ライフサイエンスコーパス: transamination

1 P-dependent reactions in solution, including transamination.

2 turnover, suggesting a lower rate of leucine transamination.

3 Hyperglucagonemia did not affect leucine transamination.

4 ces to be highly reactive toward RS-mediated transamination.

5 of E1 toward dehydration, epimerization, and transamination.

6 etone body production, glucose synthesis and transamination.

7 Neither enantiomer is a substrate for transamination.

8 HF elimination than GABA is a substrate for transamination.

9 ced functional enzymes that catalyze alanine transamination.

10 me could not efficiently catalyze kynurenine transamination.

11 d rate of inactivation by substrate-mediated transamination.

12 e protein synthesis (PS) and reduced leucine transamination.

13 nhancing AA-induced PS, and reducing leucine transamination.

14 for allosteric activation and glutamate from transaminations.

15 also presented that this substrate-mediated transamination accelerates normal degradation of S-adeno

16 residues critical for the dehydration versus transamination activity.

17 ne carbon flux, indicating increased leucine transamination (an important biochemical process for nit

18 ized to monitor stereoselective biocatalytic transamination and assign the absolute configuration of

19 complish this by introducing three exogenous transamination and deamination cycles, which provide an

20 lglycine decarboxylase, which catalyzes both transamination and decarboxylation half-reactions in its

21 r many important enzymatic reactions such as transamination and decarboxylation.

22 from the BCATc(-/-) mouse exhibit lower Leu transamination and higher intracellular Leu concentratio

23 imates of the in vivo rates of phenylalanine transamination and protein degradation.

24 es may also be common to pyridoxal-catalyzed transamination and related reactions in biological syste

25 ys performed with these mutants show that RS transamination and subsequent modification with alkoxyam

26 Transamination and the two decarboxylase systems (NADP-m

27 compartment model and assuming insignificant transamination and transmethylation in this tissue.

28 reactions typically proceed by electrophilic transamination and/or addition-elimination reaction mech

29 ecific activity with the serine : glyoxylate transamination, and apparent Km measurements indicate th

30 involves a carboligation step, a subsequent transamination, and finally a Pictet-Spengler reaction w

31 thway intermediates revealed that methionine transamination, and not the transmethylation or transsul

32 into the hepatic vein, leucine oxidation and transamination, and synthesis and degradation of hepatic

33 d to undergo beta-elimination in addition to transamination, and the transamination product of N-term

34 nd introducing the nitrogen by oxidation and transamination at C-3.

35 tetrahydrohydroxyphenylpyruvate (H(4)HPP), a transamination away (via BacF) from 2S-H(4)Tyr.

36 to 3,5-dihydroxyphenylglyoxylate, which is a transamination away from Dpg.

37 boxylase-catalyzed decarboxylation-dependent transamination between 2-aminoisobutyrate (AIB) and pyru

38 notransferase (ALT) catalyzes the reversible transamination between alanine and 2-oxoglutarate to for

39 used radiochemical procedure, which measures transamination between alpha-ketoiso[1-14C]valerate and

40 Transamination between glutamine and alpha-keto-gamma-me

41 Transamination between L-glutamate (or L-phenylalanine)

42 The products resulting from transamination between L-phenylalanine and the alpha-ket

43 al phosphate-dependent enzyme that catalyzes transamination between primary amines and alpha-keto aci

44 notransferases were identified that catalyze transamination between several L-amino acids (e.g., phen

45 y to act as a substrate for GABA-AT, not for transamination, but for HF elimination.

46 ital to the 1,3-prototropic shift central to transamination, but not to reactions catalyzed by alanin

47 lases were inactivated by substrate-mediated transamination, but this reaction occurred much more fre

48 The hBCATm-catalyzed transamination can be described in molecular terms toget

49 including hydrazone formation and Katritzky transamination, can be monitored simultaneously without

50 al recombinant enzyme that catalyzes alanine transamination, confirming that the enzyme is an ALT.

51 d (DP), whose formation involves consecutive transamination, cyclization, and isomerization steps.

52 The combined transamination-deoxygenation activity places ColD in a c

53 he putative contribution of two beta-alanine transamination enzymes, namely 4-aminobutyrate-2-oxoglut

54 4-amino-4,6-dideoxy-d-glucose that couples a transamination equilibrium to the thermodynamically favo

55 ism of inactivation most probably involves a transamination followed by aromatization to form an arom

56 The rate-determining step for transamination follows the formation of the quinonoid in

57 m of DGD-PLP is 25 s(-1), while that for the transamination half-reaction between DGD-PMP and pyruvat

58 The primary [2-(2)H]-L-alanine KIE on the transamination half-reaction is unity.

59 The maximal rate constant for the transamination half-reaction of the potassium form of DG

60 the ketimine intermediate for the L-alanine transamination half-reaction.

61 ad-time of the stopped-flow in the L-alanine transamination half-reaction.

62 and breaking in both the decarboxylation and transamination half-reactions occurs at the "A" subsite,

63 The spectra for the first species in the transamination half-reactions of L-alanine and L-aminobu

64 osphate (PLP) catalyzed decarboxylations and transaminations have been revisited experimentally.

65 AAs also enhanced leucine transamination in both splanchnic and muscle beds.

66 zyme that catalyzes both decarboxylation and transamination in its normal catalytic cycle.

67 had no effect on protein dynamics or leucine transamination in splanchnic bed.

68 yzes two reaction types, decarboxylation and transamination, in the same active site.

69 The fact that a transamination initiates this pathway could help explain

70 oves the alpha-amino group of L-arginine via transamination instead of oxidative deamination by dehyd

71 city for beta-elimination/replacement versus transamination is dictated in part by the protonation st

72 Ethylamine transamination is inhibited 4-fold by Al(3+) metalation,

73 d 4-fold by Al(3+) metalation, while alanine transamination is inhibited only 1.3-fold.

74 ucing bacteria, its catalysis of periplasmic transaminations is most likely a general tool for specif

75 tory T (iTreg) cells, we show that increased transamination, mainly catalysed by GOT1, leads to incre

76 that the enzyme metabolizes 1 according to a transamination mechanism.

77 the transmethylation, transsulfuration, and transamination metabolic pathways.

78 transaminase responsible for catalyzing the transamination of 3-hydroxykynurenine (3-HK) to xanthure

79 is primarily responsible for catalyzing the transamination of 3-hydroxykynurenine (3-HK) to xanthure

80 the pyridoxal phosphate-dependent equatorial transamination of 3-oxo-alpha-D-glucose 6-phosphate to f

81 ate from [alpha,delta-(15)N(2)]ornithine and transamination of [(15)N]glutamate to [(15)N]aspartate.

82 It catalyzes the transamination of a number of amino acids and uses many

83 eading to accelerated leucine catabolism and transamination of alpha-ketoglutarate to glutamate, with

84 , catalyzing the N-acetylornithine-dependent transamination of alpha-ketoglutarate.

85 cids were the preferred amino donors for the transamination of alpha-ketomethiobutyrate to methionine

86 This enzyme catalyzed the transamination of aspartate, glutamate, phosphoserine, a

87 BCAT1 catalyzes the transamination of branched-chain amino acids while conve

88 ation was achieved via a bisulfite-catalyzed transamination of cytosine after endonuclease cleavage o

89 ary amides of iron(II), were obtained by the transamination of Fe{N(SiMe(3))(2)}(2), with HN(SiMe(3))

90 The (R)-enantiomer also inhibits the transamination of GABA 10 times more effectively than th

91 The best enzyme mimic accelerated the transamination of indole-3-pyruvic acid by a factor of 4

92 thionine decarboxylase by substrate-mediated transamination of its pyruvoyl cofactor.

93 These data indicate that KICSIS requires transamination of KIC and glutamate to leucine and alpha

94 erase II (hKAT-II) efficiently catalyzes the transamination of knunrenine to kynurenic acid (KYNA).

95 mKAT III is able to efficiently catalyze the transamination of kynurenine to KYNA and has optimum act

96 ased by d-amphetamine may interfere with the transamination of L-kynurenine to KYNA specifically in t

97 Transamination of L-leucine with alpha-ketoglutarate res

98 , including those formed by TATase-catalyzed transamination of l-phenylalanine, l-tyrosine, l-tryptop

99 chain aminotransferase) catalyzes reversible transamination of leucine and alpha-ketoglutarate to KIC

100 The kinetic parameters determined for the transamination of phenylalanine by TATase (kcat = 180 s-

101 rst step in phenyllactic acid synthesis, the transamination of phenylalanine to phenylpyruvate.

102 sms, an aminotransferase is required for the transamination of prephenate into arogenate, but the ide

103 of UDP-glucuronic acid, followed by the C-4" transamination of the product to generate the novel suga

104 nvolve oxidation of the 5'-alcohol by Pac11, transamination of the resulting aldehyde by Pac5, and de

105 One plausible explanation is the transamination of the three acids to produce glutamic ac

106 Transamination of {(PEt(3))(2)RhN(SiMePh(2))(2)} (1a) or

107 or a range of protein substrates, N-terminal transamination offers a convenient way to install a reac

108 Neither compound can be oxidized by a transamination or addition/elimination mechanism, but bo

109 ionine and derived-sulfur metabolites in the transamination pathway activate the GCN5 acetyltransfera

110 SP, probably using the same methionine (Met) transamination pathway as macroalgae and phytoplankton(1

111 to dopamine and suggest this may occur via a transamination pathway in which DHPPA is an intermediary

112 The transamination product of leucine, alpha-ketoisocaproic

113 ation in addition to transamination, and the transamination product of N-terminal Gln was resistant t

114 matic ketoacids, including indolepyruvate, a transamination product of tryptophan.

115 ularly leucine, and can be reproduced by its transamination product, ketoisocaproic acid.

116 ed Delta(1)-piperideine-2-carboxylate as its transamination product.

117 were employed to detect the presence of the transamination products 2-ketoarginine and L-alanine, th

118 imulates PHAS-I phosphorylation although the transamination products of isoleucine and valine are ine

119 dapD and dapE mutants and to catalyze LL-DAP transamination, providing functional evidence for a role

120 treatment reduced leucine nitrogen flux and transamination rates in subjects with type 2 diabetes.

121 iabetic subjects, but leucine nitrogen flux, transamination rates, and plasma ketoisocaproate level w

122 capable of facilitating further steps of the transamination reaction after the formation of the exter

123 rcaptopyruvic acid (VI, formed by a Cys-APAP transamination reaction in kidney), 3,3'-biacetaminophen

124 This was followed by a bisulfite-catalyzed transamination reaction in order to biotinylate the dsDN

125 The transamination reaction of ethylamine is 75-fold slower

126 specific protein modification method using a transamination reaction that chemoselectively oxidizes t

127 usively catalyze a decarboxylation-dependent transamination reaction to form pyridoxamine 5-phosphate

128 no group of TM to a carbonyl group through a transamination reaction with glyoxylate produced a prote

129 The transamination reaction with l-alanine was coupled in th

130 (CH(3))(2)N)(4)Ti, TDMAT), which undergoes a transamination reaction with sufficiently nucleophilic a

131 ate at which the enzyme catalyses its normal transamination reaction.

132 the block of its conversion to lactate, with transamination reactions converting pyruvate to form the

133 We previously showed that in decarboxylative transamination reactions under credible prebiotic condit

134 xpressed in Escherichia coli catalyzed three transamination reactions using the following amino donor

135 somal photorespiratory enzyme that catalyzes transamination reactions with multiple substrates.

136 ozymes, the channeling of metabolic flow via transamination reactions, and active transport mechanism

137 This finding establishes RS as a transamination reagent that is particularly well suited

138 lt, RS) was identified as a highly effective transamination reagent when paired with glutamate-termin

139 benzenesulfonate (Rapoport's salt, RS) as a transamination reagent, which oxidizes the N-terminal am

140 creening platform as a method to explore new transamination reagents while simultaneously identifying

141 From methionine, the steps are transamination, reduction and S-methylation to give the

142 This pathway involves an initial transamination step followed by tautomerization to form

143 ependent and its catalysis is initiated by a transamination step in which pyridoxal 5'-phosphate (PLP

144 organic synthesis, including the following: transamination substitution reactions with virtually any

145 uence of the need for increased reactions of transamination to cope with the liver metabolic derangem

146 pha-ketobutyrate and ammonia) and L-alanine (transamination to form pyruvate), which have uncharged s

147 tein was proposed to catalyze the subsequent transamination to form UDP 2-acetamido-3-amino-2,3-dideo

148 alpha-(32)P]UDP-glucuronic acid, followed by transamination to generate [alpha-(32)P]UDP-l-Ara4N, whe

149 ual aspartate was liberated enzymatically by transamination to oxaloacetate with aspartate aminotrans

150 c acid is derived from phenylalanine via its transamination to phenylpyruvate, and mining of the tran

151 suppressed by hepatic and renal beta-alanine transamination upon oral beta-alanine intake.

152 Although leucine oxidation and KIC transamination were blocked in BCATm(-/-) islets, KIC ox

153 ction of BCATc correlates with increased Leu transamination, whereas T cells from the BCATc(-/-) mous

154 nates the pyridine nitrogen for catalysis of transamination, while both alanine racemase and O-acetyl

155 l-4-chloro-piperidine, were accomplished via transamination with a quaternary ammonium piperidone or

156 ine in the reaction mixture is followed by a transamination with oleylamine, the solvent of the react

157 acid is a substrate for YwfG, which promotes transamination (with L-Phe as amino donor), to form tetr