ライフサイエンスコーパス: transactivation domain

1 nt on a key C-terminal domain located in its transactivation domain.

2 etains (TA) and the other lacks (DeltaN) the transactivation domain.

3 o a truncated isoform lacking the C-terminal transactivation domain.

4 ear hormone receptors through its N-terminal transactivation domain.

5 regulated neurotransmitter phenotype via its transactivation domain.

6 rminal proline-, serine-, and threonine-rich transactivation domain.

7 ough fusion to the Herpes Simplex Virus VP16 transactivation domain.

8 16) becomes well-defined upon binding of the transactivation domain.

9 and a STAT4beta isoform lacking a C-terminal transactivation domain.

10 n the C-terminus of Sox2, which contains its transactivation domain.

11 Tyr-267 and Tyr-363, both located within the transactivation domain.

12 Rather, WxxLF functioned as an autonomous transactivation domain.

13 for TAZ1 binding through its own disordered transactivation domain.

14 finger pair domain in Zap1 contains the AD2 transactivation domain.

15 vage sites were identified in the N-terminal transactivation domain.

16 (TCA) to proline (Pro) (CCA) within the REL transactivation domain.

17 nding domain to a highly potent EWS (or FUS) transactivation domain.

18 some processing but independent of NF-kappaB transactivation domain.

19 phosphoacceptor residue, Ser(64), within the transactivation domain.

20 ed with ERK5 or ERK5(1-740), which lacks the transactivation domain.

21 c p53 but not to a p53 mutant that lacks the transactivation domain.

22 n of Ser63/Ser73 located in the NH2-terminal transactivation domain.

23 YA is only a tyrosine phosphatase and has no transactivation domain.

24 al transducer and activator of transcription transactivation domain.

25 soforms that contain (TA) or lack (DeltaN) a transactivation domain.

26 esidues regulates p107 affinity for the E2F4 transactivation domain.

27 n maps to a conserved site within the POU1F1 transactivation domain.

28 in reader module, and by employing an acidic transactivation domain.

29 eraction was determined to be near the FOXO3 transactivation domain.

30 MDMX that has sequence similarity to the p53 transactivation domain.

31 man cells, whereas the RRs were fused with a transactivation domain.

32 e variant of p63, which lacks the N-terminal transactivation domain.

33 minal Rel homology domain and the C-terminal transactivation domain.

34 3 by binding separately or in concert to its transactivation domain.

35 the TIP60 acetyltransferase domain and c-Myb transactivation domain.

36 TNFalpha with a truncated HSF1 that lacked a transactivation domain.

37 original Nrf2 (now Nrf2a) but lacks the Neh4 transactivation domain.

38 ylates NFAT1 in Ser-32 within its N-terminal transactivation domain.

39 ecruit coactivators via HIF-alpha C-terminal transactivation domains.

40 ides derived from the p63 and p73 N-terminal transactivation domains.

41 AT NH2-terminal modulatory and COOH-terminal transactivation domains.

42 the rel homology domain but not at its known transactivation domains.

43 he combined properties of amino terminal and transactivation domains.

44 elenoprotein, is proposed to carry redox and transactivation domains.

45 ains were tightly bound to the Neh4 and Neh5 transactivation domains.

46 dent phosphorylation within their respective transactivation domains.

47 ented phosphorylation of Ser(536) within the transactivation domain 1 of NF-kappaB p65/RelA, a critic

48 evolution into v-Rel are deletion of c-Rel's transactivation domain 2 (cTAD2) and mutations in cTAD1.

49 nstrate direct binding of both ssDNA and the transactivation domain 2 of p53 (p53TAD2) to DBD-F, as w

50 PDX-1 consists of an N-terminal transactivation domain, a homeodomain responsible for DN

51 /p300 (CBP/p300) that binds to the HIF-alpha transactivation domain, a new group of transcription coa

52 ontain a PST (Proline-Serine-Threonine)-rich transactivation domain, a threonine phosphatase motif (T

53 identified in the NH2-terminal region of the transactivation domain: a cluster of weak phosphorylatio

54 ion of target genes by GR is mediated by two transactivation domains: activation function 1 (AF1) in

55 e effects of the three MAPK pathways on Nrf2 transactivation domain activity demonstrated that both E

56 TAK1, predominantly via PPARalpha N-terminal transactivation domain (AF-1) thereby masking the TAK1 k

57 of breast cancers, contains an unstructured transactivation domain (AF1) in its N terminus that is a

58 tly as a recombinant peptide, the N-terminal transactivation domain (AF1) of the GR shows little stru

59 Expression of the Myc transactivation domain alone induces a transcription-ind

60 Loss of the RelB transactivation domain alters NF-kappaB-dependent transc

61 ng on the C-terminal ligand-binding and AF-2 transactivation domains, an assembly of an active transc

62 d proteins, called STATgamma, which lack the transactivation domain and behave as functional dominant

63 LX1 is a critical component of the transactivation domain and has been shown to mediate C/E

64 ssays identified that Stat3 binds to the p65 transactivation domain and is present in the NF-kappaB D

65 lass of isoforms, which lacks the N-terminal transactivation domain and is synthesized from an intern

66 8), located at the end of the amino-terminal transactivation domain and next to the Pit1-Oct-Unc86 (P

67 the presence of p50 homodimers, which lack a transactivation domain and rely on the transcriptional c

68 ta suggest that the Neh3 domain may act as a transactivation domain and that it is possibly involved

69 lar ATM kinase through its carboxyl-terminal transactivation domain and that this interaction blocked

70 cate that the interaction occurs via the p53 transactivation domain and the Aurora A catalytic domain

71 o1, an activity dependent on M303 in c-Myb's transactivation domain, and likely the recruitment of co

72 h required expression of both the N-terminal transactivation domain, and the C-terminal ligand bindin

73 nctional activity to serve as an independent transactivation domain, and the combination of three seq

74 However, mutants of E2F-1 that lack the transactivation domain are still able to induce cell dea

75 pression, we show that HOXA9 DNA binding and transactivation domains are essential.

76 d identified S118 within the N-terminal AF-1 transactivation domain as an additional element for regu

77 creen was performed using the p65 C-terminal transactivation domain as bait and identified the produc

78 and the S442D change increases activity in a transactivation domain assay.

79 addition, we demonstrate that transformation/transactivation domain-associated protein (TRRAP) and Ti

80 TAp63 isoforms possess a transactivation domain at the N terminus and are able to

81 We further show that the transactivation domain at the NH(2) terminus of p63 repr

82 d Chk1-dependent phosphorylation of the RelA transactivation domain at threonine 505, a site required

83 The acidic transactivation-domain-bearing (TA) isoforms of p63 and

84 cture, but an important pocket near the AF-2 transactivation domain becomes accessible only in struct

85 l half of the AhR, and the degeneracy in the transactivation domain between the mAhR and the hAhR res

86 The HIF-1alpha and CITED2 transactivation domains bind to TAZ1 through helical mot

87 A molecule of VH9 was located in each transactivation domain binding site, and the four non-MD

88 n of residues S650 and S975 weakens the E2F4 transactivation domain binding.

89 domain, which overlaps with the site of E2F transactivation domain binding.

90 The Myc transactivation domain binds to the transcription initia

91 The beta-catenin transactivation domain bound directly to isolated MED12

92 The transactivation domain but not the DNA binding domain of

93 5-37 kDa that retains intact DNA-binding and transactivation domains but lacks the 147 amino acids at

94 kDa that comprises the IRF dimerization and transactivation domains but lacks the DNA-binding domain

95 ation required a transcriptionally competent transactivation domain, but not the DNA binding function

96 phosphorylated at multiple sites within its transactivation domain by the JNKs, and c-Jun phosphoryl

97 the binding interface between the C-terminal transactivation domain (C-TAD) of hypoxia-inducible fact

98 roline hydroxylation motifs and a C-terminal transactivation domain (C-TAD) with an asparagine hydrox

99 hypoxic activation of HIF-1alpha C-terminal transactivation domain (C-TAD), but not HIF-1alpha-N-ter

100 g domain, dimerization domain, or C-terminal transactivation domain [C-TAD]) of HIF-2alpha with the a

101 xylation of residue Asn803 in the C-terminal transactivation domain (CAD) of hypoxia-inducible factor

102 -Cas9 proteins (dCas9) fused to heterologous transactivation domains can act as a potent guide RNA se

103 ulated genes strongly suggests that specific transactivation domains can be a major determinant of ge

104 other P63 isoform which lacks the N-terminal transactivation domain compared to TAP63alpha, using the

105 of 20S (APIS), binds specifically to the E1A transactivation domain, conserved region 3 (CR3).

106 However, we found that a longer N-terminal transactivation domain construct p53(1-57) bound tightly

107 ts suggest that similar mutations in the REL transactivation domain contribute to the development of

108 omoter, whereas NFI-A-short, which lacks the transactivation domain, counteracted the activation.

109 s HIF-1alpha by hydroxylating the C-terminal transactivation domain (CTAD) of HIF-1alpha at HIF-Asn(8

110 sactivation domain (NTAD) and the C-terminal transactivation domain (CTAD).

111 Only STAT5A and its transactivation domain-deficient mutant STAT5ADelta749 s

112 element-controlled reporter through an Arnt transactivation domain-dependent mechanism.

113 erminal half of the receptor, containing the transactivation domain, determines the cellular localiza

114 of several other serine residues within the transactivation domain did not substantially affect REL'

115 However, the transactivation domain does not appear to play a role in

116 We propose that Myc transactivation domain-driven RNA Pol II CTD phosphoryla

117 bit the specific association between the E2F transactivation domain (E2F(TD)) and the Rb pocket domai

118 such that it mimics and directly blocks E2F transactivation domain (E2F(TD)) binding.

119 s MEF2C via three residues in the C-terminal transactivation domain, establishing MEF2C as a direct t

120 that either contain (TA) or lack (DeltaN) a transactivation domain, fail to develop stratified epith

121 alization signal; a DNA-binding domain and a transactivation domain follow.

122 Phosphorylation of a p53 transactivation domain fragment at Ser(20) by these enzy

123 EWS-FLI1 harbors a strong transactivation domain from EWSR1 and the DNA-binding ET

124 t aspartic acid 137 separates the N-terminal transactivation domain from the C-terminal DNA binding a

125 scaffolds for the interaction of disordered transactivation domains from a wide variety of partners,

126 IF-1 transcriptional activity and HIF-1alpha transactivation domain function by oxygen-independent me

127 MCM3 inhibits transactivation domain function, whereas MCM7 enhances H

128 The fact that a dominant transactivation domain fused to Meis1 replaces the essen

129 demonstrated that different segments of Nrf2 transactivation domain have different transactivation po

130 eptides that display key residues of the p53 transactivation domain have emerged as bona fide clinica

131 ons of wild-type or mutant p53 with inactive transactivation domain I (p53(Q22/S23)) undergo apoptosi

132 and dimerization domains but differ in their transactivation domains, implying they may have unique t

133 In contrast, the transactivation domain in ELK1 was only required for act

134 and multiple site phosphorylation of the p53 transactivation domain in mediating its interaction with

135 d functional dominance of the NH(2)-terminal transactivation domain in the steroid receptor subfamily

136 rylates Thr90 of the Tal1 protein within its transactivation domain in vitro and in vivo.

137 Expression of the Myc transactivation domain increases CDK mRNA cap methylatio

138 N-terminal phosphorylation of the c-Jun transactivation domain increases target gene transcripti

139 ytokine production, in part by targeting the transactivation domain-induced recruitment of the histon

140 3alpha, a p63 isoform lacking the N-terminal transactivation domain, induces epithelial-mesenchymal t

141 y GSK3beta at three specific residues in its transactivation domain inhibits MEF2D transcriptional ac

142 The transactivation domain initiates with an extended region

143 Pax transactivation-domain interacting protein (PTIP) is a w

144 hy (SBMA), and the nuclear protein PTIP (Pax Transactivation-domain Interacting Protein), a protein w

145 on timing regulatory factor 1 (RIF1) and Pax transactivation domain-interacting protein (PTIP), in th

146 Pax transactivation domain-interacting protein (PTIP, or PAX

147 RCA1 C-terminal) domain-containing PTIP (Pax transactivation domain-interacting protein) chromatin re

148 oted by the BRCT domain-containing PTIP (Pax transactivation domain-interacting protein).

149 Pax2 transactivation domain interaction protein (PTIP), a pro

150 the recently described nuclear protein, Pax2 transactivation domain interaction protein (PTIP)-associ

151 -terminal region of Elf3, which contains the transactivation domain, interacts with its C terminus, w

152 ults indicate that precise folding of the E2 transactivation domain is crucial for its interaction wi

153 Although its C-terminal transactivation domain is dispensable for transcriptiona

154 ation, their relevance in the amino-terminal transactivation domain is unclear.

155 n factor c-Jun, at multiple sites within its transactivation domain, is required for JNK-induced neur

156 l for mammary gland development and contains transactivation domain isoforms, which have tumor-suppre

157 tor both in vitro and in vivo through a Gli3 transactivation domain (MBD; MED12/Mediator-binding doma

158 Through binding to p53 at its N-terminal transactivation domain, mdm2 directly blocks the transcr

159 within the N-terminal 35 amino-acid minimal transactivation domain (MTD).

160 erine-rich N-terminal region (called minimal transactivation domain, MTD), which, when combined with

161 Importantly, replacement of the N-terminal transactivation domain (N-TAD) (but not the DNA binding

162 nal activation domains called the N-terminal transactivation domain (NTAD) and the C-terminal transac

163 The NH(2)-terminal transactivation domain, nuclear localization signal, and

164 consisting of a LexA DNA binding domain, the transactivation domain of a transcriptional activator, a

165 ribed: (i) pocket protein binding blocks the transactivation domain of activator E2Fs, inhibiting E2F

166 KLF4 directly interacts with the C-terminal transactivation domain of beta-catenin and inhibits p300

167 n of Tax1BP1 interacting with the N-terminal transactivation domain of BPV1 E2.

168 Thus the transactivation domain of c-Jun recruits Mbd3/NuRD to AP

169 the folding of the intrinsically disordered transactivation domain of c-Myb (c-Myb) upon binding its

170 X domain of the CREB-binding protein and the transactivation domain of c-Myb.

171 tivated protein (MAP) kinase site within the transactivation domain of C/EBPepsilon, as being phospho

172 gamma fusion protein that is composed of the transactivation domain of CREB3L2 and all functional dom

173 The transactivation domain of E2 is crucial for interaction

174 The transactivation domain of E2 is required for each of the

175 cient cell lines and that the amino-terminal transactivation domain of E2 mediates association with t

176 om G1 to S phase, by directly binding to the transactivation domain of E2F and by binding to the prom

177 ciferase construct that was dependent on the transactivation domain of E2F1.

178 This amino acid lies in the transactivation domain of EBNA-2, and the S442D change i

179 l regulation of the intrinsically disordered transactivation domain of ERalpha.

180 pendently recruits one SRC-3 protein via the transactivation domain of ERalpha; the two SRC-3s in tur

181 l, Sp1-interactive domain and the C-terminal transactivation domain of FoxO4 are required for FoxO4-a

182 PTEN and FOXO3a regulate the transactivation domain of HIF-1alpha.

183 cetyltransferase activity, by the C-terminal transactivation domain of HIF-alpha (HIF-alphaCAD).

184 a short oligopeptide derived from a minimal transactivation domain of human beta-catenin was stronge

185 Using a series of deletion mutants, the transactivation domain of IGFBP-5 was mapped to its N-te

186 ing mutations were located in the C-terminal transactivation domain of KAT6A: NM_001099412.1: c.3116_

187 A PY motif in a transactivation domain of KLF5 is necessary for its inte

188 a 56-amino-acid sequence adjacent to a known transactivation domain of KLF5 significantly reduced its

189 typical point mutation in the amino-terminal transactivation domain of Myc(His), suggesting that most

190 r(893)), all of which are located within the transactivation domain of myocardin.

191 ajor satellite transcription, and the strong transactivation domain of NANOG is required for this org

192 -dependent) phosphorylation of Ser536 in the transactivation domain of NF-kappaB p65.

193 The transactivation domain of NFAT3 is found between amino a

194 a specific in vitro interaction between the transactivation domain of p53 (p53TAD) and a segment of

195 The interaction between the transactivation domain of p53 (p53TAD) and the N-termina

196 ns that have a higher affinity for the BOX-I transactivation domain of p53 and a reduced I(0.5) for p

197 The MDM2 N-terminal domain can bind to the transactivation domain of p53 and downregulate its abili

198 E1A efficiently competes with the N-terminal transactivation domain of p53 for binding to TAZ2 and th

199 The N-terminal transactivation domain of p53 interacts with several dom

200 We found that the transactivation domain of p53 made specific interactions

201 ve shown that Ser(20) phosphorylation in the transactivation domain of p53 mediates p300-catalyzed DN

202 HDM2 binds to an alpha-helical transactivation domain of p53, inhibiting its tumor supp

203 TFAM binds primarily to the N-terminal transactivation domain of p53, with a K(d) of 1.95 +/- 0

204 y MDM2 and/or MDMX binding to the N-terminal transactivation domain of p53.

205 clin/Cdk9 kinase complexes was mapped in the transactivation domain of p53.

206 f FAK directly interacts with the N-terminal transactivation domain of p53.

207 e N-terminal domain of MDM2 (MDM2N) with the transactivation domain of p53.

208 In addition, the N-terminal transactivation domain of p63 is indispensable for its p

209 involves phosphorylation of Ser(536) in the transactivation domain of RelA.

210 demonstrate that phosphorylation within the transactivation domain of RelA/p65(S536) displaces SMRT-

211 705)-STAT3 and indicated that the C-terminal transactivation domain of RTA was required for enhancing

212 gh its Armadillo repeats with the C-terminal transactivation domain of Sox9.

213 induced phosphorylation at serine 754 in the transactivation domain of STAT3.

214 The 55-residue C-terminal transactivation domain of Stat3alpha is deleted in Stat3

215 ively active Stat5a, but did not require the transactivation domain of Stat5a.

216 udy demonstrates for the first time that the transactivation domain of the AhR influences important b

217 The transactivation domain of the E2 protein is necessary an

218 led by Delta40p53, a p53 isoform lacking the transactivation domain of the full-length protein that m

219 The interaction between the acidic transactivation domain of the human tumor suppressor pro

220 cific RING-B-box E3 ligase and ligand of the transactivation domain of the serum response transcripti

221 minal domain of MDM4 binds to the N-terminal transactivation domain of the tumor suppressor p53 and i

222 from the intrinsically disordered N-terminal transactivation domain of the tumor suppressor p53, both

223 ctrum of amino-acid substitutions within the transactivation domain of the v-maf avian musculoaponeur

224 f the IGF binding, nuclear localization, and transactivation domain of this multifunctional IGFBP.

225 F1 to the DNA binding domain of Gal4 and the transactivation domain of VP16, respectively, showing th

226 edicted to result in the loss of part of the transactivation domain of YAP1, and sequencing of cDNA f

227 Here, we identify serine 118 in the transactivation domain of YY1 as the site of CK2alpha ph

228 ERGalt retains the DNA-binding and transactivation domains of ERG, but it inhibits wild-typ

229 on factor sequences reveals that established transactivation domains of many transcription factors co

230 strated that the acidic domain, one of three transactivation domains of MTF-1, is required for recrui

231 genesis studies indicate that the C-terminal transactivation domains of Myocd and Smad3 are required

232 mplicated the RBPjk-association molecule and transactivation domains of Notch3 in generating choroida

233 apoptosis is reliant on the DNA-binding and transactivation domains of p53 but not on the acetylatio

234 ch four domains of p300 wrap around the four transactivation domains of p53.

235 3) Both zinc finger and glutamine-rich transactivation domains of Sp1 are involved in the Sp1-m

236 reas the DeltaN isoforms (lacking the acidic transactivation domain) of p63 and p73 are frequently ov

237 at select serine residues in the C-terminal transactivation domain on REL's transforming ability.

238 Two transactivation domains, one N-terminal and one C termin

239 -dependent degradation domain and C-terminal transactivation domain, our understanding of the contrib

240 A GATA4 mutation in the transactivation domain, p.G115W, was identified in famil

241 A well studied short sequence of the p53 transactivation domain, p53(15-29), binds weakly to four

242 dy, we probed the anticancer therapeutic p53 transactivation domain (p53TAD)/MDM2 interaction and its

243 transactivation potential of different Nrf2 transactivation domain regions by using the Gal4-Nrf2 ch

244 Interestingly, disruption of the transactivation domain relieves the autoinhibition of El

245 n because AHR mutants lacking DNA binding or transactivation domains repressed E2F-dependent expressi

246 L14 activates transcription in yeast, with a transactivation domain residing within the N-terminal re

247 It binds to the transactivation domain (residues 1-61) of p53 via an ext

248 rther delineate the functional region of the transactivation domain responsible for mitotic chromosom

249 Deletion of the transactivation domain retains the chromatin binding abi

250 cotransfection of an Rta mutant lacking its transactivation domain robustly restores transcriptional

251 a Gal4-Nrf2-(1-370), which contains the full transactivation domain showed very potent transactivatio

252 coding for proteins containing an N-terminal transactivation domain (TA isoforms) and for proteins la

253 horylated by IkappaB kinase (IKK) at S536 in transactivation domain (TAD) 1.

254 t lacks highly conserved residues within the transactivation domain (TAD) and has weak affinity for k

255 lly contain a DNA-binding domain (DBD) and a transactivation domain (TAD) and, although there are sev

256 In addition, the transactivation domain (TAD) appears to determine the pr

257 eracted with six proteins of 35-152 kDa, its transactivation domain (TAD) interacted with four protei

258 The C-terminal transactivation domain (TAD) of BMAL1 (brain and muscle

259 ultiple residues within the carboxylterminal transactivation domain (TAD) of c-Fos, thus resulting in

260 ween the intrinsically disordered N-terminal transactivation domain (TAD) of p53 and the TAZ1 and TAZ

261 The transactivation domain (TAD) of p53 binds directly to se

262 binding interactions between the N-terminal transactivation domain (TAD) of p53, the TAZ1, TAZ2, KIX

263 ding of MDM2 to the intrinsically disordered transactivation domain (TAD) of p53.

264 le Ser/Thr residues that were located in the transactivation domain (TAD) of Stat3 and this in turn c

265 ivators on an alpha-helix located within the transactivation domain (TAD) of the BMAL1 C terminus.

266 interaction domain in the acidic C-terminal transactivation domain (TAD) of TRIP-Br2.

267 al ensembles of the intrinsically disordered transactivation domain (TAD) of tumor suppressor p53 and

268 rix binding domain (SAPD) and the C/EBPdelta transactivation domain (TAD).

269 e Rel homology domain (RHD) and a C-terminal transactivation domain (TAD).

270 te that the latter residues constitute their transactivation domain (TAD).

271 h ligand-induced phosphorylation of the PRLr transactivation domain (TAD).

272 or, p53, requires direct binding between its transactivation domain (TAD, 1-57) and the transcription

273 family bind to the intrinsically disordered transactivation domain (TAD; residues 1-57) and C-termin

274 histone acetyltransferase (HAT) activity and transactivation domains (TAD) play essential roles for t

275 BP TAZ1 and TAZ2 domains in complex with the transactivation domains (TADs) of signal transducer and

276 amphioxus HIFalpha isoforms had 2 functional transactivation domains (TADs).

277 in the endoplasmic reticulum (ER) whilst its transactivation domains [TADs, including acidic domain 1

278 epithelial isoform containing the N-terminal transactivation domain (TAp63).

279 ingle amino acid substitutions within the E2 transactivation domain that are defective for both trans

280 influence Elf3 binding to DNA, including the transactivation domain that behaves as an autoinhibitory

281 roximity and orientation, and the C-terminal transactivation domain that interacts specifically with

282 pression, including a DNA binding domain and transactivation domains that are contained in the C-term

283 ic Notch protein (Notch1 ankyrin with Notch3 transactivation domain) that displayed superior signalin

284 f several functional domains: the N-terminal transactivation domain, the central sequence-specific DN

285 ted the phosphorylation of STAT1-S727 in the transactivation domain, thereby reducing recruitment of

286 ulatory motifs are located in the C-terminal transactivation domain, they are likely to be important

287 nted through direct recruitment of the NANOG transactivation domain to major satellites.

288 a more 'stand-alone' situation target Oct-4 transactivation domains to DNA using heterologous bindin

289 e relative contribution of the two HIF2alpha transactivation domains to hypoxic gene activation and r

290 et domain, and that both E1A-CR1 and the E2F transactivation domain use similar conserved nonpolar re

291 f the bovine papillomavirus type 1 (BPV1) E2 transactivation domain was generated based on its homolo

292 ese functions were restored only when a VP16 transactivation domain was substituted.

293 e human papillomavirus type 16 E2 N-terminal transactivation domain, we found that amino acids requir

294 cible inhibitory mutant of Sox9, lacking the transactivation domain, we show that Sox9 function is re

295 As Fra1 lacks transcriptional transactivation domains, we propose that Fra1 inhibits B

296 bstitutions in each conserved residue of the transactivation domain were tested for their ability to

297 e inhibitory domain (LID) that restrains the transactivation domain when glucose catabolism is minima

298 ous KLF7, we created a chimera with the VP16 transactivation domain, which displayed enhanced neurona

299 f these conserved residues revealed that the transactivation domain, which localized Ser(756) but not

300 ough its intrinsically disordered C-terminal transactivation domain with the TAZ1 (also known as CH1)