ライフサイエンスコーパス: transcription complex

1 a subunit is a part of RNA binding domain in transcription complex.

2 mponent in a newly defined, HOXA9-containing transcription complex.

3 inhibit progression of the RNA polymerase I transcription complex.

4 regulators recognize distinct states of the transcription complex.

5 motif, that were occupied by the NOTCH3/CSL transcription complex.

6 NGN2 simultaneously, forming a multi-protein transcription complex.

7 clear proteins and assembly of the NF-kappaB transcription complex.

8 the viral core, in proximity to the reverse transcription complex.

9 ng a pivotal role in regulation of the Notch transcription complex.

10 erves to bring RNA-processing enzymes to the transcription complex.

11 the assembly of a functional MHV replication-transcription complex.

12 l I-associated transcripts destabilizing the transcription complex.

13 y, is an integral part of the RNA polymerase transcription complex.

14 ith constitutive activation of the NF-kappaB transcription complex.

15 assembly and initiation of the mitochondrial transcription complex.

16 e necessary for the sigma recruitment to the transcription complex.

17 required for formation of a stable Met4-Cbf1 transcription complex.

18 ate that P-TEFb activity is regulated in the transcription complex.

19 hat Mist1 and Sp1 were found within the same transcription complex.

20 titermination-proficient modification of the transcription complex.

21 globulin genes, possibly via the spliceosome transcription complex.

22 isplacement activity when bound to a stalled transcription complex.

23 mily members and associating with CBP in the transcription complex.

24 uitment and anti-pausing modification of the transcription complex.

25 nstitutive activity of the beta-catenin-Tcf4 transcription complex.

26 al role for the CTD in CE recruitment to the transcription complex.

27 of nucleic acids at the upstream edge of the transcription complex.

28 nts within the nucleic acid framework of the transcription complex.

29 Tax facilitates the binding of CARM1 to the transcription complex.

30 al transcription as a component of RNA pol I transcription complex.

31 is an essential component of the early gene transcription complex.

32 rily conserved IDR within the metazoan TFIID transcription complex.

33 IL-23-induced SOCS1 binding to the IFN-gamma transcription complex.

34 multiple strategies for the assembly of the transcription complex.

35 y assemble the Notch1/Rbpj/Maml trimolecular transcription complex.

36 c segment that in turn is linked to a single transcription complex.

37 one chaperone FACT (facilitator of chromatin transcription) complex.

38 age complexes (Top1cc) up- and downstream of transcription complexes.

39 the yeast genome that interact with Pol III transcription complexes.

40 an bind to emerging transcripts and displace transcription complexes.

41 ) prior to its ATP-dependent dissociation of transcription complexes.

42 relevant mode of interaction within dimeric transcription complexes.

43 artially colocalize to the viral replication-transcription complexes.

44 , a DNA translocase that removes the stalled transcription complexes.

45 eleases newly synthesized RNA molecules from transcription complexes.

46 orks are arrested by encounters with head-on transcription complexes.

47 xtracellular antagonists and destruction and transcription complexes.

48 sites can be combined to form high affinity transcription complexes.

49 with coactivators, aids in the formation of transcription complexes.

50 he RapA-mediated remodeling of nonproductive transcription complexes.

51 rfering with the assembly of ATF1-containing transcription complexes.

52 s, thereby permitting assembly of functional transcription complexes.

53 cessing factors are stored for assembly into transcription complexes.

54 ssion and increasing the processivity of LTR transcription complexes.

55 in the recruitment of PCAF/P-TEFb-containing transcription complexes.

56 hey assemble with nuclear partners into NFAT transcription complexes.

57 ropriately phosphorylated as part of optimal transcription complexes.

58 xhibits a high propensity to form productive transcription complexes.

59 accumulation of backed-up arrays of stalled transcription complexes.

60 bservations of DNA scrunching on immobilized transcription complexes.

61 genes by forming chromatin-associated Notch transcription complexes.

62 ding acetylated histone tails and recruiting transcription complexes.

63 oteins bound to the template DNA, especially transcription complexes.

64 al species and, probably, different types of transcription complexes.

65 addition cycles and destabilize the initial transcription complexes.

66 those halted by protein-DNA barriers such as transcription complexes.

67 t of RNA- and chromatin-modifying factors to transcription complexes.

68 cleavage reactions in the context of stable transcription complexes.

69 nnel, restricting DksA action to a subset of transcription complexes.

70 NAP affects the activity and distribution of transcription complexes across the genome, and ultimatel

71 Formation of productive transcription complexes after promoter escape by RNA pol

72 cule techniques now permit the tracking of a transcription complex along a DNA template in real time

73 The DNA in transcription complexes also has a more open structure,

74 inst decapentaplegic homolog 3 (Smad3)/Smad4 transcription complex and by interfering with p300, a co

75 tDNAs by displacing the stable multi-protein transcription complex and by removing R-loops.

76 roteins that interact first with the reverse transcription complex and later with the preintegration

77 nent of the transcription factor IIH (TFIIH) transcription complex and plays essential roles in trans

78 ggers the dissociation of the CREB-CBP-TORC2 transcription complex and reduces gluconeogenic enzyme g

79 rs by the relative loss of the E2F4-p107-Sp1 transcription complex and replacement by the repressor E

80 K domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas

81 rminator is flexibly accommodated within the transcription complex and, unexpectedly, plays a major s

82 have identified proteins that bind tRNA gene transcription complexes and are required for tgm silenci

83 dels for communication between the tRNA gene transcription complexes and local chromatin are discusse

84 SRY competitively displaces SOX10 in such transcription complexes and represses their regulatory f

85 romote the local assembly of tissue-specific transcription complexes and show how nuclear pore compos

86 interact with the nontemplate DNA strand in transcription complexes and thus may interfere with each

87 SV rv-cyclin was found to be associated with transcription complexes and to affect transcription in a

88 targets include histones, components of the transcription complex, and components of the spliceosome

89 ion of the nuclear factor-kappaB (NF-kappaB) transcription complex, and its effect on apoE was elimin

90 he energy from ATP hydrolysis to disrupt the transcription complex, and stimulates DNA repair by recr

91 ions among TIF1gamma, the blood-specific SCL transcription complex, and the positive elongation facto

92 roach to identify Spt7, a member of the SAGA transcription complex, and the RP transactivator Ifh1 as

93 se similarity between the Pol II and Pol III transcription complexes, and additionally explain previo

94 s lacking components of chromatin modifiers, transcription complexes, and modulators of translation.

95 l machinery, the kinetics of assembly of the transcription complexes, and the synthesis and degradati

96 In the nucleus, ErbB3 interacts with transcription complexes, and thereby has a role in trans

97 ase III (Pol III) is one of three eukaryotic transcription complexes, and was identified as the compl

98 ast two-hybrid screen, we identified a novel transcription complex AR-p44-Smad1, confirmed for physic

99 The assay also reveals that stalled transcription complexes are common impediments to fork p

100 he results suggest that intergenic and genic transcription complexes are independent and possibly dif

101 about how collisions between replisomes and transcription complexes are minimized and the mechanisms

102 Transcription complexes are recruited not only to the gl

103 do not lead to replisome inactivation, that transcription complexes are the primary sources of this

104 ct early enhancers, each requiring different transcription complexes, are required for full activatio

105 s, including the FACT (facilitates chromatin transcription) complex, are central for these processes

106 dentify MAML1 and other members of the Notch transcription complex as high-confidence cellular intera

107 1 is not involved in interactions within the transcription complex as suggested by X-ray analysis.

108 essing mechanism driven by reorganization of transcription complexes as opposed to a scanning mechani

109 important molecular insights into how Notch transcription complexes assemble at different target gen

110 Pol II factors that we tested suggests that transcription complexes assemble via stochastic multiste

111 , these results suggest that the identity of transcription complex assembled in the core promoter-dep

112 Additionally, beta-catenin is present in transcription complexes assembled on the endogenous gona

113 binding regulates nucleosome positioning and transcription complex assembly >300 bp away and how core

114 omplex regulates the formation of the active transcription complex assembly (and, hence, transcriptio

115 t an early stage of chromatin remodeling and transcription complex assembly after binding of androgen

116 of both their unique and shared functions in transcription complex assembly and chromatin structure r

117 inding protein (TBP) plays a central role in transcription complex assembly and is regulated by a var

118 re, we demonstrate that the formation of the transcription complex assembly at the promoter is depend

119 In particular, we examine transcription complex assembly by the stress-directed SA

120 data suggest that MMS-induced genes undergo transcription complex assembly sequentially, first invol

121 nd suggest possible roles for this domain in transcription complex assembly.

122 r proteins to remodel chromatin and regulate transcription complex assembly.

123 at influence genomic occupancy of GR as well transcription complex assembly.

124 y ensure lambdaQ is recruited exclusively to transcription complexes associated with P(R').

125 enhancer elements regulate the assembly of a transcription complex at a promoter remains poorly under

126 genes in mouse ES cells and suggest that the transcription complex at developmental genes is differen

127 s a central role in both the assembly of the transcription complex at gene promoters and also in the

128 binding protein alpha (C/EBPalpha) to form a transcription complex at the mouse adiponectin promoter

129 oss of SRC-2 leads to destabilization of the transcription complex at the peroxisome proliferator res

130 26p is not due to the defect in formation of transcription complex at the promoter.

131 the association of MARE-binding proteins and transcription complexes at LCR HS2 and the adult betamaj

132 ERK phosphorylates additional substrates in transcription complexes at mitogen-responsive promoters.

133 hat modulate the association and activity of transcription complexes at specific genes.

134 -2alpha directly interacted with Sp1 to form transcription complexes at two tandem Sp1-binding sites

135 the source of the ssDNA cofactor within the transcription complex because removal of the non-templat

136 n is transient, as Brd4 is released from the transcription complex between positions +14 and +36.

137 an intricate network of interactions within transcription complexes between RNAP, transcription fact

138 cleotide transcripts that remain part of the transcription complex but cannot be further elongated.

139 into the assembly of a Notch pathway active transcription complex but have also raised several intri

140 parently dispensable for RfaH binding to the transcription complex but is required for the antitermin

141 plisome stalls upon collision with a head-on transcription complex, but instead of collapsing, the re

142 of SF3b RNA splicing complex and STAGA/TFTC transcription complexes, but its specific function withi

143 d, in the nucleus, disrupts functional Smad3 transcription complexes by competing with coregulators.

144 fd releases transcripts and rescues arrested transcription complexes by moving the transcription elon

145 oped a method to visualize HIV-1 DNA reverse transcription complexes by the incorporation and fluores

146 These results suggest that the transcription complex can interact with either uncharged

147 lear translocator (ARNT), to form functional transcription complexes capable of DNA binding and gene

148 Moreover, the master circadian transcription complex CLK/CYC directly regulates Mef2 tr

149 ilize the short early transcripts before the transcription complex commits for processive elongation.

150 for promoter chromatin remodeling and basal transcription complex communication.

151 Transcription complex components frequently show coupled

152 ng regulates gene expression by inhibiting a transcription complex consisting of the transcriptional

153 malignant renal proximal tumor cells, that a transcription complex, consisting of NF-kappaB p65 and m

154 itochondrial transcription and distinct from transcription complexes containing POLRMT and h-mtTFB2.

155 X-ray crystal structures of transcription complexes containing short RNAs reveal thr

156 veral direct targets of the beta-catenin/TCF transcription complex (cyclin D1, c-MYC, c-MYC-binding p

157 tions between sigma and the remainder of the transcription complex decreases.

158 rmutation requires RNA polymerase II (polII) transcription complex-dependent targeting of the DNA mut

159 translocation of RNA polymerase, leading to transcription complex dissociation.

160 enhanced retention of a U5 snRNP subunit on transcription complexes downstream of the gene.

161 RfaH is recruited to the transcription complex during RNA chain elongation throug

162 and chromatin immunoprecipitation to analyze transcription complex dynamics in gene regulation during

163 disassembly of the highly stable elongating transcription complex (EC) over windows of two to three

164 obal analysis reveals that the TFIIIB-TFIIIC transcription complex exhibits remarkable structural ela

165 This transcription complex facilitates generation of both pro

166 data indicate that the facilitates chromatin transcription complex (FACT) interacts with CKII and may

167 rimeric IFN-stimulated gene factor 3 (ISGF3) transcription complex for induction of IFN-stimulated ge

168 strate a general strategy of using embryonic transcription complexes for producing specific cell type

169 nt data arguing that sigma-dependent stalled transcription complexes form frequently in vivo, where t

170 inct mechanisms, including protein turnover, transcription complex formation and selective enzyme rec

171 comitantly disrupted myocardin/SRF and Notch transcription complex formation at respective CArG and C

172 promoter interactions, thereby facilitating transcription complex formation.

173 olymerase to the promoter and the productive transcription complex formation.

174 represents a new factor that participates in transcription complexes formed on both pol II and III pr

175 similar to the orientation and occupancy of transcription complexes formed with TFB1.

176 icated that the orientation and occupancy of transcription complexes formed with TFB2 at the strong g

177 1 on the silencer, P-TEFb interacts with the transcription complex, forming a different chromatin loo

178 matin immunoprecipitation analysis of apo A1 transcription complexes from control and ligand-activate

179 to RNA polymerase (RNAP) and removes stalled transcription complexes from DNA.

180 kinase and the polymerase associated factor transcription complex function upstream of the Spt6-Ctk1

181 iator 1, an anchor for multisubunit mediator transcription complex, functions as a transcription coac

182 Gdown1 can enter the transcription complex immediately after initiation.

183 that another major role for the Nus-modified transcription complex in rrn operons is as an RNA chaper

184 of the Hap complex human homologue NF-YA/B/C transcription complex in SURF1-deficient fibroblasts fro

185 Thus, glyco-Gag rendered the reverse transcription complex in the viral core resistant to APO

186 PKCalpha, a component of the transcription complex in tumors, is up-regulated in beni

187 BEC3 in vivo--namely, protecting the reverse transcription complex in viral cores from APOBEC3.

188 19 was not required for incorporation of the transcription complex in virus particles, the transcript

189 to regulate the recruitment and activity of transcription complexes in a tissue-specific chromatin d

190 We demonstrate that RECQ5 associates with transcription complexes in DNA replication foci and coun

191 nd tightly packed with a conserved number of transcription complexes in icosahedral capsids.

192 n structure accessibility and recruitment of transcription complexes in the beta-globin gene locus an

193 Thus, acetate directly alters transcription complexes in vitro in ways that lead to si

194 However, the nature of mitochondrial transcription complexes in vivo and the potential involv

195 ith the highly dynamic behavior of RNA Pol I transcription complexes in vivo, which undergo cycles of

196 We hypothesize that DksA binds to transcription complexes in which i6 becomes mobile, for

197 myces cerevisiae FACT (facilitates chromatin transcription) complex in assembling chromatin within op

198 required to clear protein blocks (primarily transcription complexes) in vivo, and that a polarity of

199 ed by mass spectrometry as components of the transcription complex, including RNA polymerase subunits

200 Recently, Brd4 has been found in several transcription complexes, including the general cofactor

201 R-loops, but not normal transcription complexes, induce DNA breaks and orientati

202 perative interactions of PspF with the basal transcription complex influence dynamics of the PspF hex

203 The evolutionarily conserved Six1-Eya1 transcription complex is central to mammalian organogene

204 show that a previously unrecognized kind of transcription complex is formed during RNA polymerase-ca

205 ever, the source of this cofactor within the transcription complex is not known.

206 As expected, assembly of active transcription complexes is coupled to eviction of H2A.Z

207 thways, one of which, involving the Mediator transcription complex, is associated with the shift from

208 Based on available structures of transcription complexes it has been hypothesized that th

209 We characterized transcription complexes made with RNA polymerase and the

210 that primary DNA lesions as well as stalled transcription complexes may act as signals to initiate t

211 DNA synthesis was inhibited, suggesting that transcription complexes may be formed early on L promote

212 PUFA-sensing PPARG-retinoid X receptor (RXR) transcription complex, may influence neovascularization

213 Within Hox transcription complexes, Meis binds directly to Pbx and

214 tor of the major histocompatibility class II transcription complex (MHC-II) and is critical for initi

215 The replication/transcription complex of severe acute respiratory syndro

216 It also identified LXR in the apo A1 transcription complex of TO901317-treated cells.

217 -pair crosslinking (CPX) analyses of various transcription complexes of a bacterial RNAP and crystall

218 Most transcription complexes of the inserted units terminate

219 ur length were ideal for analysis of T7 RNAP transcription complexes on bound single template DNAs.

220 that STAT5 is an early step in establishing transcription complexes on genes specifically expressed

221 that cooperative formation of dimeric Notch transcription complexes on promoters with paired sites i

222 and analysis, which enabled localization of transcription complexes on templates at kilobase resolut

223 fected cells is crucial for the formation of transcription complexes on these promoters.

224 e to unwrap the RNA by disrupting either the transcription complex or the anchoring structure.

225 -centric look at the coronavirus replication transcription complex organelle in the context of the wi

226 the nucleus, as previously described for the transcription complex Paf1.

227 The RNA Pol II transcription complex pauses just downstream of the prom

228 lunt RANK activation and as a component of a transcription complex promoting FHL2 expression.

229 Reconstitution of the his paused transcription complex provides a valuable tool for futur

230 th EKLF-dependent processes by destabilizing transcription complexes, providing a rational explanatio

231 ts, we propose that YvrHa is situated in the transcription complex proximal to the -10 element of the

232 ythropoiesis, suggesting that Ldb1-nucleated transcription complexes regulate key steps during erythr

233 We conclude that the AHR-1:AHA-1 transcription complex regulates the expression of solubl

234 lar context: recruitment of Mfd to a stalled transcription complex relieves the autoinhibition and un

235 The activator protein-1 (AP1) transcription complex remains active for long periods af

236 functional architecture of T7 RNA polymerase transcription complexes remains incomplete.

237 pite the importance of CarD, its function at transcription complexes remains unclear.

238 ef1 and beta-catenin, which form a bipartite transcription complex required for initiation of the hai

239 by evoking MAPK cascades and activating AP-1 transcription complex resulting in alterations of gene e

240 kinase 3 (Plk3) signaling and the c-Jun.AP-1 transcription complex, resulting in apoptosis of corneal

241 We further identify a novel FHL2-AR-filamin transcription complex, revealing how deregulation of thi

242 ands to be made continuously and replication-transcription complex (RTC) activity to be unstable.

243 e transcription, but whether any are reverse transcription complex (RTC) cofactors or affect reverse

244 gation studies reveal that these replication-transcription complexes (RTCs) are associated with cellu

245 y decreasing RNAP pausing and increasing the transcription complex stability, in cooperation with hos

246 ry complex interacts with the RNA polymerase transcription complex, stabilizing it and allowing trans

247 dependent DNA translocase activity to remove transcription complexes stalled at sites of DNA damage,

248 o occurs via modulation of the efficiency of transcription complex subunit capture and assembly.

249 RNA cleavage in certain types of backtracked transcription complexes, suggesting that these complexes

250 omponents of the FACT (facilitates chromatin transcription) complex, SUPT16H and SSRP1, as top host f

251 eviously, raising a question of what makes a transcription complex susceptible to DksA.

252 RNA synthesis is performed by a replication-transcription complex that includes viral and cell prote

253 s the only factor within the multimegadalton transcription complex that is obligatorily required to u

254 in the formation of a functional GATA4/FOG2 transcription complex that is required for Sox9 expressi

255 pes suggest a difference in the N74D reverse transcription complex that manifests early after infecti

256 ed a genetic pathway involving the Six1/Eya1 transcription complex that regulates cardiovascular and

257 ed that c-Myb, GATA-3, and Menin form a core transcription complex that regulates GATA-3 expression a

258 refore, c-Myb, GATA-3, and Menin form a core transcription complex that regulates GATA-3 expression a

259 the MluI cell cycle box-binding factor (MBF) transcription complex that regulates the G1/S progressio

260 Transcription complexes that assemble at the HIV-1 promo

261 mation of beta-catenin-T-cell factor (TCF)-4 transcription complexes that bind to the promoter of the

262 in the assembly of inappropriate multimeric transcription complexes that deregulate hematopoietic pr

263 oadblocks, and catalyses the reactivation of transcription complexes that have become 'backtracked'.

264 Mfd also displaces transcription complexes that have been stalled by protei

265 ption permits Mfd to act indiscriminately at transcription complexes that lack the usual determinants

266 unctions as a core component of multiprotein transcription complexes that regulate differentiation in

267 in ATP hydrolysis but fully remodels target transcription complexes, the RNAP-sigma(54) holoenzyme,

268 ation factors, guides the nontemplate DNA in transcription complexes, thereby modulating their regula

269 ed regions and assists in the passage of the transcription complex through chromatin, and it provides

270 The ability to deliver inhibitors to transcription complexes through the use of targeting/loc

271 rfaces with critical components of the Notch transcription complex to affect Notch-dependent lineage

272 o the nucleus and (ii) targeting the reverse transcription complex to be disrupted by the proteasome.

273 endent standard free energy variation of the transcription complex to model the experimentally observ

274 Recruitment of the RNA polymerase II transcription complex to the promoter of the Ifng gene h

275 s remodel substrates such as nucleosomes and transcription complexes to control a wide range of DNA-a

276 Furthermore, we show that failure of transcription complexes to escape the pause results in b

277 interact with advancing replication forks or transcription complexes to generate lethal lesions.

278 4-serves an essential role in three distinct transcription complexes to regulate cell cycle gene expr

279 and promoter interaction, and recruitment of transcription complexes to the active beta-globin promot

280 LCR HS2 is important for the recruitment of transcription complexes to the adult betamajor-globin ge

281 ricted activator NF-E2 in the recruitment of transcription complexes to the beta-globin gene locus.

282 and directly by mediating the recruitment of transcription complexes to the globin gene locus.

283 complexes that are precursors for functional transcription complexes upon addition of the remaining f

284 protein family, are required to remodel the transcription complex using energy derived from ATP hydr

285 the heterotrimeric STAT1-STAT2-IRF9 (ISGF3) transcription complex, utilized the GR cofactor GRIP1/TI

286 vering its essential cognate receptor to the transcription complex via an alternative route.

287 engagement of a multimeric bEBP with a basal transcription complex via several L1s.

288 When nuclear import of the HIV-1 reverse transcription complex was blocked by expressing a trunca

289 The presence of p53 in this transcription complex was verified by immunoprecipitatio

290 basis for such distinct temporal assembly of transcription complexes, we examined the role of core pr

291 characterize proteins associated with active transcription complexes, we purified RNA polymerase II (

292 Functional transcription complexes were assembled directly by mixin

293 tor 1 (HIF-1) and activator protein 1 (AP-1) transcription complexes were found to be responsible for

294 of reconstituting hairpin-stabilized paused transcription complexes when incubated with RNAP either

295 lear Rel/A p65, a component of the NF-kappaB transcription complex, which mediates the repression of

296 ation of its C-terminal domain with relevant transcription complexes, which promotes the stable assem

297 hybrid formation, and promote collisions of transcription complexes with replisomes.

298 Transcription complexes with similar topology may prime

299 Zeppo1 regulates transcription, complexing with Groucho and repressing E-

300 Intrinsic terminators dissociate transcription complexes without the assistance of auxili