ライフサイエンスコーパス: toxicity

1 T and was not associated with increased late toxicity.

2 concerns have been raised regarding possible toxicity.

3 The primary outcome measure was late toxicity.

4 s, until disease progression or unacceptable toxicity.

5 chemoradiotherapy but at a cost of increased toxicity.

6 arsenic might be a potentiator of manganese toxicity.

7 zalutamide-resistant xenografts with minimal toxicity.

8 , rendering this organism insensitive to its toxicity.

9 y attractive owing to their low cost and non-toxicity.

10 te disorders, uremic complications, and drug toxicity.

11 of e-cigarette aerosol have known pulmonary toxicity.

12 repair correlated with severe late radiation toxicity.

13 tions were not significantly associated with toxicity.

14 ition or independent-action) used to predict toxicity.

15 photodynamic therapy, potentiates tellurite toxicity.

16 ctive weed control while reducing freshwater toxicity.

17 in sphk2(MZ) embryos phenocopies sphingosine toxicity.

18 of ABCB1 (TTT-28) with high efficacy and low toxicity.

19 nd hyperphosphorylated tau facilitates Abeta toxicity.

20 t protocol-defined criteria for unacceptable toxicity.

21 sion-free survival (PFS), response rate, and toxicity.

22 Duchenne muscular dystrophy without apparent toxicity.

23 ownregulation of integrin alphavbeta6 and no toxicity.

24 in regulating Tau function, aggregation and toxicity.

25 ht be of concern considering their potential toxicity.

26 ve components are important drivers of Abeta toxicity.

27 ks, until disease progression or intolerable toxicity.

28 cule, but high concentrations cause cellular toxicity.

29 reat deal of concern is associated with AFB1 toxicity.

30 ongeners with evidence of neurodevelopmental toxicity.

31 in a xenograft mouse model without observed toxicity.

32 constitutive activation and severe cellular toxicity.

33 about how cells handle excess fuels to avoid toxicity.

34 active therapeutic targets and lack upstream toxicity.

35 xide, but none of them can fully explain its toxicity.

36 ML) models at the cost of severe hematologic toxicity.

37 once daily until progression or unacceptable toxicity.

38 ance without significant short- or long-term toxicity.

39 me and dyslipidemia, while avoiding systemic toxicity.

40 iscontinued therapy due to treatment-related toxicity.

41 ion, clearance from circulation and no overt toxicity.

42 atomical biomarker in MR-based studies of Mn toxicity.

43 f 1000 mg/m(2), and both had a dose-limiting toxicity.

44 e its development was hampered by peripheral toxicities.

45 e no differences in serious nonhematological toxicities.

46 hough it resulted in more frequent low-grade toxicities.

47 mation, resulting in multiple forms of brain toxicities.

48 ollow-up of 32 months, there were no grade 3 toxicities.

49 the most commonly observed treatment-related toxicities.

50 The findings suggest increased toxicity (1) when OAC is given within 1 week of the intr

51 mpounds based on exclusion criteria, such as toxicity, 36 drugs were retained.

52 Cardio MetaboChip) or arsenic metabolism and toxicity (670) among 2,428 American Indian participants

53 tural aging and prolonged oral environmental toxicity administered to mutant knockin LRRK2 mice over

54 le mechanisms, that is, direct catecholamine toxicity, adrenoceptor-mediated damage, epicardial and m

55 rial activity of 6h and 6u, coupled with low toxicity advocate their potential role as novel antimala

56 ence in the dose variation, acute esophageal toxicity (AET) and late esophageal toxicity (LET) of fou

57 t a series of patients who developed corneal toxicity after exposure to aquarium coral palytoxin.

58 s) is largely hindered by their non-specific toxicity against mammalian cells, which is usually assoc

59 charge density, the AMPs exhibited inhibited toxicity against mammalian cells.

60 curring compound in many plants, may possess toxicity against various stages of a variety of insect p

61 hrombocytopenia (21 [100%] patients for each toxicity); anaemia (14 [67%] patients); and infection (s

62 patients were analysed in the dose-limiting toxicity analysis set: three at dose level 1 (1 mg/kg),

63 l as to the kidney, leading to dose-limiting toxicities and adverse events affecting quality of life.

64 Ks, which likely explains their considerable toxicities and limited efficacy.

65 delivery to tumor with reduced dose-limiting toxicities and thus have the potential for better clinic

66 st one dose of study drug were evaluable for toxicity and all patients completing at least one cycle

67 ker of overall survival (OS) and hematologic toxicity and as a tool for response assessment in patien

68 nthesized by bacteria that, due to their low toxicity and biodegradability, are potential replacement

69 bditis elegans, to rapidly assess both acute toxicity and developmental and reproductive toxicity (DA

70 res good engraftment and leads to acceptable toxicity and disease control in the setting of high risk

71 dria, lysosomes, and F-actin demonstrate low toxicity and enable stimulated emission depletion (STED)

72 med to assess CPC's effects on mitochondrial toxicity and endocrine disruption in vitro.

73 Hg, liquid metals based on gallium have low toxicity and essentially no vapor pressure and are there

74 sure is one of the primary factors for liver toxicity and hepatocarcinoma.

75 e to treat GBM is limited by severe systemic toxicity and inefficient penetration of brain tumor tiss

76 an improve targeting, provide low off-target toxicity and most importantly reduce FTY720-induced lymp

77 nce indicates that the (G4C2)n repeat causes toxicity and neurodegeneration via a gain-of-toxic funct

78 orally bioavailable, with no overt signs of toxicity and potent activity in both murine xenograft an

79 ral PTMs whose alteration can block neuronal toxicity and prevent potential loss and swelling of the

80 Analogous binding, toxicity and rescue in yeast were observed.

81 giogenic and antitumour effects with minimal toxicity and should be investigated further.

82 DMDD caused no observable toxicity and significantly extended the survival of 4T1

83 lade and subclade level, implying that metal toxicity and stress response adaptations represent an im

84 toxic to M. smegmatis, although whether this toxicity and the associated changes in cellular morpholo

85 these landmark studies because of potential toxicity and the confounding impact of radiotherapy and

86 ion can be a critical factor in drug-induced toxicity and the development of diseases, including diab

87 l facilitate rapid screening of nanomaterial toxicity and thus inform the risk assessment of nanopart

88 To prevent photo-toxicity and to allow for long-term photo-stimulation wi

89 617 were evaluated retrospectively regarding toxicity and treatment response.

90 We hypothesize that the cellular toxicity and vasoconstrictive effects of depolarizations

91 ls into metabolites with altered activities, toxicities, and lifetimes within the body.

92 suppressive tumour microenvironments, reduce toxicities, and prevent antigen escape.

93 use is associated with high rates of abuse, toxicity, and death.

94 nd observed toxicity, residuals and observed toxicity, and residuals and concentrations of key input

95 n-selective membranes as well as high price, toxicity, and scarcity of vanadium compounds.

96 imination of the HA-1 TCR T cells in case of toxicity; and (4) a CD34-CD20 epitope to facilitate sele

97 and passive sampler phases; aquatic baseline toxicity; and relevant diffusion coefficients.

98 asing, but comparative data on their use and toxicities are limited.

99 Current trials with drugs that target BS toxicity are effective in only about 50%-60% of primary

100 or therapeutic efficacy and markedly reduced toxicity as compared to the nontargeted drug formulation

101 ate that OsMTP11 functions in alleviating Mn toxicity as its expression can rescue the Mn-sensitive p

102 Toxicity assessment is thus a major hurdle in the compou

103 will describe several mouse populations for toxicity assessment, including older models such as the

104 be clearly articulated and reflect expected toxicities associated with the therapy under investigati

105 ty in isolation and purification procedures, toxicity associated with the active compound, ecological

106 distinct adaptive strategies to deal with Cu toxicity at both the clade and subclade level, implying

107 umab has been hampered by inflammatory liver toxicity at doses >1 mg/kg.

108 ibed total daily doses in cycle 1 because of toxicities attributable to study drug, which were grade

109 ction is required for the suppression of tau toxicity by bas-1.

110 Ricin A chain can cause toxicity by inhibiting protein synthesis, and ricin B ca

111 Obesity increases risk for liver toxicity by the anti-leukemic agent asparaginase, but th

112 Such toxicity can be reversed by reducing circulating glucose

113 impaired in its ability to rescue cells from toxicity caused by SOD1 deletion.

114 arly vulnerable in early life stages, as PAH toxicity causes developmental cardiac abnormalities and

115 ungistatic nature of FLC in combination with toxicity concerns have resulted in an increased demand f

116 Radioimmunotherapy toxicity consisted of grade 3-4 thrombocytopenia in 48 (

117 toxicity and developmental and reproductive toxicity (DART).

118 lassification methodologies using an aquatic toxicity data set of 3448 chemicals, compare the approac

119 sm governing alpha-synuclein aggregation and toxicity, demonstrating the potential therapeutic value

120 weeks x 4 doses with a 4-week dose-limiting toxicity (DLT) period.

121 psin designed to determine the dose-limiting toxicities (DLTs), maximum tolerated dose, pharmacokinet

122 Toxicity, dose intensity, and a detailed safety substudy

123 to be at increased risk for developing renal toxicity due to administration of intravenous iodine- an

124 us fly tau promoter, thus avoiding potential toxicity due to genetic over-expression.

125 icantly lower dopamine uptake after rotenone toxicity, due to reduced striatal synaptosomal mitochond

126 omarker of radiation-response and esophageal toxicity, esophageal expansion, as a method to quantify

127 nificantly higher prevalence of grade 1 to 2 toxicities, especially thrombocytopenia, nausea, and ele

128 hresholds for instituting statins and statin toxicity estimates but depend greatly on the disutility

129 followed a nonlinear correlation and mixture toxicity followed the generalized concentration addition

130 neurotoxins and kidney to transform to high-toxicity forms through expanded sulfotransferases, proba

131 ransient fevers and the expected hematologic toxicities from lymphodepletion pretreatment.

132 Toxicity from acute exposure to nerve agents and organop

133 lic acid (FA) protects against developmental toxicity from certain environmental chemicals.

134 targeting guides allow for proper control of toxicity from on-target DNA damage.

135 foci decay ratio correlated negatively with toxicity grade, with a significant difference between gr

136 Only one patient experienced a dose-limiting toxicity-grade 3 transient asymptomatic hyponatremia at

137 Neither tachyphylaxis nor apparent toxicity has been noted.

138 s and pathways responsible for developmental toxicity have been largely restricted due to the limited

139 ossessing distinct structures that differ in toxicity have been observed in different pathological ph

140 synthesis pathways did not alter tau-induced toxicity; however, their function is required for the su

141 e effects against mitochondrial and synaptic toxicities in APP transgenic mice.

142 proposed novel approach accounts for mixture toxicities in characterizing in vitro pathway-based risk

143 S; yet this treatment results in no apparent toxicities in mice even after months of continuous treat

144 Loss of the DDC bas-1 reduced tau-induced toxicity in a C. elegans model of tauopathy, while loss

145 f different tau mutations with their in vivo toxicity in a well controlled Drosophila model system, w

146 spiration rate, antioxidant enzyme activity) toxicity in acute (96 h) copper and cadmium exposures, u

147 Low temperature reduced toxicity in both metals, but reduced cadmium toxicity si

148 ant SOD1 to the nucleus, resulting in higher toxicity in cells, and severer impairments in locomotion

149 d on genomic expression related to selective toxicity in chiral pesticide, nor on epigenetic changes,

150 otoxic than arginine, displaying the highest toxicity in HepG2 liver cells.

151 roduct that confers resistance to colibactin toxicity in host bacteria and which has been shown to be

152 oactivation and NA-induced respiratory tract toxicity in mouse models.

153 an spectroscopy to detect apparition of skin toxicity in patients treated with tyrosine kinase inhibi

154 t availability can also affect As uptake and toxicity in rice.

155 ls defined in relation to neurodevelopmental toxicity in rodents.

156 also attenuated 6-OHDA- or rotenone-induced toxicity in SH-SY5Y cells.

157 low toxicodynamic recovery caused carry-over toxicity in subsequent exposures, thereby resulting in a

158 city tests proved strong enantiomer-specific toxicity in the case of Tetrahymena thermophila, protozo

159 anistic interpretation of PRn poly-dipeptide toxicity in the context of a prominent form of ALS.

160 eir biomedical potentials and minimize their toxicity in the future clinical translation.

161 Conversely, reducing Rad23 levels alleviates toxicity in this SCA3 model.

162 ase genes assayed, 20 genes exhibited strong toxicity in yeast.

163 oved prophylaxis or therapy exists for these toxicities, in part reflecting an incomplete understandi

164 nervous system respond differently to photo-toxicity, in that astrocytes and microglia undergo morph

165 Common grade 1-2 toxicities included upper respiratory tract infections (

166 r false-positive diagnosis (e.g., medication toxicities); including these outcomes would further incr

167 ion of fatty acid synthase (FASN) suppresses toxicity induced by PINK1 deficiency in flies, mouse cel

168 fic aquatic species as an alternative to get toxicity information.

169 Drug toxicity is a long-standing concern of modern medicine.

170 ch mutant proteins are prone to aggregation, toxicity is also associated with soluble forms of the pr

171 Toxicity is most likely related to the concentration in

172 iption factor known for mediating xenobiotic toxicity, is expressed in B cells, which are known targe

173 therapeutically were unsuccessful because of toxicity, lack of efficacy, or both.

174 sophageal toxicity (AET) and late esophageal toxicity (LET) of four DEs were compared.

175 procedure-related complications, laboratory toxicity levels, imaging response, time to progression (

176 Establishing signatures for AG toxicity may enable more efficient evaluation of AG trea

177 g how PMEL fibrils assemble without apparent toxicity may help developing novel therapies for amyloid

178 stion, given the increasing realization that toxicity may reside in soluble conformers.

179 phasic dose-response curves, which suggested toxicity mechanisms that affected various physiological

180 9-driven HCC may be limited by dose-limiting toxicities mediated by FGFR1-3 receptors.

181 of anti-tumor potency and systemic off-tumor toxicity, micromolar affinity CAR T cells demonstrated s

182 on against predators conferred by their high toxicity might help to explain why calling has not yet d

183 nt benefits for pathway flux, as well as for toxicity mitigation.

184 iplexed barcode sequencing to identify yeast toxicity modifiers.

185 Low-toxicity myeloablative conditioning recipients have bett

186 Severe life-threatening toxicities occurred in 13 (4%) patients who received bus

187 uring enzalutamide retreatment, no grade 3-4 toxicities occurred in more than one patient.

188 One dose-limiting toxicity occurred at 200 mg (the patient did not take at

189 Grade 4 toxicity occurred in 32%, and 5% had treatment-associate

190 Discontinuations for toxicity occurred in 7.8% and 23.1% for paclitaxel and p

191 n while receiving sunitinib, or unacceptable toxicity occurred.

192 isease without significant treatment-related toxicities of first-line treatment.

193 have implications for environmental fate and toxicity of AgNP.

194 s for the assembly kinetics, morphology, and toxicity of all Abeta isoforms.

195 r, a unified model of the neurodevelopmental toxicity of BMAA in the zebrafish embryo is presented in

196 we evaluated the localization, activity, and toxicity of BoNT/C1 ad in vitro and in vivo.

197 orizon disaster drew global attention to the toxicity of crude oil and the potential for adverse heal

198 Cell-dependent minimal to no toxicity of Inh2-B1, and its abilities to down-regulate

199 resulted in the protection of cells from the toxicity of l-Abeta42 at concentrations up to 50 mum.

200 significance of nZVI-membrane interaction on toxicity of nZVI toward bacteria.

201 Additionally, the toxicity of OTA irradiated in water was tested.

202 f Neuron, Ishiguro et al. (2017) explore the toxicity of RAN translation in spinocerebellar ataxia 31

203 The toxicity of soluble metal-based nanomaterials may be due

204 Despite the known toxicity of some high-molecular-weight azaarenes, their

205 orally segregate efficacy from dose-limiting toxicity of streptozocin, a chemotherapeutic drug.

206 y by approximately 1000-fold and reduces the toxicity of Taxol towards cancer cell lines by over 200-

207 sk assessment requires information about the toxicity of the growing number of chemical products comi

208 quotient approach was applied to predict the toxicity of the quantified organic compounds for fresh w

209 This raises concerns about the potential toxicity of these nanomaterials in the environment.

210 e efficacy and/or reduce possible off-target toxicity of TNFSF ligands for cancer immunotherapy.

211 To compare the efficacy and toxicity of treating class 3 retinoblastoma vitreous see

212 litate the understanding of the mechanism of toxicity of UFP.

213 ry provides a sensitive real-time monitor of toxicity of uranium (in the U(VI) oxidation state) in a

214 ey phosphorylation-dependent mediator of the toxicity of wild-type tau and of all the FTDP-17 mutants

215 Zn(2+)) at greater temperature and salinity, toxicity of ZnO-NPs to T. pseudonana was less at 25 degr

216 fit enough for palliative treatment had more toxicities or a worse outcome than younger patients.

217 No toxicity or adverse immune consequences of vector admini

218 e of the analyzed fruit powders showed acute toxicity or genotoxicity.

219 unction mechanism; either through direct RNA toxicity or through the production of toxic aggregating

220 is preferred in the absence of concerns for toxicity or tolerance; alternatively, monotherapy with g

221 Secondary end points were patient-reported toxicity, overall survival (OS), and distant disease-fre

222 P's use of adverse outcome pathway (AOP) and toxicity pathway frameworks to organize and integrate di

223 rovide more exhaustive coverage of potential toxicity pathways being impacted, two avian ToxChip PCR

224 ibe the metabolic processing of STO-609, its toxicity, pharmacokinetics and bioavailability in a vari

225 l performance was quantified and compared to toxicity prediction modelling without utilizing radiosen

226 itro and in vivo activities, and low risk of toxicity profile except for the inhibition of CYP2C9.

227 induced a tumor response with an acceptable toxicity profile in salvage patients with liver metastas

228 Ibrutinib was well-tolerated with a toxicity profile similar to labeled indications.

229 INTERPRETATION: Avelumab has an acceptable toxicity profile up to 20 mg/kg and the maximum tolerate

230 afety and tolerability, and a more favorable toxicity profile when compared with vigabatrin.

231 siological effects and may contribute to the toxicity profile.

232 (OS) for the eribulin arm, with a manageable toxicity profile.

233 physicians to carefully balance efficacy and toxicity profiles for each individual patient.

234 The study was guided by structure-activity-toxicity-property relationships, and we demonstrate in t

235 that prion replication can be separated from toxicity, providing a novel target for therapeutic inter

236 ne patient (60 mg) had cycle 1 dose-limiting toxicity (pulmonary embolus).

237 erms of patients' outcomes and would improve toxicity, quality of life, or both.

238 Exploiting such structure-function-toxicity relationship may prove pivotal for the detectio

239 pathies," but the mechanisms underlying this toxicity remain poorly understood.

240 lly well tolerated with only 1 dose-limiting toxicity reported (grade 3 pneumonia at 20 mg/kg QW/Q2W)

241 relationships between predicted and observed toxicity, residuals and observed toxicity, and residuals

242 The toxicity seems to be acceptable considering the poor pro

243 classified 23 of 28 patients with grade >/=3 toxicity (sensitivity 82%) and 9 of 14 patients with gra

244 ffects, drug-drug interactions, and emerging toxicities should be carefully assessed when investigati

245 toxicity in both metals, but reduced cadmium toxicity significantly more.

246 ivity 82%) and 9 of 14 patients with grade 0 toxicity (specificity 64%).

247 l concerns pertaining to the instability and toxicity still remain that may potentially hinder their

248 establish phenotypes in disease modeling or toxicity studies.

249 lead compound was characterized by low dark toxicity (TC50 = 369 muM), high efficiency against other

250 rameters of the model from the design of the toxicity test (tested concentrations and observation tim

251 th in vivo target activity data (e.g. animal toxicity testing results), the integrated cheminformatic

252 hat reduce and replace the use of animals in toxicity testing.

253 Toxicity tests proved strong enantiomer-specific toxicit

254 d with higher hematologic and nonhematologic toxicity than HDAC cycles.

255 cent of patients had grade 3 or 4 neurologic toxicities that completely resolved.

256 slation of vaccine-adjuvants: reducing acute toxicities that result from systemic diffusion of many s

257 howing that resveratrol reduces beta-amyloid toxicity they also give evidence of a promising role for

258 ) of oil from the spill causes developmental toxicity through cardiac defects in pelagic fish species

259 all of which exhibited an elevated bacterial toxicity to Aliivibrio fischeri.

260 erefore, contaminated sediment risks causing toxicity to aquatic fauna.

261 olubilizing effect in this assay, showing no toxicity to bacteria or interference with the enzymatic

262 (MIC50 values), which indicates low compound toxicity to human cells in vitro.

263 ble research, specific contributions of BMAA toxicity to neurodegenerative diseases remain to be full

264 e a comparable degree of membrane damage and toxicity to S. oneidensis.

265 es at low concentrations were seen to induce toxicity to the cells, whereas at higher concentrations

266 In experimental animals, PFAAs cause toxicity to the liver, the immune, endocrine, and male r

267 r role in biotic interactions extends beyond toxicity to the microbial partners.

268 The toxicity to the retina does not seem to be significantly

269 cellularly on bacterial growth with very low toxicity towards host macrophages.

270 There were no indications of acute toxicity up to 7 days after instillation.

271 ional studies established that the increased toxicity upon mutating UbS2 stems from disrupting the au

272 h, 21h, and 72h were tested for efficacy and toxicity using a mouse SW620 xenograft model.

273 rban wetland sediments by assessing sediment toxicity using the amphipod Austrochiltonia subtenuis.

274 The underlying mechanism of toxicity was explored via comparing biological responses

275 In Cd-Cu-Ni mixtures, the toxicity was less than additive, additive, or more than

276 ty was uncommon; as expected, haematological toxicity was more common in patients treated with ASCT t

277 The incidence of IRIS, and drug toxicity was not significantly different between trial a

278 No systemic toxicity was noted with the expanders and histology show

279 Clinical characteristics were assembled, and toxicity was recorded using the Common Terminology Crite

280 F rates than historical data with CRT alone, toxicity was substantial, and LRF still occurs in approx

281 Grade 4 non-haematological toxicity was uncommon; as expected, haematological toxic

282 Although OP(DTT) per mass (toxicity) was highest for ultrafine particles, estimated

283 family dopamine receptors can ameliorate tau toxicity, we screened a collection of C. elegans mutatio

284 Toxicities were anticipated and managed with appropriate

285 The most common toxicities were neutropenia (96%), leukopenia (84%), thr

286 No unexpected toxicities were recorded.

287 ilirubin, and alkaline phosphatase grade 3/4 toxicities were, respectively, 3%, 10%, and 0% for CP-A;

288 Adherence to treatment and toxicity were analysed in the safety population, consist

289 higher sensitivity to catecholamine-induced toxicity were identified as mechanisms associated with t

290 otal amount of drug administered could lower toxicities while not compromising on the effectiveness o

291 es of chemical analogs that reduce host cell toxicity while maintaining blood-stage and gametocytocid

292 , IA was most accurate in predicting mixture toxicity, while CA was the most conservative.

293 However, aminoglycoside toxicity will likely prevent widespread clinical applica

294 ctive in autophagy displayed augmented APOL1 toxicity with all isoforms.

295 LR and BLM models predicted species-specific toxicity with similar precision; adjusted R(2) and R(2)

296 ulating pore-water exposure) revealed higher toxicity, with LC50 values between 78.3 and 161.6 mumol

297 revealing that each of the dipeptides caused toxicity, with poly GA being the most toxic.

298 2 years or disease progression, intolerable toxicity, withdrawal of consent, or investigator decisio

299 ering of BoNT has the potential to eliminate toxicity without disrupting neuron-specific targeting, t

300 tals require careful monitoring due to their toxicity, yet current methods are too complex or bulky f