ライフサイエンスコーパス: trans isomer

1 he protein-ligands about the Mg(2+) (cis and trans isomers).

2 ild-type-like conformations that contain the trans isomer.

3 The third step leads back to the stretched trans isomer.

4 n addition product was observed only for the trans isomer.

5 he corresponding difference for the C-3, C-4 trans isomer.

6 at 382 nm indicates that the compound is the trans isomer.

7 ion of the intermediate to the product trans,trans isomer.

8 ulated rate acceleration with respect to the trans isomer.

9 the proton in the spectrum for the C-3, C-4 trans isomer.

10 sted the cis isomer was more stable that the trans isomer.

11 accumulate cis-lycopenes instead of the all-trans isomer.

12 the dark consisted predominantly of the all-trans isomer.

13 TCC is significantly faster than that of the trans isomer.

14 ediate, and isomerization of cis-gDFC to its trans isomer.

15 es of retinoic acids is specific for the all-trans isomer.

16 e in cis-beta-carotene and a decrease in the trans isomer.

17 M followed by Fischer indolization gives the trans isomer.

18 formation of the species with the incorrect trans isomer.

19 ch in turn interacts more favorably than the trans isomer.

20 stituted porphyrin without the corresponding trans isomer.

21 toisomerization of 11-cis-retinal to its all-trans isomer.

22 )-anti-trans-isomer and 18% for the (+)-anti-trans-isomer.

23 ution and exhibits the same ratio of cis and trans isomers.

24 d to establish the identities of the cis and trans isomers.

25 s isomers, and 0.7-3.2 for cis/cis and trans/trans isomers.

26 r species indicates a 1:2 mixture of cis and trans isomers.

27 ad better affinity for the receptor than the trans isomers.

28 lta8 desaturation products, predominantly as trans isomers.

29 corporation of the cis faster than their all-trans isomers.

30 are slightly more likely to react than their trans isomers.

31 2.8 (P for trend <0.01) for a total of 18:2 trans isomers.

32 was photoisomerized to a mixture of cis- and trans-isomers.

33 nes are more reactive than the corresponding trans-isomers.

34 te yields as a separable mixture of cis- and trans-isomers.

35 c-pVDZ//BHHLYP/6-311+G**) than the known tri-trans isomer 1 (CTCTCT) and 2.4 kcal/mol lower than the

36 ) and cross-reactivity for anions, while the trans-isomer 1 shows a more selective response to anions

37 The trans-isomer 10b inhibited AD169 strain of HCMV (EC50 15

38 -3 is only about 2-fold more potent than its trans isomer (+)-11.

39 peridionone 16a is epimerized to the desired trans isomer 16b, which is directly crystallized from th

40 Amino alcohol 2-MAP was prepared from its trans isomer 2, which in turn was synthesized via hydrob

41 wo central five-membered rings then gave the trans isomer 26.

42 limination to give the alkyl 3cCO, while the trans isomer, 2c, does not react; retro alpha-eliminatio

43 The geometric trans-isomer 3a of combretastatin A-4 was converted to t

44 reement with previous work, the "twist-boat" trans isomer (3A) is the most stable isomer of 1,7,9-tri

45 logically active compounds from the inactive trans isomer (3a) of stilbene 1a, after asymmetric dihyd

46 (CTCTCT) and 2.4 kcal/mol lower than the di-trans isomer 4 (CCTCCT), for which there is indirect evi

47 derivatives were synthesized and the racemic trans isomer, (+/-)-5, was further resolved into two ena

48 cy was noted between cis analogue 43 and its trans isomer 54.

49 levated 11,000-fold and that of the (+)-anti-trans-isomer 6000-fold, relative to the reversion freque

50 when compared to their isomeric alpha,beta-(trans)-isomer (8b, 9b, and 10b).

51 emical cis-trans isomerization of enone 9 to trans isomer 9a followed by a thermal Diels-Alder reacti

52 The trans isomer adopts two well-defined turns in solution,

53 The trans isomer adopts two well-defined turns in solution,

54 new methodology for identifying 16:1 cis and trans isomers allowed us to address the subject presente

55 s of zeatin have been directed mostly at the trans isomer, although cis-zeatin and its riboside occur

56 much higher enantioselectivity than with the trans isomers, although CPO gives similar catalytic acti

57 5-oxodecahydroquinoline to the corresponding trans isomer and a coupling, followed by a diastereosele

58 plex DNA but that only the presence of a (+)-trans isomer and a methylated C 5' to the adduct resulte

59 fied from molecular modeling studies for the trans isomer and five conformations for the cis isomer,

60 expected to increase the propensity for the trans isomer and perturb the isomerization reaction requ

61 ether with chemical isomerization to its all-trans isomer and reduction to all-trans-retinol by RDH c

62 3.1 (P for trend <0.01) for a total of 18:1 trans isomers and 1.0, 1.5, 2.5, and 2.8 (P for trend <0

63 bypass was found to be 32% for the (-)-anti-trans-isomer and 18% for the (+)-anti-trans-isomer.

64 nteraction appeared preferential for the all-trans-isomer and was directly measurable through fluores

65 ly in the stratum corneum of the skin as the trans-isomer and, upon exposure to UVB radiation, conver

66 acids, particularly unsaturated fatty acids, trans-isomers, and specific released free fatty acids.

67 Both the enantiomeric forms of the trans isomer are obtained in excellent yields and enanti

68 ne-directed kinases acting on the GR, as cis/trans isomers are distinct pools with different interact

69 As previously found, trans isomers are nonselective blockers of DA, 5HT, and

70 Faster reactions of trans isomers are observed for substitutents known (RS,

71 the equilibrium fractions of 13-cis and all-trans isomers are pH dependent; the fraction of all-tran

72 The slower reactions of the trans isomers are the judged to be "abnormal".

73 from all cis to all trans and supports a cis,trans isomer as a tenable intermediate.

74 Therefore, we suggest that the trans isomer assembles on the NP surface giving the enha

75 (tetraol tetraacetates, two pairs of cis and trans isomers at the 9,10 positions) by the exocyclic N2

76 to accommodate the nonnative peptidyl-prolyl trans-isomer at Pro32.

77 Pin1 that isomerizes ATR from cis-isomer to trans-isomer at the phosphorylated Ser428-Pro429 motif.

78 e can be explained by destabilization of the trans isomer because of unfavorable electronic and steri

79 ed to be an "upside-down" version of the all-trans isomer because the structural rearrangements obser

80 The trans isomer binds the WW domain with approximately 22 m

81 We identified the zeatin isolated as the trans isomer by HPLC and by a radioimmunoassay in which

82 chloropropene (1,3-D, which includes cis and trans isomers), chloropicrin (CP), and methyl iodide (Me

83 in the ternary complex generates the active trans-isomer competent for carbonyl bond activation by a

84 When DMS could not separate cis and trans isomers completely, as was the case with sphingomy

85 The trans isomer composition changes from 68% in the cationi

86 to any form prior to analysis increases the trans isomer composition.

87 For the first time, the cis/trans isomer content of menaquinone-7 in food products h

88 e, with the deprotonated cis- and protonated trans-isomers corresponding to its ON and OFF states, re

89 he cyclic peptides, with the ratio of cis to trans isomers depending on the position and stereochemis

90 isomer has anti-cancer activity, whereas the trans-isomer does not.

91 nverts stearoyl-ACP into the allylic alcohol trans-isomer (E)-10-18:1-9-OH via a cis isomer (Z)-9-18:

92 A change to a diaxial conformation for the trans isomer facilitates anchimeric assistance by the no

93 Both, cis- and trans-isomers for jasmonic acid can be detected.

94 distinct isomers, presumably TTC and TTT cis-trans isomers, for the open-ring merocyanine product, an

95 two-state mixture of 13-cis,15-syn, and all-trans isomers found in the dark-adapted wild-type protei

96 by all three isozymes; a preference for the trans isomer, geranial, was observed by HPLC and by enzy

97 : 2 mixture of isomers: cis isomer neral and trans isomer, geranial; the latter structurally resemble

98 The 26-trans isomers had an activity about 400-fold more potent

99 The trans/trans isomers had the most potent activity, suggesting s

100 process consists of two states, in which the trans isomer has a stretched and the cis isomer a compac

101 isomer cannot convert to the more stable all-trans isomer in the 21Ag- state, resulting in the striki

102 The content of cis/trans isomers in certain dietary supplements exceeded th

103 ations of total lycopene and its cis and all-trans isomers in human plasma has been developed using h

104 role of selective recognition of cis versus trans isomers in response to phosphorylation of APP.

105 ier for conversion between the 4-cis and all-trans isomers in the S1 state.

106 stal into a polycrystalline aggregate of its trans-isomer in a photomechanical transformation that in

107 rmation, in opposition to the most populated trans isomer, in order to select the specific antibody c

108 affect the relative distribution of cis- and trans-isomers, indicating a separate CO-binding site.

109 Both cis and trans isomers interact with transcriptional regulators,

110 somer to the highly nonplanar and disordered trans isomer is accompanied by a dramatic rearrangement

111 yields primarily the cis isomer, whereas the trans isomer is the major product from the intramolecula

112 nd, we show that locking the switch into the trans isomer leads to shortened circadian periods.

113 we diagnostic ion abundances is >4.8 for cis/trans isomers, <0.5 for trans/cis isomers, and 0.7-3.2 f

114 photoisomerization upon exposure to visible (trans isomer, more hydrophobic) or UV (cis isomer, more

115 maintain normal visual sensitivity, the all-trans isomer must be metabolized and reisomerized to pro

116 alene anion radical precursor was the 1,7-di-trans isomer of [12]annulene.

117 ified by the active cis but not the inactive trans isomer of diamminedichloroplatinum(II), are implic

118 eaction mixture is probably due to the trans-trans isomer of diradical 3 in the triplet state.

119 The trans-trans isomer of diradical 3 was calculated to be more st

120 , palmitate, stearate, oleate, elaidate (the trans isomer of oleate), linoleate, and linolenate blend

121 vated M(I) state of rhodopsin giving the all-trans isomer of the chromophore.

122 The trans isomer of the keto-acid products is also observed

123 alysis revealed the conversion of the cis to trans isomer of unsaturated fatty acid upon short-term n

124 low energy conformers of the various cis and trans isomers of 1,1,2,2,5,5,6,6-octamethyl-1,2,5,6-tetr

125 Comparison between the cis and trans isomers of 1,2-dimethylcyclohexane, 1,4-dimethylcy

126 ctivity was observed in formation of cis and trans isomers of 1,3-d2-2-fluoropropene, whereas cis-1,3

127 Both cis and trans isomers of 1-(E)-propenyl-2-methylcyclobutane form

128 on and emission spectra of the 4-cis and all-trans isomers of 2,4,6,8,10,12,14-hexadecaheptaene are a

129 re of 2,6-cyclohexananone yields the cis and trans isomers of 2,6-dimethylcyclohexanone-2,6-bis(diaze

130 and 5-fold decreases in activity against the trans isomers of 4-OH-TAM and endoxifen, respectively, c

131 ion of these two mechanisms for both cis and trans isomers of a system employing two monodentate liga

132 nd at Pro102-Pro103 and a coexistence of cis/trans isomers of Ala104-Pro105.

133 and ERbeta binding affinity of both cis and trans isomers of dimethyl, diethyl, and dipropyl THCs wa

134 ectable glucuronidation activity against the trans isomers of either 4-OH-TAM or endoxifen.

135 f Pgp-mediated drug transport by the cis and trans isomers of flupentixol are mediated through a comm

136 d in future studies that distinguish between trans isomers of linoleic acid and trans isomers of olei

137 5% CI, 0.5 to 1.2), whereas higher levels of trans isomers of linoleic acid were associated with 3-fo

138 acids is associated with modest increase and trans isomers of linoleic acid with a larger increase in

139 to unambiguously distinguish between cis and trans isomers of monounsaturated fatty acids by the rela

140 However, trans isomers of oleic acid were not associated with ris

141 h between trans isomers of linoleic acid and trans isomers of oleic acid.

142 d phase method can baseline separate the cis-trans isomers of phosphatidylglycerol and phosphatidylch

143 d under thermal conditions were dominated by trans isomers of the azobenzene macrocycles, whereas lig

144 e(Ph)PN](3), yielded mixtures of the cis and trans isomers of the cyclic phosphazene trimers, [Me(Ph)

145 g = 1.74 and 1.09 for the respective cis and trans isomers of the diosmium cluster.

146 Both cis and trans isomers of the dopamine receptor antagonist flupen

147 of 6 with EtPCl(2) gave a 6:1 mixture of cis/trans isomers of the ethyl-substituted heterocycles 12a,

148 lves the interconversion between the cis and trans isomers of the N-terminal amide bond of the amino

149 Further, both cis and trans isomers of the photodechelated ligand-loss solvent

150 Furthermore, the equilibrium ratio of cis to trans isomers of the Pro residues is unaffected by the p

151 rter inhibitory activity of both the cis and trans isomers of these 3,4-disubstituted piperidines in

152 d if their method could separate the cis and trans isomers of vitamin A.

153 eneous unfolded state (consisting of cis and trans isomers of X-Pro peptide groups) to the native str

154 A), AA methyl ester, and linoelaidic acid (a trans-isomer of linoleic acid) failed to stimulate adhes

155 acid dehalogenase (CaaD), which converts the trans-isomers of 3-bromo- and 3-chloroacrylate to malona

156 onstants similar to those determined for the trans-isomers of 3-bromo- and 3-chloroacrylate.

157 he hydrolytic dehalogenation of the cis- and trans-isomers of 3-chloroacrylate to yield malonate semi

158 ction (SPME) method to quantify the cis- and trans-isomers of 4-MCHM.

159 d mononuclear Pt(II) compounds, the cis- and trans-isomers of [PtCl2(NH3)(L)] (L = 1-methyl-7-azaindo

160 re applied to obtain optically pure cis- and trans-isomers of whisky lactone 4a and 4b.

161 s-zeatin serves as a precursor to the active trans-isomer or has any other unique function remains to

162 Trans-isomer OSDA leads to the small-pore zeolite SSZ-39

163 1,2,3,4-tetrahydro-beta-carbolines, with the trans isomer predominating.

164 While the trans isomer primarily engages calcium influx, the cis i

165 The all-trans isomer produced by isomerization of both 9-cis and

166 trans fatty acids (r(s)=0.43) and total 18:1 trans isomers (r(s)=0.42) in erythrocytes were also more

167 g but not through an influence on the cis to trans isomer ratio.

168 In this study, we determined the cis:trans isomer ratios of PC (18:1/18:1) and related this r

169 benzisoxazol-5(3H)-ylidene)ethanal (10), the trans isomers recombined forming the corresponding nitro

170 e 1R stereoisomeric adduct, with the S and R-trans-isomers related to one another by inversion in a m

171 ic experiments performed on both the cis and trans isomers reveal the formation of a long-lived inter

172 room and low temperatures indicates that the trans-isomer should be dominant when attached onto the s

173 state and the hardness parameter eta of the trans isomer show that azobenzene and F-azobenzene are t

174 h intraperitoneal administration, all of the trans isomers showed a slow onset of at least 20 min and

175 abilizing the standard nematic phase and the trans isomers stabilizing the NTB phase.

176 s indicated that it was the level of the (+)-trans isomer that was specifically increased.

177 dipole moments, particularly, with cis- and trans-isomers that have different polarities.

178 For the trans isomers the 2-substituent itself is oriented for h

179 In contrast, for the trans isomer this ratio shows a 2-fold decrease with dec

180 n stereospecific conversion of the bound all-trans isomer to 11-cis-retinal.

181 o ceratospongamide isomers showed the trans, trans isomer to be quite planar, whereas the cis,cis iso

182 or the system to escape very easily from the trans isomer to cis isomer, and vice versa.

183 tropanes, which allows both the cis and the trans isomers to adjust themselves to the binding site o

184 toisomerization from the naturally occurring trans-isomer to the cis-isomer on exposure to ultraviole

185 C) cells to cisplatin and its less effective trans-isomer, transplatin.

186 he isomerization of cis-arylalkenes to their trans isomers using a palladium(II) catalyst is describe

187 stituted tetrahydro-beta-carbolines into the trans isomers via a potential carbocationic intermediate

188 nd trans IC(50) = 12 +/- 3 microM, where the trans isomer was equipotent to that of the saturated C(1

189 The trans isomer was found to be more favorable than cis iso

190 -2-methylcyclobutane uncontaminated with the trans isomer was prepared efficiently in five steps; the

191 tion of cis,trans and trans,cis CLA to trans,trans isomers was observed mainly for the methyl form of

192 Identification of cis/trans isomers was performed by HRMS-QTOF, whereas their

193 requency of bypass synthesis of the (-)-anti-trans-isomer was elevated 11,000-fold and that of the (+

194 ed that the activation energy of the cis- to trans-isomer was increasing in the series C(5)G3 < C(4)G

195 The trans-isomer was photoisomerized to a mixture of cis- an

196 substituted cyclopropane ring, a pair of cis/trans-isomers was obtained that introduced a spatial con

197 reduced analogue 11 (as a mixture of cis and trans isomers) was the most active in the naphthyridine

198 upled to the binding equilibrium through the trans isomer, was found to fit the data well.

199 genous PC (18:1/18:1)-cis and PC (18:1/18:1)-trans isomers were examined in mitochondrial and serum p

200 th isomers showed similar potencies, but the trans isomers were more metabolically stable in human he

201 Both the cis and trans isomers were obtained for all of the cyclic peptid

202 os of the (2S,4S)/(2R,4S) diastereomers (cis/trans isomers) were 1:1, 2:1, and 10:1 for the methyl, b

203 analogues thus obtained (three pairs of cis/trans-isomers) were growth inhibitory at low-micromolar

204 ronger hyperporphyrin effect compared to the trans isomer, which can be explained based on simple res

205 epimerization of the product mixture to the trans isomer, which is generally highly crystalline, has

206 to switch a small molecule between cis- and trans-isomers, which inhibits the catalytic activity of

207 3,6-dimethylcyclohexene in preference to its trans isomer, while the cis starting material gives neit

208 benzoyl group (via an amide bond) yields the trans isomer with a diastereoselectivity (de) of 71% wit

209 Upon irradiation of the trans isomers with UV light, >95% of the cis forms are o

210 the serine118-proline119 bond from a cis to trans isomer, with a concomitant increase in AF1 transcr