ライフサイエンスコーパス: transcellular

1 e resorption by osteoclasts requires massive transcellular acid transport, which is accomplished by t

2 reduced the development of thrombin-induced transcellular actin stress fibers, cellular contractions

3 led to the secretion of group V PLA2 and its transcellular action on neighboring human neutrophils an

4 The transcellular activity of group V PLA2 was highly depend

5 whereas group IIA PLA2 exhibited much lower transcellular activity.

6 nducing intracellular aggregation and blocks transcellular aggregate propagation.

7 howed that albumin passage was predominantly transcellular and demonstrated colocalization of albumin

8 observed, suggesting that fluid leakage was transcellular and directly attributable to infecting vir

9 plicate WNK signaling in the coordination of transcellular and paracellular flux to achieve NaCl and

10 Both transcellular and paracellular pathways of vascular solu

11 ntial physiological interactions between the transcellular and paracellular pathways of water transpo

12 ced pulmonary vascular hyperpermeability via transcellular and paracellular pathways.

13 HFg) mice were used to study cerebrovascular transcellular and paracellular permeability in vivo.

14 rimination with respect to the permeation of transcellular and paracellular probes, e.g. permeability

15 lecular mechanism involving AQP5 that allows transcellular and paracellular routes of water transport

16 ellularly, whereas sodium reabsorption takes transcellular and paracellular routes.

17 hin and between cells represent pathways for transcellular and paracellular transport of fluid.

18 the kidney, the proximal tubule allows both transcellular and paracellular transport, while the coll

19 y 36%, suggesting that Jdw was predominantly transcellular and that there was a negligible contributi

20 demonstrates that the diffusion is primarily transcellular and the main barrier is located in the lip

21 of (absorption) the biliary ductal lumen is transcellular and water channel-mediated.

22 paracellular) and through endothelial cells (transcellular) appear to be distinct processes.

23 ockout animals despite normal effects on the transcellular aquaporin-2-dependent pathway.

24 l convergence forces in the context of these transcellular arrays.

25 ced epithelial barriers in vitro, preventing transcellular bacteria dissemination.

26 d was associated with the restoration of the transcellular barrier and the re-establishment of apical

27 in endothelial cells form a paracellular and transcellular barrier to many blood-borne solutes via ti

28 thereby providing a mechanism for ameloblast transcellular bicarbonate secretion in the process of en

29 arious neural cells including neurons, their transcellular binding could be restricted to discrete si

30 bitory factor (Cif), can disrupt 15-epi LXA4 transcellular biosynthesis and function.

31 tions, namely RvTs, derived from n-3 DPA via transcellular biosynthesis and increased by atorvastatin

32 hydrolase-deficient mice, we show here that transcellular biosynthesis contributes to the production

33 providing unequivocal evidence of efficient transcellular biosynthesis of cysLTs.

34 o studies indicate that this process, termed transcellular biosynthesis, can lead to the production o

35 One intriguing aspect of LT production is transcellular biosynthesis: cells expressing 5-lipoxygen

36 Unexpectedly, proteins involved in transcellular Ca(2+) reabsorption in DCTs were not decre

37 potential vanilloid 5) is the gatekeeper of transcellular Ca(2+) reabsorption in the distal nephron.

38 mal models suggest may develop from impaired transcellular Ca(2+) reabsorption via TRPV5 in the dista

39 id type 5 (TRPV5) Ca(2+) channel facilitates transcellular Ca(2+) transport in the distal convoluted

40 l Ca(2+) channel TRPV6, which is involved in transcellular Ca(2+) transport in the intestine using th

41 ose or starch had higher rates of intestinal transcellular Ca(2+) transport, elevated intestinal and

42 riginate store-operated Ca(2+) entry-induced transcellular Ca(2+) waves that propagate glial excitati

43 activation of the basolateral CaR increases transcellular calcium transport independent of its effec

44 excavation requires both cellular energy and transcellular calcium transport, mediated by P-type ATPa

45 for CaT2 in three major tissues involved in transcellular calcium transport, namely intestine, kidne

46 dels to account for the emerging concepts on transcellular calcium transport.

47 Transcellular chaperone signaling leads to the compensat

48 We propose that transcellular chaperone signaling provides a critical co

49 This transcellular chaperone signaling response maintains org

50 ecific sensory neurons and by the process of transcellular chaperone signaling.

51 Transcellular Cl(-) and HCO(3)(-) transport is a vital f

52 ue distribution, CFEX also may contribute to transcellular Cl(-) transport in additional epithelia su

53 ated NaCl concentration is due to a block in transcellular Cl- movement.

54 solateral) receptors can mediate part of the transcellular Cl- transport by acinar and duct cells to

55 udies reveal a potentially new mechanism for transcellular Cl- transport in a CFTR-expressing tissue,

56 annels are known to play an integral role in transcellular Cl- transport in both the thin and thick a

57 e that prostacyclin generation can arise via transcellular collaboration between platelets and fibrob

58 Our data indicate that transcellular competitive processes govern synapse forma

59 ediating reversible assembly of a variety of transcellular complexes in the nervous system.

60 ng proteins are candidates to collaborate in transcellular complexes used in diverse contexts in nerv

61 Mechanical stress (30-cm H(2)O transcellular compressive stress) applied for 3 h induce

62 the junctional line, forming an integrated, transcellular contractile network.

63 Inhibition of ROCK activity, which drives transcellular contractility, restored adhesion of TNCEGF

64 adhesion to endothelial cells and augmented transcellular conversion of leukotrienes, a disturbance

65 s cells invade the central nervous system by transcellular crossing of the endothelium of the BBB.

66 gated the contribution of platelet-dependent transcellular cysLT production in AERD.

67 We examined transcellular cysLT synthesis during zymosan-induced per

68 6 microL/min per mm Hg/cm(2) with an average transcellular decrease in pressure of 3.33 +/- 0.16 mm H

69 This transcellular degradation of mitochondria, or transmitop

70 Hence, efficient transcellular delivery of IgG-based drugs across human e

71 Transcellular delivery of LTA(4) from marrow-derived cel

72 Secretion and transcellular delivery of vesicular SOCS proteins thus r

73 croparticles are generated and function as a transcellular delivery system will advance our basic und

74 Transcellular dendrites scanned the M-cell apical surfac

75 ial cells searching for areas permissive for transcellular diapedesis.

76 monstrate that virtually all, both para- and transcellular, diapedesis occurs in the context of a nov

77 absolute NL1 levels but instead depended on transcellular differences in the relative amounts of NL1

78 o hundreds of co-activated elements, and the transcellular DNase I sensitivity pattern at a given reg

79 ZO-1) and occludin and form a barrier with a transcellular electrical resistance (TCER) greater than

80 ut using diffusion of sodium fluorescein and transcellular electrical resistance (TER).

81 n, increased FITC dextran leakage, decreased transcellular electrical resistance and increased angiog

82 HC) electromotility was examined by means of transcellular electrical stimulation in a partitioning m

83 Length changes evoked by transcellular electrical stimulation were detected and m

84 This is consistent with transcellular endothelial fluid transport.

85 h kinase ligand, ephrinB1, and proposed that transcellular Eph/ephrin interactions made possible by t

86 s of Vibrio cholerae cause a decrease in the transcellular epithelial resistance of T84 intestinal ce

87 results highlight the potential relevance of transcellular exchange of LTA(4) for the synthesis of LT

88 ndicates that AQP6 is not simply involved in transcellular fluid absorption.

89 have shunted the PD, while at the same time transcellular fluid transport remained unaffected.

90 r and/or in surviving acinar cells, to drive transcellular flux of interstitial fluid into the labyri

91 n quality control mechanisms can promote the transcellular flux of these proteins in exosomes.

92 Therefore, stepwise impairment of transcellular followed by paracellular barrier mechanism

93 d with attenuated phosphorylation of the key transcellular glycoprotein (gp) 130.

94 we demonstrate that IF stresses result in a transcellular gradient in beta1-integrin activation with

95 - exchanger in the apical membrane to affect transcellular HCO3- transport.

96 Transcellular holes (mean diameter 0.6 microm) were also

97 ght to determine whether endothelial gaps or transcellular holes, similar to those found in leaky ves

98 We provide definitive evidence for transcellular (i.e., through individual endothelial cell

99 lation by approximately 60%, suggesting that transcellular ICl,swell largely mediates the increased c

100 ing limb of the loop of Henle, whereas it is transcellular in the distal convoluted tubule.

101 vectoral transport, and confocal imaging of transcellular insulin transport.

102 oligin-2 on insulin secretion is mediated by transcellular interactions.

103 llular (extracellular) route as opposed to a transcellular (intracellular) route based on the finding

104 Many studies have shown acute regulation of transcellular ion transport in airway epithelia.

105 icrovilli, aberrant junctions, and losses in transcellular ion transport pathways, likely leading to

106 ect many epithelial cell functions including transcellular ion transport, secretion, and cell death.

107 tical nodule cells contained bacteroids, but transcellular ITs were rarely observed.

108 yosin we also find evidence for formation of transcellular linear arrays incorporating these proteins

109 These studies indicate a novel mechanism of transcellular lipid metabolism whereby platelet activati

110 293 cells, group V and X PLA2s showed strong transcellular lipolytic activity, whereas group IIA PLA2

111 junctions (paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report

112 n to demonstrate the coexistence of seamless transcellular lumens and single or multicellular enclose

113 Transcellular magnesium (Mg(2+)) reabsorption in the dis

114 nism involving tight junctions and an active transcellular mechanism involving the type II sodium-dep

115 te lymph formation and suggest that LECs use transcellular mechanisms in parallel to the well-describ

116 y, yet the contributions of paracellular and transcellular mechanisms to this process in vivo are unk

117 oximal tubule of wild-type mice is primarily transcellular, mediated by AQP1 water channels, and requ

118 ric oxide (NO) is an endogenous, diffusible, transcellular messenger shown to affect regulatory and s

119 further processed by endothelial enzymes via transcellular metabolism before the resulting products t

120 fficient levels of LTB(4) production through transcellular metabolism in K/BxN serum-induced arthriti

121 acid by two cell types expressing a combined transcellular metabolon.

122 6) epithelial Mg(2+) channels participate in transcellular Mg(2+) transport in the kidney and intesti

123 ks targeted trafficking of LBRC membrane and transcellular migration by >90%.

124 We show that transcellular migration likewise requires targeted traff

125 ts) in the cremaster muscle circulation, but transcellular migration may be more important at sites s

126 In the present study, we investigated the transcellular migration of HIV-1 as a cell-free virus th

127 Increased transcellular migration of Rap1b-deficient neutrophils i

128 s been demonstrated to utilize both para and transcellular migration routes facilitated by endothelia

129 The LBRC is also recruited to mediate transcellular migration when that occurs.

130 During transcellular migration, LBRC membrane invests the trans

131 adhesion molecule were recruited to sites of transcellular migration.

132 regulate paracellular migration also control transcellular migration.

133 molecular mechanisms promote both para- and transcellular migration.

134 against PECAM or CD99, but not JAM-A, block transcellular migration.

135 enting cells (APC) and effector T cells form transcellular molecular complexes.

136 olateral membrane, and temperature-dependent transcellular movement from apical to basolateral media.

137 These processes involve transcellular movement of solutes across epithelial barr

138 intracellular actin/myosin cytoskeleton and transcellular N-cadherin adhesions.

139 al and conjunctival epithelia are capable of transcellular Na+ absorption and Cl- secretion, which dr

140 epletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick a

141 As in the synapse, transcellular neuroligin-2 interactions enhance the func

142 hese results indicate a significant role for transcellular neuroligin-2 interactions in the establish

143 lial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed

144 Advances in both paracellular and transcellular neutrophil migration through endothelial c

145 ers as a motile extracellular form that uses transcellular or paracellular migration, or by infecting

146 wed by firm adhesion, and ending with either transcellular or paracellular passage of the leukocyte a

147 Elucidation of epithelial transport across transcellular or paracellular pathways promises to advan

148 nsulin crosses the endothelium by a passive (transcellular or paracellular) or mediated process, accu

149 s promotes the neutrophil preference for the transcellular over the paracellular transmigration route

150 members of the SLC26 family that may mediate transcellular oxalate absorption.

151 Cftr(-/-) mice exhibited significantly less transcellular oxalate secretion than intestinal tissue o

152 flux from apical to basolateral surfaces by transcellular passage through cells or paracellular flux

153 ial basal membrane and transmigrated through transcellular passages formed by a ring of F-actin and c

154 Caveolin-1 expression appears to favor the transcellular path while down-regulation of caveolin-1 p

155 of a saturable Na+-dependent process by the transcellular pathway and a nonsaturable process by the

156 ibitors provides a template for generating a transcellular pathway and represents the first step towa

157 septic rats, indicating the blockade of the transcellular pathway by immunoglobulins administration.

158 Caveolae are thought to be the transcellular pathway by which plasma proteins cross nor

159 indicate that CFTR provides the predominant transcellular pathway for Cl and HCO in porcine airway e

160 The transcellular pathway is blocked by amiloride, and the p

161 ltrastructurally intact, suggesting that the transcellular pathway is responsible for the blood-brain

162 Ca(2+) entry into enterocytes as part of the transcellular pathway of calcium absorption in the intes

163 e pf values of SGLT1 and aquaporin-1 makes a transcellular pathway plausible, it renders water pumpin

164 Caveolae provide a possible, yet unproven, transcellular pathway to overcome such barriers.

165 and they crossed the HBMEC monolayers via a transcellular pathway without affecting the monolayer in

166 SPPs enhanced CsA skin penetration, via a transcellular pathway, enhancing its partitioning into k

167 cytes that they also commonly traversed by a transcellular pathway.

168 se drug transport across the BBB through the transcellular pathway.

169 ted skin relative to untreated skin, and (3) transcellular pathways are present in the LTRs of US tre

170 avasate from venules by apparently different transcellular pathways in response to vasoactive mediato

171 molecules permeate via both paracellular and transcellular pathways in the presence of PPS.

172 s, raising the possibility that vesicular or transcellular pathways may be important in lymphatic sol

173 in solid tumors, including paracellular and transcellular pathways that enable passive or active tra

174 pothesized that shifting sodium transport to transcellular pathways would lead to increased whole-kid

175 r filtration coefficient of paracellular and transcellular pathways, and a decrease in the reflection

176 herens junctions (AJs) and caveolae-mediated transcellular pathways.

177 invasion, we have examined HIV-1 uptake and transcellular penetration in an in vitro BMVEC model.

178 Both LPA and S1P prevented increased transcellular permeabilities induced by PMA, and increas

179 ed paracellular, aqueous boundary layer, and transcellular permeabilities, and the villus-fold surfac

180 irus-specific enhancement of paracellular or transcellular permeability or changes in the organizatio

181 In active celiac disease, increases in transcellular permeability to intact gliadin peptides mi

182 ty by incubation with hepatoma cells and for transcellular permeability using Caco-2 cell monolayers.

183 Transcellular permeability, scaled by k(VF), was equated

184 mediates early mast cell PGD2 production and transcellular PGE2 production in murine mast cells, and

185 ified as essential for both paracellular and transcellular PMN transmigration, and interfering with I

186 Mechanisms for transcellular pore formation in endothelium remain unkno

187 cellular calcium were required for efficient transcellular pore formation in response to podosomes.

188 palpate the surface of, and ultimately form transcellular pores through, the endothelium.

189 C extended dendrites through M-cell-specific transcellular pores to the gut lumen.

190 s are highly fenestrated cells; they contain transcellular pores with diameters between 50 to 200 nm.

191 n plasma potassium concentration by means of transcellular potassium redistribution and feedback cont

192 alidated by analyzing effects of TGFbeta2 on transcellular pressure changes and outflow facility.

193 3 microL/min per mm Hg/cm(2) with an average transcellular pressure decrease of 3.13 +/- 0.09 mm Hg.

194 P(i) reabsorption is a transcellular process that occurs along the proximal tub

195 Recent experimental evidence suggests that transcellular propagation of fibrillar protein aggregate

196 Recent studies have highlighted the transcellular propagation of protein aggregates in sever

197 vity-mediated regulation of proteostasis and transcellular propagation of protein aggregates in the n

198 Transcellular propagation of protein aggregates, or prot

199 seases, including ALS, might progress due to transcellular propagation of protein aggregation among n

200 Evidence indicates that transcellular propagation of protein aggregation, which

201 immunotherapy and small molecules, to block transcellular propagation, and new diagnostic tools to d

202 In the central nervous system, transcellular protein interactions (i.e. interactions be

203 Neuroligin-2 interactions are one of the few transcellular protein interactions thus far identified t

204 as an intermediary protein that facilitates transcellular receptor-ligand interactions.

205 LPA increases transcellular resistance across cultured rabbit corneal

206 stance, and DGPP (8:0) inhibited LPA-induced transcellular resistance in both the epithelium and endo

207 in-2, are postulated to decrease the overall transcellular resistance.

208 Transcellular retrograde signaling from the postsynaptic

209 zed intestinal epithelial cells (IECs) via a transcellular route and remain biologically active.

210 dothelial cells using one of two pathways: a transcellular route directly through the cell or a parac

211 Together, these findings identify a transcellular route for intravascular maresin 1 biosynth

212 nd drug inhibitor data are consistent with a transcellular route in which internalized, basolateral-m

213 Unexpectedly, Rap1b deficiency promoted the transcellular route of diapedesis through endothelial ce

214 f podosome formation selectively blocked the transcellular route of diapedesis.

215 WAVE2 is needed for lymphocytes to follow a transcellular route through an EC.

216 cross microvessels in adult lung occurs by a transcellular route through AQP1 water channels and that

217 all NaCl-driven water transport occurs by a transcellular route through AQP1, whereas raffinose-driv

218 ophils emigrated from cutaneous venules by a transcellular route through both endothelial cells and p

219 e found to cross the epithelium via only the transcellular route.

220 sported through the paracellular but not the transcellular route.

221 h as passive diffusion via a paracellular or transcellular route.

222 reabsorption of calcium takes place via the transcellular route.

223 s, could additionally breach the BBB via the transcellular route.

224 vidual microvascular endothelial cells (the "transcellular" route) or between them (the "paracellular

225 These findings establish new transcellular routes for producing arrays of bioactive l

226 zing flow-activated, brush border-dependent, transcellular salt and water reabsorption.

227 tr(-/-) mice in Ussing chambers and measured transcellular secretion of [(14)C]oxalate.

228 sensitive to DIDS, and saturable, indicating transcellular secretion of oxalate.

229 nce between absorption and SLC26A6-dependent transcellular secretion.

230 site of colchicine injection is mediated by transcellular signaling across the corpus callosum; and

231 e anterior end, suggesting that P4H1 enables transcellular signaling by the tip.

232 Major features of the transcellular signaling mechanism responsible for endoth

233 We describe here a transcellular signaling pathway in embryonic hippocampal

234 ore, neuronal sff expression is dependent on transcellular signaling through a non-neural toll-like r

235 These microvesicles deliver transcellular signals across antigen-dependent synapses

236 e determined whether gap junctions propagate transcellular signals during metabolic stress and whethe

237 in NaCl sensitivity functions imply that the transcellular sodium transduction pathway is necessary f

238 e contractile forces are transmitted through transcellular structures.

239 We observed robust transcellular TEM with TNF-alpha-activated HUVECs and IC

240 ell as endothelial cell shape contributed to transcellular TEM.

241 plasmic tail function preferentially reduced transcellular TEM.

242 f endothelial caveolae that is essential for transcellular trafficking of albumin and is also a criti

243 Subcellular and transcellular trafficking strategies now permit (1) opti

244 inants of N. gonorrhoeae that play a role in transcellular trafficking.

245 n stimulate Shiga toxin macropinocytosis and transcellular transcytosis alters current ideas concerni

246 nd a presumptive exocytosis component of the transcellular transcytosis route.

247 Collectively, these data suggest that the transcellular transduction pathway is both necessary and

248 Recent evidence supports transcellular transfer of tau misfolding (seeding) as th

249 nce (RNAi) specifically decreased lymphocyte transcellular transmigration.

250 id assembly and cytoplasmic envelopment, and transcellular transmission in differentiated neural prog

251 lt in overcoming this barrier and increasing transcellular transport across it.

252 n in mouse cortical collecting duct (CCD) by transcellular transport across type B intercalated cells

253 This protein is thought to function in the transcellular transport and enterohepatic circulation of

254 e examined whether TGF-beta(1) regulates the transcellular transport and metabolism of L-arginine by

255 , we examined whether thrombin regulates the transcellular transport and metabolism of L-ornithine by

256 ese include intracellular chain association, transcellular transport and secretion, proteolytic proce

257 METHODS AND We demonstrate that transcellular transport mechanisms substantially contrib

258 (i.e., apical to basolateral) Na+-dependent transcellular transport of [3H]taurocholate.

259 Transcellular transport of agonist-conjugated HAuNS was

260 as well as caveolae-mediated endocytosis and transcellular transport of albumin and uptake of cholera

261 First, we demonstrated active transcellular transport of both digoxin and quinidine in

262 Dental enamel formation depends upon the transcellular transport of Ca(2+) by ameloblasts, but li

263 diated cell association, internalization and transcellular transport of molecular IgG.

264 In summary, the transcellular transport of proteins across the podocyte

265 ntisense radiopharmaceuticals, providing the transcellular transport of these molecules is enabled wi

266 ent abilities to facilitate paracellular and transcellular transport of water and solutes.

267 hin the embryo occur through a sophisticated transcellular transport pathway causing the proteolytic

268 The FcRn-IgG transcellular transport pathway may provide a general de

269 s on the cross-talk between paracellular and transcellular transport pathways.

270 cale pipet to differentiate paracellular and transcellular transport processes at high spatial resolu

271 ondrial metabolism and biogenesis as well as transcellular transport processes involved in countercur

272 here are important differences in the Ca(2+) transcellular transport systems used by secretory- and m

273 f the passive flow of counter ions to active transcellular transport, thereby controlling net transep

274 ugh epithelial tight junctions and protected transcellular transport.

275 y that would complement known differences in transcellular transport.

276 le the collecting duct primarily facilitates transcellular transport.

277 h FcRn-independent paracellular, rather than transcellular, transport of antibodies.

278 Whereas WNK4 is known to regulate several transcellular transporters and channels involved in NaCl

279 the lack of influence of inhibitors of major transcellular transporters.

280 Transcellular tubes called infection threads then develo

281 actin cytoskeleton is the primary barrier to transcellular tunnel formation using a combination of at

282 s both passive and active resistance against transcellular tunnel formation, serving as a mechanical

283 es are sufficient to induce the formation of transcellular tunnels in HUVECs.

284 ial toxin EDIN, which can induce spontaneous transcellular tunnels, less mechanical work is required

285 opening holes in endothelial cells, known as transcellular tunnels, which are formed by contact and s

286 left, and postsynaptic specialization form a transcellular unit to enable efficient transmission of i

287 NT also facilitated transcellular uptake of (3)H-glucose and (3)H-leucine an

288 ests that these cells mediate K(+) and water transcellular uptake until the initiation of phototransd

289 d tight junctions and extremely low rates of transcellular vesicular transport (transcytosis).

290 was to determine the relative importance of transcellular (vesicular) versus paracellular transport

291 dothelium involves two different routes: one transcellular, via caveolae-mediated vesicular transport

292 significant difference in the proportion of transcellular vs. paracellular transport between male an

293 nd the vacuolar content, and to permit rapid transcellular water flow through living cells when requi

294 In nontransfected NMCs, the transcellular water flow, P(f), value was relatively hig

295 ty in cell membranes is essential to control transcellular water flows.

296 ications on adaptational processes governing transcellular water flux and/or cell survival under extr

297 Thus, AQP4-mediated transcellular water movement is crucial for fluid cleara

298 alled aquaporins (AQPs) that are involved in transcellular water transport in mammals.

299 ed deletion of Aquaporin 5 (AQP5), the major transcellular water transporter in salivary acinar cells

300 racellular, which is energy independent, and transcellular, which is energy dependent-primarily focus