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1 disengagement and, thereby, ligand-dependent trans activation.
2 in kinetin riboside as an inhibitor of CCND2 trans-activation.
3 heir abilities to enter HeLa cells and block trans-activation.
4 the COOH-terminal 98 amino acids function in trans-activation.
5 gative TIRAP blocked Rac1V12-induced HIV-LTR trans-activation.
6 e or no capacity for additive or synergistic trans-activation.
7 c1N17) partially blocked LPS-induced HIV-LTR trans-activation.
8 STAT3 and HDAC7 and modulate STAT3-mediated trans-activation.
9 verexpression will counteract Stat3-mediated trans-activation.
10 play important roles in the regulation of AR trans-activation.
11 ly(QA) domain acquired a significant role in trans-activation.
12 of the AOP2 promoter reduced LEDGF-dependent trans-activation.
13 a in mediating redox-sensitive iNOS promoter trans-activation.
14 production, resulting in the AT(2) receptor trans-activation.
15 is insufficient to support Tax-dependent LTR trans-activation.
16 ring of the two kinase domains, facilitating trans-activation.
17 ivity and for Hdac7- and HIF-1alpha-mediated trans-activation.
18 ndent TEA domain transcription factor (TEAD) trans-activation.
19 in enhanced Sp1-DNA binding activity and Sp1 trans-activation.
20 or-kappaB (NF-kappaB) resulting in HIV-1 LTR trans-activation.
21 h AR protein expression and R1881-induced AR trans-activation.
22 portant for interfering with Notch1-mediated trans-activation.
23 ent of effects on mineralocorticoid receptor trans-activation.
24 acts with Runx2 and represses Runx2-mediated trans-activation.
25 An IE62 TAD-ICP4 chimeric protein exhibited trans-activation ability (10.2-fold), indicating that th
27 he SRT were replaced with Ala, Leu, and Gly, trans-activation activities of the modified IE62 protein
28 matory mediator production but has lower GRE trans-activation activities than traditional steroids.
34 n ERalpha mutants with significantly altered trans-activation activity toward E(2) in yeast cells.
36 lin-dependent kinases (cdks) increases RUNX1 trans-activation activity without perturbing p300 intera
37 gonucleotide exhibited partial inhibition of trans-activation activity, but this was correlated with
38 utants of any nuclear receptors with altered trans-activation activity, which may greatly facilitate
41 d TLR9 in HIV-long terminal repeat (HIV-LTR) trans-activation and assessed whether TLR4 synergized wi
42 tion of NF-kappaB, as evidenced by NF-kappaB trans-activation and by p65 RelA and p50 NF-kappaB1 bind
44 first, a dileucine motif, is dispensable for trans-activation and cis-inhibition despite the endocyti
45 hibit cadmium inducibility also suppress the trans-activation and DNA binding activities of Nrf2, and
48 g-induced HIV-long terminal repeat (HIV-LTR) trans-activation and HIV-1 replication, and that LPS-ind
49 ti-apoptotic function of p53 is dependent on trans-activation and is linked to cell cycle arrest.
50 n-derived neurotrophic factor-responsive CRE trans-activation and neurotrophin protection against apo
53 n with ethylidene glucose, or by transporter trans-activation and therefore was probably due to subst
54 in that has been shown to modulate HIV-1 Tat trans-activation and to repress transcription of some ce
56 kappaBalpha degradation as well as NF-kappaB trans-activation and transformation of NIH3T3 cells.
58 inducible nuclear translocation and Hsp gene trans-activation, and in the protection of mouse cells f
59 ime that activation of Rac1 leads to HIV-LTR trans-activation, and this is mediated through TIRAP.
61 ed further that Sp2 DNA-binding activity and trans-activation are each negatively regulated in mammal
62 r, we show that Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian c
69 act with TLR2 but had no effect on HIV-1 LTR trans-activation because of its inability to activate th
70 2000 to +73) restrained C/EBP alpha-mediated trans-activation, because mutation of each single GRU el
71 in steric block inhibition of Tat-dependent trans-activation both in vitro and in cells is governed
73 n with SRCs and abolished RORgammat-mediated trans-activation but not its ability to inhibit transcri
74 methasone and was active in potentiating the trans-activation, but not the trans-repression, properti
76 ependent intracellular inhibition of Tat-TAR trans activation by the anti-TAR 3'-FAM 12-residue 7xOMe
77 both TFB promoters are required for maximal trans activation by the PGC-1 family coactivators, PGC-1
78 etic acid-induced xenobiotic stress enhances trans-activation by a chimeric fusion protein of the yea
81 findings suggested that the balance between trans-activation by AP-1 and repression through the E-bo
83 lanine, suggesting that stimulation of RUNX1 trans-activation by cdk-mediated reduction in HDAC inter
87 ation motif that abrogate acetylation reduce trans-activation by p300 without affecting the trans-rep
89 a deficiency drastically decreased NF-kappaB trans-activation by Tax, although it only modestly reduc
90 ransport function of AfAmt-2 also depends on trans-activation by the C terminus, and mutations in por
93 The EGR1 promoter was engineered to enhance trans-activation capacity and optimized for simple scree
94 these modifications, both contribute to the trans-activation capacity of PEA3, implying that a dynam
95 minus of the Nmp4 protein exhibited a strong trans-activation capacity when fused to the GAL4 DNA-bin
100 together, the results imply that employing a trans-activation deficient p53 in gene therapy approache
101 olic localization of endogenous wild-type or trans-activation-deficient p53 was necessary and suffici
102 orphic cis-regulations and to differences in trans-activation depending on the allelic form of the TF
104 nant negative form of Egr-1, which lacks the trans activation domain but retains the DNA-binding doma
107 code DNA-binding proteins with and without a trans-activation domain (TA- or Delta N-, respectively).
108 al for trans-activation, including an acidic trans-activation domain (TAD), a serine-rich tract (SRT)
111 PARalpha lacking the ligand-independent AF-1 trans-activation domain failed to inhibit STAT5b, highli
112 ucine zipper (bZIP) domain, a glutamine-rich trans-activation domain in CREB called Q2 also appeared
113 dominant-negative form of Stat5 lacking the trans-activation domain inhibited induction of cyclin D2
114 ng the HMG box domain of Lef-1 linked to the trans-activation domain of beta-catenin (Lef-1/beta-cat)
115 Notably, insertion of the glutamine-rich B trans-activation domain of SP1 into a mutant CREB polype
116 t LPS induced the phosphorylation of the p65 trans-activation domain on serine 536 in monocytes/macro
117 Instead, a 93-amino acid portion of the trans-activation domain was shown to be the minimal port
119 Ap73alpha (the p73 isoform that contains the trans-activation domain) target gene and activates the e
120 lation is mediated by a cytosolic C-terminal trans-activation domain, which carries a conserved Thr (
121 tructs, we showed that the STRA13 C-terminal trans-activation domain, which is known to bind HDAC1, m
128 without apoptosis, a p53 mutant defective in trans-activation elicits apoptosis without inducing cell
129 demonstrate this autoactivation process is a trans-activation event that is efficiently inhibited by
131 ng modules, by using a DNA binding assay and trans-activation experiments performed by analyzing prot
132 ion of the IRF-1 motif substantially reduces trans-activation from 5- to 2-fold and that inactivation
133 xpression, but did not significantly enhance trans-activation from a MHC class II promoter, indicatin
134 p53 protein (Ala135 to Val), which had lost trans-activation function and could not regulate G1/S tr
135 Treatment with C6-ceramide inhibited the trans-activation function of overexpressed Sp1, whereas
136 hibit productive infection suggests that the trans-activation function of Rta is essential for MHV-68
137 regulation, indicating that the synergistic trans-activation function of SRF and TEF-1 occurs via th
139 mine residues, was dispensable for the EICP0 trans-activation function, (vi) a motif resembling a nuc
140 Depressed E-cadherin correlated with HBxAg trans-activation function, as did the migration of HepG2
144 n responsive element TAR block Tat-dependent trans-activation in a HeLa cell assay when delivered by
145 t dose-dependent inhibition of Tat-dependent trans-activation in a HeLa cell assay when incubated for
147 of different types can inhibit Tat-dependent trans-activation in HeLa cells and have potential for de
149 m Staphylococcus epidermidis induced HIV-LTR trans-activation in human microvessel endothelial cells
150 hin the DHFR promoter increased Sp2-mediated trans-activation in transient co-transfection experiment
152 IE62 possesses several domains essential for trans-activation, including an acidic trans-activation d
153 he use of drugs that convert mutant p53 to a trans-activation-independent mediator of apoptosis may b
154 uman cells was increased by establishment of trans activation, indicating that Syg1 receptor-dependen
156 or two OMe G-clamps did not impart cellular trans-activation inhibition activity to cellularly inact
157 inactive when delivered alone, but attained trans-activation inhibition in the presence of chloroqui
159 interact directly, this finding implies that trans activation is achieved via the DNA substrate in a
160 -1 replication, and that LPS-induced HIV-LTR trans-activation is mediated through myeloid differentia
162 determine whether inhibition of CBF-mediated trans-activation is sufficient to slow proliferation.
163 tion-dependent inhibition of DNA binding and trans-activation is the key primary mechanism of BES1 re
164 nstrate that cis-inhibition of SRK, like its trans-activation, is based on allele-specific interactio
165 C-terminal end of the positioning helix, the trans-activation loop, and the recognition helix of the
169 within the alphaherpesviruses, is needed for trans-activation mediated by the acidic trans-activation
170 ts were selectively defective in DHT-induced trans activation of androgen-responsive reporter genes a
171 from CD4(+) T cells and reveal a process of trans activation of DC without secretion of polarizing c
172 e (TBH) induces human GCLC via Nrf2-mediated trans activation of the antioxidant-responsive element (
173 nteraction domain on PRC is required for its trans activation of the cytochrome c promoter and a PRC
174 o T/EBP/NKX2.1 binding sites responsible for trans activation of the gene by T/EBP/NKX2.1 in lung cel
175 the release of NF-kappaB, in regulating the trans activation of the NF-kappaB subunit p65/RelA by af
176 ORF2 also interfered with Notch-mediated trans activation of the promoter that regulates the expr
179 mediates its biological effects through the trans-activation of a unique profile of target genes.
180 ys showed that they are both required in the trans-activation of alphabeta-INR-driven DNA templates.
183 t co-expression of Brn-3b with p53 increases trans-activation of Bax promoter but not p21cip1/waf1.
184 se element modulator (CREM) and blocked both trans-activation of CCND2 by various myeloma oncogenes a
185 ifically, increased PXR binding triggers the trans-activation of critical drug-metabolizing enzymes a
189 accompany changes in conformation during the trans-activation of enzymes; however, few studies exist
190 ng hormone (LH) receptor activation leads to trans-activation of epidermal growth factor (EGF) recept
195 of their adverse effects are associated with trans-activation of genes involved with metabolic proces
196 activation is paradoxically antagonistic to trans-activation of hsp promoters by HSF1 and HSP accumu
197 of fibronectin in PaCa cells is mediated by trans-activation of IGF-IR induced by the beta3 integrin
201 eporting system where GAL4-Elk and GAL4-CHOP trans-activation of luciferase gene served as reporters
203 another Sox member, Sox5, triggered no such trans-activation of mor DP-driven luciferase activity or
206 hosphorylated SGK2 co-activates PXR-mediated trans-activation of promoters of gluconeogenic genes in
208 ble DNA binding activity, but at best modest trans-activation of reporters containing Stat6 binding s
210 We also show that UBR5 specifically enhanced trans-activation of smooth muscle-specific promoters by
217 d shock-induced apoptosis or Notch1-mediated trans-activation of the bICP0 early promoter and stimula
219 O1 in sustaining the DZ program involved the trans-activation of the chemokine receptor CXCR4, and co
222 ndent protein kinase (PKA) activity mediated trans-activation of the EGF receptor and subsequent mito
223 We demonstrated that, similar to the ovary, trans-activation of the EGF receptor was critical for go
226 E(2)-EP4 receptor signalling did not lead to trans-activation of the epidermal growth factor receptor
227 -gamma-dependent NO generation increases the trans-activation of the Fas promoter, and this increase
228 n, achieving this by reducing AP-1-dependent trans-activation of the gene by way of compromised ERK a
229 lorophyll, and, as a result of cell-specific trans-activation of the hairpin to CS, chlorophyll accum
230 ble Brassicaceae is based on allele-specific trans-activation of the highly polymorphic S-locus recep
231 nal activity of the HRES-1/Rab4 promoter via trans-activation of the HRES-1 long terminal repeat.
234 NO production, iNOS gene transcription, and trans-activation of the iNOS promoter in primary culture
236 mplicated in regulating ligand occupancy and trans-activation of the nuclear receptors belong to the
238 (2)O(2) induces tyrosine phosphorylation and trans-activation of the platelet-derived growth factor r
239 ooth muscle-specific genes and represses the trans-activation of the promoters of myocardin of these
240 glutamate to mimic phosphorylation increases trans-activation of the reporter in 293T cells and allow
242 ransfection or 9-cis-RA treatment suppressed trans-activation of the TGF-beta-responsive promoter.
246 SUMO-deficient mutant exhibited compromised trans-activation or trans-repression activities in repor
247 actors might serve to feedback inhibit their trans-activation potential and deactivate iNOS gene tran
248 of TGA1a was found to inhibit this factor's trans-activation potential by a mechanism that appears t
249 A binding analysis demonstrated that loss of trans-activation potential by the A78D mutation resulted
253 this repression is that p21SNFT inhibits the trans-activation potential of protein complexes that con
258 rates and how dsRNA binding proteins such as trans-activation response (TAR) RNA binding protein (TRB
262 entary DNA and RNA hairpins derived from the trans-activation response domain of the HIV genome.
263 al mechanism for ligand-induced refolding of trans-activation response element (TAR RNA) from human i
266 mly (15)N/(13)C-labeled 27 nt variant of the trans-activation response element (TAR) RNA from HIV-I.
267 abilizes the highly structured complementary trans-activation response element (TAR) stem-loop (TAR D
268 ed score, STSCR: We tested the method on the trans-activation response element and Rev response eleme
270 acterized RNA stem-loop structure, the HIV-1 trans-activation response element, showed that authentic
271 o small interfering RNA (siRNA), while human trans-activation response RNA-binding protein (TRBP) fun
272 roteins, protein activator of PKR (PACT) and trans-activation response RNA-binding protein (TRBP).
276 nucleic acid residues complementary to HIV-1 trans-activation responsive element TAR block Tat-depend
277 pecific interactions of Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base
281 this RNAi-enhancing activity depends on the trans-activation-responsive region RNA-binding protein.
282 o mechanical folding of RNA hairpins such as trans-activation-responsive RNA reveal distinct kinetic
287 gel-free process including cis-blocking and trans-activation steps to support scalable generation of
288 ll complement the versatile cis-blocking and trans-activation strategy to broadly advance our ability
289 st two-hybrid assay to avoid the nonspecific trans-activation that would occur with the traditional y
290 ent Pdx1 expression and function depend upon trans-activation through 5' conserved cis-regulatory reg
292 n cis amino acid activation competes with in trans activation to increase the range of amino acid sub
294 by AP2gamma in mammary epithelial cells, and trans-activation was dependent upon the region of the pr
296 via unique mechanisms (BDNF independent TrkB trans-activation).We hypothesized that other GsPCRs elic
297 g a cell-based assay for inhibition of CCND2 trans-activation, we identified the plant cytokinin kine
298 conjugates entered the nucleus or inhibited trans-activation when freely delivered, but inhibition w
299 of ATF-2 and CREB produced (G)gamma-promoter trans-activation which was abolished by a 2-base pair mu
300 decreased NF-kappaB activation and p65/RelA trans activation without affecting I-kappaBalpha degrada
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