ライフサイエンスコーパス: trabeculation

1 B2 is critical for myocyte proliferation and trabeculation.

2 stress-activated Notch signaling to modulate trabeculation.

3 ing and prevents cardiomyocyte sprouting and trabeculation.

4 lation of Notch signaling and attenuation of trabeculation.

5 ss and downregulation of Notch signaling and trabeculation.

6 yocytes, as well as regulation of myocardial trabeculation.

7 novel cellular behaviors underlying cardiac trabeculation.

8 ardial wall defect with dramatically reduced trabeculation.

9 ation, cardiac morphogenesis, and myocardial trabeculation.

10 rade the cardiac jelly and prevent excessive trabeculation.

11 le are implicated in cardiac development and trabeculation.

12 ber demarcation, hypocellularity and lack of trabeculation.

13 wed that TBX5 inhibits myocardial growth and trabeculation.

14 e head and yolk sac as well as in myocardial trabeculation.

15 gnancy, 26 women (25.4%) developed increased trabeculations.

16 sh and three treated fish types that disrupt trabeculation: (a) chemical treatment using AG1478, an E

17 At e10.5, attenuation in cardiac trabeculation and compact layer expansion is noted, with

18 Although, ventricular trabeculation and compaction are key morphogenetic event

19 Trabeculation and compaction of the embryonic myocardium

20 liferation and growth form the basis of both trabeculation and compaction, and mouse models indicate

21 r signaling pathways involved in ventricular trabeculation and compaction, we generated a series of F

22 regulating the morphogenesis of ventricular trabeculation and compaction.

23 ere was no association between the degree of trabeculation and diffuse fibrosis measured with T1 mapp

24 with a deficiency of ventricular myocardial trabeculation and impairment of cranial ganglion develop

25 s, decreased ventricular size and defects in trabeculation and in atrioventricular (AV) valve develop

26 arged fetal hearts with increased myocardial trabeculation and reduced cell compaction, mimicking the

27 gulin 1 (nrg1) in the endocardium to promote trabeculation and that forced Notch activation in the ab

28 The thickness of trabeculation and the compact myocardium were measured i

29 Trabeculation and valvular hyperplasia were diminished i

30 ement and defects in the ventricular septum, trabeculation and vasculature.

31 smooth muscle cells and impaired myocardial trabeculation and ventricular wall development.

32 RV trabeculations and papillary muscles were considered cav

33 Increased LV trabeculations and the presence of LV noncompaction were

34 ayer >2, (2) presence of >3 prominent apical trabeculations, and (3) deep intertrabecular recesses th

35 en (73%) demonstrated complete resolution of trabeculations, and 5 showed a marked reduction in the t

36 ance (MR) data were evaluated to quantify LV trabeculation as a fractal dimension (FD).

37 has smaller chambers and reduced myocardial trabeculation at E10.5.

38 proliferation and differentiation of cardiac trabeculation; (b) injection of gata1a morpholino oligom

39 r titanium (P < 0.0001), while the effect on trabeculation between treatments was not significantly d

40 tif (NTF(DeltaGPS)) in zebrafish rescued the trabeculation but not the previously described myelinati

41 looping and the establishment of ventricular trabeculation but that myocyte proliferation becomes NT-

42 ng hematopoiesis and resulting in attenuated trabeculation; (c) weak-atriumm58 mutant (wea) with inhi

43 , we observed that the initiation of cardiac trabeculation can be divided into two processes.

44 During cardiac trabeculation, cardiomyocytes delaminate from the outerm

45 P10 are associated with abnormal ventricular trabeculation/compaction and wall maturation.

46 ion in mouse second heart field (SHF) led to trabeculation defects in the right ventricle, ventricula

47 ns that alter Notch signaling also result in trabeculation defects.

48 amined the formation of these protrusions in trabeculation-deficient animals, including erbb2 mutants

49 s a possible regulatory mechanism of cardiac trabeculation development.

50 olic function changes among the quintiles of trabeculation extent.

51 These were considered in quintiles of trabeculation extent; the NC/C ratio of quintile 5 was 2

52 and smaller chambers and reduced myocardial trabeculation in mutant hearts.

53 this study was to determine if excessive LV trabeculation in population-representative individuals i

54 that results from the failure of ventricular trabeculation in the developing heart, a faithful phenoc

55 Histologic evaluation confirmed increased trabeculation in the U groups.

56 ribution of N-cadherin (Cdh2) during cardiac trabeculation in zebrafish.

57 Pregnancy induces de novo LV trabeculations in a significant proportion of women.

58 rid zone results in persistence of excessive trabeculations in postnatal heart.

59 cardiomyopathy, is characterised by abnormal trabeculations in the left ventricle, most frequently at

60 ion, to assess the development of de novo LV trabeculations in women with morphologically normal hear

61 Cardiac trabeculation is a crucial morphogenetic process by whic

62 ermine if excess greater left ventricle (LV) trabeculation is associated with decreased average regio

63 Left ventricular (LV) trabeculation is highly variable among individuals and i

64 Trabeculation is influenced by race and/or ethnicity and

65 splantation studies, we propose that cardiac trabeculation is initiated by directional cardiomyocyte

66 erentiation factor essential for ventricular trabeculation, is sufficient to induce ectopic expressio

67 ventricle, ventricular dysfunction, and deep trabeculations, is also inherited, and the genes identif

68 Greater extent of, and even excessive, LV trabeculation measured in end-diastole in asymptomatic p

69 ght ventricular myocardium (n=37; 38.1%), LV trabeculations (n=5; 5.2%), papillary muscle (n=3; 3.1%)

70 efects, hypoplastic left heart, and aberrant trabeculation) observed in patients with Holt-Oram syndr

71 The results suggest that LV trabeculations occur in response to increased LV loading

72 Average trabeculation of newly formed bone in the defect after h

73 a cardiomyopathy characterized by excessive trabeculation of the left ventricle, progressive myocard

74 c chamber, neuregulin-1 was shown to promote trabeculation of the ventricular wall.

75 der characterized by excessive and prominent trabeculations of the left ventricle, associated with pr

76 m, of blood-myocardium interface in areas of trabeculation or papillary muscles, and of the atriovent

77 red in the assessment of individuals with LV trabeculations outside the context of symptoms of heart

78 Trabeculation represents the initial ventricular growth

79 We show that trabeculation requires Brg1, a chromatin remodeling prot

80 How trabeculations resolve to form compact myocardium is poo

81 Abnormal myocardial trabeculation results in specific cardiomyopathies in hu

82 Presence of prominent left ventricular trabeculation satisfying criteria for left ventricular n

83 VNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over an

84 ntricular morphogenesis, reduced ventricular trabeculation, septal defects, and valvular overgrowth.

85 At the trabeculation stage of heart development, CHAMP expressi

86 tudy the role of N-cadherin expressed at the trabeculation stage, a replication-defective retrovirus

87 bsence of cardiomyocyte proliferation during trabeculation stages.

88 ion was worse in individuals with greater LV trabeculation, supporting the concept of hypertrabeculat

89 m(2), Chinese American participants had less trabeculation than white participants (sbeta = -0.15; P

90 ications through right ventricular free wall trabeculations that can occur after repair of conotrunca

91 Even in subjects with excessive trabeculation, there were no clinically relevant differe

92 ng non-cell-autonomously promotes myocardial trabeculation through Erbb2 and bone morphogenetic prote

93 wed that cardiac contraction is required for trabeculation through its role in regulating notch1b tra

94 , we assessed whether shear stress modulates trabeculation to influence contractile function.

95 on of neuregulin1 mRNA with gata1 MO rescued trabeculation to restore contractile function in associa

96 Eight women showed sufficient trabeculations to fulfill criteria for LV noncompaction.

97 After adjustment, greater trabeculation was associated with 21% worse myocardial s

98 entire cohort, adjusted for anthropometrics, trabeculation was higher in African American participant

99 In G+LVH- patients, apical left ventricular trabeculation was increased compared with controls (maxi

100 LV trabeculation was measured with the maximal apical fract

101 ular mechanisms of ErbB2 function in cardiac trabeculation, we analyzed erbb2 mutant hearts more clos

102 For technical reasons, the extent of trabeculation, which is expressed as the ratio of noncom

103 s characterized by the presence of extensive trabeculations, which could lead to heart failure and ma

104 frequently demonstrate left ventricular (LV) trabeculations, which may be compatible with the diagnos