ライフサイエンスコーパス: toxicology

1 ead by the COMET (Consortium for Metabonomic Toxicology).

2 are analogous to adverse outcome pathways in toxicology.

3 ved tissues and details their application in toxicology.

4 ssue models for research, drug discovery and toxicology.

5 ons with heroin use history and acute opiate toxicology.

6 ways is one of the paramount goals of modern toxicology.

7 popular seafoods, their human metabolism and toxicology.

8 ing in, or closely linked with, the field of toxicology.

9 , evolution, genomics, molecular biology and toxicology.

10 believe these efforts foretell the future of toxicology.

11 t, genetics, pathogenesis, transgenesis, and toxicology.

12 detrimental contribution to side effects and toxicology.

13 applicability of these models for predictive toxicology.

14 ns in, e.g., therapeutic drug monitoring and toxicology.

15 de-reaching implications for development and toxicology.

16 is effectively a systems-biology approach to toxicology.

17 tance as the alternative matrix for forensic toxicology.

18 Ag materials has spurred interest into their toxicology.

19 " assays in pharmaceutical and environmental toxicology.

20 ied fields like food safety, environment, or toxicology.

21 ta is being used to predict in vivo chemical toxicology.

22 for the study of development, genetics, and toxicology.

23 stigate liver damage due to drug exposure in toxicology.

24 model system for studying human disease and toxicology.

25 ivity label-free assay utility in predictive toxicology.

26 ecognized as an important component of their toxicology.

27 ields, such as biomedicine, pharmacology and toxicology.

28 oses the 21st-century transition underway in toxicology.

29 ible, hPSC-derived hepatocyte for predictive toxicology.

30 articipants was controlled by hair and urine toxicologies.

31 Transcriptome-based toxicology analysis predicted and risk-stratified patien

32 patients, for sport antidoping and forensic toxicology analysis.

33 of fundamental research on biocompatibility, toxicology and biopersistence in the living body as well

34 Cannabis use was measured by weekly urine toxicology and by self-report using the Timeline Followb

35 ool in several fields of research, including toxicology and cancer epidemiology.

36 way to expedite research in drug discovery, toxicology and cell-based sensing.

37 as been conducted extensively, the molecular toxicology and cellular mechanisms affected by proton ir

38 ively slow pace of technology development in toxicology and clinical safety evaluation, particularly

39 rganism for genetics, developmental biology, toxicology and comparative genomics, the genome of which

40 could be a powerful tool for fields such as toxicology and developmental biology to investigate whol

41 ively at concentration levels encountered in toxicology and doping.

42 s also drive the development in the field of toxicology and ecotoxicology.

43 to parent compound gossypol with respect to toxicology and efficacy, suggesting that further develop

44 applied techniques in the field of nano(eco)toxicology and environmental sciences, including atomic

45 We assessed pre-clinical toxicology and first-in-human administration of C34-PEG4

46 lesions constitutes one of the main tasks in toxicology and in assessing health risks accompanied by

47 measurement remains one of the core tasks in toxicology and in evaluating human health risks associat

48 ly, the lack of information available on the toxicology and metabolism of acetyl fentanyl precludes i

49 (such as cell spreading, adhesion, invasion, toxicology and mobility).

50 The toxicology and pharmacology data demonstrated that the f

51 ready-approved drugs with well-characterized toxicology and pharmacology is a novel way to reduce the

52 The toxicology and pharmacology literature also suggests tha

53 The preclinical toxicology and pharmacology of a copper-ATSM formulation

54 utbred mouse stocks, often used in genetics, toxicology and pharmacology research, have been generate

55 nal and hierarchical approach beginning with toxicology and pharmacology studies, progressing to huma

56 Preclinical GLP toxicology and safety pharmacology studies were without

57 Cannabis use was assessed by urine toxicology and self-report during treatment, and by self

58 able for use as reference materials for (eco)toxicology and surface water environmental studies.

59 ow an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk re

60 that are of great interest for environmental toxicology and wastewater treatment research, to conduct

61 the method holds promise for applications in toxicology and where an alternative reliable method to c

62 ert panelists in the fields of epidemiology, toxicology, and atmospheric and exposure sciences led op

63 iety of applications including drug testing, toxicology, and basic cell biology.

64 ential importance in pathological processes, toxicology, and cancer therapy.

65 environmental health science, translational toxicology, and clinical epidemiology.

66 on of the bioavailability, pharmacokinetics, toxicology, and efficacy of this series of compounds usi

67 studying aging, reproduction, neuroscience, toxicology, and infectious disease.

68 50s) play critical roles in drug metabolism, toxicology, and metabolic processes.

69 line panel) and in vivo antitumor activity, toxicology, and mouse pharmacokinetic and pharmacodynami

70 sms plays an important role in cell biology, toxicology, and nanotechnology.

71 n Agency's National Center for Computational Toxicology, and the National Human Genome Research Insti

72 Developments in epigenomics, toxicology, and therapeutic nucleic acids all rely on a

73 ortant roles in metabolic adaptation, dioxin toxicology, and vascular development.

74 cology assessment per Registry of Industrial Toxicology Animal data guidelines.

75 and clinical studies for drug screening and toxicology applications.

76 potential for imaging, pharmacokinetics, and toxicology applications.

77 s for endocrine disrupters with a predictive toxicology approach that is suitable for high-throughput

78 However, toxicology as a field has often not produced efficient a

79 llenges and problems in current practices in toxicology as applied to decision making.

80 luding immediate reactogenicity, post-dosing toxicology ascertained 24 h after study drug administrat

81 eck, we have developed a metabolizing enzyme toxicology assay chip (MetaChip) that combines high-thro

82 zed 3D cell-culture array (the Data Analysis Toxicology Assay Chip or DataChip) for high-throughput t

83 ntaining microarray (the Metabolizing Enzyme Toxicology Assay Chip or MetaChip), simultaneously provi

84 a functional HNMT in patients using in vitro toxicology assay.

85 opportunity to revolutionize predictive drug toxicology assays and allow the creation of in vitro hep

86 experiments, in vitro counter screening, and toxicology assays demonstrated that the covalent bond fo

87 orted days of cocaine use and positive urine toxicology assays for cocaine metabolites.

88 used in the screening of therapeutics and in toxicology assays for potential liabilities of therapeut

89 ect human male fertility, which common mouse toxicology assays would not reveal.

90 ctions were submitted (blinded) for standard toxicology assessment per Registry of Industrial Toxicol

91 ols for physicochemical characterization and toxicology assessment to understanding and defining dose

92 ) in drinking water is of great interest for toxicology assessment, environmental protection and huma

93 itchable sulfonylurea JB253 to comprehensive toxicology assessment, including mutagenicity and maximu

94 ng regulations specify a reduced preclinical toxicology-assessment package in order to shorten the ro

95 However, extensive toxicology assessments in a substantial number of animal

96 lacking the previously observed preclinical toxicology at comparable exposures.

97 orption, distribution, metabolism, excretion/toxicology) at very early phases of drug development, th

98 actions: advances in pesticide chemistry and toxicology, banning of many chlorinated hydrocarbons, th

99 unctions are tighter than those derived from toxicology-based, interspecies extrapolations.

100 This review takes a holistic view of bee toxicology by taking into account the spectrum of xenobi

101 Ten years ago, leaders in the field of toxicology called for a transformation of the discipline

102 vitro tool commonly used in human and rodent toxicology, can overcome such limitation.

103 d -delta) agonist were profiled by classical toxicology (clinical chemistry) and high throughput meta

104 Preclinical evaluation included toxicology (clinical examination, serial electroretinogr

105 y, with clear implications for environmental toxicology, CNS pathology, and the pharmacotherapy of CN

106 The Consortium for Metabonomic Toxicology (COMET) obtained temporal NMR spectra of urin

107 anism for studies related to carcinogenesis, toxicology, comparative immunology, disease ecology, phy

108 n a current Standard of Knowledge in general toxicology compiled from the experience and opinions of

109 ive weeks of abstinence as measured by urine toxicology confirmed self-report.

110 terials with emphasis on currently available toxicology data and methodologies for evaluating nanopar

111 clinical and/or clinical data and sufficient toxicology data and/or company development efforts to wa

112 Therefore conventional particle toxicology data are useful and relevant to the determina

113 esource, in the context of the larger DSSTox toxicology data network, as well as across large public

114 es an intuitive framework to relate in vitro toxicology data rapidly and quantitatively to exposures

115 fied using physiologic, pharmacokinetic, and toxicology data rather than simple BSA conversion.

116 t a novel model to simulate complex chemical-toxicology data sets and use this model to evaluate the

117 roach for dose-response assessment of animal toxicology data similar to how nonprobabilistic referenc

118 73 compounds with rodent pharmacokinetic and toxicology data.

119 studied and have a direct impact on all (eco)toxicology data.

120 s, and civil society and included experts in toxicology, decision science, alternatives assessment, e

121 alidation, and application of evidence-based toxicology (EBT).

122 e environmental health disciplines including toxicology, epidemiology, disease surveillance, and epig

123 omplex media such as environmental waters or toxicology exposure media, the same redox transformation

124 n nanoparticles and organisms, and classical toxicology fails to provide models for risk assessment.

125 most exclusively studied by the pharmacology/toxicology field for its role in mediating the toxicity

126 Because of toxicology findings identified in longer-term preclinica

127 (AHR), which has been central to studies in toxicology for years as the receptor for the toxicant di

128 oxicology Program's (NTP) efforts to advance toxicology from a predominantly observational science at

129 cardiovascular disease, apoptosis and other toxicology functions.

130 nts Analysis distinguished between these two toxicology genes and 11 other genes primarily involved i

131 Although individual-level toxicology has been the subject of considerable research

132 Functional toxicology has enabled the identification of genes invol

133 Toxicology has long relied on animal models in a tedious

134 ion of genomic techniques into environmental toxicology has presented new avenues to develop exposure

135 edict the impact of drug candidates on human toxicology has proven difficult.

136 Se) has a significant effect on mercury (Hg) toxicology; however, Hg exposure risk assessments usuall

137 wing compendium of data on drug efficacy and toxicology in patient populations.

138 at the 2014 annual meeting of the Society of Toxicology in Phoenix, Arizona.

139 dynamic properties, and in vivo pharmacology/toxicology in preclinical species.

140 lds of computational chemistry and molecular toxicology in recent decades allow the development of pr

141 In addition, new approaches such as Toxicology in the 21st Century (Tox21) and exposure fore

142 High-throughput screening data from Toxicology in the 21st Century (Tox21) were also conside

143 adoption of ATS were the need for expedited toxicology information, the need for reduced toxicity te

144 ponse), and be used to improve the design of toxicology investigations (e.g. to inform how NMs should

145 Exploratory toxicology investigations showed that high doses of 5-NI

146 cate that the transformation of the field of toxicology is partly implemented, but significant barrie

147 Modern toxicology is seeking new testing methods to better unde

148 Modern toxicology is shifting from an observational to a mechan

149 e of which are important in pharmacology and toxicology, is discussed.

150 e science, linked with comparable efforts in toxicology, is ushering in a new era of risk assessment

151 e dose-response curves be linear, whereas in toxicology, it results in the model of CA.

152 internal medicine, respiratory medicine, and toxicology journals studied had comprehensive COI defini

153 tation of THC and THCA will be efficient for toxicology laboratories.

154 known substance required coordination with a toxicology laboratory.

155 s reported in the environmental and nano(eco)toxicology literature and provide a tool for comparison

156 queous phase, changes in bioavailability and toxicology may result.

157 onship between activity in the DTT assay and toxicology measurements across particles of different or

158 there are little data on their stability in toxicology media.

159 egrated strategy combining pharmacokinetics, toxicology, metabonomics, genomics, and metagenomics to

160 All underwent autopsy, toxicology, microbiology, and genetic testing.

161 w report SysTox-OM as an open source systems toxicology model designed to integrate toxicological con

162 sm within a standard setup improves in vitro toxicology models in replacement strategies of animal ex

163 environmental fate of spilled oil, improved toxicology, molecular modeling of biotic/abiotic weather

164 Topics include behavioral toxicology, noise, crowding, housing and neighborhood qu

165 parative analysis predicts that the chemical toxicologies of 1 and 3 should be similar and remarkably

166 the environmental behavior, biokinetics, and toxicology of (2)(1)(0)Po and identified the need for fu

167 eral effects that appear consistent with the toxicology of (2)(1)(0)Po.

168 stion in human health sciences; however, the toxicology of chronic exposure to environmentally releva

169 enic chemicals, and monitoring the genotypic toxicology of environments.

170 Hg, the physiology/toxicology of Se, and the toxicology of Hg, we propose a new criterion for Se/Hg e

171 Furthermore, the toxicology of MP4 by evaluating the cell proliferation e

172 Most research on the toxicology of nanomaterials has focused on the effects o

173 s the importance of considering the fate and toxicology of nanoparticles in context with their releva

174 There has been much less research on the toxicology of nanoparticles that are used for biomedical

175 nteraction between Se and Hg, the physiology/toxicology of Se, and the toxicology of Hg, we propose a

176 relatively little is known about the aquatic toxicology of sealcoat-derived contaminants.

177 Generally, the toxicology of the pure compounds and their epidemiology

178 Pharmacology and toxicology of these compounds are discussed, with partic

179 has stimulated interest in the chemistry and toxicology of these compounds.

180 ch should examine the environmental fate and toxicology of these PFASs, especially their potential as

181 efore required to understand the ecology and toxicology of those bloom events and reduce their negati

182 article is to review the pathophysiology and toxicology of valproic acid and determine whether the li

183 In 40 (19%) cases, predictable toxicology or histology testing accessible by PMCT infor

184 of NPs behavior in biological specimens for toxicology or nanomedicine purposes.

185 e weeks of any non-study opioid use by urine toxicology or self-report, or 7 consecutive days of self

186 ty/volume of distribution (V(d)) for in vivo toxicology outcomes, scaled microsome metabolism/calcula

187 duced cannabis use as measured both by urine toxicology (p=0.001) and by the Timeline Followback Inte

188 tion of a drug with antiviral properties and toxicology parameters similar to 2, but with a preclinic

189 data from more than 50 years of research in toxicology, pathophysiology, and behavioral science offe

190 Sub-acute toxicology performed on rats intravenously injected with

191 st for several application fields, including toxicology, pharmacology, and therapeutics.

192 In light of its oral bioavailability, safety toxicology profile in animal studies, and efficacy with

193 outstanding potency, a favorable predictive toxicology profile, and remarkable aqueous solubility.

194 nmental Health Sciences (NIEHS) and National Toxicology Program (NTP) have developed an integrated, m

195 In 2011, the National Toxicology Program (NTP) organized a workshop to assess

196 th Sciences (NIEHS) Division of the National Toxicology Program (NTP) organized a workshop to evaluat

197 al and summary animal data from the National Toxicology Program (NTP) testing program and other depos

198 ical studies being conducted by the National Toxicology Program (NTP).

199 se and luciferase, to screen a U.S. National Toxicology Program 1,408-compound library (NTP 1408, whi

200 sment and Translation (OHAT) of the National Toxicology Program and the Navigation Guide works.

201 synthesis under development at the National Toxicology Program and under consideration by the U.S. E

202 ccess point for these purposes, the National Toxicology Program Interagency Center for the Evaluation

203 t would yield a broad assessment of National Toxicology Program's (NTP's) effectiveness across multip

204 ments with an important role in the National Toxicology Program's (NTP) efforts to advance toxicology

205 sed using guidance developed by the National Toxicology Program's Office of Health Assessment and Tra

206 te of Environmental Health Sciences/National Toxicology Program, the U.S. Environmental Protection Ag

207 ch as the Superfund Program and the National Toxicology Program, work to discover mechanisms to prote

208 a 2-year bioassay conducted by the National Toxicology Program.

209 umors) previously studied by the US National Toxicology Program.

210 rmation System Program and the U.S. National Toxicology Program.

211 Evaluating the impact of the U.S. National Toxicology Program: a case study on hexavalent chromium.

212 Finally, existing data from an independent toxicology project involving several hundred samples wer

213 extended for drug discovery/pharmacology and toxicology protocols to study the effects of drugs and t

214 e from ecology, chemistry, exposure science, toxicology, public health, bioethics, engineering, medic

215 Toxicology reports from Arizona, Georgia, North Carolina

216 canids to act as models for Arctic molecular toxicology research is unique and significant for advanc

217 animal model in biomedical and environmental toxicology research.

218 atabase (CEBS) is a comprehensive and unique toxicology resource that compiles individual and summary

219 itionally, preliminary evaluation of in vivo toxicology revealed a significant dose related cardiotox

220 personalized medicine and nutrition, inform toxicology risk assessment, and improve drug discovery a

221 nations can be used to prioritize cumulative toxicology risk assessments.

222 In toxicology screening (forensic, food-safety), due to sev

223 an enabling platform for predictive drug and toxicology screening and development of novel therapeuti

224 ed in vitro methods for human metabolism and toxicology screening based on liver slices, cultured hum

225 probability for a Bayesian model in targeted toxicology screening is introduced.

226 gerous "designer drug" analogues that escape toxicology screening, yet display comparable potency to

227 eering, and high-throughput pharmacology and toxicology screening.

228 tors; however, nephrotoxicity in preclinical toxicology species precluded development.

229 development, including pharmacokinetic (PK), toxicology, stability, and biochemical characterization

230 wide range of assays, from drug discovery to toxicology, stem cell research and therapy.

231 ecules that advanced into exploratory animal toxicology studies (two species) was examined to determi

232 will provide pharmaceutical development and toxicology studies a unique opportunity to revolutionize

233 metabolic profiles between animal groups in toxicology studies and clinical investigations of liver

234 s is crucial for early-stage drug discovery, toxicology studies and clinical trials.

235 Murine toxicology studies are also fundamental because they ide

236 Results from animal toxicology studies are critical to evaluating the potent

237 ons in, e.g., drug discovery, synthesis, and toxicology studies are envisaged.

238 Toxicology studies confirmed a wide safety margin consis

239 Additionally, plasma samples from toxicology studies confirmed that 8 did not form any rea

240 The use of chimeric mice in preclinical toxicology studies could improve the safety of candidate

241 th acute and chronic safety pharmacology and toxicology studies demonstrated a clean profile up to hi

242 t understanding of nanoparticle behavior and toxicology studies for the alveolar region.

243 Since toxicology studies have shown that the product of C-nitr

244 Three clinical toxicology studies identified neurotoxicity in newborn r

245 Preclinical toxicology studies in mice, rats, dogs, and primates did

246 iviral activity, preclincial PK profile, and toxicology studies in rat and dog supported clinical dev

247 Toxicology studies indicate that inhalation of ultrafine

248 Toxicology studies of Ag-NP transformation products, inc

249 tified 18 epidemiology studies and 21 animal toxicology studies relevant to our study question.

250 and specificity of SCr and BUN, we used rat toxicology studies to compare the diagnostic performance

251 ds away from traditional experimental animal toxicology studies to one based on target-specific, mech

252 Toxicology studies were performed in Ifnar(KO)xCD46 tran

253 Novo Nordisk has conducted extensive toxicology studies, including data on pancreas weight an

254 p experimental avenues for disease modeling, toxicology studies, regenerative medicine, and gene ther

255 ls may include interpretation of preclinical toxicology studies, selection of first in man dosing reg

256 In these preclinical toxicology studies, the dose of oseltamivir exceeded tha

257 Through a series of exploratory toxicology studies, we show that quantifying CatD target

258 will depend on the outcomes of efficacy and toxicology studies, which will provide the necessary ris

259 PBDEs, which may inform future environmental toxicology studies.

260 vitro disease modeling, drug discovery, and toxicology studies.

261 ice used for transgenesis, pharmacology, and toxicology studies.

262 nerative medicine strategies, as well as for toxicology studies.

263 was achieved for advancement into regulatory toxicology studies.

264 reversible hepatic lipidosis in repeat-dose toxicology studies.

265 the oral exposure at the efficacious dose in toxicology studies.

266 l epithelium model is potentially useful for toxicology studies.

267 e than 100 g of the final API BMS-986097 for toxicology studies.

268 atocytes for use in physiologically relevant toxicology studies.

269 t potential to be used in drug discovery and toxicology studies.

270 promising alternative to traditional animal toxicology studies.

271 spectroscopy data collected in a preclinical toxicology study as part of a larger project lead by the

272 A pilot mouse toxicology study confirmed that no evidence of significa

273 In a single-dose rat toxicology study, a site-specific anti-Her2 NDC was well

274 This lead compound completed a two week rat toxicology study, and was well tolerated at doses up to

275 In a toxicology study, SI-2 caused minimal acute cardiotoxici

276 hypersensitivity in a 90-day NHP regulatory toxicology study.

277 uirement to assess the pharmacokinetics in a toxicology study.

278 pectations that central questions of mixture toxicology such as for mechanisms of low dose interactio

279 s, including physiological studies, drug and toxicology testing and modeling disease processes.

280 ipants received behavioral therapy and urine toxicology testing throughout the trial.

281 se was determined by directly observed urine toxicology testing twice weekly.

282 s, including physiological studies, drug and toxicology testing, modeling disease processes and compl

283 metabolism, which is essential for drug and toxicology testing.

284 icable to disease modelling, drug screening, toxicology tests and, ultimately, autologous cell-based

285 uman development, accelerate predictive drug toxicology tests, and advance potential regenerative the

286 nvironmental hygiene technology, preliminary toxicology tests, mutagenicity of medicinal compounds, a

287 imeline follow back and ascertained by urine toxicology tests.

288 In regulatory toxicology, the dose-response relationship is a key elem

289 s and industries, ranging from environmental toxicology through to pharmaceutical and agrochemical in

290 f critical importance in fields ranging from toxicology to climate science, yet these properties are

291 timately be possible to develop personalized toxicology to determine interindividual susceptibility t

292 has been used in both both epidemiology and toxicology to develop the definition of "noninteraction,

293 t mainly as a result of a paradigm change in toxicology towards the use and integration of genome wid

294 new paradigm for the field of environmental toxicology: toxicants acting through AhR to target xenob

295 -to-outcome continuum of modern experimental toxicology using cheminformatics approaches and big data

296 l for studies evaluating drug metabolism and toxicology using in vitro constructs.

297 clinical pharmacology, pharmacokinetics, and toxicology usually required for introduction of novel th

298 se study, a literature survey of the nano-Cu toxicology values has been performed to calculate the ef

299 Pre-clinical toxicology was conducted in 2 species.

300 Combining computational toxicology with ExpoCast exposure estimates and ToxCast