ライフサイエンスコーパス: transactivation potential

1 ty group DNA-binding domain, inhibiting Sox9 transactivation potential.

2 -expression with Ets-2 resulted in increased transactivation potential.

3 nding to RB, all mutants retained their full transactivation potential.

4 n MafA influences both protein stability and transactivation potential.

5 TSA also stimulated PU.1 transactivation potential.

6 tion, and independent of alterations in NFAT transactivation potential.

7 of the receptor, such as ligand affinity or transactivation potential.

8 s but also at other sites that impact on its transactivation potential.

9 at least six isoforms with widely differing transactivation potential.

10 nisms that regulate nuclear translocation or transactivation potential.

11 as does full-length GATA1, but has a reduced transactivation potential.

12 nal 26-nucleotide intron that increases XBP1 transactivation potential.

13 and 688 of the hAhR, which are required for transactivation potential.

14 ppaB as well as stimulation of the NF-kappaB transactivation potential.

15 I to phosphorylate p65 to increase NF-kappaB transactivation potential.

16 esidues 207 to 300) that appears to mask Pip transactivation potential.

17 associate with HNF4 in vivo and enhance its transactivation potential.

18 fers their SAA promoter-binding activity and transactivation potential.

19 erations in HNF-4alpha-binding abilities and transactivation potentials.

20 otein products with distinct DNA binding and transactivation potentials.

21 /Cbfa1 isoforms with possible differences in transactivation potentials.

22 In addition, mutations that reduce the GABP transactivation potential also impair the C1-GABP intera

23 f Nrf2 transactivation domain have different transactivation potential and different MAPKs have diffe

24 n of CREB correlated with a decrease in CREB transactivation potential and reduced interaction betwee

25 uced NF-kappaB activation by controlling its transactivation potential and that this response is asso

26 ellular localization, cofactor interactions, transactivation potential and transcriptional output.

27 dividual REs exhibited marked differences in transactivation potentials and widespread evolutionary t

28 FOXP3, including regulation of DNA binding, transactivation potential, and proteasomal degradation.

29 terminal EYA domain negatively regulates EYA transactivation potential, and that GROUCHO-SINE OCULIS

30 as the Q-rich subdomain is critical for hAhR transactivation potential, and the acidic subdomain by i

31 Consequentially, the disparity in transactivation potential between p63 variants has given

32 A, and the -20A allele confers no additional transactivation potential beyond that of a mutated vecto

33 cetyltransferases may serve to modulate NF-Y transactivation potential by aiding disruption of local

34 We provide evidence that the loss of transactivation potential by ER in the presence of TCDD

35 ansactivation assays, murine B-myb exhibited transactivation potential comparable to that of c-myb.

36 t through binding to E2F and attenuating its transactivation potential, cyclin E does not reverse dom

37 ptor, and mAhR and hAhR have similar overall transactivation potential in a cell-based reporter syste

38 mutant also led to a dramatic decrease in AR transactivation potential in a hormone-dependent manner.

39 Co-expression of Pin1 enhances LSF transactivation potential in reporter assays.

40 f three acidic domains, which exhibit potent transactivation potential in vitro, had no effect on the

41 HDAIs repress both HIF-1alpha and HIF-2alpha transactivation potential independently of von Hippel-Li

42 iminishes cell growth; (2) androgen receptor transactivation potential is augmented by IL-8 and (3) a

43 We and others have previously shown that AR transactivation potential is dependent on the presence o

44 A-S binds directly to Oct-1, exhibits potent transactivation potential, is selectively recruited to t

45 d L3 in the DNA-binding domain that tune the transactivation potential nearly equally in p73, p63 and

46 es directly with the experimentally measured transactivation potential of a large set of mutagenized

47 The transactivation potential of a panel of supertrans p53 m

48 Remarkably, the full transactivation potential of AF-2 is inhibited by the re

49 We show the global viral transactivation potential of all four RTA isoforms and d

50 showed that APH-3 and APH-4 upregulated the transactivation potential of all tested Jun family membe

51 Despite this, CpdA inhibits DNA-binding and transactivation potential of AR.

52 ts demonstrate, for the first time, that the transactivation potential of ARNT in a dimer context can

53 ession of Cx43 in cardiomyocytes reduced the transactivation potential of beta-catenin.

54 veness of MMP-9 promoter and compromised the transactivation potential of both SAF-1 and AP-1.

55 phatase inhibitor, we demonstrated increased transactivation potential of both Sp1 and SAF as a conse

56 iral transactivator, is able to suppress the transactivation potential of c-Myb protein by competing

57 These data suggest that the transactivation potential of CREB may be modulated throu

58 srupt CARD-CARD interactions, diminished the transactivation potential of DC-CIITA.

59 In this study, we investigated the transactivation potential of different Nrf2 transactivat

60 promoter, thereby reducing functionally the transactivation potential of E47 on insulin gene transcr

61 inding ability of ER81 but also enhances the transactivation potential of ER81.

62 We have mapped the transactivation potential of EYA to an internal proline-

63 The transactivation potential of full-length CREB fused to t

64 eacetylase activity is indispensable for the transactivation potential of HIF-alphaCAD and support a

65 roaches, here we show that HDAIs repress the transactivation potential of HIF-alphaCAD.

66 hanism, we provide a model that explains the transactivation potential of homo- and heterotetramers c

67 in kinase A (PKA)-mediated modulation of the transactivation potential of human aryl hydrocarbon rece

68 sidues for interaction and modulation of the transactivation potential of Jun factors.

69 ic bHLH proteins, drastically diminishes the transactivation potential of MyoD and abolishes both p30

70 totic pathway can occur independently of the transactivation potential of p53 in hamster cells.

71 The transactivation potential of p65 following TNF stimulati

72 -kappaB predominantly by upregulating of the transactivation potential of p65.

73 DBH promoter, nor did it alter the decreased transactivation potential of PHOX2B variants in 293T cel

74 ort, we demonstrate that BRMS1 decreases the transactivation potential of RelA/p65 and ameliorates th

75 phosphorylation site considerably lowers the transactivation potential of SAF-1.

76 ed induction of the DNA-binding activity and transactivation potential of SAF-1.

77 and Ser207 residues is required for the full transactivation potential of Smad3, and that these resid

78 ion of Sp1, and insulin further enhanced the transactivation potential of Sp1.

79 protein (CBP) potentiated the NaBu-mediated transactivation potential of Sp1/Sp3, but expressing sev

80 We previously reported that the transactivation potential of SRC-3 is controlled in part

81 results suggest that Thr(757) modulates the transactivation potential of Stat5 by a mechanism(s) tha

82 XAP2 also represses the transactivation potential of the AhR, in contrast to pre

83 ne whether cyclin D1 directly influences the transactivation potential of the androgen receptor, a tr

84 promoter, and p38 MAP kinase, which enhances transactivation potential of the bound NF-kappaB p65 (Re

85 n vitro and was required for stimulating the transactivation potential of the co-activator following

86 PTEN also inhibited the transactivation potential of the cyclic AMP-response ele

87 paB abundance but correlated with diminished transactivation potential of the p65 subunit.

88 ID2 can suppress the transactivation potential of the positive elements of th

89 MEK1 overexpression enhances TCDD-initiated transactivation potential of the receptor.

90 he ability of the deacetylase to inhibit the transactivation potential of the RelA/p65 protein.

91 lear translocation, but rather modulated the transactivation potential of the RelA/p65 subunit of NF-

92 -threonine kinase inhibitor H7 inhibited the transactivation potential of Thr-, Val-, and Asp-Stat5 t

93 As HBZ differentially modulates the transactivation potential of various Jun family members,

94 alanine (Y537F) mutant retains 70-75% of the transactivation potential of wild type hER in a yeast re

95 Luciferase assays were used to examine the transactivation potentials of Otx2 and beta-catenin on t

96 n determining the distinct context-dependent transactivation potentials of the individual T3R isoform

97 during spermatogenesis may reflect distinct transactivation potentials of the two proteins.

98 ATM phosphorylation sites displayed enhanced transactivation potential, resistance to inhibition by I

99 SUMO-1 cotransfection led to augmented Oct4 transactivation potential that was reduced when the Oct4

100 example, the mutant S139F in p73 has higher transactivation potential towards selected REs, enhanced

101 r Jun kinase 1, and does not depend on c-Jun transactivation potential, ubiquitination, or its intera

102 that the effect of phosphorylation on B-Myb transactivation potential was enhanced by phosphorylatio

103 We find that this domain of Stat2 has transactivation potential, which correlates with its bin

104 2) was observed to have dramatically reduced transactivation potential with the plasminogen activator

105 ms showed very low levels of transcriptional transactivation potential with the same reporter genes.

106 sphorylation events on Mi, which up-regulate transactivation potential yet simultaneously target Mi f