ライフサイエンスコーパス: toxicological

1 ing compounds with known pharmacological and toxicological activities according to the degree of toxi

2 itivity of parameters on the model output of toxicological activity was examined across possible rang

3 HVO showed significant toxicological advantages over all other fuels.

4 thods should be more suitable for systematic toxicological analysis (STA).

5 es of three proficiency tests for systematic toxicological analysis and of 103 authentic human urine

6 Of great relevance, our preliminary toxicological analysis indicates that GEBR-32a is not cy

7 bes a sudden death with negative autopsy and toxicological analysis.

8 racteristics, which allows a more systematic toxicological analysis.

9 structure-activity relationships by linking toxicological and chemical mechanistic insights to the i

10 Since toxicological and cytological measurements did not highl

11 ty of studies of nanometre-scale aerosols of toxicological and environmental concern.

12 ied by awareness about their related adverse toxicological and environmental impacts.

13 impact of engineered nanoparticles (NPs) in toxicological and environmental media are driven by comp

14 ty-adjusted life years lost, using available toxicological and epidemiological information.

15 stances across multiple media, including non-toxicological and non-chemically deleterious effects.

16 le arsenic(III) compounds can exert profound toxicological and pharmacological effects, their modes o

17 Although investigation of the toxicological and physiological actions of alpha/beta-un

18 s of PoP and PoPx, further investigations in toxicological and sensory aspects of PoP and PoPx should

19 ter the expression of CYP26 enzymes may have toxicological and therapeutic importance.

20 nucleic acid-based probes for intracellular, toxicological, and environmental monitoring.

21 We showed that in a toxicological application, metabolic monitoring yields q

22 identified the following physicochemical and toxicological aspects as well as knowledge gaps that sho

23 During the toxicological assay, loss of C60 due to sorption to test

24 Incorporating C. elegans toxicological assays as part of a battery of in vitro an

25 in an established caries model; and (2) that toxicological assays of these lactobacilli will show the

26 iated with these models pose a challenge for toxicological assays to accurately report treatment outc

27 uctures of an arsenolipid is pivotal for its toxicological assessment and in understanding the arseni

28 ng, the application of these advances to the toxicological assessment of chemicals and chemical produ

29 that ATS were already viable approaches, for toxicological assessment of one or more end points in th

30 tailed ADME studies and in vitro and in vivo toxicological assessment.

31 usually performed as a part of a traditional toxicological assessment; however, it often requires add

32 In the field of toxicological bioassays, the latest progress in Raman sp

33 Moreover, the putative toxicological burden is unknown.

34 c role of soluble p17 species in HAND, their toxicological capability was evaluated in vivo.

35 in order to link their chemical evolution to toxicological changes.

36 el (ULSD) fuel on the physical, chemical and toxicological characteristics of diesel particulate matt

37 and 4% oxygen levels on physicochemical and toxicological characteristics of particulate emissions f

38 This can be problematic because toxicological characterization is lacking for many emerg

39 gen detection methods in order to guide post-toxicological chemical assessments.

40 s of 56 and 29 ng/g, which are equivalent to toxicological concentrations of 123 and 18 ng WHO-TEQDL-

41 the paradigm of hormesis, the biological and toxicological concept that small quantities have opposit

42 etables was estimated using the threshold of toxicological concern (TTC) approach.

43 itude below the long-term daily threshold of toxicological concern (TTC) of 1.5 mug/g and the potenti

44 pecific migration limits (SML) and threshold toxicological concern (TTC) recommended values according

45 n the marine environment and OH-PBDEs are of toxicological concern and are therefore of interest to m

46 ficult to identify which compounds may be of toxicological concern and should be prioritized for furt

47 ated from mining activities, which may be of toxicological concern to organisms that bioaccumulate th

48 No toxicological concern was associated to mycotoxins expos

49 seabird eggs from the Canadian Arctic are of toxicological concern.

50 centrations, many of them raise considerable toxicological concerns, particularly when present as com

51 n Se-Hg interactions, considers not only the toxicological consequences of Hg exposure but also the b

52 hese studies strongly suggest that there are toxicological consequences of ozone to human skin.

53 ation of action), concerns over the possible toxicological consequences of protein haptenization have

54 uce aflatoxin exposures and to attenuate the toxicological consequences of unavoidable exposures shou

55 = 0.983), which could result in significant toxicological consequences to the mussels and higher tro

56 sponse in the context of pharmacological and toxicological constraints.

57 stems toxicology model designed to integrate toxicological context into gene expression experiments.

58 els (metabolomics) aligned by their detailed toxicological context.

59 and lead should play an important role in a toxicological context.

60 CEBS will store toxicological contexts including the study design detail

61 enated byproducts of PPCPs that have limited toxicological data and significant uncertainty with rega

62 Epidemiological and toxicological data demonstrating immunosuppressive and i

63 city of oil has generally relied on existing toxicological data for a relatively few standard test sp

64 It is shown in this essay how some specific toxicological data has been misused by those aiming to d

65 Given the lack of toxicological data on palytoxins by inhalation exposure,

66 the first to integrate quantitative in vitro toxicological data with analytical chemistry and human e

67 A correlation of the toxicological data with physicochemical parameters of MO

68 re still to be set due to the lack of proper toxicological data.

69 ts are discussed in the light of established toxicological dose-response and mixture toxicity models.

70 also compared to known in vitro and in vivo toxicological effect concentrations.

71 However, considering the toxicological effect of arsenic and the oxidative instab

72 life-history trait interactions underlying a toxicological effect on population growth rate, should b

73 be needed to correlate the growing number of toxicological effects associated with atrazine exposure

74 The toxicological effects of arsenicals depend on their oxid

75 ription factor responsible for mediating the toxicological effects of dioxin and xenobiotic metabolis

76 volatiles, antimicrobials, as well as on the toxicological effects of durian fruit consumption.

77 In addition to the direct toxicological effects of elevated metals and reduced pH,

78 odel to characterise the pharmacological and toxicological effects of LiCl and VPA using gene express

79 in metallodrug development and beyond to the toxicological effects of metal ions more generally.

80 nteractions between nanoparticles change the toxicological effects of single ENMs in unexpected ways.

81 hroughput examination of the therapeutic and toxicological effects of target compounds in realistic t

82 cidence in the early 1960s due to the tragic toxicological effects of the drug thalidomide, which had

83 odel for studying the cellular and molecular toxicological effects on the liver after chronic exposur

84 etabolic vulnerability, as well as potential toxicological effects, inherent in the more potent prima

85 loped a powerful new model for understanding toxicological effects, mechanisms, and health impacts of

86 ing new testing methods to better understand toxicological effects.

87 ounds that are implicated in a wide range of toxicological effects.

88 c (S)-NFL leads to much higher than presumed toxicological effects.

89 t water quality and introduce potential (eco)toxicological effects.

90 o correlate these with uptake efficiency and toxicological effects.

91 he environment and might then jointly elicit toxicological effects.

92 de novel insights into identifying potential toxicological end points and molecular mechanisms, often

93 Toxicological end points, including mortality, hatching

94 rtebrate model in conjunction with assessing toxicological end points.

95 AA); this rank order was observed with other toxicological end points.

96 ly uninformative and potentially insensitive toxicological end points.

97 tem cell-derived hepatocytes demonstrate all toxicological endpoints examined, including steatosis, a

98 ols, animal characteristics and conventional toxicological endpoints such as histopathology findings

99 er guidelines for PFAAs, including choice of toxicological endpoints, uncertainty factors, and exposu

100 e that predict tissue, organ or whole animal toxicological endpoints.

101 posing pharmacology may extend to additional toxicological endpoints.

102 lue of these new technologies in relation to toxicological evaluation and the protection of human hea

103 was also confirmed during in vitro cellular toxicological evaluation of LCPM for the case of polyure

104 a correct identification, quantification and toxicological evaluation of the respective metabolites,

105 w of migration of monomers and additives and toxicological evaluation.

106 safety margin to the efficacious exposure in toxicological evaluations supported progression to Phase

107 t it can be used to propose THDCs for future toxicological evaluations.

108 o can be a valuable complement to inhalation toxicological evaluations.

109 ection in indoor environments and increasing toxicological evidence suggesting a potential for advers

110 Recent toxicological evidence suggests that FM550 may be endocr

111 transparency, efficiency, and acceptance of toxicological evidence, with benefits in terms of reduci

112 pidly expanding, creating an urgent need for toxicological examination of the exposure potential and

113 Further epidemiological and toxicological examinations of likely biological pathways

114 ure to susceptible populations; and e) using toxicological findings for risk assessment and remediati

115 United States, we have established that the toxicological footprint (TF) increased by 3.3% (88.4 Mt)

116 ydes and possess important physiological and toxicological functions in areas such as CNS, metabolic

117 ational database to analyze data obtained in toxicological gene array experiments with hydrazine-expo

118 RA focuses on management of a toxicological hazard in a specific exposure scenario, wh

119 We also address the toxicological impact and the limitations in translating

120 Animal experiments to assess their chronic toxicological impact are time consuming.

121 hrough two novel applications: Estimation of toxicological impact of new drugs and drug mixtures as w

122 rning specific studies on bare NPs and their toxicological impact on cells.

123 30%, <450 nm) has the potential for stronger toxicological impacts relative to those of other Cu mine

124 This investigation assessed the aquatic toxicological implications of copper oxide (CuO) nanosph

125 nail Otala lactea as models to determine the toxicological implications of sodium tungstate and an ag

126 required to fully understand the levels and toxicological implications of the identified metabolites

127 tribromoethene has been demonstrated to show toxicological implications.

128 hemical property, usage characteristics, and toxicological information are available.

129 Data which is a data standard for capturing toxicological information for animal studies and Clinica

130 There is a lack of publically available toxicological information for the main contaminant 4-met

131 cts (DBPs) in drinking water; however, their toxicological information is scarce.

132 als were entered into commercial use without toxicological information.

133 Hence, the toxicological interaction between OA and contaminants co

134 ore this scenario, we probe the chemical and toxicological interactions of nanosilver (n-Ag) and nano

135 As part of forensic toxicological investigation of cases involving unexpecte

136 This very first in vitro toxicological investigation on a deep-sea fish opens the

137 death despite comprehensive pathological and toxicological investigation.

138 neurological manifestations was subjected to toxicological investigations but was found to have no sp

139 ication of free nanoparticle release and the toxicological investigations of the released particles f

140 y appears to have potential for forensic and toxicological investigations, as suggested through the a

141 g an oxazolidinone on the scaffold mitigated toxicological issues often seen with topoisomerase inhib

142 al tool to systematically integrate existing toxicological knowledge from a mechanistic perspective t

143 ts should strategically attempt to fill this toxicological knowledge gap so human health risk assessm

144 l drugs were below typical physiological and toxicological levels.

145 lls can identify potential chemical targets, toxicological liabilities and mechanisms useful for eluc

146 oach may have wide application to de-risking toxicological liabilities in drug discovery.

147 ividual PAHs, and we describe the paucity of toxicological literature for many of these compounds.

148 investigational study to identify potential toxicological markers for an observed muscle toxicity as

149 lular perturbations associated with relevant toxicological mechanisms.

150 harmacological mode of action that relies on toxicological mechanistic effects on molecular target si

151 tes, enzymes, hormones, and blood cells) and toxicological (metals and minerals) variables.

152 ncy Center for the Evaluation of Alternative Toxicological Methods developed the Integrated Chemical

153 brafish can be used as a clinically relevant toxicological model amenable to the identification of ad

154 Daphnia pulex is a widely used toxicological model and is known for its sensitivity to

155 We present a simple toxicological model that can explain t(2) scaling.

156 e models of ion speciation (WHAM VI) and eco-toxicological models such as the biotic ligand model (BL

157 monoxide (CO) poisoning is a common cause of toxicological morbidity and mortality.

158 ed the issue of fish consumption choice from toxicological, nutritional, ecological, and economic poi

159 t reliable cell sources for pharmacological, toxicological or metabolic studies.

160 mechanistic and cellular events underlying a toxicological outcome allows the prediction of impact of

161 s as a tool to identify mechanisms affecting toxicological outcomes among related compounds.

162 ystems creates complex mixtures with unknown toxicological outcomes.

163 antifying the trend of the physiological and toxicological parameters of the model.

164 Following treatment, toxicological parameters reflecting distinct mechanisms

165 bolic and lipidomics datasets with classical toxicological parameters we developed a hypotheses free,

166 Standard toxicological parameters were assessed.

167 histiotypes if relevant pharmacodynamic and toxicological parameters were considered.

168 A "toxicological pathway color code model" is introduced to

169 Efforts in many countries have focused on a toxicological pathway-based vision for human health asse

170 PAHs usually elicit similar toxicological pathways but do so with varying levels of

171 e-gene deletion mutants, we have studied the toxicological pathways of a 60-nm cationic (amino-functi

172 plied technology allowing many insights into toxicological pathways of environmental contaminants.

173 From a toxicological perspective, the linkages between maternal

174 e was rationally designed based on chemical, toxicological, pharmacokinetic, and pharmacodynamic cons

175 This work provides a toxicological platform to study mammalian aging and sugg

176 dynamic cell state trajectories and estimate toxicological points of departure.

177 Little is known, however, concerning the toxicological potency of DES in fish.

178 hould be considered when the therapeutic and toxicological potential of green tea supplementation is

179 nia brevis, are essential when assessing the toxicological potential of this dinoflagellate.

180 The Toxicological Prioritization Index (ToxPi) was developed

181 The agency also developed a toxicological prioritization tool, ToxPi, to facilitate

182 ngineer a pharmacophore in order to overcome toxicological problems while maintaining iron clearing e

183 rucial component of many pharmacological and toxicological processes, and studies have suggested that

184 provide deeper insight into therapeutic and toxicological processes, revealing at the molecular leve

185 Compound 27 stands out due to its favorable toxicological profile and physicochemical properties, wh

186 receptor agonists with a pharmacological and toxicological profile compatible with clinical developme

187 ay a role in the overall pharmacological and toxicological profile of metallodrugs.

188 has been paid to the studies describing the toxicological profile of PtNPs with an attempt to draw c

189 Also, the in vivo toxicological profile of the PLL-dendrimer molecules was

190 on by In(NO3)3 and ITO indicating a critical toxicological profile that needs further investigation.

191 h solubility in aqueous media, an acceptable toxicological profile, and oral efficacy.

192 ne (CI) group of marine toxins with a unique toxicological profile.

193 notechnology research community and produced toxicological profiles for selected ENMs, as well as imp

194 orane anions have been synthesized and their toxicological profiles obtained in rats.

195 microarrays and RNA-sequencing technologies, toxicological profiles of contaminants could be identifi

196 ge of the mechanism of formation, levels and toxicological profiles of the chemical products in the a

197 ut remains limited due to uncertainty in the toxicological profiles of the nanoparticles (NPs).

198 The toxicological profiles of two trioxolanes were comparabl

199 = 140 nM) and favorable pharmacokinetic and toxicological profiles.

200 ifferences which may explain their different toxicological profiles.

201 ols both in terms of biological activity and toxicological profiling in vitro and in vivo.

202 t of physicochemical, biopharmaceutical, and toxicological profiling.

203 /A1 to -5 have distinct in vitro and in vivo toxicological properties and that, unlike those for BoNT

204 ct molecules with similar pharmacological or toxicological properties by gene expression profile.

205 fining the compounds to improve efficacy and toxicological properties for efficient blocking of malar

206 the early recognition of pharmacological and toxicological properties in chemicals and new drug candi

207 formation on the complex physicochemical and toxicological properties of both toner powders and print

208 significantly affect the physicochemical and toxicological properties of LCPM released during thermal

209 to study the phytochemical constituents and toxicological properties of seagrasses when considering

210 ion of pharmacological, pharmacokinetic, and toxicological properties of synthesized analogs resulted

211 This may affect the physiological or toxicological properties of the treated food.

212 parent mexiletine and to have more favorable toxicological properties than mexiletine.

213 armacokinetic, in vivo efficacy, safety, and toxicological properties, compound 37 was selected for f

214 A metabolic and toxicological re-evaluation was performed after 6 and 12

215 d and seven additional online biomedical and toxicological referencing libraries to identify literatu

216 Next, we search for evidence of toxicological relationships between these genetic and en

217 The toxicological relevance and widespread occurrence of fat

218 nal bioanalysis might reveal an even greater toxicological relevance of HPCs.

219 To understand the toxicological relevance of the OH-HBQs, we studied the i

220 tes are estimated for particles of different toxicological relevance, that is, minerals, iron oxides,

221 on byproducts (N-DBPs) has increased because toxicological research has indicated that they are often

222 Toxicological research in the 1930s gave the first indic

223 ted in the United States National Center for Toxicological Research Liver Toxicity Knowledge Base (NC

224 Much of the important biological and toxicological research on (2)(1)(0)Po is more than four

225 Toxicological research suggests that coarse particles (P

226 This advance is critical for biomedical and toxicological research, as well as in fundamental studie

227 The ability of a substance to induce a toxicological response is better understood by analyzing

228 In vitro toxicological response to As varies substantially, deter

229 ate two additional biological processes: the toxicological response to compounds such as 2,3,7,8-tetr

230 ne regulation and has also been studied as a toxicological response to juvenoid hormone analog insect

231 p, a comprehensive set of genes important in toxicological responses (represented by 2200 cDNA probes

232 Most of the biochemical, biological, and toxicological responses caused by exposure to PAHs and p

233 SCs) enable the study of pharmacological and toxicological responses in patient-specific cardiomyocyt

234 s, but its contribution toward heterogeneous toxicological responses is poorly understood.

235 formation System (IRIS) completed an updated toxicological review of dichloromethane in November 2011

236 onmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in Septe

237 uman health effects of TCE in the U.S. EPA's toxicological review.

238 umption of these waters does not represent a toxicological risk for an adult.

239 Our investigation suggests a toxicological risk of metal oxide NP pollution in the aq

240 rrogates to investigate the aqueous fate and toxicological risk of metal oxide NPs associated with wa

241 tion of toxic As species by plants suggested toxicological risk to higher organisms known to utilize

242 the top of aquatic food chains constitutes a toxicological risk to humans and other top predators.

243 chemicals in their overall human and animal toxicological risk.

244 l value of the mushroom, as well as possible toxicological risks associated with its consumption.

245 However, little is known about the toxicological risks of the ingredients used.

246 echanisms against pathogens, incurring lower toxicological risks than conventional agrochemicals.

247 kinetic modeling aided in characterizing the toxicological role of the complex metabolism and multipl

248 on human leukaemic U937 cells and sufficient toxicological safety on normal human white blood cells w

249 adverse outcome pathway (AOP) concept in the toxicological sciences.

250 bstacle to the development of cost-effective toxicological screening methods for engineered nanomater

251 ys can reduce the cost and time required for toxicological screening of environmental chemicals and c

252 t laboratories to facilitate high-throughput toxicological screening of pharmaceutical agents and tre

253 NBP assays are used in the toxicological screening of pharmaceutical compounds, det

254 Forensic and clinical toxicological screening procedures are employing liquid

255 Despite their widespread use for toxicological screening, biomedical research and pharmac

256 n suspect chemicals, which combines expanded toxicological screening, neurobiological research and pr

257 a novel Bayesian probabilistic algorithm for toxicological screening.

258 s in the aquatic environment differ in their toxicological sensitivity to the various chemicals they

259 y systems indicating activation of different toxicological signaling pathways is one of the paramount

260 interdependent effects for the activation of toxicological signaling pathways.

261 Assessing the toxicological significance of complex environmental mixt

262 th broad coverage of chemical and biological/toxicological space.

263 ing, selection of appropriate in vivo model, toxicological studies (including toxin production) and d

264 New epidemiological and toxicological studies addressing the potential health im

265 Classical toxicological studies are effective for characterizing p

266 nsortia, intramural research activities, and toxicological studies being conducted by the National To

267 extrapolating synergy observations from (eco)toxicological studies done at high exposure levels.

268 Toxicological studies have correlated inflammatory effec

269 ted particles (PEPs) continues to grow, most toxicological studies have not used the actual PEPs but

270 Toxicological studies have reported that linuron acts as

271 s from metal devices as well as guidance for toxicological studies in humans.

272 n the removal of these lesions and for human toxicological studies in the future.

273 urther profiling, but, unfortunately, in GLP toxicological studies it showed liver findings in rat an

274 Toxicological studies of these mixtures are needed to un

275 Detailed preclinical pharmacokinetic and toxicological studies reveal no observable drawbacks.

276 Toxicological studies revealed that repetitive injection

277 ing models for assessing epidemiological and toxicological studies to reach consensus on probabilitie

278 to measure concentrations typically used in toxicological studies, and uses inexpensive, commerciall

279 ughput screening for clinical diagnostic and toxicological studies, as well as molecular phenotyping

280 ish (Danio rerio) is a widely used model for toxicological studies, in particular those related to in

281 omedical applications, and for metabolic and toxicological studies, is a cutting-edge research topic.

282 Polychaetes are frequented in toxicological studies, one reason being that some member

283 gical advance with potential applications in toxicological studies.

284 ular redox changes induced by xenobiotics in toxicological studies.

285 ta-driven integration of epidemiological and toxicological studies.

286 lung, enhancing its utility in clinical and toxicological studies.

287 nds 11b and 11j into further preclinical and toxicological studies.

288 sed therapeutics and for pharmacological and toxicological studies.

289 cies place considerable reliance on nonhuman toxicological studies.

290 pid and sensitive way to monitor OH-PCBs for toxicological study in the laboratory, as well as a usef

291 This assay was successfully applied to a toxicological study.

292 g rat urine collected during the course of a toxicological study.

293 these results, prior studies, and extensive toxicological support, the association between PM2.5 and

294 An emerging body of evidence points to the toxicological susceptibility of aquatic reptiles to Hg e

295 opment of reliable and efficient methods for toxicological testing and investigation of nano-bio inte

296 and West Virginia) that routinely performed toxicological testing on drivers involved in such crashe

297 and used in prioritization for more in-depth toxicological testing.

298 In recent years additional analytical and toxicological tests were included in the test panel with

299 ther, for substances for which there is good toxicological understanding, a regulatory approach based

300 a great importance from the nutritional and toxicological view.