ライフサイエンスコーパス: transcription elongation

1 ults reveal a global requirement for Spt5 in transcription elongation.

2 ex is a critical step for P-TEFb to activate transcription elongation.

3 the incorporation of 2'-fluoro dNMPs during transcription elongation.

4 looped enhancer contacts during synchronous transcription elongation.

5 specific and direct epigenetic sensor during transcription elongation.

6 x with RNA polymerase II (and I) to regulate transcription elongation.

7 is may be a general pathway of regulation of transcription elongation.

8 y and disassembly of nucleosomes, as well as transcription elongation.

9 ow levels of Paf1 on Pol2 are sufficient for transcription elongation.

10 nfer robustness on processes associated with transcription elongation.

11 sense variant in an ELL2 domain required for transcription elongation.

12 vivo influence of positioned nucleosomes on transcription elongation.

13 e mechano-chemical coupling mechanism of the transcription elongation.

14 ide, suggesting a role for RSC in regulating transcription elongation.

15 s to interrogate mechanisms of regulation of transcription elongation.

16 nd facilitate Pol II transition during early transcription elongation.

17 (CycT1) or T2 (CycT2), activates eukaryotic transcription elongation.

18 FIIS) and IIF (TFIIF) are known to stimulate transcription elongation.

19 ase II, ultimately leading to stimulation of transcription elongation.

20 llow release of paused RNAPII and productive transcription elongation.

21 ycT1 or CycT2 and CDK9, activates eukaryotic transcription elongation.

22 on the role that both CDK9 and MYC exert in transcription elongation.

23 n of pachytene piRNA precursors by promoting transcription elongation.

24 cleosome reassembly at coding regions during transcription elongation.

25 protein networks involved in early steps of transcription elongation.

26 Pcf11 in primary CD4(+) T cells induces HIV transcription elongation.

27 ffect on gene expression was due to impaired transcription elongation.

28 cycle inhibitor is regulated at the level of transcription elongation.

29 recruitment of RNA-processing factors during transcription elongation.

30 relating with sites of H3K79 methylation and transcription elongation.

31 ting they have important regulatory roles in transcription elongation.

32 play multiple phenotypes indicating impaired transcription elongation.

33 n the endomembrane system and the process of transcription elongation.

34 nd Vps75 may also play separate roles during transcription elongation.

35 h reduced pol II density suggesting enhanced transcription elongation.

36 sely, loss of ASH1 function had no effect on transcription elongation.

37 release of the RNA polymerase II complex for transcription elongation.

38 rocessing tight protein-DNA complexes during transcription elongation.

39 histone chaperones as general regulators of transcription elongation.

40 1, two histone modifications associated with transcription elongation.

41 could regulate virulence gene expression and transcription elongation.

42 lation and may determine the overall rate of transcription elongation.

43 ify in the same complex, likely during early transcription elongation.

44 lucidate key roles for Rad26 in both TCR and transcription elongation.

45 r and specifically regulates the step of HIV transcription elongation.

46 ranslation initiation, RNA stability, and/or transcription elongation.

47 bsequent release of paused pol II needed for transcription elongation.

48 ndent histone H3 acetylation is required for transcription elongation.

49 Fft3), to overcome the nucleosome barrier to transcription elongation.

50 nd, under cold stress, also in mitochondrial transcription elongation.

51 BET proteins as master regulators of global transcription elongation.

52 n complexes, bind nucleic acids, and promote transcription elongation.

53 how these minor-groove binders affect pol II transcription elongation.

54 lates RNA polymerase II (RNAPII) pausing and transcription elongation.

55 protein transport and localization, and (iv) transcription elongation.

56 xerts its suppressive function by regulating transcription elongation.

57 or binding, as well as interfere with pol II transcription elongation.

58 es the ARS gene family through modulation of transcription elongation.

59 Remarkably, productive transcription elongation across these enhancers is predo

60 We present evidence that KIS promotes transcription elongation and counteracts Polycomb group

61 Deletion of Spt5 KOW4-5 domains decreases transcription elongation and derepresses TCR.

62 osome assembly and H2A-H2B deposition during transcription elongation and DNA replication.

63 Broad H3K4me3 is associated with increased transcription elongation and enhancer activity, which to

64 on a DNA segment by transcription slows down transcription elongation and eventually stops transcript

65 he expressome structure can only form during transcription elongation and explains how translation ca

66 ctional role of TOP2A cleavage in regulating transcription elongation and gene activation.

67 ription but does enhance the overall rate of transcription elongation and maintains transcription rei

68 ts by overexpression) complex is involved in transcription elongation and mRNA export.

69 teins, implicate TFII-I in the regulation of transcription elongation and provide insight into the ro

70 C) plays critical roles in RNA polymerase II transcription elongation and regulation of histone modif

71 ubcomplex with Rpb7, play important roles in transcription elongation and repression of transcription

72 The core role of NusG is to enhance transcription elongation and RNA polymerase processivity

73 ongation regulator TCERG1 physically couples transcription elongation and splicing events by interact

74 le for H2A.Z in coordinating the kinetics of transcription elongation and splicing.

75 ase binds to RNA-polymerase (RNAP) II during transcription elongation and suppresses transcription-as

76 for Thr4 in engaging the machinery used for transcription elongation and termination.

77 It was found that UV light inhibited transcription elongation and that recovery of RNA synthe

78 he linear Brownian ratchet kinetic model for transcription elongation and the backtracking model for

79 itment of ERalpha and RNAPII, and stimulates transcription elongation and transcription-coupled histo

80 richia coli UvrD binds RNA polymerase during transcription elongation and, using its helicase/translo

81 tin immunoprecipitation assay and assays for transcription elongation, and it provides a framework to

82 nucleoside triphosphate (NTP), catalysis of transcription elongation, and translocation in both euka

83 -order multiprotein complexes, which promote transcription, elongation, and splicing of a wide range

84 atalytic cores and fundamental mechanisms of transcription elongation are conserved, the initiation s

85 The coliphage HK022 protein Nun transcription elongation arrest factor inhibits RNA poly

86 These data therefore reveal transcription elongation as a point of regulatory contro

87 entially, sigma70 acts at other sites during transcription elongation as well.

88 Here, we use a single-molecule transcription elongation assay to study the effects of b

89 Using in vitro transcription elongation assays, we show that OGA activi

90 developing a class of molecules that license transcription elongation at targeted genomic loci.

91 ansition of stalled RNAPII into a productive transcription elongation at the promoter-proximal region

92 f the PRC1 members or UBR5 alone derepressed transcription elongation at these sites, suggesting that

93 ed conformation that is highly competent for transcription elongation but repressive to TCR.

94 By inhibiting transcription elongation, but not initiation, pre-treatm

95 Gp39 also accelerates transcription elongation by decreasing RNAP pausing and

96 inhibit RNA polymerase II (Pol II)-dependent transcription elongation by inhibiting the positive tran

97 Regulation of transcription elongation by positive transcription elong

98 HIV-1 Tat stimulates transcription elongation by recruiting the P-TEFb (posit

99 these transcription factors enhance overall transcription elongation by reducing the lifetime of tra

100 Regulation of transcription elongation by RNA polymerase II (Pol II) i

101 mers (CPDs) in the template DNA strand stall transcription elongation by RNA polymerase II (Pol II).

102 or groove sensor." Prolonged interference of transcription elongation by sequence-specific minor groo

103 n vivo, that DksA/ppGpp increase fidelity of transcription elongation by slowing down misincorporatio

104 reported earlier that in the absence of the transcription elongation complex (EC), N interacts with

105 and both proteins remain associated with the transcription elongation complex (TEC) as it escapes the

106 factor in vivo by loading directly onto the transcription elongation complex (TEC) in trans.

107 termination factor capable of disrupting the transcription elongation complex (TEC), detail the rate

108 e conclude that changes in properties of the transcription elongation complex closely correlate with

109 We found that several components of the PAF1 transcription elongation complex contribute to Chd1 recr

110 and CRISPR loci, Spt4/5 is recruited to the transcription elongation complex during early elongation

111 Thus, the transcription elongation complex Paf1, the histone methy

112 F4/FMR2 (AFF) family protein AFF3 within the transcription elongation complex SEC-L3.

113 single strand RNA segment in the backtracked transcription elongation complex strongly promotes trans

114 Mis-incorporation causes the transcription elongation complex to backtrack, releasing

115 hat PHF6 physically associates with the PAF1 transcription elongation complex, and inhibition of PAF1

116 n binds at the upstream fork junction of the transcription elongation complex, similar to sigma2 in t

117 liable model of the complete NusG-associated transcription elongation complex, suggesting that the NG

118 g an atypical pathway for the formation of a transcription elongation complex.

119 d signal-induced recruitment of the positive transcription-elongation complex P-TEFb and thereby prev

120 scription initiation complexes also occur in transcription elongation complexes and facilitate pause

121 family bind at the upstream fork junction of transcription elongation complexes and modulate RNA synt

122 Collisions between paused transcription elongation complexes and replication forks

123 es viral gene expression by recruiting human transcription elongation complexes containing P-TEFb, AF

124 e we show that DksA/ppGpp do not destabilise transcription elongation complexes or inhibit their back

125 pp contribute to prevention of collisions of transcription elongation complexes with replication fork

126 lso found to be associated with a network of transcription elongation components including the super

127 Transcription elongation consists of repetition of the n

128 6me3 that links the histone-variant-mediated transcription elongation control to tumour suppression.

129 f topoisomerase I with RNA polymerase during transcription elongation could efficiently relieve trans

130 ral control of chromatin dynamics during the transcription elongation cycle.

131 ss of BRD4 at super-enhancers and consequent transcription elongation defects that preferentially imp

132 A chemical inhibitor of transcription elongation, DRB, had no effect on ASH1 rec

133 particularly large impact on the dynamics of transcription elongation during stationary phase.

134 study shows the profound impact of Top1cc on transcription elongation, especially at intron-exon junc

135 KIS promotes transcription elongation, facilitates the binding of the

136 Both screens revealed roles for the positive transcription elongation factor (P-TEFb) component Cycli

137 The positive transcription elongation factor (P-TEFb) is required for

138 irus (HIV-1) by recruiting the host positive transcription elongation factor (pTEFb) to the RNA polym

139 ression through the regulated binding of the transcription elongation factor AFF3 between a DMR and a

140 ified a blockade in the specialized positive transcription elongation factor b (P-TEFb) activation me

141 romodomain protein 4 (BRD4) and the positive transcription elongation factor b (P-TEFb) and facilitat

142 CDKC;2 functions in an Arabidopsis positive transcription elongation factor b (P-TEFb) complex and i

143 ator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regu

144 pisomal plasmids also released free positive transcription elongation factor b (P-TEFb) from its inhi

145 DX21 facilitates the release of the positive transcription elongation factor b (P-TEFb) from the 7SK

146 do not find evidence for a role of positive transcription elongation factor b (P-TEFb) in the establ

147 t (transactivator of transcription)-positive transcription elongation factor b (P-TEFb) interaction a

148 ation, in particular members of the positive transcription elongation factor b (P-TEFb) involved in t

149 The positive transcription elongation factor b (P-TEFb) is involved i

150 lthough the level of binding of the positive transcription elongation factor b (P-TEFb) kinase was no

151 zed as the catalytic subunit of the positive transcription elongation factor b (P-TEFb) of RNA polyme

152 Human positive transcription elongation factor b (P-TEFb) phosphorylate

153 tion of transcription elongation by positive transcription elongation factor b (P-TEFb) plays a centr

154 The positive transcription elongation factor b (P-TEFb) promotes tran

155 virally encoded Tat protein hijacks positive transcription elongation factor b (P-TEFb) to phosphoryl

156 Positive transcription elongation factor b (P-TEFb), a complex of

157 RNP) sequesters and inactivates the positive transcription elongation factor b (P-TEFb), an essential

158 AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentia

159 The positive transcription elongation factor b (P-TEFb), comprised of

160 hat RBPJ binds CDK9, a component of positive transcription elongation factor b (P-TEFb), to target ge

161 main of RNA polymerase II (RNAPII), positive transcription elongation factor b (P-TEFb), which is com

162 ) is best known as the inhibitor of positive transcription elongation factor b (P-TEFb), which regula

163 controlling the nuclear activity of positive transcription elongation factor b (P-TEFb).

164 pendent kinases CDK13 and CDK11 and positive transcription elongation factor b (P-TEFb).

165 iption elongation by inhibiting the positive transcription elongation factor b (P-TEFb, a complex of

166 its previously reported effects on positive transcription elongation factor b and HMBA inducible pro

167 ogether with CDK9, the component of positive transcription elongation factor b complex responsible fo

168 domain and increased recruitment of positive transcription elongation factor b to the LTR promoter.

169 egulate transcription by recruiting Positive Transcription Elongation Factor b to the promoter region

170 pendent of the reduction of P-TEFb (positive transcription elongation factor b) levels caused by NF90

171 (CCNT2), the regulatory subunit of positive transcription elongation factor b, a complex that inhibi

172 kinase heterodimer that constitutes positive transcription elongation factor b, is a well-validated t

173 nd BD2 and forms a complex with the positive transcription elongation factor b, which controls phosph

174 This general transcription elongation factor binds to RNA polymerase

175 The transcription elongation factor eleven nineteen lysine-r

176 elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be

177 EPOP interacts with the transcription elongation factor Elongin BC and the H2B d

178 Transcription elongation factor GreA efficiently blocked

179 d that, in this circumstance, DksA acts as a transcription elongation factor in vivo.

180 SDG8, directly or indirectly through IWS1, a transcription elongation factor involved in BR-regulated

181 c bypass rate, which is exacerbated by TEFM (transcription elongation factor mitochondrial).

182 e both previously characterized genes (e.g., transcription elongation factor NusA and tumor necrosis

183 The transcription elongation factor NusG facilitates this te

184 The bacterial transcription elongation factor NusG stimulates the Rho-

185 d termination, it is fully responsive to the transcription elongation factor NusG.

186 oteins LARP7 and MePCE captures the positive transcription elongation factor P-TEFb and prevents phos

187 In contrast, the positive transcription elongation factor P-TEFb is a local explor

188 We found that targeting the transcription elongation factor Spt4 selectively decreas

189 l interaction between Rtf1 and the essential transcription elongation factor Spt5.

190 rt in Science that targeted reduction in the transcription elongation factor SUPT4H1/SUPT5H reduces b

191 We found that interaction of human transcription elongation factor TEFM with mitochondrial

192 which we here show to be independent of the transcription elongation factor TEFM.

193 domain resembling the central domain in the transcription elongation factor TFIIS.

194 NusG/Spt5 is a transcription elongation factor that assists in DNA-temp

195 protein is a universally conserved bacterial transcription elongation factor that binds RNA polymeras

196 ucing factor (DSIF or Spt4/5) is a conserved transcription elongation factor that both inhibits and s

197 Our results establish UvrD as a bona fide transcription elongation factor that contributes to geno

198 Spt5, a transcription elongation factor, and Rpb4, a subunit of

199 s protein was previously shown to be a viral transcription elongation factor, and the present finding

200 Here, we identify TFIIS.h, a transcription elongation factor, as a new transcriptiona

201 The RNA polymerase II (Pol II) transcription elongation factor, Elongin A (EloA), is me

202 The bacterial transcription elongation factor, NusA, functions as an a

203 dition to serving as a histone chaperone and transcription elongation factor, Spt6 counteracts repres

204 longation by recruiting the P-TEFb (positive transcription elongation factor-b) (CycT1:CDK9) C-termin

205 d form by activating Ell2 (which encodes the transcription-elongation factor ELL2).

206 tep, we designed sequence-specific synthetic transcription elongation factors (Syn-TEFs).

207 ate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as polymera

208 binding complex (CBC) directs recruitment of transcription elongation factors and establishes proper

209 that Nap1 genetically interacts with several transcription elongation factors and that both Nap1 and

210 Transcription elongation factors associate with RNA poly

211 disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core compone

212 ing study of the interactions of RNAPII with transcription elongation factors TFIIS and TFIIF, which

213 tion factors, histone-modifying enzymes, and transcription elongation factors to activate BR-induced

214 erases, bromodomain-containing proteins, and transcription elongation factors to mediate chromatin re

215 acetylation, and tethers chromatin modifiers/transcription elongation factors to target genes.

216 We found unexpectedly that, similar to known transcription elongation factors, these and several othe

217 usters have been identified, those affecting transcription elongation have not been broadly investiga

218 t that Vps factors enhance the efficiency of transcription elongation in a manner involving their phy

219 ion overcomes RNAP II pausing to enhance HIV transcription elongation in infected primary T cells, de

220 ion factor that both inhibits and stimulates transcription elongation in metazoans.

221 s in the nontemplate DNA strand and regulate transcription elongation in response to these signals.

222 rovide the first base-pair resolution map of transcription elongation in S. pombe and identify diverg

223 liver tumors and highlight the relevance of transcription elongation in the addiction of cancer cell

224 Escherichia coli NusG enhances transcription elongation in vitro by a poorly understood

225 to DNA oligonucleotides to assess RNA Pol II transcription elongation in vitro.

226 ed assays elucidate this important aspect of transcription elongation in vivo.

227 (pol II) encounters numerous barriers during transcription elongation, including DNA strand breaks, D

228 es and facilitates multiple processes during transcription elongation, including the regulation of hi

229 benzimidazole (DRB), an RNA Pol II-dependent transcription elongation inhibitor, and flavopiridol inh

230 t flavopiridol, a CDK9 inhibitor that blocks transcription elongation, inhibits eRNA production but d

231 e that an attenuation-like mechanism governs transcription elongation into the mgtCBR coding region.

232 RNA polymerase II (RNAPII) transcription elongation is a highly regulated process t

233 Transcription elongation is a key regulatory step in gen

234 Pyrophosphate ion (PPi) release during transcription elongation is a signature step in each nuc

235 on of the poly(A) sites of RPB2, the rate of transcription elongation is an important determinant.

236 Regulation of transcription elongation is based on response of RNA pol

237 interactive looping element and showed that transcription elongation is dispensable for promoter/enh

238 Transcription elongation is frequently interrupted by pa

239 Transcription elongation is interrupted by sequences tha

240 The movement of RNA polymerase (RNAP) during transcription elongation is modulated by DNA-encoded ele

241 ococcus pneumoniae and provide evidence that transcription elongation is rate-limiting on highly expr

242 rmination, the process that marks the end of transcription elongation, is regulated by proteins that

243 een identified from in vitro measurements of transcription elongation kinetics.

244 sistent with the role of NuA4 in stimulating transcription elongation, loss of EAF5 or EAF7 resulted

245 raft mouse models, suggesting that targeting transcription elongation machinery may be an effective t

246 ethered to a small molecule that engages the transcription elongation machinery.

247 Our results suggest that transcription elongation may be a highly regulated step

248 trate that in the presence of KMT2B, neither transcription elongation nor RNA polymerase II binding i

249 erons, as well as in regulating the rates of transcription elongation of all genes.

250 o show that it can enhance the efficiency of transcription elongation of apoptosis-associated bax gen

251 IF1gamma in erythropoiesis by regulating the transcription elongation of erythroid genes.

252 Fbeta) signaling is elevated due to enhanced transcription elongation of key pathway genes, leading t

253 longation complexes (SECs) are essential for transcription elongation of many human genes, including

254 ation factor b (P-TEFb), which regulates the transcription elongation of RNA polymerase II and contro

255 ip110 interaction with Tat directly enhanced transcription elongation of the LTR promoter.

256 ly activated by cyclin C and is required for transcription elongation of the serum response genes (im

257 ario of the mechano-chemical coupling in the transcription elongation of the single-subunit polymeras

258 ssibility of nucleosomal DNA and inefficient transcription-elongation of WASp-target TH1 genes.

259 small number of regulatory factors influence transcription elongation on a global scale.

260 n, but also at further control steps such as transcription elongation or RNA processing.

261 ivin/SMAD2,3 signaling selectively increases transcription elongation, P-TEFb occupancy, and Ser7P-RN

262 activity regulation in the initial and final transcription elongation phases.

263 These data indicate that transcription elongation plays a major role in RSV-induc

264 The rate of transcription elongation plays an important role in the

265 or estrogen-induced genes, estrogen enhances transcription elongation, potentially through recruitmen

266 ich mimics sigmaR4, is released gradually as transcription elongation proceeds, whereas YvrHa, which

267 trol of H3K36 methylation during the dynamic transcription elongation process.

268 Transcription elongation programs are vital for the prec

269 remains in the 7SK-unbound state to sustain transcription elongation programs remains unknown.

270 the activation and maintenance of inducible transcription elongation programs.

271 tion of the large, widespread NusG family of transcription elongation proteins and found that it incl

272 rsal or fixed and change in response to both transcription elongation rate and frequency as well as r

273 olecules revealed a pronounced defect in the transcription elongation rate in FRDA cells when compare

274 est that some static gene features influence transcription elongation rates and that cells may alter

275 understand the impact of local modulation of transcription elongation rates on the dynamic interplay

276 mRNA isoform production, by (i) influencing transcription elongation rates, (ii) binding to pre-mRNA

277 the G2/M cell cycle stage which could affect transcription elongation, rather than an indirect conseq

278 The human transcription elongation regulator TCERG1 physically cou

279 In melanoma, we identify HEXIM1, a transcription elongation regulator, as a melanoma tumor

280 During transcription elongation, RNA polymerase has been assume

281 t Paf1 functions: a core general function in transcription elongation, satisfied by the lowest Paf1 l

282 initiation), transcription initiation rate, transcription elongation speed (i.e. mRNA chain-growth s

283 genomic scale, the distinct contributions of transcription elongation speed and rate of RNA polymeras

284 impact of specific transcription factors on transcription elongation speed versus TAE to be studied.

285 H2A.Z impairs transcription elongation, suggesting that spliceosome re

286 that plays multiple key regulatory roles in transcription elongation, termination and coupling trans

287 at other aspects of gene expression, such as transcription elongation, termination, and polyadenylati

288 ine 5'-diphosphate 3'-diphosphate (ppGpp) in transcription elongation that couple this alarmone to DN

289 ulation of RNAPII CTD phosphorylation during transcription elongation that is likely to be highly con

290 ion factors promote pause release leading to transcription elongation, the role of epigenetic modific

291 A polymerase II (Pol II) processivity during transcription elongation through cyclin T1 and Cdk9 recr

292 iption elongation factor b (P-TEFb) promotes transcription elongation through phosphorylation of the

293 mplex with P-TEFb, the kinase that initiates transcription elongation, to inhibit elongation at tumor

294 machineries, plays a key role in maintaining transcription elongation when translation and transcript

295 Moreover, DksA has a substantial effect on transcription elongation where it prevents the collision

296 RNA processing and chromatin modification to transcription elongation, whereas bacterial NusG partici

297 A and NusG are major regulators of bacterial transcription elongation, which act either in concert or

298 It uses reversible inhibition of transcription elongation with 5,6-dichloro-1-beta-D-ribo

299 ution of mechanisms that functionally couple transcription elongation with diverse events that occur

300 One such factor is Spt6, which couples transcription elongation with histone chaperone activity