ライフサイエンスコーパス: tractable

1 strategies to make these species genetically tractable.

2 help make highly diverse sequence data more tractable.

3 cognition, makes this problem experimentally tractable.

4 olate the classical assumptions that make RL tractable.

5 ng key resources in the published literature tractable.

6 ity of MLL fusions and MOZ-TIF2, revealing a tractable aberrant epigenetic circuitry mediated by KDM4

7 We have realized practical, tractable algorithms for each of these models.

8 e levels, while presenting an experimentally tractable alternative to animal studies.

9 ual cortex (V1) is enhanced by locomotion, a tractable and accessible example of a time-locked change

10 he Drude oscillator model is computationally tractable and available in a wide range of simulation pa

11 till ensuring that the computations would be tractable and capable of delivering nearly efficient out

12 Insects provide experimentally tractable and cost-effective model systems to investigat

13 Using a tractable and easily manipulated insect host-pathogen sy

14 circuit controlling breathing is inimitably tractable and may inspire general strategies for elucida

15 circuit controlling breathing is inimitably tractable and may inspire general strategies for elucida

16 By providing a computationally tractable and numerically consistent framework to evalua

17 -poor, yet suitable host plant compared to a tractable and nutrient-rich diet that is free of plant d

18 istance and quarantined pathogens, becomes a tractable and powerful approach in breeding programs.

19 We demonstrate the method is tractable and self-consistent and generalizes to data se

20 period, that the microgels are mechanically tractable, and that, for microscale cell assemblages of

21 ts establish planarians as an experimentally tractable animal model for research into the pathophysio

22 sis are ill defined due to the prior lack of tractable animal models.

23 for feeding behaviour in small, genetically tractable animals such as Drosophila melanogaster.

24 Here we demonstrate a tractable approach for fully reprogramming adult mouse e

25 ptor (S1P1R) signaling provided a chemically tractable approach for the effective blunting of cytokin

26 n pairs of targeted loci, providing a highly tractable approach for the study of genomic rearrangemen

27 nalling contribute to disease, and suggest a tractable approach for therapeutic intervention in PAH.

28 In our novel, computationally tractable approach to RNA-ligand kinetics, we overcome t

29 loid malignancies provides an experimentally tractable approach to understanding early tumorigenesis.

30 These results provide tractable approaches for predicting resistance and desig

31 The emergence of tractable approaches to the genetic manipulation of chla

32 More generally, this approach should prove tractable as an alternative to nucleic-acid based sequen

33 t evolutionary models for indels that are as tractable as the analogous models for substitution event

34 This new method is computationally tractable at very large sample sizes and leverages genom

35 oom temperature, only bulky styrenes lead to tractable aziridino products.

36 coccus caseolyticus str 115 in a genetically tractable Bacillus subtilis strain to parse the processi

37 the stage for more aggressive attempts at a tractable, biologically based nosology.

38 ether, we propose that CCAT1 is a clinically tractable biomarker for identifying patients who are lik

39 ngineering and regenerative medicine present tractable biomimetic systems with potential applications

40 riation on health and disease experimentally tractable by enabling the bridging of genotypes to pheno

41 proach is made computationally efficient and tractable by the use of: (1) sparse grid interpolation t

42 Moreover, in genetically tractable Caenorhabditis elegans models, expression of a

43 ressed or functional in less therapeutically tractable cancers such as Group 3 (G3) medulloblastoma.

44 lle size scaling in the cell provides a more tractable case for testing Huxley's model.

45 epresent a diverse population of genetically tractable cells that mediate neural circuit-specific rol

46 om two different retinal images represents a tractable challenge in sensory neuroscience that has so

47 These asymmetric responses pose a tractable challenge to process-based models attempting t

48 ign and biophysical characterization against tractable chemical synthesis: Complexity-building nitro-

49 eport analysis of CTD Tyr1 using genetically tractable chicken DT40 cells.

50 smoother contact pattern and more precisely tractable chromosome conformations, and the large-scale

51 led receptor family that represents a highly tractable class of drug targets.

52 cord share a core vertebrate plan, but at a tractable complexity.

53 ndependent random variables, leading to more tractable computation.

54 ave function can reduce this complexity to a tractable computational form for some notable cases of p

55 nization and entrainment, are experimentally tractable constructs that may be analyzed and compared b

56 T5 will inform efforts in an experimentally tractable context to identify more detailed, mechanistic

57 ome-default target morphology, and provide a tractable control point for investigating cryptic phenot

58 e levels, we formulated ECM as a numerically tractable, convex optimization problem.

59 We develop tractable count-based models, which are amenable to effi

60 ltured, Sphaerothecum destruens, we obtained tractable data on infectivity and pathogen life cycle fo

61 Here, we identify experimentally tractable diatom silicic acid transporter (SIT) homologu

62 carbohydrases concurrent with the unique and tractable dietary resources of their hosts.

63 ate their role in these diseases and provide tractable disease models for further investigation, we a

64 the onset of disease, and permit the use of tractable disease models.

65 Thus, RORgammat is a tractable drug target for the treatment of cutaneous inf

66 Importantly, tractable drug targets exist within these molecular syst

67 The intensively studied, genetically tractable endospore-former, Bacillus subtilis, is an ide

68 Using the genetically tractable euryarchaeon Haloferax volcanii as a model sys

69 data, LD score regression is computationally tractable even for very large sample sizes.

70 The approach is computationally tractable, even for a relatively large number of dynamic

71 We study an analytically tractable evolutionary model, in which cues are integrat

72 granulomas has been hindered by a paucity of tractable experimental animal models.

73 In addition, we establish a tractable experimental model system to investigate the i

74 However, without a tractable experimental model, the mechanism of human PGC

75 uman tropism of the virus and the paucity of tractable experimental models.

76 crophages and dendritic cells and provides a tractable experimental system for understanding how an e

77 ding of how resistance emerges and a lack of tractable experimental systems hinder progress.

78 e future is rich with potential to integrate tractable experimental systems like theirs with hypothes

79 We conclude that not all PPIs are equally tractable for blocking by small molecules, and detailed

80 hat makes the computation of chemical shifts tractable for chemists who may otherwise have only rudim

81 cept for an imaging approach that is readily tractable for clinical translation.

82 bout which RNA secondary structures might be tractable for downstream sequence design, increasing the

83 tics make this method highly predictable and tractable for generation of programmable allelic series

84 ies with electron microscopy, this method is tractable for imaging large fields of view.

85 In addition, this model is tractable for investigation and testing of therapeutic i

86 each possible model structure, which is not tractable for models of the size presented in this work.

87 rboring ALK mutations may be therapeutically tractable for personalized treatment of certain aggressi

88 pes based on data from unrelated individuals tractable for the first time to our knowledge.

89 ot require prephasing and is computationally tractable for whole-genome imputation.

90 pdating, we derive a simple, computationally tractable formula for weak selection to favor cooperatio

91 e jointly analyzed through a computationally tractable formulation of partial least squares regressio

92 We show that tractable functions can be used to define upper and lowe

93 Our technique is computationally tractable, generally outperforms other methods, is exten

94 Combining two tractable genetic models, the bacterium E. coli and the

95 e consequences of G4C2 repeat expansion in a tractable genetic system, we generated transgenic fly li

96 One of the more tractable goals of quantitative neuroscience is to devel

97 ing electrophysiological recordings from the tractable gustatory system of the moth Manduca sexta, we

98 -inducible cspD2 promoter in the genetically tractable Haloarchaeon, Halobacterium sp.

99 me complex affective phenomena theoretically tractable, help refine accounts of social perception, an

100 ogether, this study establishes E. coli as a tractable host for P450 chemistry, highlights the potent

101 sis of a bacterial host-switching event in a tractable host species, we traced the evolutionary traje

102 f study of the readily cultured, genetically tractable human gut Bacteroides has revealed important i

103 We also demonstrate a tractable human niche model for studying homing and engr

104 Creating spontaneous yet genetically tractable human tumors from normal cells presents a fund

105 in human evolutionary genetics would become tractable if we were able to directly measure evolutiona

106 They are also numerous and, in many cases, tractable in an experimental and field setting.

107 ves are slow, complex, and not recombinantly tractable in traditional industrial hosts.

108 es and xenotransplantation studies with this tractable in vitro system of CD44L to CD44H cell convers

109 features of the human midbrain may provide a tractable in vitro system to study the human midbrain an

110 ast cancer research is hampered by a lack of tractable in vivo model systems that accurately recapitu

111 tituted with a human immune system provide a tractable in vivo model to assess human immune cell func

112 m-level environmental exposures to provide a tractable influence on subcellular phenotypes, such as g

113 ate can now be investigated in a genetically tractable insect species.

114 r an invertebrate boule homolog and offers a tractable invertebrate model system for studying the pre

115 gest C. elegans may be the first genetically tractable invertebrate opioid model.

116 One arena where this might be tractable is by studying the dynamics and dissemination

117 of the wild-type animals and is analytically tractable, it fails at reproducing the behavior of mutan

118 The small sea anemone Aiptasia provides a tractable laboratory model for investigating these mecha

119 dy virus-host interactions in experimentally-tractable Lepidopteran systems.

120 ed for genomics-based breeding approaches is tractable, making red clover a suitable candidate for as

121 ial glia, far from the soma, and establish a tractable mammalian model for studying mRNA transport an

122 hanisms of BC progression in an unbiased and tractable manner, using transposon-based insertional mut

123 flow for identification of pharmacologically tractable markers of behaviourally characterized cell po

124 emergent pattern of cell sizes, we propose a tractable mathematical model that depends on intercellul

125 menological model of motor unit fatigue as a tractable means to predict muscle fatigue for a variety

126 e specific manner using a few experimentally tractable measurements.

127 ured dopaminergic neurons, an experimentally tractable, mechanistically revealing neuronal system.

128 s reaction centre is a relatively robust and tractable membrane protein that has potential for exploi

129 The availability of computationally tractable metadata is especially important for the effec

130 leveraging recent identification of a novel, tractable methanotrophic bacterium, Methylomicrobium bur

131 findings suggest that Scissor can provide a tractable method to examine the potential fate of a biop

132 Inspired by effective yet tractable methods of population-level analysis using flo

133 Tractable methods to identify and interrogate pathways i

134 cases, relatively quick tests in genetically tractable microbes can determine whether a prediction me

135 Tractable microbial communities are needed to bridge the

136 can be valuable models for processes in less tractable microbiota.

137 hococcus elongatus PCC 7942 is a genetically tractable model cyanobacterium that has been engineered

138 ut of the analysis, allowing computationally tractable model fitting to genome-wide data.

139 RacPyV provides a naturally occurring and tractable model for a novel mechanism of polyomavirus-me

140 Thus the upd region serves as a genetically tractable model for coordinate regulation of tandemly du

141 alian neural stem cell (NSC) lines provide a tractable model for discovery across stem cell and devel

142 by Yersinia pseudotuberculosis represents a tractable model for investigating the genetic basis for

143 blish the zebrafish as a facile, genetically tractable model for leprosy and reveal the interplay bet

144 igher-order gustatory circuits in the highly tractable model for neurobiology, Drosophila melanogaste

145 istant pathogens, with S. sonnei acting as a tractable model for studying how antimicrobial-resistant

146 sociated GARS mutations and provide a rapid, tractable model for studying newly identified GARS varia

147 erm cells, provides a simple and genetically tractable model for the interplay between cells during o

148 ilability of genetic tools make Drosophila a tractable model for understanding descending motor contr

149 An abstract, analytically tractable model of the ITDP driven ensemble architecture

150 The larval imaginal discs of the genetically tractable model organism Drosophila melanogaster have co

151 sive stress on the growth of the genetically tractable model organism Saccharomyces cerevisiae We use

152 chromosome in its entirety, in a genetically tractable model organism.

153 n part because mice and other experimentally tractable model organisms are thought to not have this t

154 bility to study phenotypic trait variance in tractable model organisms using unbiased mutagenesis scr

155 is most directly addressable in genetically tractable model organisms, including invertebrates such

156 g unbiased forward genetics in even the most tractable model organisms.

157 tuf genes in Salmonella as a quantitatively tractable model system for gene conversion.

158 ce, and that Foxp2 mutant mice may provide a tractable model system for the study of the gene's role

159 idian) parasites in bird communities offer a tractable model system to examine the potential for path

160 easily accessible source of MSCs but also a tractable model system to study their function and prope

161 died the expression of these carriers in the tractable model system, the zebrafish (Danio rerio), add

162 tation-dependent phenotypes in a genetically tractable model system.

163 mulus specificity of repetition priming in a tractable model system; the feeding network of Aplysia.

164 are complex, but laboratory investigation of tractable model systems in which protective immunity is

165 The Drosophila egg chamber provides a tractable model to dissect such contributions during mor

166 thering within a single species, providing a tractable model to investigate the molecular basis of sk

167 The larva provides a tractable model to investigate the regulation and conseq

168 0 degrees C and therefore is a valuable and tractable model to study the mechanisms of biomineralisa

169 lying circuit, therefore makes this system a tractable model with which to discover how optimal cue c

170 By considering a simplified tractable model, we identify different homology testing

171 xamine genotype-phenotype relationships in a tractable model.

172 ants in LOAD will facilitate the creation of tractable models for investigation of disease-related me

173 low-complexity communities that can serve as tractable models to understand community dynamics.

174 mans or conserved in the more experimentally tractable mouse.

175 These findings provide a tractable, natural system towards investigating the caus

176 Its tractable nature allows it to serve as a paradigm for ho

177 The tractable nature of dragonflies for physiological experi

178 This study illustrates the tractable nature of WGS data and outlines an approach fo

179 Whereas behaviour in the analytically tractable network is a direct but not trivial consequenc

180 ry chimera, with 25% of its phylogenetically tractable nucleus-encoded proteins deriving from green a

181 ococcus elongatus PCC 7942, is a genetically tractable obligate phototroph that is being developed fo

182 hich has been categorized as among the least tractable of its class.

183 classification and gene identification to be tractable on modern large data sets.

184 evalence, with important aspects potentially tractable only within a multivariate framework.

185 membrane fusion systems are not genetically tractable, only few such investigations have been report

186 overed a bimodal behavior in the genetically tractable organism Drosophila melanogaster that allowed

187 lasmodium falciparum into a genetically more tractable organism.

188 lated processes using mutants in genetically tractable organisms such as Arabidopsis thaliana is limi

189 The availability of genetically tractable organisms with simple genomes is critical for

190 The lack of tractable P. vivax animal models constitutes an obstacle

191 to restore beta-cell mass, and highlights a tractable pathway for future drug discovery efforts.

192 transport that regulates a pharmacologically tractable pathway necessary for PDAC tumor growth and me

193 ns in purified virus and infected cells, and tractable peptides for monitoring Gag levels were identi

194 olutionary processes requires experimentally tractable, phylogenetically divergent organisms that dif

195 Furthermore, we use the genetically tractable Plasmodium knowlesi model and recently develop

196 tein functions and also establishes a rapid, tractable platform to facilitate future in vivo studies

197 malleable and suggest that RHH proteins are tractable platforms for the rational design of diverse D

198 es is the characterization of experimentally-tractable pre-clinical models that exhibit multi-domain

199 This study introduces a highly tractable preclinical model for interrogating sex differ

200 Here we take advantage of tractable primary human lymphoid organ aggregate culture

201 Bundle assembly is a tractable problem in molecular and cellular systems biol

202 Thus, fear mechanisms represent a tractable PTSD biomarker in the study of sex differences

203 Computational modeling provides tractable, quantitative methods to test hypotheses of re

204 oincidence, happen to be those that react at tractable rates on laboratory time scales at -78 degrees

205 isplaying muted Lewis acidity and affiliated tractable rates, reveals a rate-limiting complexation vi

206 us emerge as highly portable, evolutionarily tractable regulatory modules through which to create pat

207 tested by studying specific, experimentally tractable regulatory systems using the tools of modern s

208 of complex communities over time and space a tractable research pursuit for small research groups.

209 ism of electron conduction across the highly tractable Rhodobacter sphaeroides reaction centre is cha

210 We have extended this work to the more tractable RSV Gag.

211 hit-and-run algorithm, enabling reliable and tractable sampling of genome-scale biochemical networks.

212 eralized collagen fibrils in bone, allow for tractable sampling requirements and numerical efficiency

213 nK inhibitors and activators with chemically tractable scaffolds.

214 SH2-kinase interface as a pharmacologically tractable site for allosteric inhibition of Bcr-Abl.

215 es is poorly understood because of a lack of tractable small- animal models.

216 MAV-1 infection of susceptible mice is a tractable small-animal model for encephalitis, and the v

217 priority, and women's cancers are not only a tractable socioeconomic policy target in themselves, but

218 These results provide a mechanistically tractable solution to the credit assignment problem.

219 iversified, secluded and yet microscopically tractable space.

220 Small, genetically tractable species such as larval zebrafish, Drosophila,

221 n has not yet been examined in a genetically tractable species such as mice.

222 the Iberian ribbed newt Pleurodeles waltl, a tractable species suitable for laboratory research.

223 lue of comparative approaches in genetically tractable species to understand the genetic basis for ev

224 Two genetically tractable species, mice and flies, are together providin

225 nterneurons in both mice and non-genetically tractable species, thus opening the possibility to study

226 lying attentional behaviors in a genetically tractable species.

227 ddition, the related and more experimentally tractable SSS member PutP (the Na(+)/proline transporter

228 Since D(3)E is based on an analytically tractable stochastic model, it provides additional biolo

229 quantitative genetics in animal models is a tractable strategy for examining both the genetic basis

230 inhibition of endothelial ALK1 constitutes a tractable strategy for interfering with metastatic disse

231 e brain, and suggest voltage modulation as a tractable strategy for intervention in certain classes o

232 e major genomic subgroups, represented by 16 tractable subsets with a particular cell surface phenoty

233 bial communities represent an experimentally tractable system for defining mechanisms that influence

234 lation by Hedgehog signaling present a novel tractable system for dissection of glia biology.

235 or viral genome packaging and will provide a tractable system for further dissecting papillomavirus a

236 sting genetic tools in Drosophila, this is a tractable system for studying axonal transport over the

237 e Caenorhabditis elegans germline provides a tractable system for studying the mechanisms that contro

238 ket within the immunity protein represents a tractable system for the rationale design of small molec

239 array of forty polarized cells is a uniquely tractable system for the study of polarization dynamics

240 behavior in response to an odor, providing a tractable system for understanding how stochastic circui

241 The volvocine green algae are a tractable system for understanding the genetic basis of

242 scular junction (NMJ) provides a genetically tractable system in which to analyse the segregation of

243 ir mechanism of catalysis is unknown, and no tractable system is available for study.

244 cialized eggshell structures, has provided a tractable system to ask these questions.

245 ctin in exocytosis and provide a genetically tractable system to image the temporal and spatial dynam

246 We used Drosophila as a genetically tractable system with a simpler gut bacterial population

247 To explore its functions in a genetically tractable system, we expressed the human DISC1 in fruit

248 distance gene regulation in this genetically tractable system.

249 saged, and these unique mouse models provide tractable systems for therapy testing and understanding

250 , organotypic culture models have emerged as tractable systems to recapitulate the complex three-dime

251 engineered mouse (GEM) models have served as tractable systems to study the role of the cell of origi

252 tic-competitive transition in experimentally tractable systems.

253 Together these imaging assays constitute a tractable, systems-based platform for studying otherwise

254 naling axis may serve as a pharmacologically tractable target during infection and inflammation.

255 ed viruses, we propose the capsid as a novel tractable target for flavivirus inhibitors.

256 r MYC recruitment to chromatin and uncover a tractable target for the discovery of anticancer therapi

257 e and are the first to confirm ks-vFLIP as a tractable target for the treatment of PEL and related di

258 agonists of cannabinoid 1 receptor (CB1R), a tractable target for treating several pathologies affect

259 yltransferase is an essential and chemically tractable target in malaria parasites both in vitro and

260 s, the Plasmodium proteasome is a chemically tractable target that could be exploited by next-generat

261 isease-associated aggregates and amyloid are tractable targets and that enhanced disaggregases can re

262 a rigorous investigation of therapeutically tractable targets at distinct phases of PDA development

263 loid-based pathways they regulate, represent tractable targets for anticancer therapy in select tumor

264 pathways they regulate might represent more tractable targets for drug therapy.

265 s, raising the possibility that these may be tractable targets for miRNA-based therapies for OS.

266 To identify tractable targets of YAP pathway, we have performed a pa

267 ing in situ genome engineering approaches as tractable techniques to manipulate microbial communities

268 ng genetically relevant traits that are more tractable than the behavioral symptoms that classify men

269 problem has only recently started to become tractable, thanks to the development of new long read se

270 rinated alcohols are relatively abundant and tractable, the corresponding aldehydes are often not com

271 Here, we present a new tractable theoretical framework to model and decode the

272 Here, we develop a tractable theoretical framework to study the putative ro

273 ng cause of CICI and that PFT-mu may offer a tractable therapeutic strategy to limit this common side

274 fferent hepatic insults and represents a new tractable therapeutic target for treating liver fibrosis

275 indings identify ABL1 as a pharmacologically tractable therapeutic target in glycolytically dependent

276 ntification and prioritization of chemically tractable therapeutic targets is a significant challenge

277 in malignant diseases, along with serving as tractable therapeutic targets.

278 Metagenome data from a tractable, thermoacidophilic microbial community in Yell

279 l lines to identify synergistic combinations tractable to clinical translation.

280 tion on curved surfaces, for which it is not tractable to incorporate particle interactions even thou

281 Mutations readily tractable to rescue broadly fell into two groupings: tho

282 r therapeutic invention in NSCLC that may be tractable to small-molecule inhibitors, as a new point t

283 x biological systems, which are now becoming tractable to structure solution.

284 Combination therapies deemed immediately tractable to translation included ABT-263/crizotinib, AB

285 Our organoid system provides a genetically-tractable tool that will allow these human-specific feat

286 Dynasore is a tractable tool to explore the complexity of cholesterol

287 emains unclear, largely because of a lack of tractable tools and models.

288 ergent channel domains may therefore provide tractable tools for probing the functional architecture

289 : It causes human cancers, and it exhibits a tractable transition from its latent to its productive c

290 impairment, and the paucity of identifiable tractable treatment targets.

291 autistic behaviours and/or provide a novel (tractable) treatment target.

292 (2-Cl), which can be converted into the more tractable trifluoride analogue ((o-(Ph2P)C6H4)2SbF3)AuCl

293 One strategy for reaching a tractable understanding of circuit function is to seek t

294 ens expressed by cancer cells illustrate the tractable use of endogenous gammadelta T cells for immun

295 rom their parental compounds, yet chemically tractable using copper-free bioorthogonal chemistry.

296 s a physically plausible and computationally tractable way to include enzyme kinetics into constraint

297 -trait genotype-phenotype maps might only be tractable when jointly considering multiple phenotypes.

298 s, quantification of each population becomes tractable, which is a critical measurement need for toxi

299 dying cannabinoid signaling in a genetically tractable whole-animal model.SIGNIFICANCE STATEMENTCanna

300 dying cannabinoid signaling in a genetically tractable, whole-animal model.