ライフサイエンスコーパス: transcription

1 on, including extremely widespread noncoding transcription.

2 view is that they can initiate bidirectional transcription.

3 t that predicted the initial wave of zygotic transcription.

4 tains an AD required for Rap1-dependent gene transcription.

5 breast cancer resistance protein (BCRP) gene transcription.

6 hesis as well as c-di-GMP-induced stalk gene transcription.

7 uence the pause-initiation limit to regulate transcription.

8 sis, and regulation of apoptosis and nuclear transcription.

9 cks repressor complexes to enable viral gene transcription.

10 by epigenetically activating Wnt target gene transcription.

11 aling via signal transducer and activator of transcription.

12 ating a positive feedback loop that sustains transcription.

13 o an intricate relationship between DSBs and transcription.

14 ivators contribute to the regulation of CCC1 transcription.

15 increased levels of sigma(F) -directed gene transcription.

16 sion, often mediated by global regulators of transcription.

17 activating H3K4-trimethyl marks promoting AR transcription.

18 single sigma factor to regulate chloroplast transcription.

19 o reveal the heterogeneity in IL-4-induced I transcription.

20 in, is critical for the eventual recovery of transcription.

21 level that cannot support productive reverse transcription.

22 hanges in chromatin states alter kinetics of transcription.

23 lymphoma/signal transducer and activator of transcription 3 pathway in keratinocytes.

24 Jak2 and signal transducer and activator of transcription 3 phosphorylation and the expression of do

25 increased signal transducer and activator of transcription 3 phosphorylation, reduced IL-2 production

26 diated by signal transducer and activator of transcription 3 through an IL-23/acutely transforming re

27 sting platform relies on a defined exogenous transcription activator capable of binding a unique reco

28 Transcription activator-like (TAL) effectors from Xantho

29 ty map of promoters and enhancers, revealing transcription-activity-linked genomic interactions in th

30 Slow transcription also evoked a hyperphosphorylation of CTD

31 inding of the repressor factor RE1-silencing transcription (also known as neuron-restrictive silencer

32 he oocyte-to-embryo transition by activating transcription, altering protein-coding sequences, produc

33 portance of RALY as an indirect regulator of transcription and cell cycle progression through the reg

34 bpA, show the effects of RbpA truncations on transcription and cell physiology, and indicate addition

35 crucial for cell identity by enhancing both transcription and Drosha/DGCR8-mediated primary miRNA (p

36 ons of genes is negatively regulated by gene transcription and may be modified by early-life experien

37 alpha (TNFalpha) selectively reduces BMPR-II transcription and mediates post-translational BMPR-II cl

38 Analyzing genome-wide transcription and repair by next-generation sequencing,

39 virus assembly and as a template for genome transcription and replication.

40 rors the rapid and dynamic induction of DLL4 transcription and that this pathway is required for DLL4

41 The effect of PDF on clock gene transcription and the known role of PDF in enhancing PER

42 Adaptation generally occurs via changes in transcription and translation.

43 remodeling complex is required for oncogenic transcription and tumor growth in non-small-cell lung ca

44 emonstrate a key role for HDAC1 in PU.1 gene transcription and, more importantly, uncover a novel mec

45 leads to an upregulation of HBV replication, transcription, and antigen expression.

46 in modifications associated with euchromatic transcription, and couple RNAi-mediated transcript degra

47 romatin accessibility, enhances histone gene transcription, and promotes HLB formation.

48 se were closely associated with translation, transcription, and replication.

49 either significantly increase T-box-mediated transcription antitermination, while other compounds cou

50 In both cases, altered transcription appears to be the progenitor, with subsequ

51 ing lipophilic ligands and adapting cellular transcription appropriately.

52 RXRA regulates transcription as part of a heterodimer with 14 other nuc

53 nase A pathway is potently inducing IL-1beta transcription, as well as boosting the ability of LPS to

54 DNA binding and transcription assays demonstrated that the minor T allel

55 segments, Rad21 or SMC3 (cohesin components),transcription at transcription start sites (TSS), and th

56 gulation such as the "hit-and-run" model and transcription bursting that could not be obtained by in

57 s, which resulted in a minimal impact on MYC transcription, but did not result in a statistically sig

58 histone phosphorylation, in turn, regulates transcription by attenuating the effect of local arginin

59 Bacterial 6S RNAs globally regulate transcription by binding RNA polymerase (RNAP) holoenzym

60 sults suggest that CTCF promotes HSV-1 lytic transcription by facilitating the elongation of RNA Pol

61 nique strategy for selectively targeting MYC transcription by pharmacological means as a potential tr

62 f MCL-1 mitochondrial localization and BFL-1 transcription by the viral EBNA3A protein.

63 Conflicts between replication and transcription challenge chromosome duplication.

64 Previously, we showed that the transcription co-factor CRP2 was a regulator of smooth m

65 FOXO has been shown to interact with diverse transcription co-factors and integrate signals from mult

66 a subunit is a part of RNA binding domain in transcription complex.

67 hybrid formation, and promote collisions of transcription complexes with replisomes.

68 tween patients in XP subgroups with impaired transcription coupled nucleotide excision repair (TC-NER

69 ensatory roles for global-genome (XPC-1) and transcription-coupled (CSB-1) NER in ICL sensing were ex

70 Eukaryotic transcription-coupled repair (TCR) is an important and w

71 repeat-encoding RNA (TERRA), but the role of transcription, CTCF, and TERRA in telomere replication i

72 suggest that in the absence of conventional transcription cycles, RBCs maintain a circadian rhythm i

73 Downregulation of transcription depends on ATM kinase activity and on the

74 microenvironments are highly differentiated transcription domains.

75 as new regions of the genome become open for transcription during terminal differentiation, blocking

76 le for H2A.Z in coordinating the kinetics of transcription elongation and splicing.

77 We found that several components of the PAF1 transcription elongation complex contribute to Chd1 recr

78 and CRISPR loci, Spt4/5 is recruited to the transcription elongation complex during early elongation

79 The RNA polymerase II (Pol II) transcription elongation factor, Elongin A (EloA), is me

80 dition to serving as a histone chaperone and transcription elongation factor, Spt6 counteracts repres

81 ate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as polymera

82 The transcription error rate estimated from mistakes in end

83 TREX (TRanscription-EXport) is a multiprotein complex that pla

84 cing expression of microphthalmia-associated transcription factor (MITF), and subsequent reductions i

85 Comprehensive transcription factor (TF) annotation discovered 978 TFs

86 Plants have significantly more transcription factor (TF) families than animals and fung

87 cer associate domain (TEAD) and runt-related transcription factor 2 (RUNX2) transcription factors, re

88 We administered lentiviral transcription factor activated luciferase/eGFP reporter

89 into "functional subsets" according to their transcription factor and cytokine profiles.

90 ndently, and then simultaneously, mutating a transcription factor and the associated promoter it repr

91 The multispecific transcription factor and tumor suppressor FOXO3 is an im

92 rosophila, graded expression of the maternal transcription factor Bicoid (Bcd) provides positional in

93 attempted to determine the interplay between transcription factor binding motif evolution and GRN top

94 s by temporal expression pattern, identified transcription factor binding motifs enriched in each clu

95 Finally, by integrating transcription factor binding motifs in a machine learnin

96 on self-organizing maps with sequence-based transcription factor binding prediction led to the ident

97 < 1e-05) CpGs are significantly enriched for transcription factor binding sites of EBF1, EP300, and C

98 d a structure-based method for prediction of transcription factor binding sites using an integrative

99 of this fragment by promoting serum response transcription factor binding to a cryptic cis-element.

100 enriched for histone-tail modifications and transcription factor binding with particular relevance f

101 indings demonstrate that during evolution, a transcription factor can act through multiple mechanisms

102 Analysis of enriched transcription factor DNA-binding sites in the promoters

103 icantly with those bound by the S-phase gene transcription factor E2F1.

104 We find the transcription factor early growth response 3 (EGR3) is i

105 functions are transcriptionally regulated by transcription factor EB (TFEB) through the induction of

106 aloric restriction, is known to activate the transcription factor EB (TFEB), a master regulator of li

107 ranslocation of the lysosomal stress-sensing transcription factor EB and, eventually, cell death.

108 to disrupt a consensus binding site for the transcription factor ETS within an enhancer region.

109 ate lymphoid cells (ILC2) share cytokine and transcription factor expression with CD4(+) Th2 cells, b

110 Members of the MiT transcription factor family are pivotal regulators of se

111 The forkhead box transcription factor FOXC1 plays a critical role in embr

112 els promote the expression of the promitotic transcription factor FOXM1 (Forkhead box protein M1).

113 nodes in the metabolic network, the forkhead transcription factor FOXO has been shown to interact wit

114 suppress the induction of expression of the transcription factor Foxp3 in T cells, trans-presentatio

115 of structural variants, as they affect more transcription factor hubs in the tissue-specific network

116 cer located upstream of HLX (which encodes a transcription factor implicated in sprouting angiogenesi

117 Thus, two enhancers integrate combinatorial transcription factor input, feedback and redundancy to g

118 We found that the TCR-signal-induced transcription factor Irf4 is essential for the different

119 The p53 transcription factor is a critical barrier to pancreatic

120 Unexpectedly, the transcription factor is an ortholog of the stomatal regu

121 This 'master regulator' transcription factor is at the top of the hierarchy of t

122 ion defects that are mimicked by loss of the transcription factor KLF4.

123 ver-enriched, endoplasmic reticulum-tethered transcription factor known to regulate the hepatic acute

124 -fructose diet in mice and that loss of this transcription factor leads to hepatic inflammation and e

125 nge from changes in protein conformation and transcription factor localization to chromosome reorgani

126 The transcription factor Meis1 drives myeloid leukemogenesis

127 caused by mutations in the gene encoding the transcription factor Methyl CpG Binding Protein 2 (MECP2

128 ooperate to bind components of the available transcription factor milieu.

129 contained the gene microphthalmia-associated transcription factor Mitf that has previously been assoc

130 e the Arabidopsis thaliana SG2-type R2R3-MYB transcription factor MYB15 as a regulator of defense-ind

131 NAc-modified proteins at the promoter of the transcription factor MYBL1, which was also characterized

132 owed that Tnc expression is repressed by the transcription factor Nkx2-1, a well-established suppress

133 lved in neural differentiation, and that the transcription factor OLIG2 is a central node in the affe

134 Here we describe a parasite-specific transcription factor PfAP2-I, belonging to the Apicomple

135 sed auxin biosynthesis, mediated by the bHLH transcription factor PHYTOCHROME-INTERACTING FACTOR 4 (P

136 Regulatory networks that include the Gata2 transcription factor play central roles in hematopoietic

137 Zbtb16-encoded transcription factor PLZF directs the differentiation of

138 rtly by intercellular communication, and the transcription factor PqsR is a necessary component in th

139 We now show that the homeodomain-containing transcription factor Prep1 is a repressor of adipogenic

140 At the 1q24 locus, we hypothesized that the transcription factor PRRX1 could be a strong candidate g

141 ecies Arabidopsis thaliana, the AP2-type AP2 transcription factor represents a major A-function prote

142 enes and reduces the DNA occupancy of YY1, a transcription factor required for OL maturation.

143 The high-mobility group box transcription factor SOX4 is the most highly expressed S

144 ling, as manifested by downregulation of the transcription factor Sp1.

145 otein kinases required for activation of the transcription factor Spo0A.

146 ransition, it is antagonized by the MADS box transcription factor SQUAMOSA (SQUA).

147 The hybrid transcription factor SS18:SSX alters SWItch/Sucrose Non-

148 Nuclear Factor Y (NF-Y) is a heterotrimeric transcription factor that binds CCAAT elements.

149 TonEBP/NFAT5 is an osmo-sensitive transcription factor that controls expression of genes c

150 ing framework, we identify EOR-1 as a unique transcription factor that may regulate chromatin dynamic

151 YTOCHROME INTERACTING FACTOR 4 (PIF4), a key transcription factor that promotes hypocotyl growth.

152 this study, we describe the dual role of the transcription factor Xylanase promoter binding protein 1

153 B cells expressing the T-bet transcription factor, a marker for ABCs, were generated

154 The E26 transformation-specific transcription factor, ETV4, which is induced by FGF sign

155 vestigated whether variation in binding of a transcription factor, the vitamin D receptor (VDR), whos

156 ion of the SAM pointed domain-containing ETS transcription factor, which contributes to goblet cell h

157 eceptor (ADORA2A) promotes hypoxia-inducible transcription factor-1 (HIF-1)-dependent endothelial cel

158 Finally, analysis of transcription factor-binding site motifs of differential

159 lly through mechanisms other than changes in transcription factor-binding sites that drive patterning

160 variants, of which at least six (35%) alter transcription factor-DNA binding in neuroblastoma cells.

161 A different transcription factor-encoding gene, nkx1-1, is required

162 reading frame of ERG, encoding an ETS family transcription factor.

163 scovered 30 years ago as a rapidly inducible transcription factor.

164 Several Kruppel-like transcription factors (KLF), including KLF15, are induce

165 ion by increasing expression of two cellular transcription factors (KLF4 and BLIMP1) which cooperativ

166 criptional dysregulation induced by aberrant transcription factors (TF) is a key feature of cancer, b

167 Transcription factors (TFs) are proteins that bind to sp

168 ith the adipogenic cocktail, which activates transcription factors (TFs) glucocorticoid receptor (GR)

169 Characterizing the binding specificities of transcription factors (TFs) is crucial to the study of g

170 In the 25 related transcription factors (TFs), our analysis of The Cancer

171 Three transcription factors act on these enhancers to determin

172 Smad transcription factors activated by TGF-beta or by BMP re

173 are cognate binding sites for the identified transcription factors and are necessary and sufficient f

174 cells expressed reduced levels of B-lineage transcription factors and B cell receptor (BCR)/pre-BCR-

175 me-wide functional screen to interrogate the transcription factors and cofactors in thermogenic gene

176 Proteome-wide identification of both, transcription factors and coregulators, can profoundly i

177 ) cell functional subsets are defined by key transcription factors and output of cytokines, such as I

178 underlying redox-regulation of AP-1 Fos/Jun transcription factors and provide structural insight for

179 lterations in the RB-regulated E2F family of transcription factors are infrequent, casting doubt on a

180 tion, we used the Atonal family of proneural transcription factors as a model.

181 PSC-CMs) were transduced with the neurogenic transcription factors Brn2, Ascl1, Myt1l and NeuroD.

182 egulatory Factor (MyRF) is one of the master transcription factors controlling myelin formation and d

183 ctor 1 (EBF1) and paired box 5, two critical transcription factors directing B cell lineage specifica

184 ntification and characterization of 175 bHLH transcription factors from apple (Malus x domestica).

185 in vitro Furthermore, SRC-2 coactivated the transcription factors GATA-binding protein 4 (GATA-4) an

186 xperiments revealed a critical role for FOXO transcription factors in mediating these proliferative v

187 ection promoted the expression of osteogenic transcription factors in normal jaw bone MSCs.

188 the present work we examine three dimers of transcription factors in the NFkappaB family: p50p50, p5

189 tly targeted Smad4, Hif1a, and Rora, all key transcription factors in the Th17 cell gene-expression p

190 ptual framework for how different classes of transcription factors interact to select and activate re

191 that the differentiation-dependent cellular transcription factors KLF4 and BLIMP1 induce lytic EBV r

192 by the expression of GRF1 and possibly other transcription factors of the GRF family.

193 e, the phosphate starvation (PHO) responsive transcription factors Pho4 and Pho2 are required for gen

194 Pioneer transcription factors recognise and bind their target se

195 Additionally, transcription factors regulating lignin biosynthesis wer

196 Several transcription factors regulating pancreas lineage specif

197 creted proteins controlled by a group of MYB transcription factors that are required for sperm releas

198 and promoters, which is mediated by pioneer transcription factors that recruit activating chromatin

199 iral proteins EBNA3A, EBNA3B, and EBNA3C are transcription factors that regulate a multitude of cellu

200 istinguishing features such as gene sets and transcription factors that show different activities amo

201 YTOCHROME INTERACTING FACTOR (PIF) family of transcription factors which have been shown to be involv

202 min A, acts as a ligand for nuclear receptor transcription factors with more than 500 known target ge

203 ulation of two basic helix-loop-helix (bHLH) transcription factors with predicted effector binding el

204 swap-minus (dsm) mutations are functional as transcription factors yet are defective in replication o

205 cosanoid-forming enzymes as well as relevant transcription factors, allowing us to better understand

206 f p38 and JNK, phosphorylation of downstream transcription factors, and overexpression of IFN-beta mR

207 periments on cells depleted for the Forkhead transcription factors, Fkh1 and Fkh2, previously associa

208 tors of gene expression, including other AP2 transcription factors, histone-modifying enzymes, and re

209 andidate genes, including cell type-specific transcription factors, neurotransmitter-synthesizing enz

210 rrelated with the expression of multiple ETS transcription factors, particularly in SDHD promoter wil

211 runt-related transcription factor 2 (RUNX2) transcription factors, respectively.

212 reduced expression of Th1 and Th2 associated transcription factors, Tbet and GATA3, and reduced produ

213 with non-sex-specific terminal selector-type transcription factors, whereas the sex specificity of dm

214 the expression of additional coactivators or transcription factors.

215 r consensus binding motifs for Nr4a and NFAT transcription factors.

216 ptides and vesicular release components, and transcription factors.

217 g the root-specific family of SCARECROW-Like transcription factors.

218 binding sites of the FOXA1, FOXA2 and HNF4A transcription factors.

219 acktracked RNA polymerase and hence promotes transcription fidelity.

220 ot activate interferon-stimulated gene (ISG) transcription following treatment with the noncanonical

221 ification for DNase-seq, analysis of nascent transcription from Global-Run On (GRO-seq) data, and cha

222 tly, HMBA has also been shown to trigger HIV transcription from latently infected cells, via a CDK9/H

223 However, primary transcription from pre-formed RNPs deposited by infectin

224 ed viral-mediated gene transfer to block the transcription function of CREB, SRF, and MEF2 in the vis

225 Studies of mitochondrial transcription have used a reductionist approach, perhaps

226 eeper understanding of the evolution of gene transcription in and between plant species, we performed

227 Nerve injury induces changes in gene transcription in dorsal root ganglion (DRG) neurons, whi

228 romoter that leads to downregulation of KCC2 transcription in prenatally exposed offspring.

229 ch glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultures.

230 ar barrier function through a non-canonical, transcription-independent signalling mechanism that driv

231 Several studies have defined transcription-induced nucleosome intermediates using onl

232 esponses in fission yeast cells by promoting transcription initiation.

233 Hence, nascent transcription is a rich source of information on the reg

234 Although this change in transcription is associated with a similar modest change

235 RNA sequencing confirmed that Hh-mediated transcription is increased in B-lineage cells from Gli3-

236 an be rapidly suppressed by IL-10 even after transcription is initiated, and this is associated with

237 the basis by which Cdx members impact their transcription is poorly understood.

238 ct of genetic variation on the regulation of transcription, isoform usage, and allele-specific expres

239 lts show that TCF19 interacts with an active transcription mark and recruits a co-repressor complex t

240 regulation raises the intriguing notion that transcription of an mRNA, despite carrying a canonical c

241 nstrated that mTORC1-S6K1 signaling controls transcription of CHK1 via Rb-E2F by upregulating cyclin

242 Additionally, we observed an increase in transcription of dipeptidylpeptidase 4, as well as a pla

243 The epigenetic mechanisms that (dys)regulate transcription of Dlg4/PSD95, or other plasticity genes,

244 tic cell identity tra-1, which represses the transcription of dmd-3 in hermaphrodite PHC.

245 gatively affects its ability to activate the transcription of downstream genes and promote cell proli

246 r, arising from a mutation that disrupts the transcription of Fragile X Mental Retardation Protein (F

247 JQ1 alters transcription of genes controlled by the host protein BA

248 radient is established in response to graded transcription of glycolytic enzymes downstream of fibrob

249 3 and BR signaling converge to influence the transcription of hypocotyl growth-promoting SAUR19 subfa

250 , which is essential for the replication and transcription of influenza virus RNA.

251 We find that transcription of nearly all mRNAs is strongly dependent

252 DnaA activates transcription of sda, and Sda inhibits histidine protein

253 ufC and sufD (sufD*), resulting in decreased transcription of sufSUB Consistent with the transcriptio

254 Transcription of telomere repeats can initiate at subtel

255 for > 94% of all transcripts, with increased transcription of the entire locus driving Flt1 upregulat

256 ed for visualizing distinct kinetic steps of transcription on a single-copy gene in vivo.

257 s known about how archaeal cells orchestrate transcription on a systems level.

258 and Mus musculus) showed a human-like mtDNA transcription pattern, the invertebrate pattern (Drosoph

259 Transcription perturbation experiments further indicate

260 early changes in HCV-specific CD8(+) T cell transcription preceded the overt establishment of T cell

261 its human tRNA(Lys3) to serve as the reverse transcription primer via an interaction between lysyl-tR

262 thesis.IMPORTANCE The fates of HIV-1 reverse transcription products within infected cells are not wel

263 ng are largely independent of alterations in transcription rate during the early stages of stress res

264 + T-cell, as indicated by an increased viral transcription rate in these cells.

265 support grows for the notion that the act of transcription rather than the RNA product itself is func

266 transcript isoforms with opposite effects on transcription recovery after UV-induced DNA damage.

267 understanding of the molecular mechanism of transcription regulation on cellular stress and reveal f

268 n using the network controlled by the fungal transcription regulator Ndt80.

269 role of epigenetic regulation of key cardiac transcription regulators.

270 tified locations of elongation complexes and transcription-repair coupling events in genes throughout

271 s that encode the E2 protein, which controls transcription, replication, and genome maintenance in in

272 analysis by techniques that rely on reverse transcription (RT) such as RT-qPCR and RNA-Seq.

273 es advantage of characteristic bidirectional transcription signatures at active TSSs in GRO/PRO-seq d

274 arly elongation within 500 base pairs of the transcription start site and akin to its bacterial homol

275 Spt4/5 is recruited proximal to the transcription start site on the majority of transcriptio

276 r SMC3 (cohesin components),transcription at transcription start sites (TSS), and the number of CCCTC

277 's enrichment or biased distribution towards transcription start sites in the promoters of co-express

278 ongly enriched in repressed regions and near transcription start sites, whereas the genetically regul

279 Transcription start-site (TSS) selection and alternative

280 of HMGA1 to stimulate beta-catenin-dependent transcription, suggesting that interactions between ORF2

281 eletion resulted in additive effects on CCC1 transcription, suggesting that other activators contribu

282 -catenin signaling elicits context-dependent transcription switches that determine normal development

283 studied nuclear, bacterial, or bacteriophage transcription systems but that similarities are found on

284 Here we report that PTCL are sensitive to transcription-targeting drugs, and, in particular, to TH

285 hts into the mechanism underlying eukaryotic transcription termination.

286 F100 in locating poly(A) sites and affecting transcription termination.

287 e recruitment of FACT (facilitates chromatin transcription that enhances the engagement of Pol II int

288 identified for their role in modulating CREB transcription, the past 5 years has seen an expansion in

289 ogen receptor alpha (ERalpha) regulates gene transcription through two activation functions (ERalpha-

290 ribosomes may contribute to the coupling of transcription to translation.

291 f cancer cell identity and promote oncogenic transcription to which cancer cells become highly addict

292 In contrast, most transcription units (gene bodies) in the human genome ar

293 lysis reveals that a total of 37 genes in 24 transcription units (TUs) belong to OmpR regulon.

294 transcription start site on the majority of transcription units, while on a subset of genes, includi

295 ction in CLL cells, stimulating PKCbeta gene transcription via increased association of SP1 and decre

296 HIV-1 transcription was quantified by measuring plasma HIV-1 R

297 ntrol pancreatic and beta-cell type-specific transcription, which are found within areas I (bp -2694

298 ed nucleotide is incorporated during reverse transcription, which greatly facilitates the protocol by

299 anscriptional chromatin modifications during transcription, which is affected by the strength of hist

300 improved the CRY2/CIB1-based light-inducible transcription with split construct optimization.