ライフサイエンスコーパス: transannular

1 ring system was proposed to originate from a transannular 1,3-dipolar cycloaddition between a nitrone

2 Thus, theory predicts that the proposed transannular 1,3-dipolar cycloaddition is a plausible st

3 ations (M06-2X) predict that the uncatalyzed transannular 1,3-dipolar cycloaddition of the putative l

4 These reactions involve a novel N-assisted, transannular 1,5-hydride shift.

5 za-Prins cyclization featuring an unexpected transannular 1,5-hydride transfer.

6 Transannular 2,6-disubstituted pyrans, like the one foun

7 luded intermolecular Pauson-Khand reactions, transannular [4 + 2] cycloaddition reactions, intermolec

8 identified a cyclase, SpnF, that catalyses a transannular [4+2] cycloaddition to form the cyclohexene

9 gly support the plausibility of the proposed transannular [6 + 4] cycloaddition in the biogenesis of

10 The transannular [6 + 4] cycloaddition proposed as a step in

11 We show that transannular addition occurs readily with an alpha,beta-

12 rotonated aminoketone 2 and the O-protonated transannular addition product 3, the interconversion rat

13 ne was prepared as a substrate for divergent transannular aldol reactions.

14 dition products derive from an unprecedented transannular alkene insertion of an 11-membered Pd(Ar)(O

15 Here we report a transannular approach to selectively manipulate the C-H

16 nzazepin-1-yl radical formation, followed by transannular attack and formation of a 2-(indol-1-yl)phe

17 h of these oxazolidinones was accompanied by transannular attack at the epoxide by nitrogen, resultin

18 er of the C11 alpha-proton to C7 to initiate transannular B/C-ring closure to the taxenyl cation, fol

19 A transannular BCP in the central cross-over region for th

20 is-enone was found to be inactive toward the transannular bis-Michael reaction under the conditions e

21 nate aluminum center causes variation in the transannular bond distance.

22 erate housane-type [2.1.0]bicyclopentanes by transannular bond formation.

23 ucture (C(s) symmetry) that includes a weak, transannular bonding interaction between the carbene car

24 d 13C NMR studies, is consistent with proper transannular bonding so as to deliver the entire C1-C26

25 cond stable radical cation with an elongated transannular C-C bond and an increased flap dihedral.

26 e the first of these options involves direct transannular C-C bond formation, the other two embody th

27 e with subsequent oxacarbenoid formation and transannular C-H insertion proceeds via monosolvated dim

28 jugation, transannular pi(alkene)...C(+) and transannular C-H...C(+) interactions-were uncovered, con

29 te the carbon skeleton of hirsutellone B via transannular carbon-carbon bond formation were undermine

30 actin natural products, during which a novel transannular cation-olefin cyclization was observed.

31 Transannular chemical reactions are unparalleled in thei

32 cyclo[3.3.0]octenone adducts, resulting from transannular closure of the intermediate eight-membered-

33 edented C-C bond forming lactamization and a transannular condensation; (c) a one-pot organocatalytic

34 15) N couplings reveal heretofore undetected transannular contacts (laddering) with lithium acetylide

35 available C21-oxygenated lactam, followed by transannular cyclization and in situ trapping of a trans

36 A transannular cyclization and reduction of a bridgehead a

37 hesis of Aspidosperma alkaloids based on the transannular cyclization of a chiral lactam precursor.

38 Investigation of the transannular cyclization of cyclooctene, cyclodecene, an

39 btle stereochemical differences between this transannular cyclization process and transannular Diels-

40 esent study describes the investigation of a transannular cyclization strategy for constructing bicyc

41 rate the efficiency and the potential of the transannular cyclization tactic for the creation of bicy

42 f 14-membered macrocyclic lactones underwent transannular cyclization to give polycyclic products wit

43 ve of 5-aza-trans-cyclooctene that underwent transannular cyclization upon treatment with bromine.

44 These include reductive transannular cyclization, adaptation of the Ramberg-Back

45 ctive Pictet-Spengler reaction followed by a transannular cyclization.

46 to the hexahydropyrrolizine framework in the transannular cyclization.

47 ilding blocks that did not prove amenable to transannular cyclization.

48 s has been developed employing electrophilic transannular cyclizations of 8-, 9-, and 10-membered uns

49 Transannular cyclizations of some products may lead to i

50 on-Khand reactions, other intermolecular and transannular cycloaddition reactions included intermolec

51 Stepwise pathways for these transannular cycloaddition reactions were shown to predo

52 iels-Alder reaction likely occurs before the transannular cycloaddition.

53 one 12 did not produce the expected bicyclic transannular Diels-Alder (BTADA) product 13, heating the

54 Transannular Diels-Alder (TADA) reactions that occur bet

55 y calculations were performed on a set of 13 transannular Diels-Alder (TADA) reactions with 10-18-mem

56 tion of 26 and the highly diastereoselective transannular Diels-Alder cyclization of macrocyclic octa

57 Semiempirical calculations of the transannular Diels-Alder cycloaddition cascade were carr

58 tes 12-14 give very similar distributions of transannular Diels-Alder cycloadducts, indicating that t

59 roduced from a remarkably diastereoselective transannular Diels-Alder reaction of lactone 9.

60 Key features of the synthesis include the transannular Diels-Alder reaction of macrocyclic pentaen

61 for the target molecule featured a novel bis-transannular Diels-Alder reaction that casted stereosele

62 olved the first reported example of a double transannular Diels-Alder reaction to fashion the key ele

63 the biosynthesis of spinosyn A, catalyzes a transannular Diels-Alder reaction.

64 f 31 triggered a sequence of stereoselective transannular Diels-Alder reactions (32 -->34; 63%) formi

65 udy of elements of stereochemical control in transannular Diels-Alder reactions leading to the decahy

66 ward by Schmitz involving intermolecular and transannular Diels-Alder reactions of two [12]-paracyclo

67 en this transannular cyclization process and transannular Diels-Alder reactions.

68 The transannular diphosphorus bisanthracene adduct P2A2 (A =

69 rs of magnitude; it is hypothesized that the transannular dipole so induced interacts favorably with

70 Conformational features, transannular distances and dynamic behavior were studied

71 one behaves similarly, and the presence of a transannular double bond does not alter the outcome.

72 is detailed herein was the development of a transannular enamide alkylation for late-stage formation

73 m anionic oxy-Cope rearrangement/methylation/transannular ene cyclization of 21 and subsequent introd

74 olled intramolecular Diels-Alder reaction, a transannular enolate alkylation, an effective Stille car

75 A transannular etherification reaction gave access to tetr

76 tive aza-Prins cyclization with a subsequent transannular etherification.

77 pha-ketol generation, an EtAlCl(2)-catalyzed transannular hydride shift, regioselective monomesylatio

78 The operation of several unusual transannular hydride shifts is also detailed.

79 2S,4S)-4-methoxyproline (mop) eliminates the transannular hydrogen bond and restores a prototypical C

80 ed enforce a C(gamma)-endo ring pucker but a transannular hydrogen bond between the hydroxyl moiety a

81 This same transannular hydrogen bond enhances an n-->pi* interacti

82 chiral ground state with an intramolecular, transannular hydrogen bond.

83 ADEP-ClpP crystal structure is fortified by transannular hydrogen bonding and can be further stabili

84 ole of stereochemistry, amide bond geometry, transannular hydrogen bonding, and polarity on antitumor

85 ydrogens that were proposed to be engaged in transannular hydrogen bonds.

86 he large (13)C coupling as resulting from a "transannular hyperfine interaction".

87 A transannular incision was performed in 75% of cases and

88 bilization afforded the singlet state by the transannular interaction appears to be largely offset by

89 d to diastereoselective outcomes dictated by transannular interactions in the transition states.

90 the product in a conformation that minimizes transannular interactions, thus leading to different ste

91 agonists around DTrp-Lys is stabilized by a transannular intramolecular hydrogen bond(s) between Phe

92 The design employs transannular (intramolecular) hydrogen bonds (H-bonds),

93 fic azabicycloalkanone amino acids by way of transannular iodolactamization reactions.

94 core system, followed by either a biomimetic transannular Mannich reaction to access himeradine A (1)

95 elective formal [3 + 3]-cycloaddition, and a transannular Mannich reaction to construct the core of t

96 We systematically explored a transannular Michael reaction cascade for stereoselectiv

97 reaction of macrocyclic pentaene 11 and the transannular Morita-Baylis-Hillman cyclization of 12 tha

98 nes, tricyclic neutral molecules featuring a transannular N --> Al bond, can act as Lewis acids that

99 o NH protons, and two polarization-enhanced, transannular N-HO-HN hydrogen bond chains, each involvin

100 Transannular N...C=O interactions were also observed in

101 te salt of O-protonated 3 indicates that the transannular N.CO bond of 3 is formed to an extent of on

102 bond hydrolysis, which we attributed to the transannular nature of the amino acid analogs.

103 We hypothesize that a transannular oxa-conjugate addition in a macrocyclic lau

104 In this study, we demonstrate that a transannular oxa-conjugate addition strategy is a viable

105 that must arise from a bromonium ion induced transannular oxonium ion formation-fragmentation could a

106 Bromonium ion induced transannular oxonium ion formation-fragmentation gave th

107 It was more common in patients with transannular patch (TAP) repair compared with non-TAP re

108 At cardiac repair, a transannular patch for right ventricle outlet reconstruc

109 outflow tract obstruction was managed with a transannular patch in 49 patients and a right ventricle-

110 nd diastolic volume increased by 49.4% after transannular patch repair (62.3-93.1 mL/m(2); P=0.028) b

111 nexus of late morbidity and mortality after transannular patch repair of tetralogy of Fallot.

112 One month after transannular patch repair, the hTPV was implanted, follo

113 imaging, surgical pulmonary valvectomy, and transannular patch repair.

114 at repair was 2.9 years, and 82 (23%) used a transannular patch repair.

115 Insertion of a transannular patch was a predictor for late arrhythmias

116 No new transannular patches were required.

117 be performed safely with low requirement for transannular patching (TAP) and thereafter allow normal

118 In addition to the first successful transannular Pauson-Khand reactions, other intermolecula

119 within the AbyU active site to facilitate a transannular pericyclic reaction.

120 The (1)O(2) generated was trapped as the transannular peroxide (DPAO(2)) of 9, 10-diphenylanthrac

121 of internal stabilization-hyperconjugation, transannular pi(alkene)...C(+) and transannular C-H...C(

122 ious bond critical points (BCPs), two weaker transannular points in the central cross-over region.

123 ty to predict and control the outcome of the transannular reaction.

124 ntermediate, and the regioselectivity of the transannular reactions were analyzed by density function

125 c groups (O, NH) was investigated on the 1,6-transannular ring closure of 1,6-cyclodecadiyne (8a).

126 erization of two alkyne units as well as the transannular ring closure reaction of a nonconjugated di

127 species were prepared via microwave-mediated transannular ring-opening of an epoxyketone.

128 is and an intramolecular lactonization via a transannular S(N)i reaction.

129 Transannular SL sutures were placed at the valve center

130 ed by electrophilic C19-amide activation and transannular spirocyclization.

131 ans in acyclic neopeltolide intermediates, a transannular strategy for construction of this ring syst

132 nd intramolecular variants are widely known, transannular versions of this reaction are unknown and t