ライフサイエンスコーパス: toxicant

1 odes of action of a widespread environmental toxicant.

2 mals, we conclude that BPA is a reproductive toxicant.

3 rtilization (IVF), we consider it an ovarian toxicant.

4 90% using elemental mercury as a model vapor toxicant.

5 e to such damage, caused by an environmental toxicant.

6 Methylmercury (MeHg) is a known neuro-toxicant.

7 ssible impacts on sensitivity estimates to a toxicant.

8 endocrine disruptor, is a neurodevelopmental toxicant.

9 hthylisothiocyanate (ANIT), a BDEC-selective toxicant.

10 ages, even though aged animals received less toxicant.

11 uated by gadolinium chloride, a Kupffer cell toxicant.

12 a means of assessing the role of a potential toxicant.

13 responses following exposure to some contact toxicants.

14 lying the cytotoxic effects of environmental toxicants.

15 nd early childhood exposure to environmental toxicants.

16 technique for unmasking negative effects of toxicants.

17 tematic approach for identifying responsible toxicants.

18 a role in cell cycle changes in response to toxicants.

19 also play a role in risks from environmental toxicants.

20 ve lung injury caused by smoke and pulmonary toxicants.

21 city aiding in the identification of primary toxicants.

22 s of chironomid larvae exposed to four model toxicants.

23 ood, are known carcinogens and developmental toxicants.

24 ers that inhibit the release or transport of toxicants.

25 n shown to be reproductive and developmental toxicants.

26 ased mechanistic profiling of potential (eco)toxicants.

27 the physicochemical properties of potential toxicants.

28 sity and fat metabolism in lieu of exogenous toxicants.

29 ures, antibiotic exposure, and environmental toxicants.

30 d as the result of exposure to environmental toxicants.

31 hat all three come from different classes of toxicants.

32 inergic neurodegeneration induced by various toxicants.

33 -type plants, with or without treatment with toxicants.

34 armers are also exposed to other respiratory toxicants.

35 transepithelial transport study of drugs and toxicants.

36 us and exogenous stressors, such as heat and toxicants.

37 , including drugs, dietary constituents, and toxicants.

38 on, neurotransmission, and susceptibility to toxicants.

39 ioactivating a number of pulmonary-selective toxicants.

40 osmotic or oxidative stress, and exposure to toxicants.

41 species diversity hinders the adaptation to toxicants.

42 regnancy disruptive effects of environmental toxicants.

43 fish communities challenged by anthropogenic toxicants.

44 icity differences among a variety of similar toxicants.

45 as wood preservatives, and as environmental toxicants.

46 Cyanogenic glycosides are natural plant toxicants.

47 lobacter salinarum that dimerizes to extrude toxicants.

48 n from neurotoxic insult by the dopaminergic toxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (M

49 neuronal cells treated with the parkinsonian toxicant 1-methyl-4-phenylpyridinium (MPP(+)) as well as

50 ructural similarity to the Parkinson disease toxicant, 1-methyl-4-pheynlpyridinium.

51 tered after exposure to the model testicular toxicant, 2,5-hexanedione (HD) using microarrays; 2) exp

52 m for the field of environmental toxicology: toxicants acting through AhR to target xenobiotic efflux

53 Studies have shown that the toxicant-activated aryl hydrocarbon receptor (AHR) may d

54 Third, the same six delayed toxicants administered i.p. to mice at multiple doses in

55 hance our understanding of how environmental toxicants affect brain function.

56 sure is one of the most common environmental toxicants affecting children.

57 e to either temperature or time with the air toxicant analyte, and various concentrations thereof).

58 vironmental contaminant that is both a human toxicant and carcinogen.

59 , an in vivo metabolite of the environmental toxicant and common environmental pollutant trichloroeth

60 Arsenic is an epigenetic toxicant and could influence fetal developmental program

61 rom damage induced by thioacetamide, a liver toxicant and hepatocarcinogen.

62 More importantly, respiratory toxicants and carcinogens activate both the PI3K-Akt pat

63 Assessment of exposure to tobacco-related toxicants and carcinogens at the population level is thu

64 protect cells and tissues from a variety of toxicants and carcinogens by increasing the expression o

65 simultaneous measurement of tobacco-related toxicants and carcinogens in wastewater are not availabl

66 In addition to mitogens, various toxicants and carcinogens persistently induce FRA-1 expr

67 insight into the population exposure to both toxicants and carcinogens resulting from tobacco use.

68 ty and carcinogenic potency of a plethora of toxicants and carcinogens.

69 er 344 rats to low doses of model testicular toxicants and classically characterized the testicular i

70 ughput screening to determine the effects of toxicants and drugs on their biological targets.

71 Long-term exposures to environmental toxicants and endogenous electrophiles are causative fac

72 pragmatism in the selection of volatiles and toxicants and in defining their roles in formulations.

73 udied the impacts of smoked cigarette filter toxicants and microfibres on the polychaete worm Hediste

74 ul for the detection of a variety of harmful toxicants and pathogens to protect human health and nati

75 everages and soups are good to cleanse liver toxicants and prevent liver diseases.

76 The actions of environmental toxicants and relevant mixtures in promoting the epigene

77 kpoint that senses exposure to environmental toxicants and responds by signaling cell cycle inhibitio

78 sed extensively for studies on environmental toxicants and salt (NaCl) homeostasis.

79 uals who worked on the spill were exposed to toxicants and stressors that could lead to adverse effec

80 s developed and applied for the detection of toxicants and/or inhibitors to digesters.

81 n early genetic event in response to a renal toxicant, and its conserved, stress-associated, expressi

82 erts the cisplatin-cysteine S-conjugate to a toxicant, and the data are consistent with the hypothesi

83 of hundreds of approved and withdrawn drugs, toxicants, and biochemical standards in various organs o

84 dered carcinogenic and/or neurodevelopmental toxicants, and children's exposure to these compounds is

85 ater column to smoking debris and associated toxicants, and highlight the risks posed by smoked cigar

86 Exposure to environmental stressors, toxicants, and nutrient deficiencies can affect DNA in s

87 the most commonly encountered environmental toxicants, and research from model systems has suggested

88 respect to their detection capabilities for toxicants, and therefore offering an interesting perspec

89 nary TFF3 levels did not respond to nonrenal toxicants, and urinary albumin faithfully reflected alte

90 which in utero adjustments to environmental toxicants are conferred.

91 gy are changing the way pesticides and other toxicants are evaluated.

92 ain the gene-environment effects of chemical toxicants are largely unknown.

93 Exposure to the environmental toxicant arsenic, through both contaminated water and fo

94 known as an effective mutagen, clastogen and toxicant as well as an effective inducer of sister-chrom

95 the potency of six delayed neurotoxicants or toxicants as in vitro inhibitors varies from IC50 0.02 t

96 There are many secondary targets for OP toxicants as observed for example with the major insecti

97 e as potent Ahr activators and developmental toxicants as PAHs.

98 he detection of low molecular weight natural toxicants, as an alternative to toxin-conjugates.

99 We have coined the term toxicant-associated steatohepatitis (TASH) to describe t

100 e-cell array system for a diverse variety of toxicants at different dose concentrations.

101 nsumers reduce exposure to mercury and other toxicants at the cost of reduction in cardioprotective f

102 rong evidence suggests that BPA is a uterine toxicant because it impaired uterine endometrial prolife

103 Toxicant bioaccumulation poses a risk to many marine mam

104 rstanding kinetic and geochemical effects on toxicant bioavailability is key, and these are influence

105 mode of action of the putative developmental toxicant both prior to and during pregnancy.

106 ertal female mice with the mitotic germ-cell toxicant busulphan eliminates the primordial follicle re

107 Peroxynitrite is an endogenous toxicant but is also a cytotoxic effector against invadi

108 ches was less than 5-fold, covering baseline toxicants but as well compounds with presumed specific m

109 docrine disruptor and potential reproductive toxicant, but results of epidemiologic studies have been

110 bstances (PFASs) are suspected developmental toxicants, but data on PFAS concentrations and exposure

111 ine pesticides (OCPs) are neurodevelopmental toxicants, but few studies have examined associations wi

112 organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal

113 ), mercury (Hg), and cadmium (Cd), are known toxicants, but their associations with the thyroid axis

114 rrent exposures to pathogens, allergens, and toxicants by inducing the complex innate and acquired im

115 how early-life exposure to an environmental toxicant can be a risk factor for childhood obesity.

116 ongly suggest that corneal injury induced by toxicants can be treated using anti-inflammatory agents

117 suggest that exposure to the same amount of toxicants can disproportionately compromise ecosystem pr

118 Although defining the effects that toxicants can have on the immune system is a valuable co

119 s after exposure to another model testicular toxicant, carbendazim (CBZ).

120 early metaplastic changes induced by various toxicants/carcinogens.

121 Vanadate, an environmental toxicant, causes developmental defects in the central ne

122 thermore use this information for successful toxicant classification in unknown samples.

123 In the mutation assay analysis, as the toxicant concentration increased, there was an increase

124 es that were exposed to substantially higher toxicant concentrations after the sixth generation were

125 Toxicant concentrations were highest and had the greates

126 ential mechanism through which environmental toxicants contribute to PD pathogenesis.

127 ighting the significance of IL-10 as an anti-toxicant cytokine.

128 tinuous microfluidic perfusion as a means of toxicant delivery.

129 (PAHs) are widely distributed environmental toxicants derived from sources that include cigarette sm

130 amaging effects of exposure to environmental toxicants differentially affect genetically distinct ind

131 Although results infer that sensitivity to toxicants differs across biogeographic ranges, shallow-w

132 toxicology for years as the receptor for the toxicant dioxin, is rapidly gaining interest in immunolo

133 tous compound that is emerging as a possible toxicant during embryonic development.

134 and interspecific life history variation on toxicant dynamics in marine mammals.

135 uch of this information relies on the use of toxicants (e.g. CdCl(2)), making it difficult to relay t

136 rence increased our process understanding of toxicant effects in macroinvertebrate communities and he

137 Toxicant effects on feeding and maintenance resulted in

138 ly Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project.

139 can be adapted to accommodate other types of toxicant, environmental samples and other aquatic ovipar

140 ted rat liver shows striking similarity with toxicant-exposed cells in vivo, indicating that gross sy

141 omise in identifying biomarkers for disease, toxicant exposure and stress.

142 e Chironomus riparius to withstand long-term toxicant exposure has been attributed to genetic adaptat

143 of this homeostasis due to aging, injury or toxicant exposure may contribute to accumulation of beta

144 ed that gene expression is more sensitive to toxicant exposure than life cycle end points, underlinin

145 ius can indeed withstand long-term sublethal toxicant exposure through phenotypic plasticity without

146 ronomus riparius indeed copes with prolonged toxicant exposure through phenotypic plasticity.

147 luency, they were used for studies including toxicant exposure, immunoblotting, immunofluorescence an

148 pressed proteins in small fish species after toxicant exposure.

149 s, higher fish intake often leads to greater toxicant exposure.

150 mitochondrial dysfunction and environmental toxicant exposures ('four major areas').

151 ochondrial dysfunction (145 of 153, 95%) and toxicant exposures (170 of 190, 89%).

152 flammation and oxidative stress, followed by toxicant exposures and mitochondrial dysfunction.

153 he relevance of preconceptional and prenatal toxicant exposures for genomic stability in offspring is

154 s best known for responding to environmental toxicant exposures to induce a battery of xenobiotic-met

155 ysregulation/inflammation, oxidative stress, toxicant exposures, genetics and neuroimaging.

156 which may alter human risks associated with toxicant exposures.

157 between miRNA and mRNA due to environmental toxicant exposures.

158 However, mapping only adverse outcomes of a toxicant falls short of describing the stress or adaptiv

159 en redesigned to help identify environmental toxicants, food contaminants and supplements, drugs, and

160 ed in this study not only can quickly detect toxicants for anaerobic digestion but also can efficient

161 stolochic acids I and II are prevalent plant toxicants found in the Aristolochiaceae plant family.

162 The identification of TRPA1 activation by toxicants from cigarette smoke and polluted air, such as

163 artitioning to describe vertical transfer of toxicants from mother to offspring during gestation and

164 However, pretreatment with the macrophage toxicant GdCl(3), the xanthine oxidase (XO) inhibitor al

165 on, rats were pretreated with the phagocytic toxicant GdCl3, which significantly decreased the produc

166 ystem to identify genes induced by the renal toxicant, gentamicin, that may function in nephron neoge

167 the offspring generations (F1-F5), after the toxicant had been removed from the diet.

168 Warming in combination with toxicants had little effect at the individual and popula

169 consistent means of exposure owing to short toxicant half-life in aquatic media, uptake of chemical

170 nvestigating combined effects of warming and toxicants has been a topic of little research, but negle

171 earch on neurodevelopmental effects of these toxicants has produced conflicting results.

172 It is recognized that cellular responses to toxicants have a highly dynamic nature, and exhibit both

173 tigations of ENMs (as opposed to traditional toxicants) have been reported, but have not yet been sys

174 A number of environmental factors (e.g. toxicants) have been shown to promote the epigenetic tra

175 of contamination by methylmercury and other toxicants, higher fish intake often leads to greater tox

176 effect on behavior, fitness, and response to toxicants; however, this is rarely considered in ecotoxi

177 LB/cJ mice were exposed to different contact toxicants, identifying trimellitic anhydride (TMA) for f

178 We contend that to advance our knowledge of toxicant impacts on arthropods, the population growth ra

179 es also suggest that BPA may be a testicular toxicant in animal models, but the data in humans are eq

180 rs examined the effects of acrolein, a major toxicant in cigarette smoke, on oxidative mitochondrial

181 Selenium (Se) is a developmental toxicant in oviparous vertebrates.

182 esults show that acrolein is a mitochondrial toxicant in RPE cells and that acrolein-induced oxidativ

183 ethoxylates (NP(EO)n and OP(EO)n) are major toxicants in agrochemicals used around beehives.

184 ed with tumorigenic potency of environmental toxicants in coexposure scenarios, including possible sy

185 analysis (EDA) enables the identification of toxicants in complex contaminated environmental samples.

186 omplex environmental mixtures to responsible toxicants in effect-directed analysis (EDA).

187 t also has the ability to degrade halophenol toxicants in its living environment.

188 ate, transport, and bioavailability of these toxicants in organisms.

189 studies also show the role of environmental toxicants in perturbing the gut microbiome and its metab

190 Ragworms exposed to smoked cigarette filter toxicants in seawater at concentrations 60 fold lower th

191 Therefore, when organisms are exposed to two toxicants in sequence, the toxicity can differ if their

192 tured nanoparticles (NPs) can associate with toxicants in the aqueous phase and these associations ca

193 tes makes it important to be able to monitor toxicants in the feed to anaerobic digesters to optimize

194 isms that facilitate or hinder adaptation to toxicants in the field.

195 Molecular dynamics simulations of these 14 toxicants in the pore region of the alpha1beta2gamma2 GA

196 heir presence may offer some protection from toxicants in the tear film, because mucins could functio

197 olychlorinated biphenyls (PCBs) were used as toxicant, in concentrations of 0.02 mug/ml, 0.04 mug/ml,

198 c and epidemiologic data implicate exogenous toxicants, including cytotoxic drugs, benzene, radiation

199 n the metabolism of exogenous and endogenous toxicants, including those stimulated by stress.

200 The results indicate a dissociation between toxicant-induced alpha-synuclein deposition and neurodeg

201 aspermatogenesis reboots meiosis and reseals toxicant-induced BTB disruption, even though it fails to

202 xplore the molecular mechanism(s) underlying toxicant-induced cell injury.

203 ric partner of activator protein 1 (AP1), in toxicant-induced epithelial injury, repair, and cellular

204 hether hepatic steatosis sensitizes liver to toxicant-induced injury and investigated the potential m

205 er preservation for transplantation and drug/toxicant-induced injury.

206 Importantly, toxicant-induced nephron neogenesis in goldfish (Carassi

207 We hypothesized that toxicant-induced testicular injury can be detected in sp

208 mRNA transcripts are indicators of low dose toxicant-induced testicular injury in the rat.

209 Vapers' toxicant intake was calculated for scenarios in which di

210 xposure to nerve agents and organophosphorus toxicants is due to irreversible inhibition of acetylcho

211 nd early childhood exposure to environmental toxicants is increasingly recognized as contributing to

212 The disposition of toxicants is often affected by their binding to serum pr

213 the various assays used to screen potential toxicants is the antioxidant response element beta lacta

214 iption factor that responds to environmental toxicants, is increasingly recognized as a key player in

215 y only when, in the absence of exposure to a toxicant, it has a parasitic interaction with the host p

216 trachlorodibenzo-p-dioxin (TCDD), a powerful toxicant known to disturb tooth development.

217 odibenzo-p-dioxin (TCDD) is an environmental toxicant known to inhibit Ab secretion and Ig expression

218 Air pollution contains many toxicants known to affect neurological function and to h

219 model to examine the dependence of offspring toxicant load on birth order, food density, and interspe

220 or hydrolyzing various xenobiotic agents and toxicants, many of which target the central and peripher

221 igate how prenatal exposure to environmental toxicants may alter the typical developmental trajectory

222 Exposure to certain environmental toxicants may be associated with increased risk of devel

223 omplex I, either by mutations or exposure to toxicants, may be a risk factor for Parkinson's disease.

224 Toxicant measures were linked to pod, age, and birth ord

225 s and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruptio

226 ated with various dose levels of three model toxicants, mitomycin C, hydrogen peroxide, and lead nitr

227 constraint on adaptive solutions to complex toxicant mixtures at each site.

228 res on EED development, including a role for toxicant modulation of gut immune system and microbiome

229 ough scat employed in this study may improve toxicant monitoring in the marine environment and promot

230 or the oxidative metabolism of environmental toxicants, natural products, and therapeutics.

231 antageous in the study where further organic toxicants occurred.

232 Mercury (Hg) is a toxicant of global concern that accumulates in organisms

233 ult mice by administration of naphthalene, a toxicant of nonciliated respiratory epithelial cells (Cl

234 s and exposure pathways, identify additional toxicants of concern and populations at risk, and examin

235 ted here can be broadly applied because many toxicants of different chemical classes are electrophile

236 d reliably describes the effects of chemical toxicants on C. elegans growth and development.

237 s demonstrate the influence of environmental toxicants on human retroelement activity.

238 1-+4 degrees C), the effects of hypothetical toxicants on suborganismal processes, including feeding,

239 resistance to inhibition by organophosphorus toxicants (OP) for mutants of butyrylcholinesterase (EC

240 d as pesticides, mycotoxins, process-induced toxicants or packaging contaminants, were carefully chos

241 s such as the possibility that environmental toxicants or viruses may initiate PD pathogenesis in the

242 anged from tens to thousands of nanograms of toxicants per milligram of e-liquid vaporized, and they

243 ral similarities to the highly characterized toxicants polychlorinated dibenzo-p-dioxins.

244 CPO and several other OP toxicants potently inhibit CPO-BP in vivo (i.p., 2 h) (5

245 ase T1 (GSTT1) that metabolize environmental toxicants predispose to subtypes of AML, including thera

246 associated with AalphaC and other arylamine toxicants present in tobacco smoke.

247 responses globally upon exposure to chemical toxicants, presents promises for next-generation toxicit

248 ity of E. verrucosus to persisting low-level toxicant pressure.

249 The two testicular toxicants produced distinct molecular signatures with on

250 The liver toxicants profile contained the ARE-bla and relevant Pub

251 We conclude that repeated toxicant pulse of populations that are challenged with i

252 Contact toxicant reactions are accompanied by localized skin inf

253 nophil-mediated events following TMA contact toxicant reactions increase skin sensory nerve substance

254 evaluation of concordance between different toxicants requires evaluations of in vitro systems that

255 tion and, thus, the potential for developing toxicant resistance.

256 (PAHs), the widely distributed environmental toxicants shown to induce porphyrin accumulation causing

257 This is illustrated by the observation of toxicant-specific changes in the spectrum of tRNA modifi

258 However, the toxicants stored in lipids may have more substantial imp

259 s affect exposure dose and the nature of the toxicant studied and have a direct impact on all (eco)to

260 ly Life Exposures in Mexico to Environmental Toxicants) study during 1994-1995.

261 nclude potential therapeutic agents and also toxicants such as epibatidine and neonicotinoid insectic

262 Environmental toxicants such as industrial wastes, air particulates fr

263 With this method, different toxicants such as metals and organic compounds were anal

264 Environmental toxicants such as pesticides exert strong selection pres

265 Exposure to environmental toxicants, such as inorganic arsenic (iAs), has also bee

266 is known about whether prenatal exposure to toxicants, such as lead, may also confer such risks.

267 tein or CPO-BP) is not one of these known OP toxicant targets.

268 enic [As(III)] is a well-known environmental toxicant that causes a wide range of organ-specific dise

269 Using DMMP as a model compound of a toxicant that may be used in a chemical attack, we used

270 reshwater crustacean Gammarus pulex and four toxicants that act on different targets (diazinon, propi

271 istant coatings, are suspected developmental toxicants that are ubiquitous and persistent in the envi

272 stic convergence between otherwise unrelated toxicants that provides predictions about common neurode

273 or the readout of the biological effect of a toxicant through metabolomic-derived pathway analysis, a

274 posed to relatively enriched levels of metal toxicants through their habitat and lifestyle, and this

275 These results show that B(e)P is a toxicant to human retinal pigment epithelial cells in vi

276 rigins that can contaminate water and become toxicants to aquatic species or other living beings via

277 ystem that allows pharmacological agents and toxicants to be more easily studied in a model where fir

278 tes, dietary constituents, and environmental toxicants to highly excretable glucuronides.

279 microfibres (cellulose acetate) and harmful toxicants to marine environments.

280 ray of defense mechanisms that interact with toxicants to obviate their deleterious effect.

281 isks associated with lactational transfer of toxicants to the infant must be considered when judging

282 ation into the contribution of environmental toxicants to the risk of preeclampsia has been sparse.

283 This study emphasizes the need to assess toxicants together with other risk factors relevant to h

284 understanding of an organism's response to a toxicant under ecologically relevant conditions and prov

285 environmental pollutants may be reproductive toxicants underscores the need for prospective studies o

286 Our study suggests that metal toxicant uptake and essential element deficiency during

287 al reproductive cycle, and we add a model of toxicant uptake and partitioning to describe vertical tr

288 rooctanesulfonate (PFOS) is an environmental toxicant used in developing countries, including China,

289 rray, able to detect four different types of toxicants, using a single photodetector (photomultiplier

290 Human BChE inhibited by OP toxicants was incubated for 4 days to 6 years.

291 rent toxicity when the exposure order of two toxicants was reversed, while maintaining the same dose.

292 disease status and exposure to environmental toxicants, we sought to develop a rapid, sensitive, and

293 Potential toxicophores for well-known toxicants were created by identifying chemical features

294 In addition, these toxicants were likely from endogenous lipid stores.

295 Liver toxicants were used as probe compounds to search PubChem

296 al oxidative stress response for known liver toxicants when no ARE-bla data were available.

297 ny insecticides are bird, fish, and honeybee toxicants, whereas herbicides and fungicides pose fewer

298 n identified as a potent immunohematopoietic toxicant with the ability to alter the number of Lin(-)

299 an exogenous role as a receptor for manmade toxicants, with their binding leading to transcription o

300 are one of the most ubiquitous environmental toxicants worldwide, with reported epidemiological evide