ライフサイエンスコーパス: transcription factor PU.1

1 is indirectly regulated by Meis1 through the transcription factor PU.1.

2 he hematopoietic cell-restricted, ets family transcription factor PU.1.

3 sion through heterodimerization with the ETS transcription factor PU.1.

4 l isoform usage by modulating binding of the transcription factor PU.1.

5 lls as well as aberrant induction of myeloid transcription factor PU.1.

6 activation of Irf8 that was dependent on the transcription factor PU.1.

7 on by modulating T(H)2 responses through the transcription factor PU.1.

8 driving the expression of the hematopoietic transcription factor PU.1.

9 olving induction of the erythroid-inhibitory transcription factor PU.1.

10 ve mechanistic role for the lineage-specific transcription factor PU.1.

11 re of these genes is their regulation by the transcription factor PU.1.

12 grin (DC-SIGN), after directly targeting the transcription factor PU.1.

13 esses nonphysiological levels of the myeloid transcription factor PU.1.

14 we found that the PF-2 gene was regulated by transcription factor PU.1.

15 mphoid system is dependent on the Ets family transcription factor PU.1.

16 osing the inhibitory functions of Id2 on the transcription factor PU.1, a master regulator of macroph

17 Furthermore, the transcription factor PU.1, a negative regulator of T(H)2

18 ave been identified, we demonstrate that the transcription factor PU.1 acts upstream of these regulat

19 The transcription factor PU.1 (also known as Spi-1) plays a

20 addition, mechanical deformation induced the transcription factor PU.1, an ets family member that is

21 155 is correlated with reduced expression of transcription factor PU.1 and CD10 in several B-lymphoma

22 tor Pgr by Notch1 overexpression through the transcription factor PU.1 and DNA methyltransferase 3b (

23 g of the macrophage- and the B cell-specific transcription factor PU.1 and exhibit histone modificati

24 DAR1 p150 promotes expression of the myeloid transcription factor PU.1 and induces malignant reprogra

25 Here we found more T cells expressing the transcription factor PU.1 and interleukin 9 (IL-9) in pa

26 we interrogated site-specific binding by the transcription factor PU.1 and its perturbation by DB270,

27 development is mediated via interacting with transcription factor PU.1 and modulating PU.1 and GATA-1

28 tudies we have investigated the roles of the transcription factor PU.1 and the coactivator OCA-B with

29 The transcription factors PU.1 and c-Myb are essential for h

30 regulated by the activation of CSF1R and the transcription factors PU.1 and C/EBPalpha as the molecul

31 erference experiments, we found that the Ets transcription factors PU.1 and GA-binding protein (GABP)

32 rn promoted expression of M-CSF receptor and transcription factors PU.1 and IRF8, thereby constitutin

33 associated with decreased expression of the transcription factors PU.1 and RelB.

34 Critical binding sites for the transcription factors PU.1 and Sp1 were identified in th

35 nes encoding the E26 transformation-specific transcription factors PU.1 and Spi-B in B cells (CD19-Cr

36 We also found that two transcription factors, PU.1 and C/EBPalpha, appear to sy

37 nes encoding the E26-transformation-specific transcription factors, PU.1 and Spi-B, in B cells (Delta

38 ne (F-gp55), aberrant over-expression of the transcription factor PU.1, and inactivating mutations in

39 CTSS and the Ets family transcription factor PU.1 are highly expressed in cells

40 lements of the CXCR1 gene and the ets family transcription factor PU.1 as a major regulator for activ

41 We have recently identified the ETS family transcription factor PU.1 as regulating heterogeneity in

42 UTX suppresses DPYD expression by inhibiting transcription factor PU.1 binding, leading to increased

43 Although the ets transcription factor, PU.1, bound to this ets site, it o

44 regulate adenovirus clearance in AMs via the transcription factor PU.1 by redirecting virion traffick

45 quencing for a subset of motif corresponding transcription factors (PU.1, C/EBPbeta, and EGR2), confi

46 of Immunity, Carotta et al. reveal that the transcription factor PU.1 controls Flt3 expression in he

47 issect feedback mechanisms through which the transcription factor PU.1 controls lymphoid and myeloid

48 id leukemia 1 protein (AML1)- and Ets family transcription factor PU.1-dependent transcription.

49 microsomal PGES (mPGES)-1 and a myeloid cell transcription factor PU.1 did not appear until later pha

50 was a critical transcriptional target of the transcription factor PU.1 during lymphopoiesis.

51 AhR expression was coregulated with the transcription factor PU.1 during myeloid subset differen

52 Knockdown of the transcription factor PU.1 (encoded by Sfpi1) leads to ac

53 The transcription factor PU.1, encoded by the Sfpi1 gene, fu

54 ted through recent reports defining roles of transcription factors PU.1, GATA-3, and E2A, their inter

55 ghlights contributions of E2A, hematopoietic transcription factor PU.1, growth factor independence (G

56 The ETS transcription factor PU.1 has a potent ability to confer

57 d backbone dynamics of the ETS domain of the transcription factor PU.1 have been determined for the f

58 presumptive target genes for the Ets-family transcription factor PU.1 have been identified in the B

59 addressed the function of a group of key DC transcription factors-PU.1, ID2, IRF4, and IRF8-in the e

60 ment is activated by cooperation between the transcription factors PU.1, IFN regulatory factor 1 (IRF

61 These components include the transcription factors PU.1, Ikaros, Bcl11a, E2A, EBF, an

62 kine receptors Flk2 and IL-7R as well as the transcription factors PU.1, Ikaros, Bcl11a, E2A, EBF, an

63 dependent on the combinatorial action of the transcription factors PU.1, Ikaros, E2A, EBF, and Pax-5.

64 of GM-CSF in the lung, and expression of the transcription factor PU.1 in alveolar macrophages of GM(

65 PPARgamma colocalizes with the hematopoietic transcription factor PU.1 in areas of open chromatin and

66 und markedly heterogeneous expression of the transcription factor PU.1 in hematopoietic stem cells an

67 identified a requirement for the ETS family transcription factor PU.1 in Th9 development.

68 s or near-complete loss of the hematopoietic transcription factor PU.1 induces acute myeloid leukemia

69 otein complex, cross-immunoreactive with the transcription factors PU.1, interferon regulatory factor

70 ion demonstrated that the key haematopoietic transcription factor PU.1 is a major upstream regulator

71 The Ets transcription factor PU.1 is a master regulator for the

72 The transcription factor PU.1 is a master regulator of myelo

73 The B-lymphocyte- and macrophage-specific transcription factor PU.1 is a member of the ets family

74 We show that the transcription factor PU.1 is a target of the BSAP-mediat

75 The transcription factor PU.1 is an important regulator of h

76 The ets transcription factor PU.1 is an important regulator of t

77 The transcription factor PU.1 is critical for multiple hemat

78 r, we show that expression of the ETS domain transcription factor PU.1 is down-regulated in cells fol

79 The myeloid-specific transcription factor PU.1 is essential for expression of

80 and that the B cell and macrophage-specific transcription factor PU.1 is essential for regulating th

81 The ETS family transcription factor PU.1 is essential for the developme

82 The ets family transcription factor PU.1 is expressed in monocytes/macr

83 The essential hematopoietic transcription factor PU.1 is expressed in multipotent th

84 The ETS family transcription factor PU.1 is expressed in Th2 but not Th

85 The transcription factor PU.1 is found only in hematopoietic

86 The transcription factor PU.1 is involved in the decision to

87 uences of miR-142 specific promoter and that transcription factor PU.1 is necessary for its exclusive

88 The ETS domain transcription factor PU.1 is necessary for the developme

89 The transcription factor PU.1 is necessary for the developme

90 The transcription factor PU.1 is often impaired in patients

91 The transcription factor PU.1 is required for normal blood c

92 The ets family transcription factor PU.1 is required for the developmen

93 Transcription factor PU.1 is required for the developmen

94 The ets-family transcription factor PU.1 is required for the proper dev

95 The transcription factor PU.1 is shown to be required for th

96 Dysregulated expression of transcription factor PU.1 is strongly associated with Fr

97 The transcription factor Pu.1 is validated as a direct targe

98 Sfpi1, encoding the lineage-specific transcription factor PU.1, is indispensable for normal m

99 s for AP1 family and the macrophage-specific transcription factor, PU.1, is conserved from lizards to

100 Expression of transcription factor PU.1 may maintain some myeloid-like

101 es thus identified were found to bind to the transcription factors PU.1, NF-EM5, E2A, ATF-1, or CREM.

102 mic cells through the action of an oncogenic transcription factor (PU.1) on a key cell cycle regulato

103 IRF4 cobound with the transcription factors PU.1 or BATF to Ets or AP-1 compos

104 haploinsufficiency for the gene encoding the transcription factor PU.1 partially suppresses the neutr

105 However, mixture of multiple transcription factors (PU.1, PIP, c-Fos, and c-Jun) can

106 Transcription factor PU.1 positively regulates J chain g

107 ger RNA for the myeloid- and B-cell-specific transcription factor PU.1 progressively increases as mar

108 n receptor fusion of the macrophage-specific transcription factor PU.1 (PUER) show that BAF/PBAF recr

109 Whereas the transcription factor PU.1 regulates IL-7Ralpha expressio

110 The hematopoietic cell-specific ets family transcription factor PU.1 regulates many lymphoid and my

111 The transcription factor PU.1 regulates the generation of ly

112 Gene targeting of transcription factor PU.1 results in an early block to f

113 s deregulation of the hematopoietic-specific transcription factor PU.1 (Spi-1) by retroviral insertio

114 The transcription factor PU.1 (Spi-1) is a well-characterize

115 Regulation of the hematopoietic transcription factor PU.1 (Spi-1) plays a critical role

116 analyses revealed that FP I was bound by the transcription factor PU.1/Spi-1.

117 o, null for the haemopoetic-lineage-specific transcription factor, PU.1, the task of phagocytosis is

118 These results elucidate how a single transcription factor, PU.1, through the cell context-spe

119 products down-regulates FcepsilonRI and its transcription factor PU.1, thus suggesting that Fcepsilo

120 Binding of the transcription factor PU.1 to its DNA binding motif regul

121 the deposition of histone variant H2A.Z and transcription factor PU.1 to key lymphoid fate regulator

122 ow that autophagy induces the degradation of transcription factor PU.1 to negatively modulate TH9 hom

123 ns specific binding sites for the Ets family transcription factor PU.1, transcription activating fact

124 In addition, the TH9 cell transcription factor, PU.1, undergoes K63 ubiquitination

125 The transcription factor PU.1 was markedly reduced in AMs of

126 We show that the ETS-family transcription factor PU.1 was required for the developme

127 neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased i

128 hybridization, mRNA expression levels of the transcription factor PU.1 were also found to be signific

129 generation of CNS macrophages relied on the transcription factor PU.1, whereas the MYB, BATF3 and NR

130 s because of inappropriate expression of the transcription factor PU.1, which binds to and represses

131 ed that this kinase activated the ets family transcription factor PU.1, which is essential for macrop

132 itioned the critical haematopoietic-specific transcription factor PU.1 within a minimally deleted reg