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1 3 months after inactivation of tetracycline transactivator.
2 nsa serendipity alpha gene linked to the Tet-transactivator.
3 asing expression of genes controlled by this transactivator.
4 until the recent discovery of NLRC5/class I transactivator.
5 rus protein known primarily as a promiscuous transactivator.
6 silence the expression of ICP0, a key viral transactivator.
7 ins, makes the fusion protein a constitutive transactivator.
8 egatively regulated by ICP4, the major viral transactivator.
9 BHV-4), termed HORF1/2, was a very efficient transactivator.
10 Thus, IE1 is a positive, gene-specific transactivator.
11 s 1 (HSV-1) is that it acts as a promiscuous transactivator.
12 d by expressing the HCMV multifunctional IE1 transactivator.
13 d also impaired nsp1beta's function as a PRF transactivator.
14 PR/Cas9 to disrupt the gene for the class II transactivator.
15 moter for an important viral transcriptional transactivator.
16 nase activation, a classic LRP1-mediated Trk transactivator.
17 to avoid the effect of the virion-associated transactivators.
18 ral or tissue-specific 'tet-on' or 'tet-off' transactivators.
19 imulation of the spared allele by artificial transactivators.
20 tors from the primitive Cbp/p300-interacting transactivator 1 expressing (CITED1+) compartment to the
21 rotein (CBP), p300, and Cbp/p300-interacting transactivator 2 (Cited2) was increased in the amygdala
22 in the early growth response 2 (Egr2/Krox20) transactivator, a critical regulator of peripheral myeli
23 iated with up-regulation of the MHC class II transactivator, a key transcription factor with deacetyl
25 oth necessary and sufficient for PMA-induced transactivator activity in PAI-2-expressing U937 cells.
28 These transacting factors are the class II transactivator and 3 subunits of regulatory factor X (RF
30 r equation) models where the transcriptional transactivator and promoter toggle between inactive and
31 ntrol of the reverse tetracycline-controlled transactivator and the tetracycline operator minimal pro
32 genes, including those expressing additional transactivators and putative oncogenes, are induced in a
34 esized ORF61, as well as IE62, the major VZV transactivator, appeared within 1 h, and they were targe
36 of small interfering RNA targeting class II transactivator attenuates major histocompatibility compl
37 In NPC, NF-kappaB p50/p50 homodimers and the transactivator Bcl-3 were detected on the EGFR promoter.
38 the specific interplay between the cellular transactivator Brn-3a, the environmental smoking-related
39 n, suggesting that it might be not a typical transactivator but an architectural transcription factor
40 a 14-kDa viral protein that acts as a potent transactivator by binding to the transactivation-respons
41 small interfering RNA targeting of class II transactivator can reduce the capacity of human endothel
42 We previously established that the class II transactivator CIITA binds GTP and disruption of the GTP
45 y mechanisms includes repression of class-II transactivator (CIITA) and MHC-II expression in infected
46 on strategies such as inhibition of class II transactivator (CIITA) and MHC-II expression, to survive
47 x (MHC)-II and its master regulator class II transactivator (CIITA) are downregulated in CML compared
48 as defined major histocompatibility class II transactivator (CIITA) as a key factor in mediating thes
50 Although complex, the co-activator class II transactivator (CIITA) is a key regulator of MHC II expr
54 y dependent upon the binding of the class II transactivator (CIITA) to the highly conserved promoters
55 ing on whether MHC-II genes and the class II transactivator (CIITA) were being expressed, two CTCF-de
56 ition of promoter activities of MHC class II transactivator (CIITA), IFN-gamma-activated site (GAS),
57 bition of MNV replication in vitro, class II transactivator (CIITA), interferon regulatory factor 3 (
59 olved interactions between CTCF and class II transactivator (CIITA), the master regulator of major hi
60 show that the promoter IV (pIV) of class II transactivator (CIITA), the master regulator of MHCII ex
61 ruitment of a master regulator, the class II transactivator (CIITA), to the MHC class II promoter.
62 ith the role of CREBBP in promoting class II transactivator (CIITA)-dependent transcriptional activat
65 or histocompatibility complex (MHC) class II transactivator, CIITA, which binds to myogenin and inhib
71 rdial cells were higher in hSCF/tetracycline transactivator compared with wild-type mice 3 days post
72 biquitin prevents destabilization of the DNA-transactivator complex by the ATPases of the 26S proteas
73 ription activator (RTA), a major lytic cycle transactivator, contributes to the development of KSHV l
74 hibits promoter function of the HLA class II transactivator, decreasing expression of genes controlle
79 HIV-1 Tat and HTLV-1 Tax, as well as the Tas transactivator encoded by primate foamy virus, fail to i
81 Tet-regulated miR30-shRNA technology, robust transactivator expression and two fluorescent reporters
86 STAT1 is an activator of CIITA, the class II transactivator for MHC II expression; CIITA expression w
87 ic patch of ubiquitin as required to protect transactivators from destabilization by the proteasomal
88 s their own transcription by suppressing the transactivator function of the CLOCK:BMAL1 heterodimer d
91 pig transgenic for a mutant (human) class II transactivator gene, resulting in down-regulation of swi
93 or, the mammalian Grainyhead-like epithelial transactivator (Get1/Grhl3), is important for epidermal
94 n overdose because of suppression of its key transactivators, hepatocyte nuclear factor (HNF)-4alpha
95 on analysis for gene transcripts of class II transactivator, HLA-DRagr;, and HLA-DRbeta1 showed maxim
103 f the SAGA transcription complex, and the RP transactivator Ifh1 as highly acetylated nonhistone spec
104 s illustrate critical roles of NLRC5/class I transactivator in MHC class I gene regulation and host d
107 -cell lymphotropic virus type I (HTLV-1) Tax transactivator initiates transformation in adult T-cell
108 d a podocyte-specific, doxycycline-inducible transactivator into a murine embryonic stem cell line wi
110 691-amino-acid (aa) KSHV Rta transcriptional transactivator is necessary and sufficient to reactivate
113 s/human herpesvirus 8 (HHV8) ORF50 encodes a transactivator, K-Rta, which functions as the switch fro
114 different tet-transactivator/reversible tet-transactivator lines supports broad functionality of tet
115 e promotion of silencer degradation by viral transactivators may be a common mechanism for regulating
117 Although FosB is likely to be involved in transactivator-mediated derepression of PAI-2 transcript
118 n the peri-infarct area of hSCF/tetracycline transactivator mice compared with wild-type mice 5 days
119 sing the responder animals with tetracycline transactivator mice under conditions in which substantia
122 acidic protein (GFAP) promoter-tetracycline transactivator mouse line with tetracycline operon-domin
124 d proteolytic turnover of the promoter-bound transactivator, nor is the activator-promoter complex co
125 ur results thus identify Hgf as an important transactivator of canonical Wnt signaling that is mediat
126 e assays indicate that KLF9 itself is a weak transactivator of CYP2D6 promoter but significantly enha
127 IP4), formin-binding protein-17 (FBP-17) and transactivator of cytoskeletal assembly-1 (Toca-1), and
128 ADAM17 has been proposed to play a role as a transactivator of epidermal growth factor receptor (EGFR
129 e hypothesis that Mesp1 is a direct upstream transactivator of Etv2 during embryogenesis and that Cre
130 tein, encoded by open reading frame 57, is a transactivator of gene expression that is essential for
133 ock transcription factor 1 (Hsf1) is a major transactivator of Hsp induction and has been proposed to
135 examination and the importance of NLRC5 as a transactivator of major histocompatibility complex (MHC)
136 TA) encoded by the gene Orf50 RTA is a known transactivator of multiple viral genes, allowing it to c
138 nuclear MT1-MMP as a previously unsuspected transactivator of signaling networks central to macropha
139 s a unique and as yet, poorly characterized, transactivator of STAT1 degradation by the ubiquitin-pro
143 mmunodeficiency virus group specific antigen/transactivator of transcription (SIV(mac239Gag/Tat)).
145 iption factors include NF-kappaB and the HIV transactivator of transcription (Tat) as well as the cyc
146 L deficient mice, we now reveal that the HIV transactivator of transcription (Tat) can induce BBB per
147 ion protein (TAT-SNAP-23) containing the HIV transactivator of transcription (TAT) cell-penetrating s
150 culture model, we show that the HIV protein transactivator of transcription (Tat) initially potentia
152 neutralizing mAb against extracellular HIV-1 transactivator of transcription (Tat) is important for t
154 yte function, we evaluated the impact of HIV transactivator of transcription (Tat) on Wnt/beta-cateni
157 ism(s) by which viral proteins such as HIV-1 Transactivator of Transcription (Tat) protein can activa
160 Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription (Tat) protein possesses
161 hondria would repair the defect, we used the transactivator of transcription (TAT) protein transducti
162 the signaling and neuroprotective effect of transactivator of transcription (TAT) protein transducti
165 neurotoxic factors such as the viral protein transactivator of transcription (Tat) that potentiate NM
166 ein-driven, doxycycline-inducible HIV type-1 transactivator of transcription (Tat) transgenic mouse m
167 Here, we investigated the effects of HIV-1 transactivator of transcription (Tat), a protein release
176 t infect neurons, but viral proteins such as transactivator of transcription and glycoprotein 120, or
178 studies, co-exposure with morphine enhanced transactivator of transcription neurotoxicity towards cu
181 s of its cyclin T1 subunit with the HIV Tat (transactivator of transcription) protein and TAR (transa
183 ting neurotoxic interactions of morphine and transactivator of transcription, and support the emergin
184 present in the HIV-1-infected brain, such as transactivator of transcription, inhibits antiviral IFN-
185 n studies with the clade C sequence of HIV-1 transactivator of transcription, which did not cause neu
187 Morphine co-exposure significantly enhanced transactivator of transcription-induced neuron death whe
189 us (HCMV) IE2 86-kDa protein is an essential transactivator of viral and cellular gene expression.
191 ation assays indicated that AP-1 is a potent transactivator of XT-I promoter and that IL-1beta-induce
193 nscription factor Nkx2-5 is one of the major transactivators of the ANF gene in the developing heart.
194 MEL-18 suppressed SUMOylation of the ESR1 transactivators p53 and SP1, thereby driving ESR1 transc
195 ransactivator ICP0 and human cytomegalovirus transactivator pp71 also stimulate the degradation of ce
197 factor Tat is known for its transcriptional transactivator properties, we present evidence for an un
199 rom the human immunodeficiency virus 1 (HIV) transactivator protein (TAT) to mesoporous silica nanopa
200 r CCL2 that of neuroprotection against HIV-1 transactivator protein (Tat) toxicity in rat primary mid
201 tion of CD8(+) T cells, and the frequency of transactivator protein (Tax)-specific CD8(+) CTLs, thoug
202 ansporter (DAT) promoter-driven tetracycline transactivator protein (tTA), we expressed mito-PstI exc
203 e we provide evidence that hepatitis B virus transactivator protein HBx stimulates the expression of
206 not initiated because the tegument-delivered transactivator protein pp71 fails to enter the nucleus a
207 ORF50, the gene that encodes the major lytic transactivator protein RTA, while mLANA did not, suggest
213 is produced by cells that express the HTLV-1 transactivator protein Tax, and that the increased CCL22
219 an upstream silencer (PAUSE-1), and a distal transactivator region between -5100 and -3300, which app
221 nes (RPGs) by making direct contact with the transactivator repressor activator protein 1 (Rap1).
222 x virus type 1 is an E3 ubiquitin ligase and transactivator required for the efficient switch between
223 KSHV K-RTA has been shown to be the major transactivator required for the initiation of lytic reac
224 inding specifically to its cognate site, the transactivator response element (TAR), Tat mediates a st
225 interaction of TOE1 with the viral specific transactivator response element as part of the inhibitor
226 ette that comprises an HSP70B promoter and a transactivator-responsive promoter and (ii) transactivat
227 transactivator-responsive promoter and (ii) transactivator-responsive promoters that drive the ICP4
228 (76%) harbored mutations in the tetracycline transactivator, resulting in expression of the MYC trans
229 reover, breeding these mice to different tet-transactivator/reversible tet-transactivator lines suppo
230 transcripts and proteins of the master lytic transactivator RTA (ORF50), early lytic genes ORF57 and
232 ing sequences of ORF50-encoding reactivation transactivator Rta and A6-encoding bZIP protein genes.
233 e sites now respond exclusively to the viral transactivator RTA and no longer to the host mediator IC
234 on interacted with the EBV immediate early R transactivator (Rta) and was found to inhibit Rta transa
235 early gene product of gammaHV68, replication transactivator (RTA), functions as a ubiquitin E3 ligase
237 D2))-directed reverse tetracycline-dependent transactivator (rtTA) and the tetracycline-responsive el
238 line (Dox)-regulated reverse transcriptional transactivator (rtTA) have many applications in biomedic
239 cell (PEC)-specific PEC-reverse-tetracycline transactivator (rtTA) transgenic mouse also efficiently
240 erse tetracycline-controlled transcriptional transactivator (rtTA), one with self-reporting GFP activ
241 ond cassette contains a reverse tetracycline transactivator, rtTA(M2), which directs the expression o
242 in (mVEcad) promoter for the expression of a transactivator, rtTA2S-M2; and the other driven by an in
243 ion is not well defined in terms of the host transactivator(s) required for iNOS gene expression.
244 e, which expresses a tetracycline-responsive transactivator selectively in the stratified squamous ep
245 e the expression of the reverse tetracycline transactivator (SP-C-rtTA) enabled functional analysis o
246 king gI promoter elements that bind cellular transactivators, specificity factor 1 (Sp1) and upstream
247 ter fidelity is most reliant on histone gene transactivators (Spt10, Spt21) and H3-H4 chaperones (Asf
248 into a heterologous tetracycline-repressible transactivator such that the transactivator transcript i
250 ain disrupts the interaction between the HIV transactivator Tat and P-TEFb and suppresses the ability
251 ess HIV transcription both through the viral transactivator Tat and via Tat-independent mechanisms.
252 that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resul
253 ansduction of human immunodeficiency virus 1-transactivator (Tat) protein and linked to the mitochond
254 iciency virus type 1 (HIV-1) transcriptional transactivator (Tat) recruits the positive transcription
258 leukemia virus (HTLV) type 1 transcriptional transactivator Tax is an oncogene sufficient to produce
260 sers, and the viral genome encodes the viral transactivator Tax, which is highly homologous to the tr
261 ve up-regulation of interferon-gamma and its transactivator Tbx21/Tbet, and amelioration of autoimmun
262 tory protein-reverse tetracycline-controlled transactivator/tetracycline operator-VEGF-C double-trans
264 development and adult life, we used an rtTA transactivator/tetracycline promoter approach that allow
269 NA-binding proteins, we created a Cas9-based transactivator that is targeted to DNA sequences by guid
270 s from biallelic gene disruption in class II transactivator that leaves other essential properties of
272 cetylases (HDACs) because pp71, the tegument transactivator that travels to the nucleus and inactivat
273 n of the Mpz gene is controlled by two major transactivators that coordinate Schwann cell development
274 mportant roles for the BZLF1 immediate early transactivator, the BHRF1 vBcl-2 homologue, and a novel
275 One such NLR protein is the MHC class II transactivator, the master regulator of MHC class II gen
276 ein Tax, which is believed to act as a viral transactivator through its interactions with a variety o
277 t NLRC5 acts in a manner similar to class II transactivator to drive MHC expression and revealed NLRC
278 ine-repressible transactivator such that the transactivator transcript is disrupted in male splice va
279 ondary somatic mutations in the tetracycline transactivator transgene, MMTV-rtTA, rendering gene expr
280 a-myosin heavy chain reverse transcriptional transactivator transgenic mice, and the double-transgeni
281 increase dendritic development, we tested a transactivator trap assay and found that the C456S varia
282 lies in the assumption that the tetracycline transactivator (TTA) acts as an inert control element an
283 ryos to drive expression of the tetracycline transactivator (tTA), the transcription factor commonly
284 he absence of tetracycline, the tetracycline transactivator (tTAV) accumulates, resulting in female d
285 ic mice carrying the tetracycline-responsive transactivator under the control of the liver activator
286 a (AML), we used a Vav promoter-tetracycline transactivator (Vav-tTA)-driven repressible TRE-NRAS(G12
287 f SVV open reading frame 61 (ORF61), a viral transactivator, was detected most frequently in latently
288 used insulinomas transfected with the CIITA transactivator, which resulted in their expression of cl
289 the tetracycline/doxycycline-controlled Tet-transactivator, while tolerated well during development
290 Here, we test whether CBP/p300-interacting transactivator with ED-rich tail 2 (CITED2), a mechanose
294 CREB-binding protein (CBP)/p300 interacting transactivator with glutamic acid (Glu) and aspartic aci
295 lementbinding protein [CBP]/p300-interacting transactivators with glutamic acid [E] and aspartic acid
297 ctivating expression of Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domai
298 with ArsA were selected by either repressed transactivator yeast two-hybrid or reverse yeast two-hyb
299 olish the SUMOylation of the EBV lytic cycle transactivator ZTA was dependent on both BGLF4 SUMO bind
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