ライフサイエンスコーパス: transcription elongation factor

1 d us to propose that TEFM is a mitochondrial transcription elongation factor.

2 skipping, resulting from the actions of ELL2 transcription elongation factor.

3 These results define Ssu72 as a transcription elongation factor.

4 the foggy/spt5 locus, which encodes another transcription elongation factor.

5 ncodes a protein similar to Spt6, a proposed transcription elongation factor.

6 that the A18R protein may act as a negative transcription elongation factor.

7 fic coactivator, but we show it is a general transcription elongation factor.

8 Cyclin T is a partner for CDK9, an RNAPII transcription elongation factor.

9 scription is dependent on the Spt6 and Spt16 transcription elongation factors.

10 etically with a number of known or suspected transcription elongation factors.

11 de concentrations or the inhibition of other transcription elongation factors.

12 on elongation factor b (P-TEFb) and negative transcription elongation factors, 5,6-dichloro-1-beta-d-

13 sitol polyphosphate phosphohydrolase family, Transcription Elongation Factor A family, LDOC1-related

14 shown that a frequently downregulated gene, transcription elongation factor A-like 7 (TCEAL7), promo

15 In order to identify previously unknown transcription elongation factors, a genetic screen was c

16 ression through the regulated binding of the transcription elongation factor AFF3 between a DMR and a

17 We conclude that transcription elongation factors alleviate fundamental c

18 We showed recently that Spt6, a transcription elongation factor and histone H3 chaperone

19 binding complex (CBC) directs recruitment of transcription elongation factors and establishes proper

20 that Nap1 genetically interacts with several transcription elongation factors and that both Nap1 and

21 Spt5, a transcription elongation factor, and Rpb4, a subunit of

22 s protein was previously shown to be a viral transcription elongation factor, and the present finding

23 2Delta double mutants (PPR2 encodes TFIIS, a transcription elongation factor) are synthetically hyper

24 Here, we identify TFIIS.h, a transcription elongation factor, as a new transcriptiona

25 Transcription elongation factors assist RNA polymerase I

26 Transcription elongation factors associate with RNA poly

27 The positive transcription elongation factor b (P-TEFb) (CDK9/cyclin

28 present evidence that Tax recruits positive transcription elongation factor b (P-TEFb) (CDK9/cyclin

29 ified a blockade in the specialized positive transcription elongation factor b (P-TEFb) activation me

30 romodomain protein 4 (BRD4) and the positive transcription elongation factor b (P-TEFb) and facilitat

31 lay between the recently discovered positive transcription elongation factor b (P-TEFb) and negative

32 lay between the recently identified positive transcription elongation factor b (P-TEFb) and negative

33 om the recent identification of the positive transcription elongation factor b (P-TEFb) and the demon

34 cyclin T1 (hCycT1) protein from the positive transcription elongation factor b (P-TEFb) binds the tra

35 1 was recently shown to inhibit the positive transcription elongation factor b (P-TEFb) by interactin

36 CDKC;2 functions in an Arabidopsis positive transcription elongation factor b (P-TEFb) complex and i

37 1), the inhibitory component of the positive transcription elongation factor b (P-TEFb) complex, as a

38 hich is the kinase component of the positive transcription elongation factor b (P-TEFb) complex, can

39 which together with CDK9 forms the positive transcription elongation factor b (P-TEFb) complex, Tat

40 Different positive transcription elongation factor b (P-TEFb) complexes iso

41 Positive transcription elongation factor b (P-TEFb) complexes, co

42 ing cyclin T partners belong to the positive transcription elongation factor b (P-TEFb) complexes, wh

43 The positive transcription elongation factor b (P-TEFb) contains cycl

44 Positive transcription elongation factor b (P-TEFb) controls the

45 ome genes has also been shown to be positive transcription elongation factor b (P-TEFb) dependent.

46 ator of paused Pol II release, that positive transcription elongation factor b (P-TEFb) directly regu

47 The positive transcription elongation factor b (P-TEFb) exists in two

48 pisomal plasmids also released free positive transcription elongation factor b (P-TEFb) from its inhi

49 DX21 facilitates the release of the positive transcription elongation factor b (P-TEFb) from the 7SK

50 Inhibition of positive transcription elongation factor b (P-TEFb) had only a mo

51 Positive transcription elongation factor b (P-TEFb) hyperphosphor

52 ymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in associatio

53 do not find evidence for a role of positive transcription elongation factor b (P-TEFb) in the establ

54 t (transactivator of transcription)-positive transcription elongation factor b (P-TEFb) interaction a

55 ation, in particular members of the positive transcription elongation factor b (P-TEFb) involved in t

56 The positive transcription elongation factor b (P-TEFb) is a cyclin-d

57 The positive transcription elongation factor b (P-TEFb) is a key cell

58 Positive transcription elongation factor b (P-TEFb) is a kinase t

59 The positive transcription elongation factor b (P-TEFb) is involved i

60 al domain of RNA polymerase II, the positive transcription elongation factor b (P-TEFb) is the critic

61 Positive transcription elongation factor b (P-TEFb) is the major

62 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, i

63 lthough the level of binding of the positive transcription elongation factor b (P-TEFb) kinase was no

64 ion elongation is stimulated by the positive transcription elongation factor b (P-TEFb) kinase, which

65 zed as the catalytic subunit of the positive transcription elongation factor b (P-TEFb) of RNA polyme

66 Human positive transcription elongation factor b (P-TEFb) phosphorylate

67 tion of transcription elongation by positive transcription elongation factor b (P-TEFb) plays a centr

68 Positive transcription elongation factor b (P-TEFb) plays an impo

69 The positive transcription elongation factor b (P-TEFb) promotes tran

70 nt and sustained HIV elongation and positive transcription elongation factor b (P-TEFb) recruitment a

71 Positive transcription elongation factor b (P-TEFb) regulates euk

72 The positive transcription elongation factor b (P-TEFb) regulates RNA

73 n is proposed to be controlled by a positive transcription elongation factor b (P-TEFb) through phosp

74 Among others, it recruits positive transcription elongation factor b (P-TEFb) to MHC class

75 virally encoded Tat protein hijacks positive transcription elongation factor b (P-TEFb) to phosphoryl

76 In host cells, Brd4 recruits positive transcription elongation factor b (P-TEFb) to stimulate

77 the cyclin T1 (CycT1) component of positive transcription elongation factor b (P-TEFb) to TAR.

78 rotein-associated factor (PCAF) and positive transcription elongation factor b (P-TEFb) to Tat/transa

79 Tat-dependent recruitment of human positive transcription elongation factor b (P-TEFb) to the HIV-1

80 the transactivator Tat recruits the positive transcription elongation factor b (P-TEFb) to the initia

81 type 1 (HIV-1) Tat protein recruits positive transcription elongation factor b (P-TEFb) to the transa

82 l transactivator (Tat) recruits the positive transcription elongation factor b (P-TEFb) to the viral

83 Tat protein requires recruitment of positive transcription elongation factor b (P-TEFb) to the viral

84 hat phospho-Ser(276) RelA binds the positive transcription elongation factor b (P-TEFb), a complex co

85 Positive transcription elongation factor b (P-TEFb), a complex of

86 RNP) sequesters and inactivates the positive transcription elongation factor b (P-TEFb), an essential

87 AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentia

88 The positive transcription elongation factor b (P-TEFb), composed of

89 Positive transcription elongation factor b (P-TEFb), composed of

90 The kinase activity of positive transcription elongation factor b (P-TEFb), composed of

91 The positive transcription elongation factor b (P-TEFb), comprised of

92 The positive transcription elongation factor b (P-TEFb), comprising C

93 The cellular positive transcription elongation factor b (P-TEFb), containing c

94 general elongation factors are the positive transcription elongation factor b (P-TEFb), eleven-ninet

95 Tat and its cellular cofactor, the positive transcription elongation factor b (P-TEFb), overcome thi

96 The CDK9-cyclin T kinase complex, positive transcription elongation factor b (P-TEFb), stimulates t

97 ase II kinase and elongation factor positive transcription elongation factor b (P-TEFb), the complex

98 hat RBPJ binds CDK9, a component of positive transcription elongation factor b (P-TEFb), to target ge

99 ase II (RNAPII) is regulated by the positive transcription elongation factor b (P-TEFb), which contai

100 ng between a prototypic AAD and the positive transcription elongation factor b (P-TEFb), which contai

101 main of RNA polymerase II (RNAPII), positive transcription elongation factor b (P-TEFb), which is com

102 ) is best known as the inhibitor of positive transcription elongation factor b (P-TEFb), which regula

103 e H3-K79 methyltransferase DOT1 and positive transcription elongation factor b (P-TEFb).

104 f transcription factor (TF) IIH and positive transcription elongation factor b (P-TEFb).

105 plex is critically dependent on the positive transcription elongation factor b (P-TEFb).

106 erase II elongation factor known as positive transcription elongation factor b (P-TEFb).

107 nal interaction between ERalpha and positive transcription elongation factor b (P-TEFb).

108 the animal CDK9-CycT complex of the positive transcription elongation factor b (P-TEFb).

109 iates its specific interaction with positive transcription elongation factor b (P-TEFb).

110 plexes, referred to collectively as positive transcription elongation factor b (P-TEFb).

111 inT1 and Cdk9 that constitutes core positive transcription elongation factor b (P-TEFb).

112 by RNA polymerase II depends on the positive transcription elongation factor b (P-TEFb).

113 requires the kinase activity of the positive transcription elongation factor b (P-TEFb).

114 nding of Tat to the cellular kinase positive transcription elongation factor b (P-TEFb).

115 transcription via the inhibition of positive transcription elongation factor b (P-TEFb).

116 ucturally and functionally from the positive transcription elongation factor b (P-TEFb).

117 ator Tat and its cellular cofactor, positive transcription elongation factor b (P-TEFb).

118 ase II (RNAPII) is regulated by the positive transcription elongation factor b (P-TEFb).

119 l replication through inhibition of positive transcription elongation factor b (P-TEFb).

120 pendent kinases CDK13 and CDK11 and positive transcription elongation factor b (P-TEFb).

121 is the human homolog of Drosophila positive transcription elongation factor b (P-TEFb).

122 , by the postinitiation activity of positive transcription elongation factor b (P-TEFb).

123 controlling the nuclear activity of positive transcription elongation factor b (P-TEFb).

124 iption elongation by inhibiting the positive transcription elongation factor b (P-TEFb, a complex of

125 uppressor through the inhibition of positive transcription elongation factor b (P-TEFb; CDK9/cyclin T

126 its previously reported effects on positive transcription elongation factor b and HMBA inducible pro

127 transcriptional complex comprising positive transcription elongation factor b and RNA polymerase II.

128 se and the catalytic subunit of the positive-transcription elongation factor b and the Tat-activating

129 ogether with CDK9, the component of positive transcription elongation factor b complex responsible fo

130 domain and increased recruitment of positive transcription elongation factor b to the LTR promoter.

131 egulate transcription by recruiting Positive Transcription Elongation Factor b to the promoter region

132 t strategies to recruit Tat and the positive transcription elongation factor b to their promoters, an

133 itional BRD4 and associated P-TEFB (positive transcription elongation factor b) complexes in the tran

134 P-TEFb (positive transcription elongation factor b) inhibitors such as fl

135 pendent of the reduction of P-TEFb (positive transcription elongation factor b) levels caused by NF90

136 nsitivity-Inducing Factor), P-TEFb (Positive Transcription Elongation Factor b), TFIIH, TFIIF, and FA

137 (CCNT2), the regulatory subunit of positive transcription elongation factor b, a complex that inhibi

138 kinase heterodimer that constitutes positive transcription elongation factor b, is a well-validated t

139 ed, cdk-9, the catalytic subunit of positive transcription elongation factor b, was significantly dow

140 nd BD2 and forms a complex with the positive transcription elongation factor b, which controls phosph

141 op structure and recruitment of the positive transcription elongation factor b.

142 domain-containing protein 4 and the positive transcription elongation factor b.

143 both Tat and the essential cellular cofactor transcription elongation factor-b (P-TEFb) by binding si

144 n and apoptosis was mimicked by the positive transcription elongation factor-b (P-TEFb) inhibitor DRB

145 longation by recruiting the P-TEFb (positive transcription elongation factor-b) (CycT1:CDK9) C-termin

146 nd of the elongation factor P-TEFb (positive transcription elongation factor-b), which consists minim

147 phorylation of RNA polymerase II by positive transcription elongation factor-b, leading to a block in

148 (CDK9), the catalytic component of positive transcription elongation factor-b, phosphorylates serine

149 Cyclin T1 (CycT1), a component of positive-transcription-elongation factor-b (P-TEFb), is an essent

150 This general transcription elongation factor binds to RNA polymerase

151 ve elongation factor (NELF), act as negative transcription elongation factors by increasing the time

152 variety of eukaryotic proteins including the transcription elongation factor CA150, the splicing fact

153 e of the first three FF domains of the human transcription elongation factor CA150.

154 he cyclin T1 (CycT1) subunit of the positive transcription elongation factor complex (P-TEFb).

155 he cyclin T1 (CycT1) subunit of the positive transcription elongation factor complex b (P-TEFb).

156 he cyclin T1 (CycT1) subunit of the positive transcription elongation factor complex, P-TEFb.

157 lysine-rich leukemia gene)/P-TEFb (positive transcription elongation factor)-containing super elonga

158 system, we characterized the association of transcription elongation factor DSIF with RNAP II elonga

159 on elongation factor b (P-TEFb) and negative transcription elongation factors, DSIF (5, 6-dichloro-1-

160 The transcription elongation factor eleven nineteen lysine-r

161 elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be

162 disordered scaffold proteins AFF1/4 and the transcription elongation factors ELL1/2 are core compone

163 hat both the splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio

164 The RNA polymerase II transcription elongation factor ELL2, which is induced i

165 d form by activating Ell2 (which encodes the transcription-elongation factor ELL2).

166 two factors that stabilize and activate the transcription elongation factor elongin A.

167 EPOP interacts with the transcription elongation factor Elongin BC and the H2B d

168 The RNA polymerase II (Pol II) transcription elongation factor, Elongin A (EloA), is me

169 ate that the A18R gene product is a negative transcription elongation factor for postreplicative vira

170 Spt4-Spt5, a general transcription elongation factor for RNA polymerase II, a

171 Transcription elongation factors from the NusG family ar

172 RFA1 interacts genetically with transcription elongation factor genes.

173 Transcription elongation factor GreA efficiently blocked

174 Transcription elongation factor GreA induces nucleolytic

175 ymerase (RNAP) secondary channel such as the transcription elongation factors GreA and GreB in E. col

176 Bacterial transcription elongation factors GreA and GreB stimulate

177 Prokaryotic transcription elongation factors GreA and GreB stimulate

178 role in LPS synthesis, including a possible transcription elongation factor (GreA), a possible queui

179 drogenase, thioredoxin peroxidase, catalase, transcription elongation factor) had C-terminal lysine r

180 plex with Rpb7, and the Spt4-Spt5 complex, a transcription elongation factor, have been shown to supp

181 d that, in this circumstance, DksA acts as a transcription elongation factor in vivo.

182 ts suggest that Rtf1 may function as a novel transcription elongation factor in yeast.

183 ism for the cooperative function of distinct transcription elongation factors in chromatin transcript

184 en spt2Delta and mutations in genes encoding transcription elongation factors, including members of t

185 transcriptional checkpoint, whereby negative transcription elongation factors induce an elongation bl

186 SDG8, directly or indirectly through IWS1, a transcription elongation factor involved in BR-regulated

187 and in the presence and absence of TFIIS, a transcription elongation factor known to increase transc

188 gion of the rtfA gene, encoding a RNA-pol II transcription elongation factor-like protein, similar to

189 c bypass rate, which is exacerbated by TEFM (transcription elongation factor mitochondrial).

190 s been identified as a component of negative transcription elongation factor (N-TEF) that causes the

191 (TAR) element, RD protein from the negative transcription elongation factor (NELF) inhibits basal tr

192 e both previously characterized genes (e.g., transcription elongation factor NusA and tumor necrosis

193 The universal bacterial transcription elongation factor NusA mediates elongation

194 We report observations suggesting that the transcription elongation factor NusA promotes a previous

195 the glyQS leader and the effect of tRNA and transcription elongation factors NusA and NusG on transc

196 rmination factor Rho and the requirement for transcription elongation factors NusA and NusG was inves

197 The bacterial transcription elongation factor, NusA, functions as an a

198 The transcription elongation factor NusG facilitates this te

199 l similarity to the Tudor-like domain of the transcription elongation factor NusG plays a critical ro

200 The bacterial transcription elongation factor NusG stimulates the Rho-

201 d termination, it is fully responsive to the transcription elongation factor NusG.

202 Transcription elongation factor NusG/Spt5 spans the cent

203 Here we show that c17orf42, hereafter TEFM (transcription elongation factor of mitochondria), makes

204 The metazoan transcription elongation factor P-TEFb (CDK-9/cyclin T)

205 oteins LARP7 and MePCE captures the positive transcription elongation factor P-TEFb and prevents phos

206 In contrast, the positive transcription elongation factor P-TEFb is a local explor

207 The human positive transcription elongation factor P-TEFb is composed of tw

208 with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the h

209 acts with TFIIH and Tat-associated kinase (a transcription elongation factor P-TEFb) and requires the

210 erases are poised to respond to the positive transcription elongation factor P-TEFb, and then enter p

211 The human positive transcription elongation factor P-TEFb, consisting of a

212 ption elongation by recruitment of the human transcription elongation factor P-TEFb, consisting of CD

213 ional elongation by recruitment of the human transcription elongation factor P-TEFb, consisting of Cd

214 Recently, a human transcription elongation factor P-TEFb, consisting of CD

215 associate with AFF4, ELLs, and the positive transcription elongation factor P-TEFb, providing eviden

216 of HIV-1 transcription is mediated by human transcription elongation factor P-TEFb, which interacts

217 ry subunit of CDK9 and as a component of the transcription elongation factor P-TEFb.

218 ese proteins are also components of positive transcription elongation factor P-TEFb.

219 e illustrates the importance of the positive transcription elongation factor (P-TEF)b in control of g

220 t ligand-activated AhR recruits the positive transcription elongation factor (P-TEFb) and RNA polymer

221 a regulatory partner of CDK9 in the positive transcription elongation factor (P-TEFb) complex, and bi

222 cyclinT1 (hCyclinT1) subunit of the positive transcription elongation factor (P-TEFb) complex, which

223 Both screens revealed roles for the positive transcription elongation factor (P-TEFb) component Cycli

224 The positive transcription elongation factor (P-TEFb) is required for

225 Positive transcription elongation factor (P-TEFb), which is compo

226 hinery through interaction with the positive transcription elongation factor, P-TEFb, and directs the

227 The positive transcription elongation factor, P-TEFb, controls the fr

228 sed and requires Tat to recruit the positive transcription elongation factor, P-TEFb, which functions

229 combination with deletions in genes encoding transcription elongation factors; p53 likewise confers h

230 tification of a human Spt4-Spt5 complex as a transcription elongation factor, provide strong evidence

231 irus (HIV-1) by recruiting the host positive transcription elongation factor (pTEFb) to the RNA polym

232 unctionally, ELL resembles Elongin (SIII), a transcription elongation factor regulated by the product

233 N-terminal bromo-adjacent homology (BAH) and transcription elongation factor S-II (TFS2N) domains and

234 Transcription elongation factor SII (TFIIS) assists RNA

235 The transcription elongation factor SII is a major component

236 is homologous to a domain in the eukaryotic transcription elongation factor SII.

237 This gene encodes a transcription elongation factor similar to but distinct

238 s, in a pattern similar to that observed for transcription elongation factor Spt16p.

239 We found that targeting the transcription elongation factor Spt4 selectively decreas

240 teraction sites of the TFE WH domain and the transcription elongation factor Spt4/5 overlap, and both

241 between three classes of these factors: (1) transcription elongation factors Spt4-Spt5, TFIIS, and S

242 KTF1 has similarity to the transcription elongation factor SPT5 and contains a C-te

243 rboxyl-terminal domain (CTD) of the S. pombe transcription elongation factor Spt5, which consists of

244 s the pol II C-terminal domain (CTD) and the transcription elongation factor Spt5.

245 protein that is structurally related to the transcription elongation factor Spt5.

246 l interaction between Rtf1 and the essential transcription elongation factor Spt5.

247 P II) carboxyl-terminal domain (CTD) and the transcription elongation factors SPT5 and Tat-SF1 in a T

248 de new evidence for a connection between the transcription elongation factor Spt6 and 3'-end formatio

249 dition to serving as a histone chaperone and transcription elongation factor, Spt6 counteracts repres

250 elongation complex (SEC) that includes known transcription elongation factors such as eleven-nineteen

251 cts early elongation complexes from negative transcription elongation factors such as NELF, DSIF, and

252 We showed previously that transcription elongation factors such as SKIP are dispen

253 We identified the transcription elongation factor suppressor of Ty 6 (Spt6

254 rt in Science that targeted reduction in the transcription elongation factor SUPT4H1/SUPT5H reduces b

255 tep, we designed sequence-specific synthetic transcription elongation factors (Syn-TEFs).

256 of the C-terminal region of cyclin T1 to the transcription elongation factor Tat-SF1 and perhaps othe

257 onucleoproteins (snRNPs) interact with human transcription elongation factor TAT-SF1 and strongly sti

258 We found that interaction of human transcription elongation factor TEFM with mitochondrial

259 which we here show to be independent of the transcription elongation factor TEFM.

260 ate of nascent transcripts is coordinated by transcription elongation factors (TEFs) such as polymera

261 ns and cyclin K generating distinct Positive-Transcription Elongation Factors termed P-TEFb.

262 tified cDNAs encoding three related forms of transcription elongation factor TFIIS (S-II) in Xenopus

263 The three structural domains of transcription elongation factor TFIIS are conserved from

264 We identified the transcription elongation factor TFIIS as its major cogna

265 s TFIIB and TFIIF, but lacks TBP, TFIIH, and transcription elongation factor TFIIS as well as the Srb

266 t evidence that the evolutionarily conserved transcription elongation factor TFIIS functions during p

267 ones that define a new, third isoform of the transcription elongation factor TFIIS in Xenopus, mouse,

268 in that is responsible for the import of the transcription elongation factor TFIIS.

269 domain resembling the central domain in the transcription elongation factor TFIIS.

270 Previously, it was shown that transcription elongation factors TFIIS and Cockayne's sy

271 ing study of the interactions of RNAPII with transcription elongation factors TFIIS and TFIIF, which

272 NusG/Spt5 is a transcription elongation factor that assists in DNA-temp

273 y between Spt5 and NusG, an Escherichia coli transcription elongation factor that binds directly to R

274 protein is a universally conserved bacterial transcription elongation factor that binds RNA polymeras

275 ucing factor (DSIF or Spt4/5) is a conserved transcription elongation factor that both inhibits and s

276 Our results establish UvrD as a bona fide transcription elongation factor that contributes to geno

277 Spt4, a transcription elongation factor that forms a complex wit

278 spt6 encodes a transcription elongation factor that genetically interac

279 TFIIS is a transcription elongation factor that has been extensivel

280 ven-nineteen lysine rich leukemia gene, is a transcription elongation factor that is induced approxim

281 composed of Cdk9 and cyclin T1, is a general transcription elongation factor that phosphorylates the

282 NusA and NusG are transcription elongation factors that bind to RNA polyme

283 SII proteins of eukaryotes and archaea, are transcription elongation factors that promote an endogen

284 We found unexpectedly that, similar to known transcription elongation factors, these and several othe

285 ylation-independent interaction of Npl3 with transcription elongation factor Tho2 and inhibited Npl3

286 horylates RNA polymerase II and the negative transcription elongation factor to stimulate the elongat

287 tion factors, histone-modifying enzymes, and transcription elongation factors to activate BR-induced

288 erases, bromodomain-containing proteins, and transcription elongation factors to mediate chromatin re

289 acetylation, and tethers chromatin modifiers/transcription elongation factors to target genes.

290 The M2-1 transcription elongation factor was not required for the

291 ipitation demonstrated that NELF, a negative transcription elongation factor, was associated with the

292 a recruitment of the cyclin T1/CDK9 positive transcription elongation factor, which phosphorylates th

293 Paf1 complex (Paf1C) is a transcription elongation factor whose recruitment is sti

294 ase-associated factor 1 complex (Paf1C) is a transcription elongation factor with known roles in Pol