ライフサイエンスコーパス: transcriptional

1 R loops, which are mainly co-transcriptional, abundant RNA/DNA hybrids, form naturall

2 affect chromatin organization, inhibits the transcriptional activation activity of PHYTOCHROME INTER

3 I2DeltaN enhanced the beta-catenin-dependent transcriptional activation and the subsequent activation

4 H2AZ regulates transcriptional activation as well as the maintenance of

5 increased the ability of estrogen to enhance transcriptional activation by ER-alpha of endogenous est

6 PRMT5 methylation of histone H3R2me1 induced transcriptional activation by recruitment of WDR5 and co

7 Evolutionary conservation of the EDC and the transcriptional activation during epidermal differentiat

8 Its transcriptional activation function requires phosphoryla

9 on plays an important role in the control of transcriptional activation in vivo.

10 h dFOXO in vitro and in vivo to regulate the transcriptional activation of insulin receptor (InR) and

11 that heme induces transcription of HAP4, the transcriptional activation subunit of the Hap2/3/4/5p co

12 x2 at T118, leading to its stabilization and transcriptional activation.

13 ex way by the concentration of the unbounded transcriptional activator ExsA.

14 Although p53 is a transcriptional activator that induces myriad target gen

15 Androgen receptor (AR) is a transcriptional activator that, in prostate cells, stimu

16 overed that DLX1 and DLX2 function as direct transcriptional activators of Brn3b expression.

17 and UC-514321 both directly target STAT3/5, transcriptional activators of TET1, and thus repress TET

18 t 95.6% of tested TEs can function as either transcriptional activators or repressors.

19 KLF1 and related family members function as transcriptional activators via recruitment of co-activat

20 RNA), which abrogates the function of CRISPR-transcriptional activators.

21 ide morphological cues that regulate certain transcriptional activators.

22 ects caused by up-regulation of beta-catenin transcriptional activities.

23 ively, our data argue that DHX15 enhances AR transcriptional activity and contributes to PCa progress

24 We also monitored the transcriptional activity from the NtPDR1 promoter in sit

25 NO2-OA inhibited TNFalpha-induced NF-kappaB transcriptional activity in human TNBC cells and suppres

26 ed nuclear entry of p50 and showed decreased transcriptional activity in luciferase reporter assays.

27 ur results suggest a mechanism in which MEF2 transcriptional activity is differentially recruited to

28 We find that Bicoid transcriptional activity is dispensable for embryonic vi

29 acetylation, enhancing the stabilization and transcriptional activity of HIF-1alpha and strengthening

30 Cs was unaffected by the absence of Vpr, the transcriptional activity of the viral long terminal repe

31 to MRTF nuclear shuttling to promote the SRF transcriptional activity required for entosis.

32 arily acetate from carbon dioxide, and their transcriptional activity was mapped to genomes from cell

33 estradiol significantly decreased NF-kappaB transcriptional activity while increasing TLR5-mediated

34 quired for cell proliferation, enhanced AR's transcriptional activity, and colocated with AR at speci

35 osine 78 stabilizes Atoh1, increases Atoh1's transcriptional activity, and is independent of canonica

36 nd mRNA expression, ultimately reducing LEF1 transcriptional activity, as judged by luciferase assay.

37 tein dominantly interfered with STAT5-driven transcriptional activity, leading to global downregulati

38 cale TADs, whose boundaries are enriched for transcriptional activity.

39 mal region of the IL22 promoter and promotes transcriptional activity.

40 namic shifts in the population and metabolic transcriptional activity.

41 esis by binding to and suppressing PGC1alpha transcriptional activity.

42 role in AR stability and is critical for its transcriptional activity.

43 vents its phosphorylation, and activates its transcriptional activity.

44 se orthologue (mG9a) potently stimulated p53 transcriptional activity.

45 In a prior genomewide transcriptional analysis, we found that IPF MPCs display

46 A comparative analysis of transcriptional and chromatin features of inactive X-lin

47 ase 3a (DNMT3a), ultimately resulting in the transcriptional and epigenetic control of gene expressio

48 differentiation at the transcriptional, post-transcriptional and epigenetic levels.

49 Transcriptional and epigenomic profiling revealed that I

50 gh the suppression of c-Fos/AP-1 activity at transcriptional and post transcriptional levels in OA ch

51 ls to their needs, but knowledge about these transcriptional and post-transcriptional modifications i

52 ale integrative analysis to propose putative transcriptional and post-translational regulatory mechan

53 or GPR56, and GPR56(+) TEMRA cells display a transcriptional and proteomic program with cytotoxic fea

54 thway, such as alternative splicing and post transcriptional and translational modifications.

55 NA processing enzyme Usb1, reconstitute post-transcriptional assembly of yeast U6 snRNP in vitro, and

56 ogical systems can provide insights into the transcriptional basis of cellular identity.

57 sembling the response to heat shock, but the transcriptional basis of this response remains unclear.

58 g the growth hormone-mediated release of the transcriptional blockade of genes associated with cell c

59 ion modulates stochastic gene expression and transcriptional bursting, with implications for regulati

60 rentiating/enucleating cells with decreasing transcriptional capacity.

61 cal analyses confirmed the cellular basis of transcriptional changes and highlighted the dramatic acc

62 Transcriptional changes in astrocytes are accompanied by

63 We studied epigenetic and transcriptional changes in HCV-infected livers in compar

64 l role in directing the discrete and gradual transcriptional changes that define T cell development.

65 To elucidate the dynamic transcriptional changes that underlie this process, we a

66 ion of IL-1R activation by Anakinra corrects transcriptional changes, restores MeCP2 levels and spine

67 t not distribution, changes in parallel with transcriptional changes.

68 ent of RNAPII through the nucleosome with co-transcriptional chromatin modifications during transcrip

69 Stromal content heavily impacts the transcriptional classification of colorectal cancer (CRC

70 rase (SAGA) chromatin-modifying complex is a transcriptional coactivator that contains four different

71 Spindlin1 (SPIN1) is a transcriptional coactivator with critical functions in e

72 MF treatment reduced nuclear localization of transcriptional coactivator with PDZ binding motif (TAZ)

73 We show that FGF18 induces transcriptional coactivator with PDZ-binding motif (TAZ)

74 Hippo pathway transcriptional coactivators TAZ and YAP and the TGF-bet

75 d Lats2, which phosphorylate and inhibit the transcriptional coactivators Yap and Taz, in nephron pro

76 ified LMO1, which encodes an LIM-domain-only transcriptional cofactor, as a neuroblastoma susceptibil

77 cell-based tissue renewal, we found that the transcriptional cofactors YAP and TAZ are required both

78 t DNA-binding events genome wide and ectopic transcriptional consequences of this binding.

79 s (4i)-naive reprogramming medium and showed transcriptional consistency of our hPGCLCs with hPGCLCs

80 Post-transcriptional control by small regulatory RNA (sRNA) i

81 es of stress response, indicating orthogonal transcriptional control mechanisms.

82 nducible postnatal deletion of Dsp under the transcriptional control of the Cspg4 locus led to ventri

83 an epitranscriptomic mechanism in heightened transcriptional coordination during mammalian cortical n

84 /2 of Ser114 and Ser446 converts Bcl3 into a transcriptional coregulator by facilitating its recruitm

85 of biotin utilization and acts as a nuclear transcriptional coregulator of gene expression.

86 assays, and risk allele carriage diminished transcriptional correlations among IFITM3-neighboring ge

87 Integration of these transcriptional data with a recently developed metabolic

88 transcription of sufSUB Consistent with the transcriptional data, the sufD* strain had multiple phen

89 Transcriptional deregulation of oncogenic pathways is a

90 erferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses

91 We also observe transcriptional downregulation of pathways mediating ene

92 Transcriptional dysregulation induced by aberrant transc

93 ERalpha therefore functions as a transcriptional effector of cytokine-induced IKKbeta sig

94 Unexpectedly, many transcriptional effects of O-GlcNAc transferase (OGT) in

95 rols the cardiac TGF-beta axis and its early transcriptional effects that lead to myocardial fibrosis

96 that enhances the engagement of Pol II into transcriptional elongation) to the coding sequence of an

97 coordinates nucleosome dis- and re-assembly, transcriptional elongation, and mRNA processing.

98 equently reduces the engagement of Pol II in transcriptional elongation, leading to promoter-proximal

99 IG-I, producing their enhanced expression by transcriptional elongation.

100 Transcriptional enhanced associate domain (TEAD) protein

101 st proliferation and differentiation through transcriptional enhancer associate domain (TEAD) and run

102 A transcriptional enhancer element from the Mason-Pfizer m

103 of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediat

104 RNAs) in early elongation and highlight that transcriptional enhancers might modulate the release of

105 us to identify pre-neoplastic epigenetic and transcriptional events.

106 Meta-analysis of RD3 transcriptional expression across normal tissues confirm

107 rate an lncRNA-mediated mechanism by which a transcriptional factor conveys a general chromatin modif

108 P response element binding protein (CREB), a transcriptional factor involved with learning and memory

109 anotransduction intersects with chemical and transcriptional factors to shape organogenesis is an imp

110 Rather than transcriptional factors, genes involved in mRNA translat

111 characterized clinical phenotype to identify transcriptional features associated with each disease cl

112 with a proliferative advantage and stem-like transcriptional features.

113 st the possibility of co-replicational or co-transcriptional folding of G-quadruplex inside the polym

114 Results ERalpha transcriptional function was abolished in the mutated 23

115 accessory proteins, and in particular their transcriptional functions, work to drive viral pathogene

116 her examine roles for cotranscriptional/post-transcriptional gene regulation during development.

117 We performed an unbiased analysis of transcriptional heterogeneity in colorectal tumors and t

118 ression of a 5' extended mRNA isoform causes transcriptional interference at the downstream promoter.

119 Here we demonstrate a transcriptional interference mechanism that is responsib

120 latent HIV-1 in infected cells and that true transcriptional latency may not be possible in vivo, esp

121 proach to elucidate how heterogeneity at the transcriptional level manifests in the physiologic profi

122 that BET proteins are regulated at the post-transcriptional level.

123 promoting MYC mRNA stabilization at the post-transcriptional level.

124 os/AP-1 activity at transcriptional and post transcriptional levels in OA chondrocytes.

125 at YY1 is mainly involved in controlling the transcriptional levels, but not the DNA methylation, of

126 m-deleted kidney macrophages exhibit a novel transcriptional lupus signature that is conserved within

127 tial link between small RNA pathways and the transcriptional machinery in Caenorhabditis elegans.

128 ion is ensured by the hermaphrodite-specific transcriptional master regulator of hermaphroditic cell

129 oted VEGF expression and secretion through a transcriptional mechanism involving STAT3 and SP4.

130 t phases of the day and may depend on a post-transcriptional mechanism.

131 requent regeneration failures in humans, the transcriptional mechanisms that control long-term surviv

132 However, the transcriptional mechanisms that determine the thermogeni

133 deeper and more precise understanding of the transcriptional mechanisms that induce and maintain the

134 However, the transcriptional mechanisms that specify human microglia

135 This identification of transcriptional mechanisms that support long-term surviv

136 nt on germline nuclear RNAi factors and post-transcriptional mechanisms.

137 owing previous growth in galactose, GAL gene transcriptional memory confers a strong fitness benefit

138 upon return to favorable conditions and six transcriptional memory types.

139 owledge about these transcriptional and post-transcriptional modifications is sparse.

140 s to be the progenitor, with subsequent post-transcriptional modulation highlighting the complexity o

141 s in inaccessible chromatin to establish new transcriptional networks throughout development and cell

142 PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks.

143 xpression of FKRP was not altered neither at transcriptional nor at translational levels, but its fun

144 Here, we report a deep transcriptional, oncogenic network regulated by miRNAs.

145 e round of infection and is due to decreased transcriptional output from the integrated viral genome.

146 ext-specific H3K4 methylation that regulates transcriptional outputs during ESC pluripotency.

147 show this competition results in reciprocal transcriptional outputs for >50 important genes.

148 is activity is mediated by an ODZ1-triggered transcriptional pathway, through the E-box binding Myc p

149 Transcriptional patterns exhibited evidence of activated

150 ing to the formation of stable and heritable transcriptional patterns.

151 indicate that R-loop induction correlates to transcriptional pausing.

152 rm for integrated analysis of functional and transcriptional phenotypes in the same single cells.

153 pol II dwell time at start sites and reduced transcriptional polarity because of strongly enhanced di

154 ween self-renewal and differentiation at the transcriptional, post-transcriptional and epigenetic lev

155 We develop a transcriptional predictor of immunotherapy response and

156 light the importance of chromatin states and transcriptional priming in dictating tumor phenotypes an

157 RNA editing is an essential post-transcriptional process that creates functional mitochon

158 (Pol2) movement through chromatin and the co-transcriptional processing and fate of nascent transcrip

159 Transcriptional profile of ABA receptor genes revealed a

160 pab1 deletion brings about a transcriptional profile similar to TORC1 inactivation, a

161 sion substantially recapitulates genome-wide transcriptional profiles and alternative splicing induce

162 neral patterns of variation for the antennal transcriptional profiles in the adult and developing olf

163 n and coexpression network analyses revealed transcriptional profiles of individual cell populations

164 We examined the transcriptional profiles of macrophages that reside in t

165 atin landscape, as well as alteration of the transcriptional profiles.

166 s of the chick tectum using microarray based transcriptional profiling and identified several novel c

167 Single-cell transcriptional profiling at E9.5 reveals that endocrine

168 uge rise in the number of publicly available transcriptional profiling datasets.

169 Genetic studies and transcriptional profiling experiments show that this sin

170 Highly induced genes identified in transcriptional profiling include those for putative enz

171 Transcriptional profiling of cDKO HSPCs revealed the act

172 Previous cardiac transcriptional profiling of LmnaH222P/H222P mouse, a sm

173 Cell-specific transcriptional profiling revealed that microglia select

174 Using whole-exome sequencing and transcriptional profiling, we found that the long non-co

175 which translates into activation of a broad transcriptional program dominated by upregulation of gen

176 ledge regarding the conservation of the DUX4 transcriptional program in other species.

177 ing apparatus supporting an antiregenerative transcriptional program that includes a subunit of the n

178 pose a unifying model in which the erythroid transcriptional program works in concert with post-trans

179 n epithelial to mesenchymal transition (EMT) transcriptional program.

180 mily zinc finger 2 (GLI2) coordinates the Hh transcriptional program; however, the GLI2 targets that

181 Transcriptional programming of regulatory mechanisms fac

182 nalyzed human breast cancer data to identify transcriptional programs associated with tumors bearing

183 g a deeper understanding of how the distinct transcriptional programs controlled by these isoforms af

184 Herein we identified the transcriptional programs regulated by CREB in astrocytes

185 rse immune cells and controlling the dynamic transcriptional programs that are a hallmark of immune c

186 Profiling of cardiomyocyte and nonmyocyte transcriptional programs uncovered several injury-respon

187 identify key regulatory networks that drive transcriptional programs.

188 d evidence of divergent, rather than common, transcriptional programs.

189 Interactions between transcriptional promoters and their distal regulatory el

190 We observe massive induction of transcriptional readthrough, both in levels and length,

191 s implicated variants in genes necessary for transcriptional regulation and function of the primary c

192 study reveals novel principles of concerted transcriptional regulation by multiple TRs at CRMs.

193 y to resolve AAI supports a crucial role for transcriptional regulation by the GR in this cell type.

194 Furthermore, we demonstrate that the transcriptional regulation by the psychiatric risk gene

195 ncRNAs) play crucial roles in epigenetic and transcriptional regulation in mammals.

196 These findings indicate that transcriptional regulation in various nonthyroid tissues

197 Wnt and Fgf pathways have opposing roles in transcriptional regulation of components of the Cxcr4-ch

198 tin immunoprecipitation analysis, suggesting transcriptional regulation of EBF1 by AHR.

199 ue-specific epigenetic event that influences transcriptional regulation of gene expression.

200 ng RNAs that play critical roles in the post-transcriptional regulation of gene expression.

201 ed, MYC selects for this pathway in part via transcriptional regulation of PKCalpha and ITPR.

202 xity, implicating long-noncoding RNAs in the transcriptional regulation of plant innate immunity.

203 Transcriptional regulation of protein-coding genes is a

204 he NanoLuc activity faithfully monitored the transcriptional regulation of SNCA following treatment w

205 e provides a valuable resource to understand transcriptional regulation of various human developmenta

206 emonstrate that PRMT5-MEP50 is essential for transcriptional regulation promoting cancer cell invasiv

207 tudies have raised several novel insights on transcriptional regulation such as the "hit-and-run" mod

208 ypes, and highlight the contribution of post-transcriptional regulation to shaping tissue-type-specif

209 their physiological counterparts, ontogeny, transcriptional regulation, and heterogeneity remains la

210 epigenetic reader BRD4 plays a vital role in transcriptional regulation, cellular growth control, and

211 Leveraging the extensive knowledge of yeast transcriptional regulation, we uncovered significant reg

212 ons for GLR channels in sperm chemotaxis and transcriptional regulation.

213 egulatory elements play an important role in transcriptional regulation; however, the extent to which

214 t, we identified a light-sensing B12-binding transcriptional regulator and demonstrated that it contr

215 is at 3 days identified activated STAT3 as a transcriptional regulator and revealed differential expr

216 the identification of Hnf4a as the potential transcriptional regulator for Dnajc22 which was further

217 Inducible entry of the NuRD-interacting transcriptional regulator Ikaros into mouse pre-B cell n

218 ely, our data uncover Nudt21 as a novel post-transcriptional regulator of cell fate and establish a d

219 lective inhibitor, potently blocks CDK9, the transcriptional regulator of MCL-1.

220 We demonstrate that the transcriptional regulator Runx1 is essential for the gen

221 ke protein 4 (SALL4), an embryonic stem cell transcriptional regulator, is re-expressed by an unknown

222 anced expression and activation of a key ISG transcriptional regulator, signal transducer and activat

223 formation of multiple cell types by the same transcriptional regulator.

224 The BET proteins are major transcriptional regulators and have emerged as new drug

225 These results revealed a complex network of transcriptional regulators and pathways that orchestrate

226 identify a network of helix-loop-helix (HLH) transcriptional regulators controlled by MYT1L, as indic

227 Overall, our in silico search for post-transcriptional regulators identified miR-495 as a novel

228 MicroRNAs (miRNAs) are important post-transcriptional regulators of gene expression and are im

229 y proteins have recently emerged as key post-transcriptional regulators of mitochondrial gene express

230 ween the symbiosis signaling pathway and key transcriptional regulators that direct AM-specific gene

231 e networks with FMRP and possibly other post-transcriptional regulators to regulate neurogenesis.

232 lays a key role in transferring signals from transcriptional regulators to RNA polymerase II in eukar

233 ral-specific inactivation of two murine post-transcriptional regulators, Pumilio 1 (Pum1) and Pum2, s

234 n, we identified up to 161 genes that encode transcriptional regulators, some of unknown function in

235 The transcriptional regulatory function of DDB2 is significa

236 However, it is unknown how the transcriptional regulatory mechanisms underlying these f

237 We define an IEC transcriptional regulatory network that is shared betwee

238 Modeling of transcriptional regulatory networks (TRNs) has been incr

239 For example, transcriptional regulatory networks consist of interacti

240 onary forces of rigidity and plasticity over transcriptional regulatory programs.

241 the distribution of mutational effects of a transcriptional regulatory system differs from the distr

242 tic ablation of Zbtb7b impaired cold-induced transcriptional remodeling in brown fat, rendering mice

243 effects on NNMT were caused by PAX3-mediated transcriptional repression and overexpression of NNMT bl

244 Although their mechanism of transcriptional repression has been well studied for ove

245 own synthesis in stromal cells by signaling transcriptional repression of 15-PGDH elucidates long so

246 roto-oncogene c-Myb in TAMs induced a stable transcriptional repression of 5-LO.

247 Fs act as tumor suppressors, most likely via transcriptional repression of cell cycle genes in respon

248 , we identify a novel B-lymphoid program for transcriptional repression of glucose and energy supply.

249 Hence, high resolution mapping of transcriptional repression reveals complex and interdepe

250 lysine residues on histone tails, promoting transcriptional repression via condensation of chromatin

251 promoters in a CG context is associated with transcriptional repression, including at genes silenced

252 NACC1 encodes a transcriptional repressor implicated in gene expression

253 d the EMT inducers ZEB1, ZEB2, and the snail transcriptional repressor SNAI2, each crucial factors in

254 B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the diffe

255 nhancers that are known to be repressed by a transcriptional repressor.

256 expressed Ets DNA-binding domain-containing transcriptional repressor.

257 control occurs through cryptochromes (CRYs)-transcriptional repressors and components of the circadi

258 300, whereas KLF3 and related members act as transcriptional repressors via recruitment of C-terminal

259 d in lineage differentiation but can undergo transcriptional reprogramming in a bidirectional manner

260 yme (Esigma(70)) and plays a key role in the transcriptional reprogramming upon shifts between expone

261 work provides a comprehensive framework and transcriptional resource of multiple cardiac cell popula

262 tween these metabolic modes requires a rapid transcriptional response and this is orchestrated by Sur

263 st plant root exudates resulted in different transcriptional response between species.

264 downstream coactivators that coordinate the transcriptional response have not been fully illustrated

265 Here we show that the transcriptional response in neurons is exquisitely sensi

266 Here, we systematically integrate the transcriptional response of B-ALL to GCs with a next-gen

267 in vitro approaches to characterize the SOS transcriptional response to DNA damage in the Patescibac

268 High-throughput screening of the host transcriptional response to various viral infections pro

269 e there are much data to support the role of transcriptional responses downstream of pattern recognit

270 scription factors that appear to drive these transcriptional responses, including members of the E2F

271 In accordance with transcriptional responses, we found persistent degradati

272 regulation of gene expression by cis-acting transcriptional riboswitches located in the 5'-untransla

273 This work reveals an incredible post-transcriptional robustness in T3SS assembly and aids its

274 In this study, we investigated this novel transcriptional role for CLOCK in human neurons by perfo

275 ach (master regulator analysis) to combine a transcriptional signature for oncogenic KRAS derived fro

276 d BMBs shared specific activation-associated transcriptional signatures but differed in other signatu

277 of Th2 responses is associated with distinct transcriptional signatures in DCs in vivo, reflecting th

278 e amino acid response and ER stress response transcriptional signatures.

279 regulation in plants, as a factor promoting transcriptional silencing at the transgenic RD29A promot

280 -coding RNA production, DNA methylation, and transcriptional silencing.

281 methylation and expression of an alternative transcriptional start site, including AKT3 The novel AKT

282 D-associated susceptibility regions with the transcriptional start sites of 304 target genes.

283 methylated adenine clusters surrounding the transcriptional start sites of expressed genes; its dist

284 MYC ESE looping to the transcriptional stat site of MYC was dependent on EBNAs.

285 We find that transcriptional state is a major predictor of Hi-C conta

286 ing in these cells, converting the transient transcriptional state to a stably resistant state.

287 developmental promoters represents a poised transcriptional state.

288 isms that underpin rapid transitions between transcriptional states, and elucidates the temporal orde

289 primary regulator of cytopathicity and host transcriptional suppression.IMPORTANCE Viruses must supp

290 The SMYD2 transcriptional target gene Ptpn13 also linked SMYD2 to

291 2 deletion in p53(-/-) cells upregulated p53 transcriptional target genes that induce apoptosis and c

292 cover that receptor tyrosine kinase AXL is a transcriptional target of BCL6 in GBM and mediates parti

293 In turn, AMPK activates FOXO3A and its transcriptional target, PUMA, which induces anoikis to s

294 27, and increased expression of PML, a STAT3 transcriptional target.

295 RY1 variant causes reduced expression of key transcriptional targets and lengthens the period of circ

296 Transcriptional targets include cell cycle and epigeneti

297 oles for MYF5 and MYOD convergence on common transcriptional targets to regulate human RMS growth.

298 and led to downregulation of canonical PU.1 transcriptional targets.

299 al start site, including AKT3 The novel AKT3 transcriptional variant and methylation changes were con

300 ession is activated by the novel TetR-family transcriptional zinc-sensing regulator SczA.