ライフサイエンスコーパス: transcription machinery

1 conveys regulatory information to the basal transcription machinery.

2 ical utilization and better recycling of the transcription machinery.

3 ption activity after initial assembly of the transcription machinery.

4 neous binding of the large RNA polymerase II transcription machinery.

5 als elicit distinct modes of assembly of the transcription machinery.

6 ct sequence-specific activators to the basal transcription machinery.

7 cated as a component of the RNA polymerase I transcription machinery.

8 DNA access by transcription factors and the transcription machinery.

9 activity by controlling DNA accessibility to transcription machinery.

10 to directly inhibit activation of the basal transcription machinery.

11 e transcriptional activators and the general transcription machinery.

12 r chromatin modifying complexes or the basal transcription machinery.

13 omatin structure and regulation of the basal transcription machinery.

14 he sigma(54) factor makes with the bacterial transcription machinery.

15 factor between NF-kappaB, CBP, and the basal transcription machinery.

16 quences by creating steric obstacles for the transcription machinery.

17 nto open chromatin that is accessible to the transcription machinery.

18 get genes, chromatin, accessory proteins and transcription machinery.

19 chromatin remodeling and recruitment of the transcription machinery.

20 metazoans is Cdk7, which is also part of the transcription machinery.

21 t depends on components of the Pol I general transcription machinery.

22 gulatory mechanisms coevolved with the basal transcription machinery.

23 between the upstream activators and general transcription machinery.

24 as a conduit between activators and the core transcription machinery.

25 may lead to species specificity of the rDNA transcription machinery.

26 tors that enhance their binding to the basal transcription machinery.

27 direct physical interaction with the head-on transcription machinery.

28 moter, suggesting this virus encodes its own transcription machinery.

29 unction of RNA polymerase II and the general transcription machinery.

30 rDNA looping that promotes recycling of the transcription machinery.

31 romatin remodeling and assembly of the pol I transcription machinery.

32 TA-binding protein, and TFIIB of the general transcription machinery.

33 interact with TAFII68, a member of the basal transcription machinery.

34 deacetylation and interaction with the basal transcription machinery.

35 ly, whereas Mot1 promotes disassembly of the transcription machinery.

36 unctional relationship between Dbp5p and the transcription machinery.

37 ctivities of components of the general/basal transcription machinery.

38 nction properly in the context of the oocyte transcription machinery.

39 to other regulatory factors and the general transcription machinery.

40 ation by preventing recruitment of the basal transcription machinery.

41 in the interaction between GR and the basal transcription machinery.

42 Sp1/Sp3 complex, and its impact on the basal transcription machinery.

43 between transcription factors and the basal transcription machinery.

44 chanism involving interaction with the basal transcription machinery.

45 t promoter regions to regulate access by the transcription machinery.

46 dies as sites for preassembly of the nuclear transcription machinery.

47 mplex is recruited by the RNA polymerase III transcription machinery.

48 cruitment of RNA polymerase II and the basal transcription machinery.

49 P-Jkappa, Notch IC, and MAML1 on the general transcription machinery.

50 s, PcG proteins, and proteins of the general transcription machinery.

51 proteins between the receptor and the basal transcription machinery.

52 RSAM1 may aberrantly affect the formation of transcription machinery.

53 nucleates the assembly the RNA polymerase II transcription machinery.

54 tion factor and an integral component of the transcription machinery.

55 II, indicating that Npl3 associates with the transcription machinery.

56 teracting with AR and by targeting the basal transcription machinery.

57 er and when a gene becomes accessible to the transcription machinery.

58 s with a putative coactivator or part of the transcription machinery.

59 limiting the accessibility of a gene to the transcription machinery.

60 ctional contact with components of the basal transcription machinery.

61 otein complex that initiates assembly of the transcription machinery.

62 rve distinct roles in the Pol II and Pol III transcription machinery.

63 iption initiation by the human mitochondrial transcription machinery.

64 associated adaptor complex accesses the core transcription machinery.

65 thus providing a direct link to the general transcription machinery.

66 rial DNA copy number can be regulated by the transcription machinery.

67 te DNA's flexibility and the assembly of the transcription machinery.

68 modeling factors and interact with the basal transcription machinery.

69 omplex that nucleates formation of the basal transcription machinery.

70 n factors and the RNA polymerase II (RNAPII) transcription machinery.

71 inding transcription factors and the general transcription machinery.

72 expression of nuclear genes for the plastid transcription machinery.

73 ), chromatin regulators (CRs), and the basal transcription machinery.

74 ugh the head and middle modules to the basal transcription machinery.

75 es influence promoter activity and the cbbLS transcription machinery.

76 e target genes to limit accessibility to the transcription machinery.

77 etween transcription factors and the general transcription machinery.

78 uclear compartmentalization of the genes and transcription machinery.

79 is not a core component of the mitochondrial transcription machinery.

80 mechanism that permits access to DNA by the transcription machinery.

81 ole as a core component of the mitochondrial transcription machinery.

82 pecific initiation by the core mitochondrial transcription machinery.

83 ermore is uniquely associated with the basal transcription machinery.

84 from the NPR1 signaling node to the general transcription machinery.

85 ding proteins, chromatin remodelers, and the transcription machinery.

86 e protein was not evident in the Pol I basal transcription machinery.

87 n eukaryotic Pol I, II, and III and archaeal transcription machineries.

88 s to link the H2B ubiquitylation and general transcription machineries.

89 able to replicate its RNA by use of cellular transcription machineries.

90 ctory to recombination and RNA polymerase II transcription machineries.

91 eplication complex with the Pol I and Pol II transcription machineries.

92 ld for interactions between the splicing and transcription machineries.

93 ndent encounters between DNA replication and transcription machineries.

94 ent recruitment of hBRE1-hRAD6 to the Pol II transcription machinery; (4) that H2B ubiquitylation per

95 higher plants is dependent on two different transcription machineries, a plastid-encoded bacterial-t

96 oops are tethered to "factories" through the transcription machinery-a polymerase (active or inactive

97 Elucidating the mechanisms by which the transcription machinery accesses promoters in their chro

98 In yeast, Paf1 is part of the transcription machinery, acting as a docking protein in

99 est that Ku also interacts with the cellular transcription machinery, although the mechanism and sign

100 histone tails and components of the general transcription machinery, although the relative contribut

101 The distribution of the transcription machinery among different sub-nuclear doma

102 anscriptional activation by recruiting basal transcription machinery and acetylating histones.

103 tely require chromatin to assemble the basal transcription machinery and activate transcription.

104 d/or various components of the general/basal transcription machinery and are essential for regulated

105 trinsic DNA specificity and suggest that the transcription machinery and associated promoter accessib

106 the promoter prevents the assembly of basal transcription machinery and binding of ubiquitous transc

107 S. pombe, it was accepted by the endogenous transcription machinery and caused initiation to be rest

108 redominant organizational theme by which the transcription machinery and chromatin regulators are pos

109 the proteasome directly influences both the transcription machinery and chromatin structure, factors

110 o study the localization and dynamics of the transcription machinery and DNA in live bacterial cells,

111 coactivators to communicate with the general transcription machinery and establish transcriptional pr

112 a molecular link between upregulation of the transcription machinery and genomic instability in cance

113 operative binding of these components of the transcription machinery and indicating that it is the PI

114 BP) is a central component of the eukaryotic transcription machinery and is subjected to both positiv

115 s crucial for the interaction with the basal transcription machinery and is thus required for p53's a

116 hanisms behind assembly of the mitochondrial transcription machinery and its regulation are poorly un

117 cupancy of the Methanocaldococcus jannaschii transcription machinery and its transcriptome.

118 th ribosomal DNA clusters recruits the pol I transcription machinery and maintains these loci in a tr

119 ween the NPR1 signaling node and the general transcription machinery and may relay signals from both

120 NAP is a critical component of the S. aureus transcription machinery and plays an important role duri

121 e of 19S ATPases in the assembly of CIITApIV transcription machinery and provide additional insight i

122 The basal transcription machinery and regulatory components are dy

123 ting tissue-selective functions of the basal transcription machinery and reveal intricate networks of

124 of lignin biosynthesis, and suggest that the transcription machinery and signalling pathways respondi

125 activators, in addition to interacting with transcription machinery and stabilizing chromatin.

126 forge a strong link between PPIases and the transcription machinery and suggest a new model for how

127 ransduction of cellular signals to the basal transcription machinery and that one of these signals co

128 Second, the transcription machinery and the splicing machinery, whic

129 isms requires spatiotemporal coordination of transcription machinery and the transcription factors at

130 t a model in which TREX is recruited via the transcription machinery and then Yra1p and Sub2p are tra

131 ors that are sufficient to recruit the basal transcription machinery and therefore activate transcrip

132 demonstrate a direct connection between the transcription machinery and ubiquitin-mediated proteolys

133 ithin promoters of active genes to allow the transcription machinery and various transcription factor

134 the level of combined effects on the general transcription machinery and, in addition, a direct role

135 RNA aptamers compatible with the cell's own transcription machinery and, thus, expressable inside ce

136 ky O(6)-alkylguanines blocks GGR, stalls the transcription machinery, and diverts the damage to trans

137 condensin, which interacts with the Pol III transcription machinery, and that transcription levels o

138 ator complex that interacts with the general transcription machinery, and the highly regulated PGC-1a

139 collision between replication forks and the transcription machinery, and the persistence of RNA-DNA

140 ), which leads to interaction with the basal transcription machinery, and ultimately with RNA polymer

141 reported that defined components of the host transcription machinery are recruited to human cytomegal

142 structure, composition and accessibility to transcription machinery are strictly and dynamically con

143 specific DNA binding factors and the general transcription machinery are unaffected by the status of

144 oncoding genome elements, and epigenetic and transcription machinery, are essential for establishing

145 ot due to nonspecific effects on the general transcription machinery as the VP16 transactivation doma

146 We derived comprehensive views of the transcription machineries assembled at estrogen-responsi

147 We infer cis-dependent perturbation of transcription machinery assembly by transcriptional inte

148 evel of continued transcription output after transcription machinery assembly.

149 The host cell transcription machinery associated with the specific IL-

150 e different targets within the basal pol III transcription machinery at different times during the ce

151 nd/or stability inhibits the assembly of the transcription machinery at normally quiescent promoters,

152 ether with RNA polymerase II, form the basal transcription machinery at the core promoter.

153 so discuss novel roles for the mitochondrial transcription machinery beyond transcription initiation,

154 In yeast the RNA pol III transcription machinery bound to tRNA genes function wit

155 between gene specific factors and the basal transcription machinery but little is known regarding th

156 re is not only a fundamental property of the transcription machinery, but it is emerging as an import

157 enrichment of Mediator and RNA polymerase II transcription machinery, but not that of LDTFs, MLL3/MLL

158 lted in effective recruitment of the general transcription machinery, but some reduction in histone m

159 single-stranded DNA (ssDNA) generated by the transcription machinery, but the detailed mechanism rema

160 NA for transcription factors and the general transcription machinery, but whether mammalian chromatin

161 ults link the Mediator complex and the basal transcription machinery by a regulatory pathway involvin

162 t proteins, implying that Tat influences the transcription machinery by aiding CBP/p300 to acquire ne

163 mechanism by which E1A hijacks the cellular transcription machinery by competing with essential tran

164 pecific regulation of Mediator and the basal transcription machinery by HMGA1.

165 ription without interacting with the general transcription machinery by looping-out the intervening D

166 ion dynamics of eukaryotic RNA polymerase II transcription machinery by MAPKs, CTD kinases, and phosp

167 of 18S rDNA into HeLa nuclei show that pol I transcription machinery can be recruited to rDNA promote

168 Thus, the general transcription machinery can contribute to nucleosome rem

169 TA element and the components of the general transcription machinery can lead to variations in the fo

170 a mechanism for how a component of the basal transcription machinery can mark the activators it has e

171 iffering modes of its recognition by general transcription machinery can provide an additional layer

172 ng how the organization of chromatin and the transcription machinery co-evolve.

173 ncorporate greater mechanistic detail of the transcription machinery compared to existing models and

174 A polymerase II (Pol II), the major cellular transcription machinery component, is an important step

175 The core human mitochondrial transcription machinery comprises a single subunit bacte

176 ances in understanding the RNA polymerase II transcription machinery, conserved coactivator complexes

177 ins to transmit the activating signal to the transcription machinery, depending on whether it is boun

178 We report a mechanism through which the transcription machinery directly controls topoisomerase

179 upstream of the HO gene is induced, and the transcription machinery displaces promoter-bound SBF, pr

180 (c) identification of a new component of the transcription machinery, DksA, that is absolutely requir

181 ditions, occupancy of a large portion of the transcription machinery does not.

182 h TFAM is absolutely required to recruit the transcription machinery during initiation of transcripti

183 interactions between the major components of transcription machinery during the early stages of the t

184 Global transcription machinery engineering (gTME) is an approac

185 ysis of Library Enrichments (SCALEs), global transcription machinery engineering (gTME), and gene-dis

186 nit diversity and specificity in the general transcription machinery for orchestrating multicellular

187 The basal eukaryotic transcription machinery for protein coding genes is high

188 FIIF efficiently recruits FCP1 to the pol II transcription machinery for recycling of the polymerase.

189 on with novel SUMO substrates found in basal transcription machinery for RNA polymerases I, II, and I

190 Transcription machinery from a variety of organisms show

191 ulatory effects on its cognate eukaryal-type transcription machinery from an upstream activating regi

192 that PcG proteins do not merely prohibit all transcription machinery from binding the template but in

193 , chromatin modifying enzymes, and the basal transcription machinery govern cellular differentiation,

194 han a simple chromosome-wide separation from transcription machinery, governs gene silencing over the

195 Recently, the core human mitochondrial transcription machinery has been defined, comprising a b

196 s detected in S regions, suggesting that the transcription machinery has paused and stalling is aboli

197 d at the heart of the polymerase II (pol II) transcription machinery has remained constant over the c

198 Alternate forms of the general transcription machinery have been described in several t

199 early demonstrated, the contributions of the transcription machinery have not been firmly established

200 ese two strands are synthesized in different transcription machineries in the cells, but the nature o

201 factors TAFII250 and TFIIB assemble into the transcription machinery in a stress- and promoter-specif

202 dered recruitment of components of the basal transcription machinery in concert with alterations in c

203 supports NS1 nuclear function to hijack host transcription machinery in favor of viral RNA synthesis,

204 rate that SWI/SNF influences the most robust transcription machinery in proliferating cells.

205 The results suggest that the LTR-assembled transcription machinery in synthesizing non-coding, LTR

206 To understand the contribution of the transcription machinery in the disassembly of the +1 H2A

207 nitiation, it is a required component of the transcription machinery in this promoter.

208 eir associated activators, while the general transcription machinery including core promoter recognit

209 teractions with components of the U6 general transcription machinery, including SNAP(C) and TFIIIB.

210 nd represents a fundamental component of the transcription machinery, interacting with the RNA polyme

211 neries in the cells, but the nature of these transcription machineries is not clear.

212 oth prokaryotes and eukaryotes, and that the transcription machinery is a molecular tie.

213 ng stationary phase when the majority of the transcription machinery is bound by the RNA.

214 n profile, suggesting that the mitochondrial transcription machinery is coordinately regulated in res

215 Although the dynamics of transcription machinery is essential to genome regulatio

216 r hMLH1 expression levels indicates that the transcription machinery is intact even in non-expressing

217 red and no ATF4 interaction with the general transcription machinery is necessary.

218 e role of components of the RNA polymerase I transcription machinery is paramount to understanding re

219 inued transcription output after assembly of transcription machinery is unaffected by curcumin.

220 AC and tTAF cell type-specific chromatin and transcription machinery leads to loss of Polycomb and re

221 ven O-GlcNAcylation of key components of the transcription machinery may epigenetically modulate gene

222 upstream of transcription start sites; (c). transcription machinery may hinder access of NER factors

223 ive and negative regulators with the general transcription machinery modulates transcription.

224 proteins revealed associations with cellular transcription machinery; modulators of transcription; co

225 We also find association of SDG8 with the transcription machinery, namely RNA polymerase II and th

226 atin remodeling complex, NURF, and the basal transcription machinery near the transcriptional start s

227 f RNA polymerase II (Pol II) and the general transcription machinery near the TSS.

228 We also show that Pax5 targets the basal transcription machinery of c-fms by interacting with a b

229 known about how archaeal viruses perturb the transcription machinery of their hosts.

230 ad-on encounters between the replication and transcription machineries on the lagging DNA strand can

231 FIID and assembles with POL II and the basal transcription machinery on promoters in vivo.

232 ceptor (AR) may communicate with the general transcription machinery on the core promoter to exert it

233 nd impeding the efficient recruitment of the transcription machinery on the promoter of an activated

234 and 3) direct interference with the general transcription machinery or activators.

235 domain that interacts specifically with the transcription machinery or nearby factors.

236 ositively depending upon whether the general transcription machinery or RNA polymerase III is prefere

237 by facilitating or obstructing the action of transcription machinery or the access to chromosomal DNA

238 s little effect on accessibility of SINEs to transcription machinery or their expression in vivo.

239 rnberg, on the structure and function of the transcription machinery; Peter Novick, on the regulation

240 ization of the genes, enhancer elements, and transcription machinery plays an essential role in tissu

241 ovide the first insights into how the Pol II transcription machinery processes the most abundant DNA

242 ncluding a critical component of the general transcription machinery proteins, the TATA box binding p

243 Saccharomyces cerevisiae) mitochondrial (mt) transcription machinery provide mechanistic understandin

244 After initiation, a subset of the transcription machinery remains at the promoter, forming

245 Collisions between replication and transcription machineries represent a significant source

246 act that eukaryotes with well-developed gene transcription machinery require transcription factor fle

247 The archaeal basal transcription machinery resembles the core components of

248 Recent studies of the three eukaryotic transcription machineries revealed that all initiation c

249 orrelate with the RNA polymerase II, Pol II, transcription machinery significantly better than with E

250 Mediator is required for recruitment of the transcription machinery subsequent to chromatin remodeli

251 mber of promoters have key components of the transcription machinery, such as TATA-binding protein (T

252 en Xeed and a component of the Xenopus basal transcription machinery, TAF(II)32.

253 ch region bound to components of the general transcription machinery [TATA-binding protein (TBP), TAF

254 eractions with one or more components of the transcription machinery, termed the "target." The identi

255 protein 1], Fhl1, Ifh1, Sfp1, and Hmo1), the transcription machinery (TFIIB, TFIID, and RNA polymeras

256 her member of the RNA polymerase III general transcription machinery, TFIIIB.

257 hormone-regulated enhancers and the general transcription machinery that binds the S14 proximal prom

258 omponent of the eukaryotic RNA polymerase II transcription machinery that binds to TATA boxes located

259 enome of coronaviruses encodes a replication/transcription machinery that is unusually complex and co

260 nsferase p300, and components of the general transcription machinery that, by themselves, suffice for

261 tionally obligatory subunit of the bacterial transcription machinery, the RNA polymerase.

262 othecin, or by collision with replication or transcription machinery, thereby causing protein-linked

263 ptional activators and the RNA polymerase II transcription machinery; therefore, our data suggest tha

264 nveys its stimulatory effects on its cognate transcription machinery through direct recruitment of th

265 RNA synthesis occurs in the Pol I and Pol II transcription machineries, thus extending the capability

266 hought to recruit limiting components of the transcription machinery to a core promoter.

267 tiation requires recruitment of the complete transcription machinery to a promoter, a process facilit

268 o the ability of the promoter to recruit the transcription machinery to a specific site.

269 w how chromatin structure interacts with the transcription machinery to accomplish rigorous spatial r

270 e minimal DNA region that recruits the basal transcription machinery to direct efficient and accurate

271 s in part by facilitating recruitment of the transcription machinery to DNA.

272 tion factor (pTEFb) to the RNA polymerase II transcription machinery to enable an efficient HIV-1 RNA

273 ow phages fine-tune the activity of the host transcription machinery to ensure both successful and ef

274 xes facilitates gene activation by assisting transcription machinery to gain access to targets in chr

275 factor TFIID facilitates recruitment of the transcription machinery to gene promoters and regulates

276 gets two critical components of the myogenic transcription machinery to inhibit terminal differentiat

277 hey interact with each other and the general transcription machinery to maintain on or off states of

278 ons that mediate aberrant recruitment of the transcription machinery to MLL target genes.

279 her a protein effector can interact with the transcription machinery to prematurely terminate transcr

280 nt of the transcriptional regulators and the transcription machinery to promoter chromatin is coordin

281 med the remarkable capability of the reverse transcription machinery to recognize short regions of se

282 iption factors and components of the general transcription machinery to regulatory regions upstream o

283 associates with the RNA polymerase I (Pol I) transcription machinery to suppress rRNA gene transcript

284 Recruitment of transcription machinery to target promoters for aberrant

285 enetic mark that promotes the recruitment of transcription machinery to the Cd8 enhancers.

286 ed through either coordinated recruitment of transcription machinery to the gene promoter or regulate

287 iption in DCs by prolonging binding of basic transcription machinery to the IFN promoters, thereby pl

288 le-specific activator MyoD recruits the core transcription machinery to the promoter of a key regulat

289 ruit and/or stabilize binding of the general transcription machinery to the proximal promoter of thei

290 expression by blocking access of the general transcription machinery to the underlying DNA sequences.

291 eflect the need for an optimally functioning transcription machinery under conditions of lowered intr

292 nto a mechanism by which RECQ5 regulates the transcription machinery via its dynamic interaction with

293 oA AD transmits its activating signal to the transcription machinery, we defined specific subregions,

294 ver the regulatory properties of the general transcription machinery, we have isolated the hTAF(II)55

295 Several components of the translation and transcription machinery were identified, including trans

296 sions that occur between the replication and transcription machineries when genes are encoded on the

297 via RNA polymerase II, bridging the general transcription machinery with gene-specific regulatory pr

298 t of the general RNA polymerase II (RNAP II) transcription machinery with intrinsic sequence-specific

299 implementations of the interaction of basal transcription machinery with promoter DNA, depending on

300 by the differences in the interaction of the transcription machinery with the different promoters.