ライフサイエンスコーパス: transcarbamylase

1 ep trefoil knot was found in acetylornithine transcarbamylase.

2 designate this enzyme as an acetylornithine transcarbamylase.

3 is protein is a novel N-succinyl-L-ornithine transcarbamylase.

4 thine transcarbamylase rather than ornithine transcarbamylase.

5 region, and the pyrB gene encoding aspartate transcarbamylase.

6 dence of the kinetic parameters of aspartate transcarbamylase.

7 inhibitors specific to this novel family of transcarbamylases.

8 rginine biosynthesis and on the evolution of transcarbamylases.

9 ficant domain closure take place as in other transcarbamylases.

10 pressing the liver-specific enzyme ornithine transcarbamylase administered to the lungs of various st

11 display the star phylogeny; namely onithine transcarbamylase and tryptophan synthetase.

12 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), and mevalona

13 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), which cataly

14 D (carbamoyl-phosphate synthase 2, aspartate transcarbamylase, and dihydroorotase complex) activation

15 for carbamyl phosphate synthetase, aspartate transcarbamylase, and dihydroorotase).

16 mpestris, the protein annotated as ornithine transcarbamylase, and encoded by the argF gene, is unabl

17 and regulation of Escherichia coli aspartate transcarbamylase, and modeling has suggested that long r

18 N-Acetyl-l-ornithine transcarbamylase (AOTCase), rather than ornithine transc

19 bstrate binding and catalysis in other known transcarbamylases are not conserved.

20 oyl-phosphate synthetase 2 (CPS2), aspartate transcarbamylase (ATCase) and dihydroorotase (DHOase) ac

21 nal transition of Escherichia coli aspartate transcarbamylase (ATCase) by measuring (1) hydration cha

22 Aspartate transcarbamylase (ATCase) is a highly regulated, dodecam

23 ne transcarbamylases (OTCases) and aspartate transcarbamylases (ATCases); however, the second substra

24 e incorporated into 'mature' human ornithine transcarbamylase cDNA and overexpressed in Escherichia c

25 ediated gene transfer of the human ornithine transcarbamylase cDNA.

26 Crystal structures of this novel transcarbamylase complexed with carbamyl phosphate and N

27 iency (0.35 +/- 0.11), and partial ornithine transcarbamylase deficiency (0.26 +/- 0.06) from normal

28 , retinitis pigmentosa (RPGR), and ornithine transcarbamylase deficiency (OTC).

29 chieved significant improvement of ornithine transcarbamylase deficiency (OTCD) in a mouse model thro

30 etency in female heterozygotes for ornithine transcarbamylase deficiency (OTCD).

31 Ornithine transcarbamylase deficiency (OTCD, OMIM 311250), the mos

32 he long-term outcome in girls with ornithine transcarbamylase deficiency enrolled in studies of treat

33 Girls with symptomatic ornithine transcarbamylase deficiency who are treated with drugs t

34 32 girls (age, 1 to 17 years) with ornithine transcarbamylase deficiency who had had at least one epi

35 in neurological symptoms or death (ornithine transcarbamylase deficiency).

36 including acute liver failure and ornithine transcarbamylase deficiency, the most frequent urea-cycl

37 acity in 19 women heterozygous for ornithine transcarbamylase deficiency.

38 henotype in women heterozygous for ornithine transcarbamylase deficiency.

39 , and urea kinetics in healthy and ornithine transcarbamylase-deficient (OTCD) subjects and the possi

40 stable phenotype correction in the ornithine transcarbamylase-deficient Spf(ash) mouse and the neonat

41 the mitochondrial-localized mutant ornithine transcarbamylase (DeltaOTC).

42 n evolution and that the canonical ornithine transcarbamylase-dependent pathway became the prevalent

43 he carbamoyl-phosphate synthetase2-aspartate transcarbamylase-dihydroorotase (cad) gene as possibly c

44 Carbamoyl phosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD) is an enzyme requi

45 e carbamoyl phosphate synthetase 2/aspartate transcarbamylase/dihydroorotase multi-enzyme complex.

46 rate of CAD (carbamyl-P synthetase/aspartate transcarbamylase/dihydroorotase) gene amplification is e

47 gest strongly that it is a new member of the transcarbamylase family.

48 The monomer has the consensus transcarbamylase fold with two structural domains linked

49 ticle, we demonstrate that a human ornithine transcarbamylase gene containing various PTC-inducing no

50 Although many mutations in the ornithine transcarbamylase gene have been correlated with 'late on

51 d a cDNA sequence coding for human ornithine transcarbamylase in a yeast/bacterial shuttle vector, wh

52 ine transcarbamylase that replaces ornithine transcarbamylase in the canonic arginine biosynthetic pa

53 e recently reported for N-acetyl-L-ornithine transcarbamylase indicates that amino acid residue 90 (B

54 ors by treatment with the specific aspartate transcarbamylase inhibitor N-phosphonacetyl-l-aspartate

55 Ornithine transcarbamylase is a highly conserved enzyme in arginin

56 Ornithine transcarbamylase is an X-linked mitochondrial enzyme tha

57 This new family of transcarbamylases lacks the DxxSMG motif that is charact

58 A transcarbamylase-like protein essential for arginine bio

59 mes argininosuccinate synthase and ornithine transcarbamylase, making them arginine auxotrophic.

60 ulline occurs due to arginase- and ornithine transcarbamylase-mediated reactions and this limits the

61 The structure of aspartate transcarbamylase of Escherichia coli ligated to products

62 cies of the mitochondrial enzymes, ornithine transcarbamylase (OTC) and carbamyl-phosphate synthase (

63 Pea (Pisum sativum L.) ornithine transcarbamylase (OTC) antisera were used to investigate

64 zed a gene coding for mature human ornithine transcarbamylase (OTC) by recursive PCR using 18 oligode

65 A murine model of ornithine transcarbamylase (OTC) deficiency was used in this study

66 al and biochemical presentation of ornithine transcarbamylase (OTC) deficiency, we identified copy-nu

67 o the XLPRA locus, and to the gene ornithine transcarbamylase (OTC) in dogs.

68 in the urea cycle disorder enzyme, ornithine transcarbamylase (OTC).

69 expression and activity of hepatic ornithine transcarbamylase (OTC).

70 Escherichia coli ornithine transcarbamylase (OTCase) catalyzes the production of L-

71 carbamylase (AOTCase), rather than ornithine transcarbamylase (OTCase), is the essential carbamylase

72 inding site is similar to those in ornithine transcarbamylases (OTCases) and aspartate transcarbamyla

73 otif that is characteristic of all ornithine transcarbamylases (OTCases) and contains a novel proline

74 plant pathogens that utilize acetylornithine transcarbamylase rather than ornithine transcarbamylase.

75 ed a synthetic gene encoding human ornithine transcarbamylase (sOTC), designed to allow mitochondrial

76 homonas campestris a novel N-acetylornithine transcarbamylase that replaces ornithine transcarbamylas

77 Additional putative transcarbamylases that might also be misannotated were f

78 nts of two systems, hemoglobin and aspartate transcarbamylase, that are well described by the classic

79 ate binding occurs in N-succinyl-L-ornithine transcarbamylase, while movement of the 80 loop and sign