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1 inetic isotope effect studies on recombinant trans-sialidase.
2 readily sialylated upon addition of parasite trans-sialidases.
5 ceptor TrkC is activated by T. cruzi surface trans-sialidase, also known as parasite-derived neurotro
6 se, expresses a membrane-bound neuraminidase/trans-sialidase, also known as parasite-derived neurotro
7 -1) along with the T. cruzi Tc24 antigen and trans-sialidase antigen 1 (TSA1), induced significant nu
11 with a trypomastigote population expressing trans-sialidase effectively released IL-6, but did not u
13 his study, the effectiveness of the T. cruzi trans-sialidase family (ts) genes ASP-1, ASP-2, and TSA-
17 (ANYKFTLV) and subdominant TSKB74 (VNYDFTLV) trans-sialidase gene (TS)-encoded epitopes with up to 40
19 CD8+ T cells recognizing the immunodominant trans-sialidase gene-encoded peptide TSKB20 (ANYKFTLV) a
20 cruzi expresses a developmentally regulated trans-sialidase implicated in the pathogenesis of Chagas
22 ing this observation, we found that purified trans-sialidase induces the selective release of biologi
23 , introduction of small amounts of exogenous trans-sialidase into suspensions of nonpenetrating TS- p
24 unique findings presented here suggest that trans-sialidase is a major inducer of IL-6 secretion in
26 ATCC 29149 strain produces an intramolecular trans-sialidase (IT-sialidase) that cleaves off terminal
29 hat the T. cruzi gp83 ligand, a cell surface trans-sialidase-like molecule that the parasite uses to
31 families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel famil
32 s demonstrated with a genetically engineered trans-sialidase mutant, an enzymatically active polypept
34 itation and competition assays show that the trans-sialidase/parasite-derived neurotrophic factor (PD
40 of the CD4 cells are stimulated by a single trans-sialidase superfamily epitope and suggest that a c
41 g T. cruzi infection the CD4 response to the trans-sialidase superfamily is critical to the protectiv
42 ly epitope and suggest that a combination of trans-sialidase superfamily proteins combines to stimula
47 nasal immunizations with the unique T. cruzi trans-sialidase (TS) antigen protect against gastric and
51 ed that mice primed for a few hours with the trans-sialidase (TS) of Trypanosoma cruzi, the agent of
52 evant to this observation, we found that the trans-sialidase (TS) of Trypanosoma cruzi, the etiologic
55 parasite-derived neurotrophic factor (PDNF)/trans-sialidase with neurotrophic receptors TrkA and Trk
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