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1 unctional K(ATP) channels are present in the trabecular meshwork.
2 production in both the ciliary body and the trabecular meshwork.
3 a rat model by laser photocoagulation of the trabecular meshwork.
4 that involved laser photocoagulation of the trabecular meshwork.
5 expression of cochlin in human glaucomatous trabecular meshwork.
6 ular matrix protein produced by cells of the trabecular meshwork.
7 ferential flow pathways are present in human trabecular meshwork.
8 of caveolae in the Schlemm's canal (SC) and trabecular meshwork.
9 tion of extracellular matrix material in the trabecular meshwork.
10 nt determinants of fluid outflow through the trabecular meshwork.
11 e cytoskeleton and cell adhesions within the trabecular meshwork.
12 ocilin in the juxtacanalicular region of the trabecular meshwork.
13 f each of eight male monkeys by lasering the trabecular meshwork.
14 t enables it to bind specifically within the trabecular meshwork.
15 ance to outflow of aqueous humor through the trabecular meshwork.
16 in disease and with experiments on perfused trabecular meshwork.
17 ilar to that of the human iris than to human trabecular meshwork.
18 the injected eye by laser application to the trabecular meshwork.
19 than 4% of the genes expressed by the human trabecular meshwork.
20 low structures, Schlemm's canal (SC) and the trabecular meshwork.
21 n of SLT was performed to 360 degrees of the trabecular meshwork.
22 the posterior cornea initiating beneath the trabecular meshwork.
23 lt rhesus macaques by laser treatment to the trabecular meshwork.
24 echiae, and pigmentary dispersion within the trabecular meshwork.
25 chlemm's canal with no visible damage to the trabecular meshwork.
26 9 rhesus macaques by laser treatment to the trabecular meshwork.
27 ered in the ciliary muscle (46 +/- 5.6%) and trabecular meshwork (37 +/- 8.3%) of treated eyes relati
30 se fibronectin syntheses and accumulation in trabecular meshwork and accelerate the depletion of trab
34 expressing rats was associated with fibrotic trabecular meshwork and increased levels of F-actin, pho
35 not secreted in two ocular cell types, human trabecular meshwork and retinal pigment epithelial cells
37 pressed within human retina, optic nerve and trabecular meshwork and that ABCA1 and AFAP1 are also ex
38 use of the lack of coagulation damage to the trabecular meshwork and the demonstrated efficacy in pat
39 red cells of both the ciliary epithelium and trabecular meshwork and to lower mouse intraocular press
40 n antioxidant enzyme in protecting the lens, trabecular meshwork, and cornea against oxidative damage
41 ced damage to the anterior chamber angle and trabecular meshwork, and reduced postoperative use of st
42 rat iridocorneal angle (iris, ciliary body, trabecular meshwork, and Schlemm's canal) and used to co
44 comatous subjects were analyzed to determine trabecular meshwork anteroposterior length and 3 anterio
45 d a significant positive association between trabecular meshwork anteroposterior length and all anter
46 d a significant positive association between trabecular meshwork anteroposterior length and all anter
47 ere used to evaluate the association between trabecular meshwork anteroposterior length and anterior
51 of severely hypomorphic Schlemm's canal and trabecular meshwork, as well as elevated IOP, demonstrat
52 sured as the perpendicular distance from the trabecular meshwork at 500 mum and 750 mum anterior to t
53 -3) cell line and primary cultures of bovine trabecular meshwork (BTM) cells were used in these studi
54 nd/or vehicle, or mechanical blockade of the trabecular meshwork by protein aggregates or contaminant
55 of outflow facility is mediated through the trabecular meshwork CB1 receptor, with an involvement of
59 r full-length myocilin purified from a human trabecular meshwork cell expression system alters outflo
62 MP1 expression was measured in primary human trabecular meshwork cells (HTM) treated with dexamethaso
63 ferential expression of scAAV-infected human trabecular meshwork cells (HTM) was determined by microa
64 embranes of primary cultures of living human trabecular meshwork cells (hTMC) without the application
65 function in vitro by infecting primary human trabecular meshwork cells and in vivo by injecting livin
66 cular meshwork, which is a scenario toxic to trabecular meshwork cells and leads to early onset of oc
67 ression of CB1 receptors on cultured porcine trabecular meshwork cells and the coupling of these rece
68 B2 cannabinoid receptors on cultured porcine trabecular meshwork cells and the coupling of these rece
70 between high glucose-induced alterations in trabecular meshwork cells and those of vascular endothel
71 e of the actin cytoskeleton and adhesions of trabecular meshwork cells are important determinants of
72 t MYOC appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism
76 ronectin and several other ECM components in trabecular meshwork cells from the anterior segment of t
79 meshwork tissue from glaucoma donors and in trabecular meshwork cells insulted by dexamethasone (DEX
84 In MAP kinase assays, treatment of porcine trabecular meshwork cells with 100 nM of JWH015 activate
86 ve signals were detected on cultured porcine trabecular meshwork cells with an anti-CB1 antibody in i
87 ve signals were detected on cultured porcine trabecular meshwork cells with an anti-CB2 antibody.
88 lar meshwork and accelerate the depletion of trabecular meshwork cells, a characteristic feature of t
89 , noladin ether treatment caused rounding of trabecular meshwork cells, and there was a decrease of a
90 l CB2 cannabinoid receptors are expressed in trabecular meshwork cells, and these receptors are invol
91 ead to its misfolding and aggregation within trabecular meshwork cells, and ultimately, ER stress-ind
92 h factor-beta induces actin stress fibres in trabecular meshwork cells, indicating that the cells bec
93 bolites may increase oxidative damage to the trabecular meshwork cells, resulting in elevation of int
104 between extracellular matrix expression and trabecular meshwork contractility appears to coordinatel
107 s vector could facilitate the development of trabecular meshwork drugs for gene therapy for glaucoma.
108 n-secreted myocilin leads to HTM cell death, trabecular meshwork dysfunction and, ultimately, a domin
112 d effective long-term gene expression in the trabecular meshwork following intracameral delivery of a
115 aling pathway inhibitor, in the glaucomatous trabecular meshwork (GTM), and found that key canonical
118 queous humor in the human eye is through the trabecular meshwork (HTM) and Schlemm's canal (SC).
119 ed by alizarin red staining in primary human trabecular meshwork (HTM) cells and alkaline phosphatase
121 media derived from primary cultures of human trabecular meshwork (HTM) cells has confirmed secretion
122 re to determine if oxidative stress on human trabecular meshwork (HTM) cells influences the stability
123 s by Q-PCR and ELISA, respectively, in human trabecular meshwork (HTM) cells transfected with miR-29b
130 n nonpigmented ciliary epithelial (NPCE) and trabecular meshwork (HTM-3) cells were treated with spir
131 creases in human cortical neuronal (HCN-1A), trabecular meshwork (HTMC), and pulmonary artery smooth
134 are consistent with changes observed in the trabecular meshwork in glaucoma and suggest that at leas
135 creased resistance to AH outflow through the trabecular meshwork in ocular hypertension patients.
140 e most abundant genes expressed by the human trabecular meshwork included ferritin H, eukaryotic tran
141 f the calcification inducer BMP2 gene to the trabecular meshwork induces elevated IOP in living rats
143 t well understood but has been attributed to trabecular meshwork injury from repeated injections, a p
145 ce to aqueous humor (AH) outflow through the trabecular meshwork is a primary risk factor for open-an
146 ance in the aqueous drainage tract distal to trabecular meshwork is potentially an important determin
148 h more advanced glaucoma suggesting that the trabecular meshwork is the primary impediment to outflow
149 and a resulting fibrotic activity within the trabecular meshwork may result in ocular hypertension, w
150 e calcification marker, ALP, in glaucomatous trabecular meshworks might be indicative of an undergoin
151 mouse eye, it is difficult to dissect mouse trabecular meshwork (MTM) tissues and establish MTM cell
154 Narrow angles were defined as posterior trabecular meshwork not visible for >/=2 quadrants on no
155 eye tissue sections and primary normal human trabecular meshwork (NTM) cells were studied by Western
158 Increased fibronectin accumulation in the trabecular meshwork of glaucomatous eyes may contribute
160 ser photocoagulation was then applied to the trabecular meshwork of one eye to induce chronic elevati
161 ser photocoagulation was then applied to the trabecular meshwork of one eye to induce chronic elevati
162 ser photocoagulation then was applied to the trabecular meshwork of one eye to induce chronic unilate
166 orylation of ERK1/2 was also observed in the trabecular meshwork of transgenic mice expressing 6-fold
167 ened at least 180 degrees (visible posterior trabecular meshwork on gonioscopy) after laser iridotomy
168 Both ABCA1 and PMM2 are expressed in the trabecular meshwork, optic nerve and other ocular tissue
171 o there is a crescent interest in increasing trabecular meshwork outflow by extracellular matrix remo
172 Modulation of new agents that act mainly on trabecular meshwork outflow may be the future hypotensiv
177 monophosphate (AMP) and adenosine in porcine trabecular meshwork (PTM) cells treated with adenosine t
179 m for this complication may be injury to the trabecular meshwork resulting from rapid elevations in I
180 iris, sclera, ciliary muscles, ciliary body, trabecular meshwork, retina and optic nerve were establi
182 rols and seven with unilateral laser-induced trabecular meshwork scarification and ocular hypertensio
185 ing of the actin cytoskeleton may render the trabecular meshwork stiffer and more resistant to aqueou
186 logical and pathogenic mechanisms within the trabecular meshwork that are relevant to intraocular pre
188 the presence of calcification markers in the trabecular meshwork tissue from glaucoma donors and in t
191 logical evaluation revealed a well-organized trabecular meshwork tissue, exhibiting denser matrix in
192 protein found in the extracellular matrix of trabecular meshwork tissue, the anatomical region of the
193 adly expressed in most tissues including the trabecular meshwork (TM) and heterozygous Sod2 knockout
195 (PG) receptors in primary cultures of human trabecular meshwork (TM) and Schlemm's canal (SC) cells
197 esistance, its segmental distribution in the trabecular meshwork (TM) and the effect on outflow facil
204 ' effects on hydraulic conductivity of human trabecular meshwork (TM) cell monolayers were evaluated.
207 tween nitric oxide (NO)-induced decreases in trabecular meshwork (TM) cell volume and NO-induced incr
208 aqueous humor outflow; agents that decrease trabecular meshwork (TM) cell volume increase the rate o
211 e expression and distribution of MRP4 in the trabecular meshwork (TM) cells and its role in homeostas
212 t-soluble CD44 (sCD44)-which is cytotoxic to trabecular meshwork (TM) cells and retinal ganglion cell
213 tagonist gremlin is elevated in glaucomatous trabecular meshwork (TM) cells and tissues and elevates
214 production in low-passage porcine and human trabecular meshwork (TM) cells and transformed human TM
216 ular matrix (ECM) proteins were evaluated in trabecular meshwork (TM) cells by cDNA microarray, q-PCR
217 tudy was to determine whether cultured human trabecular meshwork (TM) cells express BMP1, BMP1 expres
220 the release of exosomes containing MYOC from trabecular meshwork (TM) cells is constitutive or regula
222 matrix metalloproteinase (MMP)-2 and -14 on trabecular meshwork (TM) cells that resemble podosomes o
223 Interactions were also examined in bovine trabecular meshwork (TM) cells through a mammalian two-h
224 he present study was to examine responses of trabecular meshwork (TM) cells to cyclic biomechanical s
226 took advantage of the phagocytic property of trabecular meshwork (TM) cells, and developed a novel ma
227 GRbeta and Hsp90 in normal and glaucomatous trabecular meshwork (TM) cells, as well as in TM cells o
228 PE cells, human lens epithelial cells, human trabecular meshwork (TM) cells, human choroidal endothel
229 re (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular m
230 rane localization of GTP-binding proteins in trabecular meshwork (TM) cells, using immunofluorescence
236 ositol) profiles of control and glaucomatous trabecular meshwork (TM) derived from human donors.
237 ix metalloproteinases (MMPs) are involved in trabecular meshwork (TM) extracellular matrix metabolism
238 irculation, we pursued proteomic analyses of trabecular meshwork (TM) from glaucoma and age-matched c
241 c lens in enucleated porcine eyes and of the trabecular meshwork (TM) in human corneoscleral rim tiss
244 -1 (matrix metalloproteinase [MMP]-3) by the trabecular meshwork (TM) initiates extracellular matrix
245 f extracellular matrix (ECM) proteins in the trabecular meshwork (TM) is associated with TM dysfuncti
250 ctional changes in the unlasered portions of trabecular meshwork (TM) of laser-treated primate eyes a
251 often elevated in the aqueous humor (AH) and trabecular meshwork (TM) of patients with primary open-a
253 by the MGP gene promoter specifically to the trabecular meshwork (TM) provides a new tool for specifi
255 ion (SHG), were used to obtain images of the trabecular meshwork (TM) region within an intact mouse e
256 excitation fluorescence (TPEF) of the human trabecular meshwork (TM) reveals beams of heterogeneous
258 was to determine the localization of TNC in trabecular meshwork (TM) tissue and to analyze the effec
261 emistry, and inside-out patch clamp in human trabecular meshwork (TM) tissue or primary cultures of n
262 he MMP-3 increase that occurs in response to trabecular meshwork (TM) treatment by laser trabeculopla
263 ly in the regulation of ECM synthesis in the trabecular meshwork (TM) under basal and TGF-beta2 stimu
265 s morphologic and biochemical changes in the trabecular meshwork (TM), an ocular tissue involved in r
266 10 most highly expressed genes in the human trabecular meshwork (TM), and its expression is affected
267 tes from outflow pathway tissues such as the trabecular meshwork (TM), but the associated molecular e
270 ptor activation in primary cultures of human trabecular meshwork (TM), Schlemm's canal (SC), and cili
271 to endoplasmic reticulum (ER) stress in the trabecular meshwork (TM), the tissue that regulates IOP.
272 ueous humor but accumulated in the ER of the trabecular meshwork (TM), thereby inducing ER stress in
287 50]) and angle opening (all 4 quadrants with trabecular meshwork [TM] visible on gonioscopy after LPI
290 he juxtacanalicular connective tissue of the trabecular meshwork together with inner wall endothelium
293 eyes were classified as narrow if posterior trabecular meshwork was not visible and open if the angl
296 sly thought to be primarily expressed in the trabecular meshwork, which are highly expressed by RGCs
297 acellularly instead of being secreted to the trabecular meshwork, which is a scenario toxic to trabec
298 aint staining of collagen type I in areas of trabecular meshwork with high MMP1 transgene expression.
300 trates efficient transgene activation in the trabecular meshwork, with additional sites of transgene
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