ライフサイエンスコーパス: trans-acting factor

1 nd RNA-binding proteins known as ITAFs (IRES trans-acting factors).

2 the genome-wide specificity of a particular trans-acting factor.

3 ongly suggest that PTB-1 is a universal IRES-trans-acting factor.

4 that exon repetition is caused by a specific trans-acting factor.

5 y the nascent transcript in the absence of a trans-acting factor.

6 able to confer regulation in response to the trans-acting factor.

7 ral component of the flagellum, but rather a trans-acting factor.

8 dentifying all regions bound by a particular trans-acting factor.

9 fication of RNA-binding proteins that act as trans-acting factors.

10 nfluenced by both local sequence context and trans-acting factors.

11 nscriptional regulator that binds to several trans-acting factors.

12 in metazoans without prior knowledge of the trans-acting factors.

13 edox activator (and named Ref-1) for several trans-acting factors.

14 onfiguration in which they are shielded from trans-acting factors.

15 on by modulating the DNA binding activity of trans-acting factors.

16 n the precursor messenger RNA and a range of trans-acting factors.

17 ccurs in the absence of other viral cis- and trans-acting factors.

18 y influenced by supplementary host and viral trans-acting factors.

19 lationally with the help of various cis- and trans-acting factors.

20 rplay of cis-acting sequences and associated trans-acting factors.

21 lencing of this exon is mediated by multiple trans-acting factors.

22 er, suggesting the superimposed influence of trans-acting factors.

23 that act through ubiquitous cis-elements and trans-acting factors.

24 r autosomal phenotypes may be due to cis- or trans-acting factors.

25 ndently controlled by the locally associated trans-acting factors.

26 m involving several cis-acting sequences and trans-acting factors.

27 es are responsive to a multitude of distinct trans-acting factors.

28 ustered redundant protein-binding motifs and trans-acting factors.

29 by the availability of positive and negative trans-acting factors.

30 forms with tRNA in the absence of additional trans-acting factors.

31 the HIV-1 PPT/U3 junction in the absence of trans-acting factors.

32 lation, mainly because it affects binding of trans-acting factors.

33 mining the accessibility of chromatin DNA to trans-acting factors.

34 lation requires the modulated interaction of trans-acting factors.

35 tial to identify predicted binding sites for trans-acting factors.

36 combination is tightly regulated by cis- and trans-acting factors.

37 g is determined by underlying sequence or by trans-acting factors.

38 st genes by adenosine triphosphate-dependent trans-acting factors.

39 cription is also influenced and regulated by trans-acting factors.

40 r genes, which are bound by numerous unknown trans-acting factors.

41 combination and are themselves regulated by trans-acting factors.

42 f functioning in the presence of the correct trans-acting factors.

43 regulated by a variety of different cis- and trans-acting factors (4, 5).

44 mutation (SHM) require transcription and the trans-acting factor activation-induced cytidine deaminas

45 cis- and trans-acting factors affect gene expression and response

46 nism of mutagenesis, we examine here cis and trans-acting factors affecting thyA131 mutational hotspo

47 egion of the message, and in the presence of trans-acting factors allow the ribosome to be recruited

48 protein-protein interactions that engage the trans-acting factor also contribute to context-dependent

49 3' adenylation and uridylation status, with trans-acting factors also impacting RNA homeostasis.

50 Trans-acting factors also modulate TNR instability risk,

51 oth a lower affinity of the 27 nt site for a trans-acting factor and lower abundance of the transcrip

52 of a human porphyria due to a mutation in a trans-acting factor and the first association of CEP wit

53 omes during cell division is ensured by both trans-acting factors and cis-acting chromosomal sites.

54 The identification of the trans-acting factors and cis-regulatory modules that are

55 a link between the complex of commonly used trans-acting factors and Enc, a factor that is required

56 lthough it has been suggested that identical trans-acting factors and Gap1p ubiquitin acceptor sites

57 uctures that regulate their interaction with trans-acting factors and indicate that mRNA structural r

58 rough a complex interaction between cis- and trans-acting factors and the endoplasmic reticulum trans

59 s how cis-acting sequence elements influence trans-acting factors and the local chromatin environment

60 recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NM

61 us transcription, upon induction by specific trans-acting factors, and plays a significant role in cl

62 The three known trans-acting factors are a Sec-specific translation elon

63 torial regulatory activity and that multiple trans-acting factors are involved in the regulatory effe

64 of ribosomes occurs in the cytoplasm, where trans-acting factors are removed and critical ribosomal

65 ry elements, e.g., promoters, enhancers, and trans-acting factors, are essential for the proper contr

66 lar cis requirements reflect conservation of trans-acting factors, as human Shn1 (hShn1; HIVEP1) can

67 ssection of both cis-regulatory elements and trans-acting factors, as well as the interpretation of v

68 KLF4 was identified as a major trans-acting factor at two proximal Sp1 sites; active Rh

69 grams requires the choreographed assembly of trans-acting factors at enhancers and promoters during c

70 s-regulatory target sites of known and novel trans-acting factors at the transcriptional and post-tra

71 As a variety of trans-acting factors [AU-binding protein (AUBP)] are kno

72 f libraries to provide a prediction of which trans -acting factors binding sites are disrupted/create

73 We have further identified key trans-acting factor binding sites and nuclear factors AP

74 Multiple trans-acting factor binding sites were selectively ident

75 regulation in certain contexts via enhancing trans-acting factor binding to chromatin in vivo.

76 Trans-acting factor binding to small DNA motifs (cis-ele

77 tprinting technique was then used to compare trans-acting factor binding to the IGRP promoter in situ

78 tified the splicing factor SAP155, as an RNA trans-acting factor binding to the purine-rich CRCE 1.

79 previously mapped deletions, and studied the trans-acting factors binding to these sites in the beta-

80 to the enhanced production of viral or host trans-acting factors, but is associated with cis-acting,

81 ass the intricate interplay between cis- and trans-acting factors, chromatin, and the core transcript

82 hown that alterations in the expression of a trans-acting factor constitute a critical driver of gene

83 RNA cis elements and trans-acting factors contributing to HPV18 alternative R

84 However, RNA cis-regulatory elements and trans-acting factors contributing to HPV18 alternative R

85 oach to identify the cis-acting elements and trans-acting factors contributing to the tight repressio

86 se data highlight the nature of the cis- and trans-acting factors controlling the beta-cell-specific

87 of nuclear levels and acetylation status of trans-acting factors critical in determining the off/on

88 s cis-acting sequences in the mRNA and novel trans-acting factors dedicated to Sec incorporation.

89 or recessive model, and is not determined by trans-acting factors differing between hMLH1 expressing

90 These trans-acting factors display overlapping RNA substrate s

91 ge portion of the binding sites for the same trans-acting factor do not reside in alignable regions.

92 This suggests that at least some detected trans-acting factors do not equally affect recombination

93 These trans-acting factors enable the faithful delivery of sev

94 o condition specific binding of at least one trans-acting factor essential for site recognition.

95 Recent studies indicate that trans-acting factors establish this stereotypical array.

96 Combinatorial interactions among trans-acting factors establish transcriptional circuits

97 In this report, we show that the trans-acting factor FliX predominantly functions as a ne

98 Genetic experiments have indicated that the trans-acting factor FliX regulates FlbD in response to t

99 ng protein 1) was originally discovered as a trans-acting factor for the "zipcode" in the 3' untransl

100 ow that Zar2 contains a zinc finger and is a trans-acting factor for the TCS in maternal mRNAs in imm

101 d transcription factor, CTCF, as a candidate trans-acting factor for X-chromosome selection.

102 ighly dependent on precise concentrations of trans-acting factors for the activation of different gen

103 analysis and define cis-acting elements and trans-acting factors for the core LANAp.

104 eneral, cellular IRESs require non-canonical trans-acting factors for their activity, however, very f

105 their biogenesis is partially dependent on a trans-acting factor FPA.

106 results illustrate a mechanism that controls trans-acting factor function in a locus-specific manner,

107 hemical studies, we investigated whether the trans-acting factors function indirectly or directly by

108 ory elements, and possibly the corresponding trans-acting factors, function via mechanisms highly spe

109 To gain insight into trans-acting factors, genetic rescue of AdoMetDC RNAi kn

110 ents, raising the possibility that undefined trans-acting factors governing mRNA stability and transl

111 To identify cis- and trans-acting factors governing nucleocytoplasmic traffic

112 ment activity requires the binding motif for trans-acting factors Gsh1/Barx2/Brn3.

113 ression is controlled exclusively by protein trans-acting factors has been challenged recently by the

114 A number of trans-acting factors have also been described to play a

115 These IRES trans-acting factors have been elegantly studied in vitr

116 Although no proven trans-acting factors have been identified, a likely cand

117 g an edited C and unidentified site-specific trans-acting factors have been shown to be important for

118 or distinguishing cis-acting components from trans-acting factors-have provided the impetus for these

119 d causes defects in the recycling of several trans-acting factors (hEnp1, hRio2, hLtv1, hDim2/PNO1, a

120 al mediator of this transport process is the trans-acting factor heterogeneous nuclear ribonucleoprot

121 ng the interaction of a requisite c-MYC IRES trans-acting factor, heterogeneous nuclear ribonucleopro

122 on are considered an important complement to trans-acting factors, histone modifications and non-codi

123 n rates are potentially affected by cis- and trans-acting factors, i.e., genotype-specific modifiers

124 However, little is known about the trans-acting factors important for the intranuclear traf

125 We speculate that an unidentified trans-acting factor in enterohemorrhagic E. coli (EHEC)

126 in the coding region of LHR mRNA, acts as a trans-acting factor in this process.

127 histone tail domains regulate the binding of trans-acting factors in chromatin.

128 in the upstream region of the gene, multiple trans-acting factors in the gene network can influence t

129 cause both alleles are subjected to the same trans-acting factors in the hybrid, the data suggest the

130 siRNA was used to evaluate the role of trans-acting factors in transcription of TJ genes in res

131 Isolation of trans-acting factors, in vitro transcriptional and gel r

132 microtubules, the molecular motor dynein and trans-acting factors including Egalitarian and Bicaudal-

133 This localization requires several trans-acting factors, including Barentsz and the Mago-Y1

134 o well-characterized binding sites for known trans-acting factors, including hepatocyte nuclear facto

135 oximal sequence was independent of all known trans-acting factors, including ppGpp.

136 nesis involves many cis-acting sequences and trans-acting factors, including snoRNAS: We have used di

137 d by mat1 cis-acting elements and by several trans-acting factors, including swi1 (for switch), swi3,

138 ivo functional assays indicate that distinct trans-acting factors, including the E-protein/Daughterle

139 HTA2-HTB2, this repression requires several trans-acting factors, including the products of the HIR

140 both the cis-acting element, the origin, and trans-acting factors, including virally encoded origin-b

141 are more stable, suggesting that cis- and/or trans-acting factors influence S. aureus mRNA stability.

142 ps, which we predict act as landing pads for trans-acting factors influencing miRNA processing.

143 Regulation of Bril involves trans-acting factors integrating at conserved promoter e

144 controlled by multiple positive or negative trans-acting factors interacting with distinct cis-eleme

145 (mtRNAP) from Trypanosoma brucei, the first trans-acting factor involved in kinetoplast mitochondria

146 understanding of the cis-acting elements and trans-acting factors involved in expression of CBF2.

147 Trans-acting factors involved in the early meiotic recom

148 en together, these results identify cis- and trans-acting factors involved in the regulation of PF-2

149 A screen designed to identify trans-acting factors involved in these mechanisms in Sac

150 ribosomal particles have identified numerous trans-acting factors involved in this process, many prot

151 s and to analyze the cis-acting elements and trans-acting factors involved in this regulation.

152 The structure indicates that the binding of trans-acting factors is required to remodel the tertiary

153 EFG1, which encodes a trans-acting factor, is expressed as a more abundant 3.2

154 and/or post-translationally modify specific trans-acting factors, it is unclear how these mechanisms

155 Depletion of the SHMT1 IRES-specific trans-acting factor (ITAF) CUG-binding protein 1 (CUGBP1

156 gs are consistent with NCL acting as an IRES trans-acting factor (ITAF) for ORF2 translation and henc

157 mportant internal ribosome entry site (IRES) trans-acting factor (ITAF) for poliovirus IRES-mediated

158 tion factors, type 2 IRESs also require IRES trans-acting factors (ITAFs) that are hypothesized to st

159 nitiation on Type 1 IRESs also requires IRES trans-acting factors (ITAFs), and several candidates hav

160 ion-dependent CNSHA caused by mutations in a trans-acting factor (Kruppel-like factor 1) and reveal a

161 tional plasmids expressing the minimal viral trans-acting factors L and NP under control of RNA polym

162 he MOR gene is regulated by various cis- and trans-acting factors, many questions remain unanswered r

163 Finally, trans-acting factors may participate in the regulatory m

164 that these "seed" nucleosomes--together with trans-acting factors--may facilitate the establishment o

165 s a multifaceted process involving a host of trans-acting factors mediating numerous chemical reactio

166 te (-1808/-1804) and CREB being the cis- and trans-acting factors mediating the induction, respective

167 -opioid receptor (MOR1) and revealed a novel trans-acting factor, miRNA23b, that binds to the K box m

168 s local activity of super-enhancers and that trans-acting factors modulate DNA methylation profiles w

169 An interplay of cis-acting sequences and trans-acting factors modulates the splicing of regulated

170 ly silenced and intrinsically insensitive to trans-acting factors must be reevaluated.

171 The trans-acting factors necessary for the increased rate of

172 Although recent studies have uncovered trans-acting factors necessary for this regulation, limi

173 We have mapped interactions of three trans-acting factors-NF-kappaB, STAT4, and T-bet-with ci

174 ves an LCMV minigenome and the minimal viral trans-acting factors (NP and L), expressed from separate

175 ected with LCMV to provide the minimal viral trans-acting factors, NP and L, that are required for LC

176 the downstream beta major promoter, despite trans-acting factor occupancy at both sites.

177 oligoadenylate synthetase (OAS), stimulated trans-acting factor of 50 kDa (STAF-50), and ISG-15.

178 s resistance protein 1 (MxA), and stimulated trans-acting factor of 50 kDa.

179 eukaryotic pre-mRNAs requires recognition by trans-acting factors of a complex array of cis-acting RN

180 ine tract binding protein (PTB, a known IRES trans-acting factor or ITAF) is pivotal in regulating th

181 Identification of trans-acting factors or drugs capable of reactivating ga

182 ay for the effects on splicing efficiency of trans-acting factors or of alterations in the sequences

183 e motifs within the enhancer and a number of trans-acting factors play critical roles in the regulati

184 tated initiation of translation requires two trans-acting factors poly (rC) binding protein 1 (PCBP1)

185 gent cadicivirus IRESs require the same IRES trans-acting factor, poly(C)-binding protein 2 (PCBP2).

186 Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to

187 ft assay, we show that binding factor A, the trans-acting factor proposed to convey repression by its

188 Three trans-acting factors regulate expression via the 1.3-kb

189 vide the very first analyses of the cis- and trans-acting factors regulating Bril transcription.

190 rovirus (JSRV) encodes within the env gene a trans-acting factor (Rej) necessary for the synthesis of

191 ibition in this effect, suggesting that host trans-acting factors repress IRES function in a cell-typ

192 s nuclear ribonucleoprotein A2 (hnRNP A2), a trans-acting factor required for dendritic delivery.

193 fied hnRNP A1 (A1) and RPS25 as IRES-binding trans-acting factors required for ER stress-activated ac

194 and CCAAT hotspots, and identify associated trans-acting factors required for hotspot activity.

195 Then we investigated cis- and trans-acting factors required for icIL-1Ra expression an

196 Alternatively, while the trans-acting factors required for LANA expression in B c

197 To identify trans-acting factors required for mediating DNA transfer

198 Here we analyze the cis- and trans-acting factors required for MEI-S332 localization.

199 lthough genetic screens have identified some trans-acting factors required for the localization of th

200 other than Pl1-Rhoades, or in the absence of trans-acting factors required to maintain repressed stat

201 the process of cap-dependent initiation, the trans-acting factor requirements for cellular internal r

202 been well studied, little is known about the trans-acting factors responsible for developmental contr

203 this study, we sought to define the cis- and trans-acting factors responsible for initiation and main

204 To map trans-acting factors responsible, we performed flow sort

205 Trans-acting factors ribosome modulation factor (RMF) an

206 Our data suggest that the trans-acting factors rtf1p and rtf2p act through the rep

207 that the glucose response factor(s) acts as trans-acting factor(s) binding to the cis-acting repress

208 pressed U12-type splicing, suggesting that a trans-acting factor(s) binds the enhancer element to sti

209 Glucose-induced activity of the repressor trans-acting factor(s) reached a maximum at 4 h, which c

210 Furthermore, we found a trans-acting factor(s) that binds within a positive cis-

211 of evidence suggest that there is a limiting trans-acting factor(s) that plays a role in packaging.

212 of evidence suggest that there is a limiting trans-acting factor(s) that plays a role in packaging.

213 oop interaction, suggesting a model in which trans-acting factor(s) that stabilize this interaction m

214 Equally important are the trans-acting factors SBP2, Sec-tRNA[Ser]Sec, and eEFSec.

215 Tristetraprolin (TTP) is the only trans-acting factor shown to be capable of regulating AU

216 of TNF-alpha mRNA stability and is the only trans-acting factor shown to be capable of regulating AU

217 e aim of this study was to discover cis- and trans-acting factors significantly affecting mRNA expres

218 both the cis-acting element, the origin, and trans-acting factors such as virally encoded origin-bind

219 of RNA are regulated by interactions between trans-acting factors, such as microRNA and RNA-binding p

220 y cis-acting elements within the mRNA and by trans-acting factors, such as RNA-binding proteins.

221 n a manner that blocks it from responding to trans-acting factors, such that it is silent even when a

222 Different trans-acting factors (TFs) collaborate and act in concer

223 about the nucleotide sequence specificity of trans-acting factors (TFs) is essential for computationa

224 erefore, we have identified SAP155 as an RNA trans-acting factor that binds to CRCE 1, functions to r

225 says, we discovered that Sam68 is a possible trans-acting factor that binds to this region and regula

226 binding factor (CTCF) is the only identified trans-acting factor that confers enhancer-blocking insul

227 t the class II flagellar gene fliX encodes a trans-acting factor that couples flagellar assembly to F

228 silencing is largely due to an unidentified trans-acting factor that is thought to bind to the prime

229 nizes the glucocorticoid receptor as a novel trans-acting factor that regulates CFTR expression in vi

230 Here we identify hnRNP A1 as an IRES trans-acting factor that regulates cyclin D1 and c-myc I

231 We propose that smu-1 encodes a trans-acting factor that regulates the alternative splic

232 ts suggest that eve is required to produce a trans-acting factor that stimulates cell division in the

233 the class II flagellar gene, flbE, encoded a trans-acting factor that was required for FlbD activity.

234 edundancy has hampered the identification of trans-acting factors that act specifically to effect pos

235 promoter B to characterize cis-elements and trans-acting factors that affect its regulation.

236 ular situations when IRESs are required, the trans-acting factors that are necessary for IRES functio

237 forward-genetic screens aimed at identifying trans-acting factors that are required for expression of

238 We also identify two trans-acting factors that are required for post-internal

239 esults advance our knowledge of the cis- and trans-acting factors that are required for transcription

240 e better addressed by a method that maps all trans-acting factors that bind particular regions rather

241 ults should facilitate the identification of trans-acting factors that bind to these cis elements and

242 ults should facilitate the identification of trans-acting factors that bind to these elements and the

243 ) sequences, as well as by binding sites for trans-acting factors that can evict nucleosomes, such as

244 unlocalized nanos mRNA during oogenesis, but trans-acting factors that carry out this function have r

245 fy cis-regulatory elements and corresponding trans-acting factors that contribute to EC identity and

246 an intracellular network of nucleus-encoded, trans-acting factors that control almost all aspects of

247 a difference in cis-regulatory elements and trans-acting factors that control ASE laterality.

248 To identify trans-acting factors that control VEGF mRNA translation

249 ide a robust basis for extracting motifs and trans-acting factors that determine particular patterns

250 By contrast, the cis-acting elements and trans-acting factors that direct termination of non-poly

251 We also discuss protein trans-acting factors that have been implicated and the e

252 However, the trans-acting factors that interact with the methylated a

253 variations in either cis-acting elements or trans-acting factors that lead to aberrant splicing and

254 To study the cis- and trans-acting factors that mediate programmed death 1 (PD

255 er, the array of cis-regulatory elements and trans-acting factors that mediate these transcriptional

256 However, trans-acting factors that mediate XCI remain largely unk

257 ne cis-regulatory elements and their cognate trans-acting factors that modulate promoter activity in

258 Over the years, many trans-acting factors that orchestrate transcription by t

259 NA, the specific cis-acting determinants and trans-acting factors that participate in stabilizing bet

260 However, the trans-acting factors that promote the rapid decay of MFA

261 eukaryotes, these events are facilitated by trans-acting factors that propel ribosome maturation fro

262 The repression is largely mediated by trans-acting factors that recognize a conserved sequence

263 ation of a number of cis-acting elements and trans-acting factors that regulate its activity.

264 ined, little is known regarding the cis- and trans-acting factors that regulate its expression.

265 a identify Eed as a member of a new class of trans-acting factors that regulate parent-of-origin expr

266 ered its expression pattern, indicating that trans-acting factors that regulate the D. melanogaster y

267 study, we identified cis-acting elements and trans-acting factors that regulate the expression of the

268 The cis-acting DNA regulatory elements and trans-acting factors that regulate the majority of cold-

269 ically dissected the cis-acting sequence and trans-acting factors that regulate the stability of gamm

270 ternative splicing is generally regulated by trans-acting factors that specifically bind pre-mRNA to

271 ophoblasts is secondary to dominant negative trans-acting factors that suppress class II transactivat

272 shed in the maternal germline indicates that trans-acting factors that target methylation to this imp

273 ARE-binding proteins (AUBP) that function as trans-acting factors that transduce this function.

274 shared cis-regulatory signature and a common trans-acting factor, the phylogenetically conserved COE

275 The proximity of a gene or trans-acting factor to heterochromatin can have profound

276 nscripts, suggesting that PCBP1 can act as a trans-acting factor to stabilize sortilin transcripts.

277 abidopsis relies in large part on binding of trans-acting factors to cis-localized DNA sequence motif

278 erve to integrate the activities of multiple trans-acting factors to control smooth muscle alpha-acti

279 throughput system for systematically linking trans-acting factors to endogenous RNA regulatory events

280 ription is orchestrated by multiple cis- and trans-acting factors to ensure appropriate expression of

281 ion of changes in cis-regulatory elements or trans-acting factors to interspecies differences in gene

282 ranslation of dicistroviral RNAs may require trans-acting factors to stabilize PKI.

283 refore the ability of a range of known viral trans-acting factors to stimulate the Bag-1 IRES was tes

284 ells is associated with decreased binding of trans-acting factors to the ARE.

285 ranscription led to decreased binding of the trans-acting factors to their corresponding cis-acting e

286 ys showed that differences in the binding of trans-acting factors to these three elements accounts fo

287 Both activation domains employ trans-acting factors to trigger mRNA decay, and the N-te

288 In this study, we identified two p53 IRES trans-acting factors, translational control protein 80 (

289 iquitin-mediated sorting steps employ unique trans-acting factors, ubiquitination sites on Gap1p, and

290 s RNA sequence is able to bind directly to a trans-acting factor, Vg1RBP, which was previously shown

291 ne if Spn1 causes a fitness defect through a trans-acting factor, we constructed an Spn1(+) mutant th

292 Sec incorporation requires both cis- and trans-acting factors, which are known to be sufficient f

293 translation is codetermined by cellular IRES trans-acting factors, which can influence viral propagat

294 , GCA for X-linked phenotypes must be due to trans-acting factors, while GCA for autosomal phenotypes

295 e four ribosomal RNAs, mediated by a host of trans-acting factors whose specific functions remain lar

296 th C residues was deleterious, implicating a trans-acting factor with a preference for U over mixed p

297 re well studied, but how the interactions of trans-acting factors with cis-regulatory modules (CRMs)

298 binatorial interactions of sequence-specific trans-acting factors with localized genomic cis-element

299 show that two recently identified c-myc IRES trans-acting factors, Y-box binding protein 1 (YB-1) and

300 ivery of the corresponding cognate synthetic trans-acting factor ZF6-DB without the intrinsic transcr