toxic shock syndrome toxin-1 (TSST1) is a superantigenic

165 Panton-Valentine Leukocidin toxin (PVL), and toxic shock syndrome toxin-1 (tst) genes.

166 nine mutations were constructed in S. aureus toxic shock syndrome toxin-1 amino acids D120 to D130.

167 A dodecapeptide region (toxic shock syndrome toxin-1 amino acids F119-D130), rel

168 lysin streptolysin O enhanced penetration of toxic shock syndrome toxin-1 and streptococcal pyrogenic

169 The pyrogenic toxin toxic shock syndrome toxin-1 from Staphylococcus aureus

170 d theories of Kawasaki disease etiology, the toxic shock syndrome toxin-1 hypothesis and the coronavi

171 Toxic shock syndrome toxin-1 induces interleukin-8 from

172 Staphylococcus aureus superantigen toxic shock syndrome toxin-1 is a major cause of menstru

173 r, a detailed structural analysis shows that toxic shock syndrome toxin-1 lacks several structural fe

174 Toxic shock syndrome toxin-1 producing S. aureus was int

175 Toxic shock syndrome toxin-1 residue D130 may contribute

176 ly express BP107 conformational epitopes and toxic shock syndrome toxin-1 superantigen-binding capabi

177 ells were stimulated with the staphylococcal toxic shock syndrome toxin-1, enterotoxin A, or enteroto

178 - and beta-toxins, but not enterotoxin A and toxic shock syndrome toxin-1, rapidly potentiated sheddi

179 The superantigenic toxins toxic shock syndrome toxin-1, staphylococcal enterotoxin

180 enough to allow for enhanced penetration of toxic shock syndrome toxin-1, whereas streptolysin O dir

181 trains of S. aureus produce the superantigen toxic shock syndrome toxin-1, which can penetrate the va

182 irements similar to that for presentation of toxic shock syndrome toxin-1.

183 is, and Neisseria gonorrhoeae, as well as to toxic shock syndrome toxin-1.

184 as inhibition of T cell proliferation due to toxic shock syndrome toxin-1.

185 era toxin, staphylococcal enterotoxin A, and toxic shock syndrome toxin.

186 es (both MSSA and MRSA) carried the gene for toxic shock syndrome toxin; however, carriage of the gen

187 One isolate possessed the gene for toxic shock syndrome toxin; none had genes for exfoliati

188 ium or serum or in vivo in a rabbit model of toxic shock syndrome using DNA microarrays.

189 esis, a strain recovered from a patient with toxic shock syndrome was serially passaged for 6 weeks,

190 ained from seven patients with streptococcal toxic shock syndrome who received IVIG therapy, and the

191 g high-risk or protection from streptococcal toxic shock syndrome with a strong protection conferred

192 bacteremia, septic arthritis, streptococcal toxic shock syndrome, and necrotizing fasciitis) caused

193 TNF release during acute TSST1-precipitated toxic shock syndrome, and the C-terminal domain to stimu

194 rious diseases, including food poisoning and toxic shock syndrome, are termed superantigens (SAgs).

195 ted in a number of human diseases, including toxic shock syndrome, diabetes mellitus and multiple scl

196 Most strains causing toxic shock syndrome, however, produce and secrete very

197 known virulence factors in scarlet fever and toxic shock syndrome, mechanisms by how SAgs contribute

198 itis, impetigo, scarlet fever, streptococcal toxic shock syndrome, necrotizing fasciitis and myositis

199 ases of severe iGAS infection (streptococcal toxic shock syndrome, necrotizing fasciitis, septic shoc

200 igens (PTSAgs) that can cause illness, e.g., toxic shock syndrome, or synergize with a number of othe

201 iseases, including necrotizing fasciitis and toxic shock syndrome, were analyzed.

202 Staphylococcal superantigens cause toxic shock syndrome, which is characterized by massive

203 on of bacterial superantigens, most commonly toxic shock syndrome-1 (TSST-1), to specific TCR Vbeta-b

204 e outcomes such as necrotizing fasciitis and toxic shock syndrome.

205 th GAS myonecrosis who died of streptococcal toxic shock syndrome.

206 ections, including necrotizing fasciitis and toxic shock syndrome.

207 nes, ultimately causing a condition known as toxic shock syndrome.

208 n humans including necrotizing fasciitis and toxic shock syndrome.

209 arious diseases including food poisoning and toxic shock syndrome.

210 ins (SEs) that cause both food poisoning and toxic shock syndrome.

211 se ranging from pharyngitis to streptococcal toxic shock syndrome.

212 rotoxins (SEs) that cause food poisoning and toxic shock syndrome.

213 m isolated from a patient with streptococcal toxic shock syndrome.

214 h as necrotizing fasciitis and streptococcal toxic shock syndrome.

215 llin-resistant strains and organisms causing toxic shock syndrome.

216 rldwide, including necrotizing fasciitis and toxic shock syndrome.

217 profound shock associated with streptococcal toxic shock syndrome.

218 me identified in patients with streptococcal toxic shock syndrome.

219 produce disease, such as food poisoning and toxic shock syndrome.

220 d as major virulence factors responsible for toxic shock syndrome.

221 sponses in the pathogenesis of streptococcal toxic shock syndrome.

222 ed with the recently described streptococcal toxic shock syndrome.

223 multiorgan failure define the streptococcal toxic shock syndrome.

224 l bacteremia that mimics human Streptococcal toxic shock syndrome.

225 ditions, including necrotizing fasciitis and toxic shock syndrome.

226 an penetrate the vaginal epithelium to cause toxic shock syndrome.

227 o life-threatening necrotizing fasciitis and toxic shock syndrome.

228 alleles significantly increase the risk for toxic shock syndrome.

229 indings that death was due to tampon-related toxic shock syndrome.

230 7-year-old female who died of tampon-related toxic shock syndrome.

231 o mediate the symptoms collectively known as toxic shock syndrome.

232 ections, including necrotizing fasciitis and toxic shock syndrome.

233 inal mucosa, induce interleukin-8, and cause toxic shock syndrome.

234 rwhelming cytokine production, which lead to toxic shock syndrome.

235 ections to life-threatening endocarditis and toxic shock syndrome.

236 ndrome toxin-1 is a major cause of menstrual toxic shock syndrome.

237 teract with underlying immune cells to cause toxic shock syndrome.

238 class II allelic variation in streptococcal toxic shock syndrome.

239 disease in epidemics and its resemblance to toxic-shock syndrome make an infectious etiology seem mo

240 anton-Valentine leukocidin, alpha-toxin, and toxic-shock syndrome toxin 1 and increased toxin product

241 Immunoblot analysis of the enterotoxins, toxic-shock syndrome toxin 1, and SpeA with antiserum pr

242 n-Valentine leukocidin, alpha-hemolysin, and toxic-shock syndrome toxin 1, in both methicillin-sensit

243 lococcus aureus enterotoxins (S.E.) A-I, and toxic-shock syndrome toxin TSST-1 act as superantigens t

244 ion of CD14 by LPS can cause the often fatal toxic-shock syndrome.

245 evere systemic conditions such as septic and toxic shock syndromes.

246 The Staphylococcus aureus gene for toxic shock toxin (tst) is carried by a 15 kb mobile pat

247 cline, and vancomycin resistance, as well as toxic shock toxin and Panton-Valentine leukocidin.

248 k, we reported that the staphylococcal toxin toxic shock toxin-1 (TSST-1), a prototypic superantigen,

249 Surprisingly, 6 of 16 strains were the same toxic shock toxin-1 (TSST-1)-positive clone, designated

250 ich CD8(+) T cells mediate Ehrlichia-induced toxic shock, which is associated with IL-10 overproducti