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1 determine if PKA controls EBNA1's ability to transactivate.
2 ulates MYC and E2F2 and some genes that they transactivate.
5 e confirmed p53(420) is able to tetramerize, transactivate a p21 promoter, bind dynein and that the r
6 TDEC from WT expressed VDR and were able to transactivate a reporter gene whereas TDEC from KO mice
7 ional function but shows impaired ability to transactivate a subset of p53 target genes, including tw
8 C with a constitutively nuclear FoxO1 mutant transactivated a co-transfected ET-1 promoter luciferase
10 became activated to the DNA-binding form and transactivated a large number of genes in lymphoid cells
11 mized rats, we established that ligands that transactivated a model promoter 40-80% of an agonist, re
12 5.8-kb fragment consisting of these elements transactivated a reporter gene in vivo recapitulating en
14 o causes melanotic tumors, while in vitro it transactivates a Stat92E-luciferase reporter in the abse
15 te a role for AT-hooks in EBNA1's ability to transactivate, a function necessary for EBV to immortali
16 cated PtrSND1-A2(IR) lacking DNA-binding and transactivating abilities can disrupt the function of fu
17 ine zipper 1 (SPZ1) promotes EMT through its transactivating ability in increasing TWIST1 expression.
19 s that are important for the DNA-binding and transactivating activities of two naturally occurring va
21 BP transcriptional activity (by reducing its transactivating activity but not its nuclear localizatio
22 EBP/OREBP by increasing its phosphorylation, transactivating activity, and localization to the nucleu
33 nt whose nuclear localization and ability to transactivate and induce reactivation were tightly contr
35 -regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.
38 -1, in a p53-independent manner, by directly transactivating Bax, and prove that alters the B-cell CL
40 s characterized by inside-out signaling that transactivates beta(2) integrin adhesive activities.
42 ate that in response to TGF-beta1, KLF10 can transactivate both TGF-beta1 and Foxp3 promoters, implic
45 bly, we now show that both -2 and -1 PRF are transactivated by a protein factor, specifically a PRRSV
48 ated that this gene is posttranscriptionally transactivated by ICP27 in a plasmid cotransfection assa
50 ng that the binding of STAU1 to mRNAs can be transactivated by lncRNAs uncovers an unexpected strateg
51 enterohepatic circulation of bile acids and transactivated by nuclear receptor farnesoid X receptor
54 additional regions in the BoHV-1 genome are transactivated by the GR or stress-induced transcription
61 le of Aurora kinase A (AURKA) in BCSCs, as a transactivating co-factor in the induction of the c-Myc
63 with the native bacterial CRISPR RNA (crRNA)-transactivating crRNA (tracrRNA) duplex and contains a c
64 crRNA), which in combination with unmodified transactivating crRNA (tracrRNA) is shown to functionall
66 receptor (TCR), the TCR associates with and transactivates CXCR4 via phosphorylation of S339-CXCR4 i
69 d in a decrease in the ability of HIF-1alpha transactivating domain to recruit co-activators and dimi
71 ent HPV types to block the ability of p53 to transactivate downstream genes following DNA damage.
76 ay (G(q/11)-coupled phospholipase C) and the transactivated EGFR downstream signaling pathways (phosp
77 xpression by siRNA suppresses p40 effects on transactivating EGFR and Akt, preventing apoptosis, and
78 the correlation between the ability of E6 to transactivate endogenous and exogenous hTERT promoters a
79 d lysophosphatidic acid (LPA), which in turn transactivate epidermal growth factor (EGF) receptor (EG
80 n of G protein-coupled receptors (GPCRs) can transactivate epidermal growth factor receptors (EGFRs),
81 leptin and IGF-I cotreatment synergistically transactivated epidermal growth factor receptor (EGFR),
83 hat Mesp1 binds to the proximal promoter and transactivates Etv2 gene expression via the CRE motif.
84 ated that the Sp1 mutation both impaired Tat-transactivated expression and also altered basal express
86 ously, we reported that the neurotoxic HIV-1 transactivating factor (Tat) acutely disrupts mitochondr
87 e results illustrate that SARI inhibits AP-1 transactivating factor binding to the cis-element of the
90 Galpha(q) signaling by crossing tetracycline-transactivating factor/V1A mice with transgenic mice tha
92 e; however, by 24 weeks of age, tetracycline-transactivating factor/V1A-TG mouse hearts had reduced c
95 the FHM nPR, whereas five progestins and P4 transactivated FHM AR, all at environmentally relevant c
97 nase transactivation and discovered that ADP transactivates Fms-like tyrosine kinase 3 (Flt3), a rece
98 ere exposed to MMP-9, EGFR was significantly transactivated, followed by p38 MAPK activation, I-kappa
99 ad box subclass M1 (FOXM1) as a co-factor to transactivate FOXM1 target genes in a kinase-independent
102 localization inhibits this newly discovered transactivating function of AURKA, sensitizing resistant
103 ing several individual RTA mutant clones for transactivating function of the RTA promoter and transco
104 uclear transcription factor, ERalpha has two transactivating functional domains (AF), AF-1 and AF-2.
105 on on DNA-binding activities, alterations in transactivating functions and interactions with cofactor
106 a guanine-nucleotide exchange factor (GEF), transactivates Galpha activity-inhibiting polypeptide 1
109 is, mitosis, adherent junctions, but also to transactivate genes involving in matrix degradation and
110 led that hearts from knockout mice failed to transactivate genes regulated by the transcription facto
113 -inducible factor 1alpha (HIF-1alpha), which transactivates genes governing angiogenesis and metaboli
114 acts as a nuclear transcription factor that transactivates genes involved in apoptosis, cell cycle r
115 f HF-SCs in vivo, we show that LHX2 directly transactivates genes that orchestrate cytoskeletal dynam
116 GLI1 undergoes nuclear translocalization and transactivates GLI1-binding sites similar to GLI1, unlik
118 tivity of all transcription factors known to transactivate heat shock protein 27 expression, these fi
121 PCD, GmNAC81 and GmNAC30 bind in vivo to and transactivate hydrolytic enzyme promoters in soybean pro
123 This is the first report to indicate that NT transactivates IGF-1R and that this response is linked t
124 transfection assays, HIF-1alpha was found to transactivate IGFBP3 through a novel hypoxia responsive
125 ient CD4 and CD8 T cells, and c-Maf directly transactivated IL-10 gene expression through binding to
129 s show marked cochlea abnormalities, and the transactivating isoform of p63 (TAp63) protein is normal
132 o SUMOylation that regulates its capacity to transactivate its target genes in normal liver and durin
133 ed that LEF1 binds to the MMP13 promoter and transactivates its expression, but we observed that SIRT
134 o a highly conserved sequence within E23 and transactivates its splicing in vitro and in vivo; this i
136 roteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and al
138 ha-hgamma(c)OPT vector lacked the ability to transactivate LMO2 protein expression, whereas the CL20i
142 age fluid from inhibitory kappaB kinase beta transactivated mice, Escherichia coli lipopolysaccharide
143 ed transgenic (inhibitory kappaB kinase beta transactivated) mice that conditionally express an activ
144 signaling, a key pathogenic pathway in PKD, transactivated miR-21 promoter in kidney cells and promo
145 y of nuclear factor kappa B (NF-kappaB) that transactivates miR-155 gene was significantly (P = 0.002
146 growth factor (VEGF) B and D, which in turn transactivate MMP-12 via PI3-K, p38 and JNK signaling pa
148 Furthermore, truncated Gli-1 (tGli-1), which transactivates molecules involved in metastasis, was det
155 2-E47 heterodimers have a reduced ability to transactivate neuronal differentiation genes compared wi
156 nd has been shown to have two activities: it transactivates Notch in neighbouring cells and cis-inhib
157 lar adhesion with Notch expressing cells and transactivates Notch to promote signaling and nuclear tr
158 r 6 results in a Serrate molecule capable of transactivating Notch but exhibiting little or no Notch
159 cription factor Kruppel-like factor 5 (KLF5) transactivates NOTCH1 in the context of p53 mutation or
161 hat retains the ability to interact with and transactivate nuclear hormone receptors through its N-te
162 ein), which contain CtrA-binding motifs, and transactivated ompA, surE and bolA promoter-lacZ fusions
163 the YBX1 protein level, which decreased YBX1-transactivated p21 expression and abolished G1 phase cel
164 hermore, we found that mutp53 proteins hyper-transactivate p53-target gene CDKN1A upon glutamine depr
165 se 1 (EGR1) transcription factor, which also transactivates p53, p73, and p300/CBP as well as other p
170 ws that HKa significantly decreases the bFGF-transactivated phosphorylation of EGFR at Tyr 1173 betwe
172 he induction of tumor suppressor p53 and p53-transactivated proapoptotic genes, (2) delayed progressi
173 is poorly understood, since IE62 efficiently transactivates promoter elements lacking this sequence.
174 TN4 and GR to putative GREs in dexamethasone-transactivated promoters, SERPINE1, ANGPLT4, CCL20, and
176 demonstrated that fluctuations in viral Tat-transactivating protein levels generate integration-site
178 istent with the ability of Raf inhibitors to transactivate Raf-1 when a PKA-activated Ras promotes Ra
183 by forming a ribonucleoprotein complex with transactivating responsive (TAR) RNA and P-TEFb, an elon
186 Additional mechanistic dissection finds TR4-transactivated SCD1 promoter activity via direct binding
187 acity to both suppress pancreatic cancer and transactivate select p53 target genes, including Ptpn14.
188 se can facilitate their known interaction in transactivating Sirtuin 1 (SIRT1), a NAD(+)-dependent hi
189 aled a subset of TP53 target genes that were transactivated specifically in sarcomas that were highly
190 sisting of DNA-binding subunit GABPalpha and transactivating subunit GABPbeta, is essential for lymph
191 t E2, acting through estrogen receptor-beta, transactivates synaptic TrkB and beta1-integrin, and via
192 al of FOXM1 is determined by its capacity to transactivate target genes that are implicated in differ
196 These effects are dependent on HIF-1, which transactivates target genes encoding metabolic enzymes a
199 ciably influence the ability of WT PHOX2B to transactivate the DBH promoter, nor did it alter the dec
201 t AR stably expressed in PCa cells failed to transactivate the endogenous AR-regulated PSA or TMPRSS2
203 mber of distinct signaling pathways that can transactivate the epidermal growth factor receptor (EGFR
204 Indeed, kinase-dead AURKA can effectively transactivate the FOXM1 promoter through a Forkhead resp
206 require Galphai subunits only as adaptors to transactivate the Gbetagamma heteromers, which then act
207 TSAR1 and TSAR2 are coregulated with and transactivate the genes encoding 3-HYDROXY-3-METHYLGLUTA
209 were sufficient to confer responsiveness and transactivate the heterologous FoxO1 promoter but not in
215 the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting i
218 f the extrinsic pathway of blood coagulation transactivate the MASP matriptase, thus connecting coagu
220 al level, we demonstrated that TAp63 and p53 transactivate the promoter and increased the expression
221 n vitro studies have shown that Foxa1/a2 can transactivate the promoters of Mucin 2 (Muc2), which is
223 Interestingly, MAZ occupies and is able to transactivate the Six4 promoter in skeletal but not card
224 ingosine-1-phosphate (S1P) has been shown to transactivate the TGFbeta receptor and activate Smad3, w
230 doid synthesis 1 (BIS1) transcription factor transactivated the expression of all of the genes encodi
235 ed that N1-ICD (Notch1 intracellular domain) transactivated the mouse Kruppel-like factor 4 (Klf) pro
239 in localized to the nucleus and specifically transactivated the SlTPS5 promoter in Nicotiana benthami
241 ver, when Sp1 and Sp3 were coexpressed, they transactivated the Tesc promoter in a synergistic manner
242 homeodomain proteins, Six1, LBX1, and HoxA5, transactivated the ZEB1 promoter, in the case of Six1, t
243 phatidylinositol (3,4,5)-triphosphate, which transactivates the Akt/mammalian target of rapamycin pat
244 n luciferase activity, suggesting that c-Jun transactivates the Aldh1a1 promoter as a homodimer and n
247 is to determine the mechanisms by which p40 transactivates the EGFR in intestinal epithelial cells.
249 Catharanthus APETALA2-domain 3 (ORCA3) that transactivates the expression of several genes encoding
252 In earlier work, we demonstrated that Sox10 transactivates the nicotinic acetylcholine receptor alph
253 Although it has been demonstrated that Tax transactivates the PCNA promoter, the mechanism of trans
254 ncodes a transcription factor that binds and transactivates the proapoptotic BCL2L11 locus encoding B
258 rm a DNA-binding complex that recognizes and transactivates the RUNX1 response element in the fhl2 pr
259 e studies support a unique concept that 5-HT transactivates the serine kinase receptor, BMPR 1A, to a
261 transfection experiments establish that NOR1 transactivates the Skp2 promoter through a nerve growth
263 te response element-binding protein (ChREBP) transactivates the txnip promoter, whereas ChREBP knockd
264 the expression of GmNAC81 and GmNAC30 fully transactivates the VPE gene in soybean protoplasts and t
267 nd SRF physically associate and synergize in transactivating the MCK promoter independently of SRF bi
268 t Pax3 synergizes with both Gli2 and Zic1 in transactivating the Myf5 epaxial somite (ES) enhancer in
269 Expression of pUL83 alone is capable of transactivating the promoter in a reporter assay, and pU
270 mic the effects of neurotrophins in vitro by transactivating their high-affinity receptor tyrosine ki
271 e direct transcriptional targets of Rta were transactivated to different levels and included the gene
274 e (as a prodrug and MMP 2-sensitive moiety), transactivating transcriptional activator peptide-PEG100
275 initially show that the ability of P6-GFP to transactivate translation is comparable to unmodified P6
276 proteins, led us to hypothesize that ROS can transactivate TrkB in CNS neurons by a zinc-dependent me
277 in axons of mammalian cortical neurons, can transactivate TrkB in neurons and heterologous cells in
279 emonstrate that spinal A2a receptor agonists transactivate TrkB receptors in the rat cervical spinal
282 cytosolic MT-3, the increased cytosolic zinc transactivates TrkB, and the enhanced Shc signaling down
283 d ECH_1038, which were expressed in DCs, and transactivated trp120 and ECH_1038 promoter-lacZ fusions
285 strate that SPZ1, a newly dscribed molecule, transactivates TWIST1 promoters, and that this SPZ1-TWIS
287 ticulum stress potentiated HIF-1 activity to transactivate VEGF expression as well as another well ch
289 id expressing the 51g mutant protein did not transactivate viral promoter activity as efficiently as
290 ese transduced viral RNAs, BZLF1 transcripts transactivated viral promoters triggering the prelatent
291 ding frame 61 (ORF61) encodes a protein that transactivates viral and cellular promoters in transient
297 e transactivation response element (TAR) RNA transactivates viral transcription and represents a para
298 the CYP24A1 gene by directly binding to and transactivating vitamin D-response elements (VDREs) with
299 255 residue interacts with STAT3 and p300 to transactivate, whereas carboxy-terminal unphosphorylated
300 e formed in living cells and that Galphai is transactivated within minutes after growth factor stimul
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