ライフサイエンスコーパス: transactivation function

1 is the critical step for FGF2-induced Runx2 transactivation function.

2 e CBP interaction domain of KLF5 reduces its transactivation function.

3 e present study provide a mechanism for KLF5 transactivation function.

4 r kappaB (NFkappaB) DNA-binding activity and transactivation function.

5 d N-terminal of p53 (p53TAD) and inhibit its transactivation function.

6 loss of ligand binding and ligand-dependent transactivation function.

7 y important roles in both ligand binding and transactivation function.

8 protein stability, nuclear localization and transactivation function.

9 e hypothesis that cyclin D1 targets the AF-1 transactivation function.

10 These 'hot spot' mutations abrogate p53's transactivation function.

11 cellular factors that may be involved in its transactivation function.

12 in that binds to HIF-1alpha and inhibits its transactivation function.

13 la (A) and Asp (D), both of which retain the transactivation function.

14 duplication regulatory pathways require its transactivation function.

15 nd that this interaction is crucial for PTTG transactivation function.

16 nase cascade plays a role in regulating PTTG transactivation function.

17 ylation site plays an essential role in PTTG transactivation function.

18 is novel role of E2F-1 is independent of its transactivation function.

19 ng that this interaction is critical for p53 transactivation function.

20 Furthermore, this motif is not critical for transactivation function.

21 occurs independently of its transcriptional transactivation function.

22 recruit CREB binding protein (CBP) for their transactivation function.

23 modifying the cysteine thiols, inhibits Tat transactivation function.

24 tly leads to an inhibitory effect on c-Jun's transactivation function.

25 1 protein can inhibit both GATA-1 and GATA-2 transactivation function.

26 nd demonstrate that HPV16 E6 can inhibit its transactivation function.

27 t TAK is a cellular factor that mediates Tat transactivation function.

28 e II, is a cofactor for Tat and mediates its transactivation function.

29 cell line results in an inhibition of p53's transactivation function.

30 ns of the PST domain are responsible for the transactivation function.

31 to Glu-271 substitution potentiated the CREB transactivation function.

32 ed the mechanism of action of the N-terminal transactivation function.

33 uppression of senescence by p53 required its transactivation function.

34 to inhibit cell growth is dependent upon its transactivation function.

35 n factor, Gal4 (residues 1 to 147), exhibits transactivation function.

36 t phosphorylation is not essential for Tat-2 transactivation function.

37 mechanisms by which ERalpha suppresses p53's transactivation function.

38 l cycle progression and also for optimal E2F transactivation function.

39 nd this modification is important in ERalpha transactivation function.

40 by directly binding Runx2 and repressing its transactivation function.

41 BP/p300 recruitment and KIX-independent CREB transactivation function.

42 H2 and COOH domains, known to be involved in transactivation function.

43 1 is involved in the regulation of NF-kappaB transactivation function.

44 at is responsible for the ligand-independent transactivation function.

45 ly non-redundant and indispensable for C-TAD transactivation function.

46 dly reduced the estrogen receptor-alpha (ER) transactivation functions.

47 s interaction is required for specific Ets-1 transactivation functions.

48 nction as a coactivator for both AF1 and AF2 transactivation functions.

49 y a role in the growth factor-mediated STAT3 transactivation functions.

50 d not require its replication initiation and transactivation functions.

51 nd participated in growth factor-mediated ER transactivation functions.

52 trogen receptor, modulates estrogen receptor transactivation functions.

53 gamma2 could not repress estrogen-induced ER transactivation functions.

54 s suggests a potential interplay between the transactivation function-1 and -2 domains of ERalpha and

55 A complementary mutant mouse lacking the transactivation function AF-2 of ERalpha (ERalpha-AF2(0)

56 ant-negative RXR alpha (dnRXR alpha) lacking transactivation function AF-2 to differentiated suprabas

57 rolaxifene antagonize one estrogen receptor transactivation function (AF-2) and agonize another (AF-

58 A ligand-inducible transactivation function (AF-2) exists in the extreme ca

59 ne receptors and contains a ligand-dependent transactivation function, AF-2.

60 P-binding domain that reduce GTP-binding and transactivation function also reduce self-association.

61 horylation of p73 at serine235 abrogates its transactivation function and causes cytoplasmic sequestr

62 pendent phosphorylation, augmentation of Sp1 transactivation function and DNA binding activity.

63 -mediated MED12 depletion enhanced, both MBD transactivation function and Gli3 target gene induction

64 ass II promoter, resulting in an increase in transactivation function and in the expression of MHC cl

65 s a dual function domain, mediating both its transactivation function and its direct mitochondrial ap

66 tumor-derived p53 mutants which retain MDM2 transactivation function and possess partial growth supp

67 n to an inactive, stable p73 mutant restored transactivation function and rendered the mutant protein

68 at heterodimerization activates AhR's latent transactivation function and silences that of Arnt.

69 de novel insights into the regulation of p53 transactivation function and suggest that Hzf functions

70 AF2 domain of ERRalpha1 is essential for the transactivation function and that deletion or mutation a

71 protein with TFIIB is necessary for its full transactivation function and that the IE-TFIIB interacti

72 We also demonstrate that Z decreases CREB transactivation function and that this inhibitory effect

73 stimulates estrogen receptor-alpha (ERalpha) transactivation functions and associates with the endoge

74 both the levels of NF-kappaB DNA binding and transactivation function, and both phases are dependent

75 IF3 is an ER coactivator, hyperstimulated ER transactivation functions, and associated with the endog

76 es with other ER coactivators, stimulates ER-transactivation functions, and associates with the endog

77 DeltaNp73 efficiently counteracts transactivation function, apoptosis, and growth suppress

78 beta that reduce or abolish ligand-dependent transactivation function are associated with resistance

79 lts illustrate that distinct DNA binding and transactivation functions are encoded within the structu

80 Although ERalpha transactivation functions are regulated by co-activator

81 -p53 interaction appears to downmodulate p53 transactivation function as indicated by PBK/TOPK knockd

82 mechanistic role in conferring an optimal ER transactivation function as well as the proliferation of

83 MTA1s peptide effectively repressed ERalpha transactivation function, as evidenced by the estrogen r

84 V-induced serine 392 phosphorylation and p53 transactivation function at higher levels of DRB suggest

85 s-BS)-dependent transcription and contains a transactivation function at its C-terminus.

86 region, which contains a ligand-independent transactivation function; (b) dependent on RXR homodimer

87 oblastoma protein but was independent of its transactivation function because AHR mutants lacking DNA

88 at the I87R mutant protein not only lost the transactivation function but also failed to bind DNA by

89 key Pro(139) residue not only disrupted the transactivation function but also resulted in the loss o

90 that this activity was independent of B-Myb transactivation function, but correlated with its capaci

91 stically increases the RA-dependent RARalpha transactivation function by enhancing the interaction of

92 ified p53, implicating modification of p53's transactivation function by protein-protein interaction.

93 ptional corepressor that inhibits HIF-1alpha transactivation function by recruiting histone deacetyla

94 human breast cancers, repression of ERalpha transactivation functions by LMO4 might contribute to th

95 ilar DNA elements as ERalpha and confers its transactivation function constitutively.

96 y, further analysis in yeast showed that the transactivation function could be retained even in the p

97 A-binding domain, while not compromising p53 transactivation function (D48H/D49H and W53S/F54S), did

98 loss of subnuclear targeting and associated transactivation functions encoded by the C-terminus of t

99 1(Waf1/Cip1) (Waf1), a major target of p53's transactivation function, has been shown to be one of th

100 e duplication in a manner independent of its transactivation function in addition to its transactivat

101 volved in the negative regulation of ERalpha transactivation function in breast cells.

102 o and in vivo, and Foxp1/2/4 repressed Runx2 transactivation function in heterologous cells.

103 tiestrogenic action of tamoxifen upon the ER transactivation function in hormone-sensitive cells.

104 Finally, while SIVagm vpr retains its transactivation function in human cells, it is unable to

105 t on normal squamous differentiation and p53 transactivation function in keratinocytes.

106 virus type 1 (HTLV-1) Tax can inactivate p53 transactivation function in lymphocytes.

107 es loss of YAP1, implicating transcriptional transactivation function in mediating force-enhanced cel

108 as a coactivator of RXRalpha, increasing its transactivation function in response to 9-cis-RA as evid

109 ERalpha has a ligand-dependent transactivation function in the ligand binding domain of

110 The important transcriptional transactivation function in the N-terminal part of the g

111 -Myb is associated with a marked increase in transactivation function in U-2 OS cells.

112 everse the mdm2-mediated inhibition of p53's transactivation function in vivo would probably target M

113 er-containing p53 target gene, modulates p53 transactivation functions in an autoregulatory feedback

114 otion, LMO4 overexpression repressed ERalpha transactivation functions in an HDAC-dependent manner.

115 can serve as a coactivator, potentiating the transactivation functions in steroid receptor HBDs, poss

116 Ser-271 but not Ser-133, and activates CREB transactivation function including brain-derived neurotr

117 , and suppresses centrosome duplication in a transactivation function-independent manner.

118 ese mutant proteins retained transcriptional transactivation functions, indicating that phosphorylati

119 Regulation of NF-kappaB transactivation function is controlled at several levels

120 s, we demonstrate that Tax inhibition of p53 transactivation function is independent of sequence-spec

121 E2F-1 transactivation function is inhibited by cyclin A-kinase

122 X2 proteins are activators of transcription; transactivation function is located in SYT.

123 This transactivation function is lost in tumor-derived pRb mu

124 of the Z(S186A) mutant form of ZEBRA, whose transactivation function is manifest only by coexpressio

125 Thus, abrogation of transactivation function is not sufficient for mutant p5

126 h inhibition, suggesting that an E2-specific transactivation function is required for growth arrest.

127 a CDK inhibitor and a major target of p53's transactivation function, is an effector of p53-mediated

128 of Cdk2-cyclin E and a major target of p53's transactivation function, is involved in coordinating th

129 The main determinants for the transactivation function lie within the structurally dis

130 racellular domain of ErbB4, and inhibits its transactivation function mediated through Yes-associated

131 that Fkbp52 exerts downstream effects on the transactivation function of AR.

132 killifish AHRR inhibited the TCDD-dependent transactivation function of both AHR1 and AHR2.

133 , for degradation, whereas it suppresses the transactivation function of both proteins.

134 ut repressed transcription by inhibiting the transactivation function of C/EBP.

135 -binding protein (CBP), and it increases the transactivation function of CBP.

136 Although the transactivation function of CIITA is well characterized,

137 The transactivation function of CREB is primarily regulated

138 o, indicating that GADD45beta influences the transactivation function of DNA-bound C/EBPbeta.

139 ng that this association is relevant for the transactivation function of E1A and VP16.

140 We conclude that the transactivation function of E2 is not essential for the

141 ion of the E2-Brd4 interaction abrogates the transactivation function of E2, indicating that Brd4 is

142 t transcriptional repression rather than the transactivation function of E2F1 may be involved in its

143 Activation of Notch interferes with the transactivation function of EBNA2, downregulates the exp

144 The p53His175 mutant suppresses the transactivation function of endogenous p53 in these cell

145 To determine whether abrogation of the transactivation function of endogenous p53 was important

146 ggesting that MTA1 might inhibit CAK-induced transactivation function of ER by recruiting HDAC.

147 The transactivation function of Ets-1 correlated with its ab

148 hese results suggest that STRAP inhibits the transactivation function of EWS by displacing p300 from

149 We compared ligand-induced transactivation function of full-length AHR1s from chick

150 The transactivation function of GP82 was not limited to GPCM

151 easome function is possibly required for the transactivation function of HBX.

152 Here we show that the transactivation function of HSF is conferred by the extr

153 hway, we found that triptolide abrogates the transactivation function of HSF1 without interfering in

154 phorylation also dramatically stimulated the transactivation function of HSF1: exposure to calyculin

155 activity of CBP does not play a role in the transactivation function of KLF5 nor does it acetylate K

156 We demonstrated that the transactivation function of KLF5 was enhanced by CREB-bi

157 ression of SHDAg does not interfere with the transactivation function of LHDAg.

158 ine-dependent transrepressor to downregulate transactivation function of MEF2 factors and that altern

159 mbined defects in DNA binding activities and transactivation function of mutant 219InsGPAX9 likely al

160 ed by mutant p53 in H1299 cells requires the transactivation function of mutant p53.

161 activity in Rb(-/-) fibroblasts restores the transactivation function of MyoD and the expression of a

162 ion of PPXY-1, but not PPXY-2, inhibited the transactivation function of NF-E2, providing support for

163 Here we demonstrate that Akt targets the transactivation function of NF-kappaB by stimulating the

164 Here we show that the transactivation function of NF-kappaB is also regulated

165 These data indicate that the transactivation function of NF-kappaB is regulated in pa

166 ed genes by inhibiting either DNA binding or transactivation function of NF-kappaB.

167 a modification proposed to contribute to the transactivation function of NF-kappaB.

168 Induction of the transactivation function of p53 after cellular irradiati

169 A double point mutation that destroys the transactivation function of p53 also abolishes its bindi

170 tration that c-Abl binds to p53, induces the transactivation function of p53 and activates p21 expres

171 Here, we show that Skp2 counteracts the transactivation function of p53 and suppresses apoptosis

172 rminal epitope in the region involved in the transactivation function of p53 and the binding of Mdm2.

173 monstrate here that both the DNA binding and transactivation function of p53 are required for ASPP1 a

174 phosphorylation of p53 at Ser20 enhances the transactivation function of p53 for p21 and mdm-2 in viv

175 sely, ectopic expression of p300 rescues the transactivation function of p53 in cells overexpressing

176 at p300 contributes to the stabilization and transactivation function of p53 in the cellular response

177 xpectedly, RA has been found to activate the transactivation function of p53 in the human embryonal c

178 Tax is able to suppress the transactivation function of p53 in three different cell

179 The uncoupling of the apoptotic function and transactivation function of p53 will also be discussed.

180 Pin1 stimulates the DNA-binding activity and transactivation function of p53.

181 tive N-terminal phosphorylation sites on the transactivation function of p53.

182 factors that appear to be important for the transactivation function of p53.

183 e ability of PTEN to inhibit the TNF-induced transactivation function of p65 is important, because ex

184 ase II (CKII) consensus motif, increases the transactivation function of PU.1.

185 tivation signals regulate the expression and transactivation function of retinoid X receptor (RXR) al

186 promoters, it can dramatically decrease the transactivation function of RRV Orf50 (Rta), which is th

187 nt evidence that ellipticine can restore the transactivation function of several transfected p53 muta

188 inding to the promoter but involves enhanced transactivation function of Sp1 via p38 MAPK activation.

189 cupancy and thereby blocking the synergistic transactivation function of Sp1.

190 induction of apoptosis was separate from the transactivation function of Tat, required expression of

191 uppression of CTD phosphatase is part of the transactivation function of Tat.

192 We analyzed the transactivation function of the acidic segment of the Ah

193 r (AR) gene is inversely correlated with the transactivation function of the AR.

194 We tested whether this transactivation function of the mutant protein is suffic

195 The transactivation function of the PST region has not been

196 on of NF-kappaB as well as by increasing the transactivation function of the RelA/p65 subunit of NF-k

197 Deletion of the hormone-dependent transactivation function of the retinoid X receptor, the

198 utated, thus suggesting that the synergistic transactivation function of the TEF-1-Max heterotypic co

199 in expression of p53 was used to examine the transactivation function of the toxic mutations when exp

200 While the transactivation function of the tumor suppressor p53 is

201 -16 in mammalian cells, had no effect on the transactivation function of their functional orthologs G

202 nted Ras pathway-mediated enhancement of the transactivation function of these proteins.

203 action with a CTD kinase is relevant for the transactivation function of these proteins.

204 tor, was found not to be able to enhance the transactivation function of this mutant, our results ind

205 These results show that the transactivation function of v-Rel is necessary but not s

206 at aa 3 and 9 are critical for an N-terminal transactivation function of v-Rel, and the analysis of s

207 to the VP16 activation domain inhibited the transactivation function of VP16.

208 rved in cycling uninduced cells inhibits the transactivation function of Zta.

209 TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for

210 Moreover, glucose stimulates the transactivation functions of c-Fos and USF1, but not c-J

211 nd provided new evidence to suggest that the transactivation functions of ER might be influenced by t

212 raction is mandatory for the recruitment and transactivation functions of ER or DLC1 to the target ch

213 protein 1 (MTA1) represses ligand-dependent transactivation functions of estrogen receptor-alpha in

214 n modulating the dimerization, stability, or transactivation functions of estrogen receptors.

215 r, UBCH7 showed no significant effect on the transactivation functions of p53 and VP-16 activation do

216 igh correlation between the transforming and transactivation functions of PTTG and also indicate that

217 The oligomerization and transactivation functions of RTA are also essential for

218 ogen-activated protein kinase and stimulated transactivation functions of the ER and expression of en

219 lished the Pak1-mediated phosphorylation and transactivation functions of the ER, while its mutation

220 The transactivation functions of the human androgen receptor

221 not activate transcription and inhibits the transactivation functions of wild-type IPF-1.

222 with the pADH vector unveiled the intrinsic transactivation functions of YY1 and SRF previously not

223 T and CDK9, two critical components for Tat transactivation function on HIV-1 long terminal repeat p

224 fic inhibitor, PP2, resulted in decreased AR transactivation function on two different reporters, mou

225 c-Rel is not sufficient to fully restore the transactivation function; other sequences in the N-termi

226 o acids and to correlate phosphorylation and transactivation function, phosphopeptide maps were produ

227 1 also interacts with RTA and inhibits RTA's transactivation function, preventing the expression of i

228 We found that S305 activation-linked ER transactivation function requires a functional S118, and

229 Activation of RelA/p65 transactivation function requires serines 529 and 536, s

230 estrogen-dependent and estrogen-independent transactivation functions signaled through hER-alpha66 a

231 We previously identified a carboxy-terminal transactivation function termed AF-2 within the last 15

232 at PELP1 modulates transcription factor E2F1 transactivation functions, that PELP1 is recruited to pR

233 e regulatory effect on their transcriptional transactivation function, the C-terminal domain of B-Myb

234 Pin1 impacts both ERalpha protein levels and transactivation function, these data implicate Pin1 as a

235 as a regulator of nuclear receptor-mediated transactivation, functions through recruitment of C-term

236 p53 at least in part depends on its transactivation function to control centrosome duplicati

237 t Nmo phosphorylation of Eya potentiates its transactivation function to enhance transcription of Eya

238 could be explained by recruitment of the Arm transactivation function to the promoters of Hh-target g

239 Mannitol does not regulate binding, transactivation functions, USF1 protein accumulation, or

240 ties of various compounds, we analyzed these transactivation functions using AF-1-truncated and AF-2-

241 Furthermore, an intrinsic transactivation function was observed in the C-terminal

242 identify essential domains required for EKLF transactivation function, we cotransfected a human eryth

243 dy the importance of phosphorylation for p53 transactivation function, we generated mutations at each

244 of molecular mechanisms underlying the Aire transactivation function, we screened an AIRE-dependent

245 various lengths of KLF5 fusion protein, the transactivation functions were localized to 156 amino ac

246 econstituted with active ZAP 70 regained the transactivation function, whereas cells expressing kinas

247 LFS) mutant was found to be defective in its transactivation function, which correlated with its inab

248 criptional complex in which EYA provides the transactivation function while SO provides the DNA bindi

249 These results indicated that a transactivation function within the LBD of the interferi

250 Whereas ZF2 contains the transactivation function, zinc regulation is dependent o