ライフサイエンスコーパス: transcobalamin

1 mentarity than those of intrinsic factor and transcobalamin.

2 proteins: haptocorrin, intrinsic factor, and transcobalamin.

3 wanted physiologic tissue uptake mediated by transcobalamin.

4 ely 20-25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is referred to as active

5 erum vitamin B12 into the fractions bound to transcobalamin and haptocorrin: two carrier proteins wit

6 wer and threefold faster, respectively, than transcobalamin binding to cyanocobalamin.

7 Transcobalamin binds cyanocobalamin-b-(5-aminopentylamid

8 Transcobalamin bound vitamin B12 (holoTC) was not influe

9 The derivative shows no binding to transcobalamin but is recognized by haptocorrin, a prote

10 rphism of the vitamin B-12 transport protein transcobalamin gene (TCN2) (rs1801198; Pro259Arg) is ass

11 been hypothesized that the response of holo-transcobalamin (holo-TC) to oral vitamin B-12 may be use

12 2 associated with the plasma binding protein transcobalamin (holotranscobalamin) have been developed.

13 ation, whereas B12 bound to non-glycosylated transcobalamin (i.e. holoTC) is not affected.

14 Transcobalamin II (TC II) receptor is expressed in the a

15 nesis of the 5'-flanking region of the human transcobalamin II (TC II) transfected in human intestina

16 Cobalamin attached to transcobalamin II (TC II), known as holo-TC II, is the a

17 75G>C) in the vitamin B12 transport protein, transcobalamin II (TCII), has been identified in which p

18 ptor, the transcobalamin II receptor and the transcobalamin II carrier protein.

19 (bp) (-581/-513) fragment derived from human transcobalamin II distal promoter constructed upstream o

20 t for 12 h also resulted in complete loss of transcobalamin II receptor (TC II-R) activity/protein le

21 Transcobalamin II receptor (TC II-R) exists as a monomer

22 esses the B12-intrinsic factor receptor, the transcobalamin II receptor and the transcobalamin II car

23 that the analogs could be effective in vivo transcobalamin II receptor imaging agents.

24 dly dividing cells up-regulate the number of transcobalamin II receptors during DNA replication.

25 cobalamin analogs for the purpose of imaging transcobalamin II receptors in malignant and nonmalignan

26 ysteine, methylmalonic acid, and the ligand, transcobalamin II, in their plasma.

27 Exogenously added transcobalamin II-[57Co]cyanocobalamin bound very poorly

28 Transcobalamin II-receptor (TC II-R) contains 10 half-cy

29 Rabbits injected with pure human placental transcobalamin II-receptor (TC II-R) failed to thrive wi

30 ort is mediated by three transport proteins: transcobalamin, intrinsic factor, and haptocorrin (HC).

31 ine the affinity of different cobalamins for transcobalamin, intrinsic factor, and nonintrinsic facto

32 irect binding assay, where recombinant human transcobalamin is conjugated to a biosensor chip, allows

33 n binding, shows that only recombinant human transcobalamin is sensitive to modification of the corri

34 ponse data for cyanocobalamin binding to the transcobalamin protein surface were globally fitted to a

35 In vitro binding of the analogs to the transcobalamin proteins was assessed by the unsaturated

36 respectively, as efficient in binding to the transcobalamin proteins when compared to cyanocobalamin.

37 ulation bound to transcobalamin (TC) via the transcobalamin receptor (TC-R).

38 uptake of cobalamin (Cbl) is mediated by the transcobalamin receptor (TCblR) that binds and internali

39 Gene defects of transcobalamin (TC) and the transcobalamin receptor (TCblR), needed for cellular upt

40 A common genetic polymorphism [transcobalamin (TC) 776C-->G] may affect the function of

41 Gene defects of transcobalamin (TC) and the transcobalamin receptor (TCb

42 Transcobalamin (TC) has been cloned and used for studyin

43 Second, Cbl bound to plasma transcobalamin (TC) II is taken up from the circulation

44 receptor (TCblR) that binds and internalizes transcobalamin (TC) saturated with Cbl.

45 The membrane receptor TCblR/CD320 binds transcobalamin (TC) saturated with vitamin B12 [cobalami

46 they obtain it from the circulation bound to transcobalamin (TC) via the transcobalamin receptor (TC-

47 The membrane receptor (TCblR/CD320) for transcobalamin (TC)-bound cobalamin (Cbl) facilitates th

48 The transcobalamin (TC, TCII) receptor (TCblR) on the plasma

49 in (TC) 776C-->G] may affect the function of transcobalamin, the protein required for vitamin B-12 ce

50 Like haptocorrin and transcobalamin, the trout cobalamin-binding protein was

51 ment of cobalamin, holotranscobalamin, total transcobalamin, total haptocorrin, and methylmalonic aci

52 C--> G polymorphism on concentrations of the transcobalamin-vitamin B-12 complex (holo-TC) and to det