ライフサイエンスコーパス: transamidase

1 ould not interact with other subunits of the transamidase.

2 tion is carried out by an ER enzyme, GPtdIns transamidase.

3 ing the presumed substrate for the yeast GPI transamidase.

4 provide a potential means for isolating the transamidase.

5 gnition of the omega site by the GPI-protein transamidase.

6 ered to be an intermediate in catalysis by a transamidase.

7 udy COOH-terminal processing by the putative transamidase.

8 cadaverine (MDC), which binds to the enzyme (transamidase) active site of tissue transglutaminase (TG

9 Ala abolishes glutaminase and Gln-dependent transamidase activities of Glu-AdT (>300-fold), but reta

10 or ATP-gammaS hydrolysis and glutaminase and transamidase activities reveals tight coupling among the

11 ar to that with ATP, but without concomitant transamidase activity and with a very low level of ATP-g

12 Transamidase activity is inhibited by direct inhibitor b

13 The transamidase activity potential of factor XIII, measured

14 We recently showed that GTP binding, but not transamidase activity, is required for TG2-dependent can

15 g/GTPase activity, and the open conformation transamidase activity.

16 y at the TG2 transamidase site, inhibit both transamidase and GTP-binding activities.

17 e that the interaction between a protein-GPI transamidase and the COOH-terminal GPI signal sequence p

18 me that catalyzes a large number of amidase, transamidase, and ester hydrolysis reactions.

19 also identify signal recognition by the GPI-transamidase as a potential step for selective small mol

20 or must first undergo cleavage by a putative transamidase between the omega and omega + 1 positions w

21 ons to an open conformation that exposes the transamidase catalytic site involved in protein-protein

22 n near the carboxyl terminus, and a putative transamidase cleavage site in the proprotein.

23 tachment 1) is an essential component of the transamidase complex along with PIGK, PIGS, PIGT, and PI

24 ts of the glycosylphosphatidylinositol (GPI) transamidase complex in human breast cancer.

25 These findings highlight the role of the transamidase complex in the development and function of

26 These results suggest that the GPI transamidase complex is composed of a group of proto-onc

27 osphatidylinositol glycan class U (PIG-U), a transamidase complex unit in the glycosylphosphatidylino

28 he ER-localized glycosylphosphatidylinositol transamidase complex, are retained in the ER.

29 identified subunits of the mammalian GPtdIns transamidase complex.

30 Genetic studies with yeast indicate that the transamidase consists of a dynamic complex of at least t

31 ryl alkylating reagents, suggesting that the transamidase enzyme contains a functionally important su

32 rexpression of different subunits of the GPI transamidase, from strong suppression by Gpi8p and Gpi17

33 I) anchoring of proteins is catalyzed by GPI transamidase (GPIT), a multisubunit, endoplasmic reticul

34 Glycosylphosphatidylinositol (GPI) transamidase (GPIT), the enzyme that attaches GPI anchor

35 iple subunit enzyme complex known as the GPI transamidase (GPIT).

36 rocessed in the endoplasmic reticulum by GPI transamidase (GPIT).

37 reticulum membrane, and GPI-anchored by GPI transamidase (GPIT).

38 GPI-attachment signal can be modified by the transamidase irrespective of whether it is first release

39 ant K cells are defective in part of the GPI transamidase machinery.

40 r glycosylphosphatidylinositol (GPI):protein transamidase, metacaspase and separase, and their differ

41 gs with HDZ provide further evidence for the transamidase nature of the enzyme and also provide a sta

42 These results suggest the carboxy-terminal transamidase recognizes a more extended structure simila

43 blocked because inhibitor interaction at the transamidase site locks the protein in the extended/open

44 inhibited by direct inhibitor binding at the transamidase site, and GTP binding is blocked because in

45 and VA5, which react exclusively at the TG2 transamidase site, inhibit both transamidase and GTP-bin

46 These findings suggest that transamidase site-specific inhibitors can inhibit GTP bi

47 However, we were surprised that transamidase site-specific inhibitors reduce cancer stem

48 w that proproteins can be crosslinked to the transamidase subunit Gpi8p, as well as to ER proteins of

49 strate and one of the genetically identified transamidase subunits.

50 In addition to being a transamidase, TG undergoes a GTP-binding/GTPase cycle ev

51 r coordinated coupling of Gln hydrolysis and transamidase transition states during catalysis, and val

52 ach by isolating binders toward Sortase A, a transamidase which is required for virulence of Staphylo

53 s suggest that Gab1p is a subunit of the GPI transamidase with distinct relationships to other subuni