ライフサイエンスコーパス: transcriptional activation

1 o viral DNA sequences, which correlates with transcriptional activation.

2 d of mRNAs that extends beyond the region of transcriptional activation.

3 er and activator of transcription 3-mediated transcriptional activation.

4 was initiated through EGR1 via ERK-regulated transcriptional activation.

5 ition of Hdac1 expression and enhanced Runx2 transcriptional activation.

6 9) was essential for obtaining PPAR-mediated transcriptional activation.

7 while maintaining very high levels of OcXII transcriptional activation.

8 H3 Lysine 4 trimethylation (H3K4me3) during transcriptional activation.

9 e regarded as an indicator of CREB-dependent transcriptional activation.

10 m of BMP-2 also drives NFATc1 expression and transcriptional activation.

11 cation controls its nuclear localization and transcriptional activation.

12 w that S/T-P phosphorylation is required for transcriptional activation.

13 imerization at two distinct domains for full transcriptional activation.

14 tivator of transcription 3 (STAT3)-dependent transcriptional activation.

15 equired for H3K4 mono- and dimethylation and transcriptional activation.

16 the IgH locus enhancers during CSR and their transcriptional activation.

17 LXXLL-4 motifs were important for successful transcriptional activation.

18 -dependent impairment of Galectin-1-mediated transcriptional activation.

19 , resulting in their histone acetylation and transcriptional activation.

20 ell coactivator (SCC) required for OCT4/SOX2 transcriptional activation.

21 due to decreased autophagy and Nrf2-mediated transcriptional activation.

22 ate GATA-2 occupancy, chromatin opening, and transcriptional activation.

23 ins of ZLD required for both DNA binding and transcriptional activation.

24 celerating DNA repair after androgen-induced transcriptional activation.

25 rement for constitutive AR-V DNA binding and transcriptional activation.

26 e the repressed domain and become subject to transcriptional activation.

27 acts with the CLOCK:BMAL1 complex to repress transcriptional activation.

28 nit MDT-15 are necessary for zinc-responsive transcriptional activation.

29 or protein constitutes a vital early step in transcriptional activation.

30 f p65 to the promoter of Beclin 1 and to its transcriptional activation.

31 tly increased in response to ATRA indicating transcriptional activation.

32 which is required for H3K4 dimethylation and transcriptional activation.

33 tosis, but is increased at certain genes for transcriptional activation.

34 of p65 at Lys-310, contributing to NF-kappaB transcriptional activation.

35 urbation, through analysis of indel rate and transcriptional activation.

36 er of maternal transcripts and inappropriate transcriptional activation.

37 rt cis-regulatory enhancer assembly for gene transcriptional activation.

38 x2 at T118, leading to its stabilization and transcriptional activation.

39 affinity and Ubx concentration required for transcriptional activation.

40 ociated with Smad2/3 binding coincident with transcriptional activation.

41 at overexpression of miR-4443 was not due to transcriptional activation.

42 stimulation and was indispensable for IRAK-M transcriptional activation.

43 must have a mechanism for rapid cessation of transcriptional activation.

44 ised p53 acetylation as well as crippled p53 transcriptional activation, accumulation and apoptotic r

45 CmpacC was confirmed to have the transcriptional activation activity by the transcription

46 affect chromatin organization, inhibits the transcriptional activation activity of PHYTOCHROME INTER

47 ing with PIF1 and preventing DNA binding and transcriptional activation activity of PIF1.

48 interacts with the PIFs and represses their transcriptional activation activity, antagonizing PIF-in

49 ancer divergence underlies the difference in transcriptional activation after GC treatment between mo

50 that autocrine LPA synthesis promotes NFAT1 transcriptional activation and ATX secretion in a positi

51 ggest that Pol II pausing is retained during transcriptional activation and can further undergo regul

52 which is associated with de novo or enhanced transcriptional activation and can translate into transp

53 trome and a genome-wide loss of ERG-mediated transcriptional activation and cell migration.

54 Many correlations between transcriptional activation and demethylation have since

55 on by aberrantly inducing both AEP-dependent transcriptional activation and DOT1L-dependent transcrip

56 omain, functionally suppressed RARA-mediated transcriptional activation and enhanced RARA interaction

57 Thus, transcriptional activation and epigenetic remodeling of

58 In particular, we observed H2A.Z loss upon transcriptional activation and H2A.Z gain upon repressio

59 rol morphogenesis by promoting GLI-dependent transcriptional activation and inhibiting the formation

60 We introduce a joint model of transcriptional activation and mRNA accumulation that ca

61 II ChIP-Seq time course data to characterize transcriptional activation and mRNA-Seq time course data

62 s promoting an energy saving program through transcriptional activation and phosphorylation of metabo

63 The mutations affected transcriptional activation and repression in a variegate

64 critical role for complementary PRMT5-MEP50 transcriptional activation and repression in cancer inva

65 Here, we report that transcriptional activation and repression of the Runx2 g

66 fundamental biological processes, including transcriptional activation and repression, DNA damage re

67 ly control function by simultaneously tuning transcriptional activation and repression, using a novel

68 and Smad1 binding were associated with both transcriptional activation and repression, with Wnt-repr

69 on plays a key role in NF-kappaBeta-mediated transcriptional activation and repression.

70 I2DeltaN enhanced the beta-catenin-dependent transcriptional activation and the subsequent activation

71 cantly reduced binding to ChlR1 but retained transcriptional activation and viral origin-dependent re

72 ar exclusion of MYB30 results in its reduced transcriptional activation and, thus, suppressed resista

73 GPC2 expression in neuroblastoma due to MYCN transcriptional activation and/or somatic gain of the GP

74 ers is a strict prerequisite for Myc-induced transcriptional activation, and DOT1L is the only known

75 F3 in the regulation of signal transduction, transcriptional activation, and effector functions of B

76 e tested multiple strategies for dCas9-based transcriptional activation, and found that simultaneous

77 on, increased FOXO1 nuclear localization and transcriptional activation, and prevented ANG1- and ANG2

78 e of events that occur from SMAD2 binding to transcriptional activation, and the mechanisms underlyin

79 enous genes are more amenable than others to transcriptional activation, and tightly regulated genes

80 The pattern of transcriptional activation appears to support a transcri

81 ay cloning strategies, which will facilitate transcriptional activation applications in both dicots a

82 H2AZ regulates transcriptional activation as well as the maintenance of

83 A transcriptional activation assay of protoplasts revealed

84 Subsequent transcriptional activation assays and chromatin immunopr

85 f a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci.

86 with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes meg

87 egantly demonstrate that DNA methylation and transcriptional activation at the HDAC9 promoter by DNMT

88 correlated with chromatin decondensation and transcriptional activation, but its regulation by histon

89 logic BET inhibition impaired GATA1-mediated transcriptional activation, but not repression, genome-w

90 ator transcriptional coactivator complex and transcriptional activation, but the roles of individual

91 increased the ability of estrogen to enhance transcriptional activation by ER-alpha of endogenous est

92 nd transcriptional attenuation due to weaker transcriptional activation by ETS2 compared to ETS1.

93 ement has a distinct role in bursting during transcriptional activation by gamma-interferon.

94 Indispensably, STAT3 transcriptional activation by IL-6 is crucial for the ar

95 MANF consequently inhibited p65-mediated transcriptional activation by interfering with the bindi

96 culture demonstrated that MYB182 can disrupt transcriptional activation by MYB134 and that the basic

97 PRMT5 methylation of histone H3R2me1 induced transcriptional activation by recruitment of WDR5 and co

98 nding sites were identified and examined for transcriptional activation by stress-induced transcripti

99 clear receptors (TRs), is able to antagonize transcriptional activation by TGF-beta/SMAD.

100 F plays an integral role in one mechanism of transcriptional activation by the LuxR-type family of qu

101 ER-alpha is required for estrogen-stimulated transcriptional activation by the receptor.

102 ATG5 represses transcriptional activation by the TGFbeta-SMAD gene regu

103 Transcriptional activation by these ZLD orthologs sugges

104 Despite overwhelming evidence that transcriptional activation by TP53 is critical for its t

105 ic targets for a range of diseases linked to transcriptional activation, cancer, viral latency, and v

106 e that we designated as the Clock-Associated Transcriptional Activation Cassette or 'CATAC'.

107 vitro androgen receptor (AR)-dependent gene transcriptional activation cell assays and in silico nuc

108 ovel class of Notch inhibitors targeting the transcriptional activation complex may represent a new p

109 ecruitment of Mastermind-like 1 to the Notch transcriptional activation complex on chromatin, thereby

110 In the SAM, they form a transcriptional activation complex with the bZIP transcr

111 ellular Notch pathway or the assembly of the transcriptional activation complex.

112 that could disrupt the assembly of the Notch transcriptional activation complex.

113 ht to form a trimeric complex that acts as a transcriptional activation complex.

114 The system relies on recruitment of Cas9 and transcriptional activation complexes to target loci by m

115 ession of cJun, which reduces FosB-dependent transcriptional activation, counteracted LID.

116 ction of DNA-PK for Pol II pause release and transcriptional activation-coupled DDR signalling on the

117 ion, HMR possesses an acidic nine-amino-acid transcriptional activation domain (9aaTAD) and a loss-of

118 ic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants.

119 Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the

120 155, and (R)-UT-155) bind the amino-terminal transcriptional activation domain AF-1, which has not be

121 We map the transcriptional activation domain of ZLD to a central re

122 nding specificity, and is independent of the transcriptional activation domain.

123 Transcriptional activation domains (ADs) are generally t

124 atalytically inactive Cpf1 nuclease fused to transcriptional activation domains to tune the expressio

125 Evolutionary conservation of the EDC and the transcriptional activation during epidermal differentiat

126 Here, we investigated its transcriptional activation during myeloid differentiatio

127 ge segregation from WT RAM sharply decreases transcriptional activation for all permutants.

128 necessary for NR-mediated SWI/SNF-dependent transcriptional activation from endogenous promoters.

129 Its transcriptional activation function requires phosphoryla

130 s that depart from YAP's canonical oncogenic transcriptional activation functions.

131 at may depart from YAP's canonical oncogenic transcriptional activation functions.

132 The subsequent zygotic transcriptional activation further elevated overall blas

133 modulator that causes (i) heat shock factor transcriptional activation, (ii) up-regulation of heat s

134 We found RA mediated transcriptional activation in germ cells of both sexes m

135 ulated in rows of cells, Atoh1 is subject to transcriptional activation in groups of prosensory cells

136 contributes to improve our understanding of transcriptional activation in human.

137 editing, as well as small molecule-dependent transcriptional activation in mammalian cells.

138 nd generation of vector systems for enhanced transcriptional activation in plants.

139 Synthetic Notch (synNotch) receptors induce transcriptional activation in response to recognition of

140 man cultured cells; the LZA element-mediated transcriptional activation in response to zinc deficienc

141 Thus, our data support a local model of L1 transcriptional activation in somatic cells, governed by

142 cal Gata3 promoter is insufficient for Gata3 transcriptional activation in T cells in vivo, precludin

143 orter mice demonstrated reduced beta-catenin transcriptional activation in the presence of LPA1 antag

144 o establish a permissive chromatin state and transcriptional activation in the sub-ventricular and ma

145 on plays an important role in the control of transcriptional activation in vivo.

146 TREs are more enriched for several marks of transcriptional activation-including expression quantita

147 In a cell-based model of transcriptional activation, increasing or decreasing the

148 degradation is essential, while RA-triggered transcriptional activation is dispensable for APL eradic

149 In RNA-virus infected cells, IRF-3's transcriptional activation is triggered primarily by RIG

150 duced, Sty1-mediated Atf1 phosphorylation in transcriptional activation is unclear.

151 epidermis, associated with a switch from p63 transcriptional activation isoforms to DeltaNp63 isoform

152 Genes with similar transcriptional activation kinetics can display very dif

153 ns2 mRNA levels via elevations in histone H3 transcriptional activation marks.

154 that these genetic differences in GR-induced transcriptional activation may mediate the risk for depr

155 These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L an

156 inhibition, AnxA4 inhibited the FSK-induced transcriptional activation mediated by the cAMP response

157 inity of two interacting protein domains and transcriptional activation of a fluorescent reporter.

158 on increases expression of AChR mRNAs due to transcriptional activation of AChR subunit genes.

159 gg2Sp ) that conferred pheromone-independent transcriptional activation of an Rgg2-stimulated promote

160 Sexual commitment requires the transcriptional activation of ap2-g (PF3D7_1222600), the

161 CDK11 increased transcriptional activation of AR gene in osteosarcoma ce

162 1 and Hey1, and a reciprocal increase in the transcriptional activation of ATF4 and NFATc1 genes.

163 s autophagy through the pRb/E2F1 pathway and transcriptional activation of autophagy-related genes an

164 cate that Egr-1 promotes Abeta synthesis via transcriptional activation of BACE-1 and suggest that Eg

165 tary genomic alterations associated with the transcriptional activation of beta-catenin and NRF2, MEK

166 SHP inhibited transcriptional activation of Bhmt and cystathionine gam

167 We find that KDM3A promotes anoikis through transcriptional activation of BNIP3 and BNIP3L, which en

168 MITF overexpression resulted in direct transcriptional activation of BPTF, as evidenced by incr

169 nal domain of CS-GRP78 with a mAb suppresses transcriptional activation of c-MYC target genes and imp

170 evoked key signaling events are required for transcriptional activation of c-MYC target genes.

171 nce, however, suggests that Yap5-independent transcriptional activation of CCC1 also contributes to i

172 induced accumulation of NOTCH and consequent transcriptional activation of Ccl2.

173 evidence of a novel pathway controlling the transcriptional activation of CD40L in bone marrow-deriv

174 This study has shown that by direct transcriptional activation of CerS6, p53 can regulate sp

175 ng in pancreatic cancer and demonstrate that transcriptional activation of clearance pathways converg

176 the expression of FOXO3, which inhibited the transcriptional activation of CTNNB1.

177 which both A- and B-sites were required for transcriptional activation of czcD expression, with the

178 Overall, we uncover a regulatory mode of the transcriptional activation of defence responses previous

179 genes involved in neuronal transmission and transcriptional activation of developmental genes, has p

180 into the epigenetic mechanisms that control transcriptional activation of early- and late-response g

181 User-friendly tools for robust transcriptional activation of endogenous genes are highl

182 onal activator VP16 (VP64) could be used for transcriptional activation of endogenous genes in plants

183 e a toxic cellular antiviral program through transcriptional activation of endogenous retroviral sequ

184 of ESR1 and ESR2, consistent with sustained transcriptional activation of ERalpha and ERbeta.

185 nts of polycomb repressive complex 2 (PRC2), transcriptional activation of ERG target genes, and incr

186 mt1 induces widespread DNA demethylation and transcriptional activation of ERVs, including CpG-rich I

187 Akt inhibition selectively blocks the transcriptional activation of Ets-1, which inhibits its

188 ncreased UPC2 levels and as a consequence to transcriptional activation of FHN1, NPR1, PRR2 and stero

189 Transcriptional activation of genes downstream of Rv2745

190 35S::SbMyb60 was associated with the transcriptional activation of genes involved in aromatic

191 t accumulation of HIF1alpha protein via both transcriptional activation of HIF1alpha mRNA and the pho

192 Recently, it was shown that the transcriptional activation of Hoxd genes during vertebra

193 l genes and the silent mating type loci, and transcriptional activation of hundreds of mRNA-encoding

194 s of transcription (STAT) signalling through transcriptional activation of IL7R.

195 rtions absent from the reference genome, the transcriptional activation of individual genomic L1HS-Ta

196 ll of the AIRE mutations resulted in loss of transcriptional activation of INS-VNTR except mutant P25

197 h dFOXO in vitro and in vivo to regulate the transcriptional activation of insulin receptor (InR) and

198 nism linking functional activity of VGSCs to transcriptional activation of invasion-related genes.

199 nt of and distinct from the known pathway of transcriptional activation of IRF-3.

200 lls with active Wnt signaling, ZEB1 enhances transcriptional activation of LAMC2 and uPA by TCF4/beta

201 MP is solely responsible for auxin-directed transcriptional activation of LFY.

202 is basal level of H2O2 acts as messenger for transcriptional activation of lignin biosynthesis in vas

203 Fatty liver development was associated with transcriptional activation of lipogenesis, FXR-RXR, PPAR

204 We found that transcriptional activation of miR-21 is a common feature

205 ultiprotein complex has an important role in transcriptional activation of mitotic genes.

206 rate that SET1A/COMPASS is required for full transcriptional activation of multiple Hox genes but fun

207 uplex interactive agent that interfered with transcriptional activation of mutated RET gene in human

208 methylation at the Nedd4-1 promoter and the transcriptional activation of Nedd4.

209 he inactivation of Nrf2 and thereby relieved transcriptional activation of OCT4 and NANOG.

210 NK4AB/ARF locus and contributes to the rapid transcriptional activation of p15(INK4B) and p16(INK4A)

211 promoter region of miR-128, and enhanced the transcriptional activation of p53 on miR-128 expression.

212 t in wild-type Arabidopsis plants as well as transcriptional activation of P5CS1 and PRO DEHYDROGENAS

213 rnative proteasome complexes did not involve transcriptional activation of PA28gamma and PA200 but ra

214 cascade, resulting in the stabilization and transcriptional activation of phosphorylated Sox2.

215 Stamen development thus appears to involve transcriptional activation of physically clustered genes

216 ilase family [SBT5.2(b)] that attenuates the transcriptional activation of plant defence independentl

217 lpha axis in which GR directly regulates the transcriptional activation of PPARalpha by binding to it

218 retinoic acid response elements and leads to transcriptional activation of RA target genes.

219 that AKT and PKR pathways contributed to the transcriptional activation of RNF213.

220 ined that TGFbeta induces pRb/E2F1-dependent transcriptional activation of several autophagy-related

221 YAP1 and TAZ directly mediated transcriptional activation of several genes in the JAK-S

222 inting to specifically follow pausing during transcriptional activation of several genes involved in

223 e demonstrate that GLIS3 is critical for the transcriptional activation of several genes required for

224 Point mutation (G239C) of Rrp2 abolishes the transcriptional activation of sigma(54) -dependent rpoS.

225 dCas9-TV confers far stronger transcriptional activation of single or multiple target

226 1, H3K9me2 and sustains H3K4me3 to prime the transcriptional activation of SNAI1 by TGF-beta signalin

227 DOT1L as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblas

228 ne 27 at its target sites, leading to robust transcriptional activation of target genes from promoter

229 s ERalpha phosphorylation, tamoxifen-induced transcriptional activation of TGFbeta, and upregulation

230 tion of alternative PA200 complexes involved transcriptional activation of the activator.

231 Additionally, an interesting transcriptional activation of the chemotaxis genes was e

232 escence in situ hybridization confirmed that transcriptional activation of the clustered genes was co

233 stones and an open chromatin domain, optimal transcriptional activation of the EKLF locus can be esta

234 asing the levels of Tnc, via CRISPR-mediated transcriptional activation of the endogenous gene, enhan

235 rine Wnt/beta-catenin signalling induces the transcriptional activation of the endogenous Myc family

236 tumor suppressors, activation that requires transcriptional activation of the expanded gene by the E

237 Here, we show that during transcriptional activation of the fission yeast fbp1 gen

238 Low-K(+)-induced transcriptional activation of the gene encoding HAK5 has

239 aling causes FoxO3 nuclear translocation and transcriptional activation of the gene encoding the plur

240 how that increasing cellular Nrf2 results in transcriptional activation of the gene for mTOR, which i

241 Transcriptional activation of the human telomerase rever

242 seen in patient biopsies and is dependent on transcriptional activation of the IFN response through t

243 ediated senescence rescue was accompanied by transcriptional activation of the melanocyte-lineage sur

244 lled using two strategies: by modulating the transcriptional activation of the microcompartment conta

245 of the MyoD transcription factor and enables transcriptional activation of the Myog promoter to initi

246 ting that both IHF and LuxR are required for transcriptional activation of the osmotic stress respons

247 homeostasis through PHR1- and PHL1-mediated transcriptional activation of the P5CS1 gene.

248 e pathological form of hypertrophy devoid of transcriptional activation of the physiological cardiac

249 triggering of nuclear Ca(2+) spiking and the transcriptional activation of the ProCgNIN:GFP reporter

250 phosphorylation at Tyr416 and with a strong transcriptional activation of the prolactin family 2 sub

251 he conserved control mechanisms are based on transcriptional activation of the respective plant speci

252 propensities of these elements and measured transcriptional activation of the resulting variants.

253 g, partly through promoter demethylation and transcriptional activation of the Wnt inhibitor secreted

254 is result in USP6 overexpression, leading to transcriptional activation of the Wnt/beta-catenin pathw

255 tig) is required for this transition and for transcriptional activation of the zygotic genome.

256 ased on the quantification of the collective transcriptional activation of their targets, to a large

257 s in the mammalian germline leads to risk of transcriptional activation of transposable elements (TEs

258 a defect in its previously described role in transcriptional activation of Wnt signalling.

259 Context-dependent mechanisms are crucial for transcriptional activation of Wnt/beta-catenin target ge

260 tes the association of YAP and TEAD, induces transcriptional activation of YAP target genes and promo

261 Here, we show that Hd3a and RFT1 can form transcriptional activation or repression complexes also

262 essing mutational impacts on DNA binding and transcriptional activation or repression.

263 scription but instead compromised subsequent transcriptional activation or transcriptional memory.

264 y and can lead to transcriptional silencing, transcriptional activation, or modulation of alternative

265 constitutively active, suggesting that this transcriptional activation pathway represents a linchpin

266 However, an efficient dCas9-based transcriptional activation platform is still lacking for

267 ese LIM complexes via NLI, and enhance their transcriptional activation potential.

268 ARNT knockdown dramatically impaired the transcriptional activation properties of the ligand-acti

269 more, this dynamic mode results from lack of transcriptional activation rather than decreased accessi

270 However, the mechanism of Rap1 transcriptional activation remains poorly understood bec

271 candidate, termed EMICERI, revealed that its transcriptional activation resulted in dosage-dependent

272 MYC-binding sites, validating an additional transcriptional activation role of MYC in cancer metabol

273 ibe a protocol for genome-scale knockout and transcriptional activation screening using the CRISPR-Ca

274 g beta-catenin nuclear dynamics to cyclin D1 transcriptional activation showed that the nuclear accum

275 Many genes exhibited strong levels of transcriptional activation, sometimes only transiently a

276 that heme induces transcription of HAP4, the transcriptional activation subunit of the Hap2/3/4/5p co

277 1 mutant effectively blocked Smads-dependent transcriptional activation, suggesting that P-Rex1 is a

278 Simultaneous editing or transcriptional activation/suppression of different gene

279 Recently, three potent dCas9-based transcriptional activation systems, namely VPR, SAM and

280 e transcriptional activation activity by the transcriptional activation test in Saccharomyces cerevis

281 (designated CRISPR-Act2.0) yielded stronger transcriptional activation than the dCas9-VP64 system.

282 been shown to be a mechanism for regulating transcriptional activation, the extent to which it is in

283 n cell-cell adhesion, whereas SYS-1 mediates transcriptional activation through interactions with POP

284 e results uncover a novel mechanism for E2F1 transcriptional activation through removal of its Lys-63

285 Instead, GABP provided transcriptional activation through the Lbr promoter in t

286 via reversible histone methylation regulates transcriptional activation throughout the malaria parasi

287 te for lineage-specific differences in egl-1 transcriptional activation, thus ensuring that EGL-1 act

288 From their transcriptional activation to their regulatory capabilit

289 de RNA (sgRNA) targeting rules for effective transcriptional activation, to demonstrate multiplexed a

290 l tri-functional CRISPR system that combines transcriptional activation, transcriptional interference

291 data suggest that a common mechanism-direct transcriptional activation-underlies the dual biological

292 The transcriptional activation was associated with structura

293 These transcriptional activations were independently validated

294 genes, which would be consistent with robust transcriptional activation, were not observed.

295 iate sites promoted Mediator interaction and transcriptional activation, whereas modification of slow

296 2 i-motif DNA, as well as being critical for transcriptional activation, whereas RRM3-4 bound only we

297 rograde complex regulates ligand-mediated AR transcriptional activation, which correlated with the mo

298 abled a screen combining gene knockouts with transcriptional activation, which revealed genetic inter

299 nal BRD4 and interacting partners to support transcriptional activation, which underlies the BRD4-NUT

300 the expression of ILK through E2F1-mediated transcriptional activation, which, in turn, controlled K