ライフサイエンスコーパス: transcriptional activation domain

1 at the C-terminus, encompassing the putative transcriptional activation domain.

2 of exon 8 and removes a majority of the Pax3 transcriptional activation domain.

3 to a previously mapped serine/threonine-rich transcriptional activation domain.

4 ect that is dependent on a C-terminal Notch1 transcriptional activation domain.

5 n bearing the DNA binding domain but not the transcriptional activation domain.

6 as the myogenin helix functions as a general transcriptional activation domain.

7 ting domain and, surprisingly, also a potent transcriptional activation domain.

8 her part of or all of the HD, but retain the transcriptional activation domain.

9 The DNA binding domain is linked to a VP16 transcriptional activation domain.

10 ino-terminal domain of CncB acts as a strong transcriptional activation domain.

11 that is likely to transmit the signal to the transcriptional activation domain.

12 nuclear matrix-targeting signal and the tau2 transcriptional activation domain.

13 s of LXR alpha or LXR beta that lack the AF2 transcriptional activation domain.

14 e N-terminal region of Myc which harbors its transcriptional activation domain.

15 vergence was most striking in the C-terminal transcriptional activation domain.

16 sor protein to mediate inhibition of the WT1 transcriptional activation domain.

17 e compensated by a microsatellite-associated transcriptional activation domain.

18 ciated and transforming mutations within its transcriptional activation domain.

19 NA-binding domain and the COOH-terminal FKHR transcriptional activation domain.

20 egion linking the DNA-binding domain and the transcriptional activation domain.

21 is proposed to serve an essential role as a transcriptional activation domain.

22 he LIM domain of Lhx2 was shown to contain a transcriptional activation domain.

23 city, while the N terminus contains a potent transcriptional activation domain.

24 3, and that this effect does not require its transcriptional activation domain.

25 ved in the ETS DNA-binding domain and acidic transcriptional activation domain.

26 ted to the -137 to -130 bp region within the transcriptional activation domain.

27 khead (FKHR) sequences that contain a potent transcriptional activation domain.

28 3 lie an apoptotic domain as well as another transcriptional activation domain.

29 erminal part of BFCOL1 contained a potential transcriptional activation domain.

30 d by binding to SRF and in particular to its transcriptional activation domain.

31 p is a Ume6p-binding protein that provides a transcriptional activation domain.

32 l 125 amino acids function as an independent transcriptional activation domain.

33 gesting that it acts as a cell-type-specific transcriptional activation domain.

34 tion of ARS 121 may occur independently of a transcriptional activation domain.

35 wild-type Sox2 but not a mutant lacking the transcriptional activation domain.

36 p53 function by binding and masking the p53 transcriptional activation domain.

37 y domain (residues 41-110), and a C-terminal transcriptional activation domain.

38 nal region (residues 448 to 644) is a potent transcriptional activation domain.

39 Additionally, we show that DPC4 contains a transcriptional activation domain.

40 lian cells, indicating that GRIP1 contains a transcriptional activation domain.

41 k4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain.

42 ect evidence that SIM in KLF4 functions as a transcriptional activation domain.

43 , NOC functions as a deadenylase but lacks a transcriptional activation domain.

44 nding specificity, and is independent of the transcriptional activation domain.

45 ues 1-30) and conserved region 3 (CR3) - the transcriptional activation domain.

46 ediated phosphorylation at a site within the transcriptional activation domain.

47 r to ZXDC, containing ten zinc fingers and a transcriptional activation domain.

48 tral test protein, and a constant C-terminal transcriptional activation domain.

49 fers from other MAPKs in possessing a potent transcriptional activation domain.

50 ase CREB binding protein (CBP) to the FoxM1B transcriptional activation domain.

51 her mutations are at the amino-terminus in a transcriptional activation domain.

52 and by RP5, a viral strain lacking the VP16 transcriptional activation domain.

53 gned to identify proteins that interact with transcriptional activation domains.

54 ment, we identified the Nmp4 DNA-binding and transcriptional activation domains.

55 A, but it is unaffected for interacting with transcriptional activation domains.

56 ch in Glu and Pro, a known characteristic of transcriptional activation domains.

57 ion proteins, these LC sequences function as transcriptional activation domains.

58 st harbors both amino- and carboxyl-terminal transcriptional activation domains.

59 with Gal4 fusion proteins containing various transcriptional activation domains.

60 A168 to G222 were identified as independent transcriptional activation domains.

61 ontains the human heat shock factor 1 (HSF1) transcriptional activation domains.

62 ependent transcription factor containing two transcriptional activation domains.

63 no detailed structures are yet available for transcriptional activation domains.

64 conserved DNA-binding domains and divergent transcriptional activation domains.

65 f HSF1 (CT) contains both the regulatory and transcriptional activation domains.

66 DP-dimerization, retinoblastoma-binding, and transcriptional activation domains.

67 nt of constituent side chains to function as transcriptional activation domains.

68 re often modular, with two or more separable transcriptional activation domains.

69 phorylated by p38 lie outside of the minimal transcriptional activation domains.

70 ns encoding the winged helix DNA binding and transcriptional activation domains.

71 ion, HMR possesses an acidic nine-amino-acid transcriptional activation domain (9aaTAD) and a loss-of

72 ontains four domains including an N-terminal transcriptional activation domain, a C-terminal regulato

73 n that it contains a cytoplasmic DNA-binding-transcriptional activation domain, a transmembrane domai

74 Acidic or type IIB transcriptional activation domains (AADs) increase rates

75 he PAX3/PAX7 DNA binding domain and the FKHR transcriptional activation domain, activate transcriptio

76 exA DNA-binding domain and FKBP12 fused to a transcriptional activation domain activated reporter gen

77 nt fusion protein, containing a heterologous transcriptional activation domain activates Sex-lethal e

78 f galactose, Gal80 binds to and inhibits the transcriptional activation domain (AD) of the GAL gene a

79 by the Gal80 protein through masking of its transcriptional activation domain (AD).

80 the lexA DNA binding domain (LEXA-MSP) and a transcriptional activation domain (AD-MSP) interact to d

81 Transcriptional activation domains (ADs) are generally t

82 155, and (R)-UT-155) bind the amino-terminal transcriptional activation domain AF-1, which has not be

83 To investigate a potential ligand-dependent transcriptional activation domain (AF-2) in the C-termin

84 ontaining a mutation in the carboxy-terminal transcriptional activation domain, AF-2, retained elevat

85 the functional significance of the two major transcriptional activation domains, AF1 and AF2.

86 binding domain changes and mutations in the transcriptional activation domain, affected different se

87 AL4-NK-4 fusion constructs, we have mapped a transcriptional activation domain (amino acids 1-110) an

88 minus of the protein encodes two independent transcriptional Activation Domains (amino acids 1-74 and

89 functional domains, including a DNA-binding/transcriptional activation domain and a large extracellu

90 cidate its function have revealed a putative transcriptional activation domain and in vitro interacti

91 SREBP-1a has a longer transcriptional activation domain and is a more potent t

92 t, MyoD stimulates the function of the MEF2C transcriptional activation domain and the activity of en

93 Fusion of these zinc finger proteins to a transcriptional activation domain and to modified ligand

94 The N-terminal region of Hic-5 possesses a transcriptional activation domain and was essential for

95 and fusion protein constructs that alter the transcriptional activation domains and the activities of

96 show that TGMV AL2, AL2(1-100) (lacking the transcriptional activation domain), and BCTV L2 can all

97 to amino acids 2829 to 2883 of MLL, a potent transcriptional activation domain, and amino acids 581 t

98 ter assays, identifying it as a proline-rich transcriptional activation domain, and indicating that t

99 TAp73 is a p73 isoform with a potent transcriptional activation domain, and loss of TAp73 pre

100 We show that an N-terminal transcriptional activation domain, and the bHLH region,

101 activity, but mutants of PU.1 that lack the transcriptional activation domain are nearly as efficien

102 Small molecule replacements of transcriptional activation domains are highly desirable

103 interaction, light-induced degradation, and transcriptional activation domains are located at the N-

104 t that individual functional elements in the transcriptional activation domains are responsible for a

105 interact with a region of p65 containing the transcriptional activation domain as demonstrated by mam

106 n analysis, it is shown that LKLF contains a transcriptional activation domain as well as a strong au

107 roline that was able to function as a potent transcriptional activation domain, as does the C terminu

108 of N-terminal truncations reveals a critical transcriptional activation domain at aa 31 to 185 and a

109 ing protein (CBP), resides in the C-terminal transcriptional activation domain at lysine 685.

110 It acts as an autonomous transcriptional activation domain at promoters containin

111 oncogene whose expression product contains a transcriptional activation domain at the C terminus.

112 at was sufficient to confer suppression of a transcriptional activation domain both in vivo and in vi

113 tein variant, MYC-S, which lacks part of the transcriptional activation domain but includes the conse

114 1 and USF2 proteins contain highly divergent transcriptional activation domains but share extensive h

115 Tax contains a transcriptional activation domain, but its ability to ac

116 onstruct (amino acid 691-750) containing the transcriptional activation domain, but not the DNA bindi

117 and the ability of TFIIB to interact with a transcriptional activation domain, but not with componen

118 Many AP-1 proteins contain defined transcriptional activation domains, but BATF and the clo

119 HIFalpha contains two transcriptional activation domains called the N-terminal

120 cated mutant of ORF50 lacking its C-terminal transcriptional activation domain, called ORF50DeltaSTAD

121 We show that the VP16 transcriptional activation domain can replace the C term

122 t a modified form of Pdx1, carrying the VP16 transcriptional activation domain, can cause conversion

123 region and a moderately conserved N-terminal transcriptional activation domain characterize the putat

124 inal 92 amino acids of LZIP contain a potent transcriptional activation domain composed of three elem

125 that CtBP1 also interacts directly with the transcriptional activation domain (conserved region 3 [C

126 IRS-4 interacts with both the transcriptional activation domain (conserved region 3) a

127 functions through the action of a conserved transcriptional activation domain, CR3.

128 lent linkage of LEF-1 to beta-catenin and to transcriptional activation domains derived from the estr

129 nuclear localization and that removal of the transcriptional activation domain did not eliminate Fish

130 regulates and small Maf proteins lacking the transcriptional activation domain down regulates ARE-med

131 58, which has been identified to be a second transcriptional activation domain, E2AD2.

132 The AZP fused to a transcriptional activation domain efficiently activated

133 enome regulation in human cells by tethering transcriptional activation domains either directly to a

134 Thus, through its kinase and transcriptional activation domains, ERK5 regulates trans

135 l, linker domain, Src homology 2 domain, and transcriptional activation domain failed to interact wit

136 ncated Fli-1 protein, lacking the C-terminal transcriptional activation domain (Fli-1(DeltaCTA)).

137 minal acidic activation domain in YAP is the transcriptional activation domain for TEAD transcription

138 egradation of HIF-1alpha and that has a VP16 transcriptional activation domain from herpes simplex vi

139 ing the DNase I-hypersensitive site required transcriptional activation domains from TFE3 and PU.1, r

140 ion of HSF1 at serine residues distal to the transcriptional activation domain functions to repress t

141 hanced the activity of p53 or its N-terminal transcriptional activation domain fused to the DNA bindi

142 EWS/FLI, consists of an EWSR1-derived strong transcriptional activation domain fused, in-frame, to th

143 gene regulation, we also found that while a transcriptional activation domain fusion, CebpFlagWdr68,

144 rged as the human cDNA that, when fused to a transcriptional activation domain, gave the strongest 3D

145 and Runt derivatives containing heterologous transcriptional activation domains (HairyAct and RunAct)

146 d form of HSF in which the carboxyl-terminal transcriptional activation domain has been deleted [HSF(

147 A similar transcriptional activation domain has been identified in

148 PRC also contains a potent transcriptional activation domain in its amino terminus

149 ns and an acidic carboxyl terminus that is a transcriptional activation domain in maize and yeast cel

150 nalysis we show that HAND2 contains a strong transcriptional activation domain in the amino-terminal

151 , which was preceded by the acquisition of a transcriptional activation domain in the ancestral A-Myb

152 the Gal4 DNA binding domain has identified a transcriptional activation domain in the C terminus of E

153 4-Nkx2.2 fusion constructs to map a powerful transcriptional activation domain in the C-terminal regi

154 deletion mutants also provide evidence for a transcriptional activation domain in the N-terminal 19 a

155 l region for this function to a proline-rich transcriptional activation domain in the NH2-terminal 80

156 the role of c-Maf (large Maf) containing the transcriptional activation domain in the regulation of A

157 nkyrin repeat domain of Notch, and contain a transcriptional activation domain in their C termini.

158 screened a Jurkat cDNA library fused to the transcriptional activation domain in yeast expressing th

159 ion with beta-catenin, and we delineated two transcriptional activation domains in beta-catenin whose

160 the Gal4 DNA-binding protein identified two transcriptional activation domains in C/EBPepsilon.

161 er (FRET) assay to monitor interactions with transcriptional activation domains in living cells.

162 We have identified potent classical transcriptional activation domains in the C termini of s

163 r receptor-binding properties and mapped the transcriptional activation domains in the two SRC1 isofo

164 All three OBP proteins contain transcriptional activation domains in their C-terminal r

165 either USF2 or GAL4 identified two distinct transcriptional activation domains in USF2, the USR and

166 expression, conservation of DNA binding, and transcriptional activation domains indicate that they ma

167 Phosphorylation of the C-terminal transcriptional activation domain induces a conformation

168 R deletion derivative lacking the N-terminal transcriptional activation domain, induction of CDI expr

169 Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances

170 Additionally, we find that the WT1 transcriptional activation domain interacts with the gen

171 The putative transcriptional activation domain is located in the C-te

172 The receptor's N-terminal transcriptional activation domain is not required for gr

173 The activity of the HSF1 transcriptional activation domains is modulated by a sep

174 ing that heat-induced phosphorylation of the transcriptional activation domains is not required for i

175 This isoform, which lacks a transcriptional activation domain, is generated by a pro

176 Aside from an N-terminal acidic transcriptional activation domain, little is known about

177 t transcription factor GAL4 revealed a major transcriptional activation domain located between aa 274

178 it duplication by dHAND requires neither the transcriptional activation domain nor the basic region,

179 g's sarcoma tumors, contains an NH2-terminal transcriptional activation domain (NTD) which resembles

180 lts are consistent with a model in which the transcriptional activation domain of activated Stat5 is

181 ate that the glutamine-rich subdomain of the transcriptional activation domain of AHR can interact wi

182 s insufficient and TGS reversal required the transcriptional activation domain of AL2.

183 In a broader sense, the transcriptional activation domain of avrXa10 may represe

184 ctivity; that the activity of the N-terminal transcriptional activation domain of Brn-3a is increased

185 Deletion of transcriptional activation domain of c-Maf (c-Maf) led t

186 To assess the role of the transcriptional activation domain of c-Rel in vivo, we g

187 ck a conserved sequence motif present in the transcriptional activation domain of class A-HSFs.

188 Elimination of the first transcriptional activation domain of E2A abolished both

189 ion involving a region within the N-terminal transcriptional activation domain of E2A-PBX1, termed th

190 ated reporter expression was mediated by the transcriptional activation domain of Elk-1.

191 The transcriptional activation domain of ERK5 is required fo

192 isolated as suppressors of a mutation in the transcriptional activation domain of GAL4.

193 Heterologous fusion proteins linking the transcriptional activation domain of herpes simplex viru

194 The amino-terminal transcriptional activation domain of HNF3beta is essenti

195 howed that amino acids 1 to 43 of the acidic transcriptional activation domain of IE62 can bind recom

196 s from MEF2, and augments the potency of the transcriptional activation domain of MEF2 fused to a het

197 s are clustered within or close to the major transcriptional activation domain of MEF2A.

198 The complexation of KIX with the transcriptional activation domain of mixed-lineage leuke

199 gnals its destruction; this degron spans the transcriptional activation domain of Myc, and includes t

200 dimerization and DNA binding domains but not transcriptional activation domain of Nrf3.

201 ltured cells, the p90MDM2 protein blocks the transcriptional activation domain of p53 and also stimul

202 p90(MDM2) inhibits p53 by blocking the transcriptional activation domain of p53 as well as by s

203 that acts as a coregulator of the N-terminal transcriptional activation domain of progesterone recept

204 We further demonstrate that tethering the transcriptional activation domain of Rap1p to DNA is suf

205 The transcriptional activation domain of RelA(p65) interacte

206 The transcriptional activation domain of RelB, but not RelA,

207 ch disrupt the DNA binding domain or the AF2 transcriptional activation domain of SF-1 do not confer

208 between BRCA1 aa 502-802 and the C-terminal transcriptional activation domain of STAT1 including Ser

209 activity interacted with the C-terminal SH2 transcriptional activation domain of Stat1.

210 like activator by fusion with the C-terminal transcriptional activation domain of STAT2 or the acidic

211 to a cellular replication origin, the acidic transcriptional activation domain of the breast cancer p

212 The transcriptional activation domain of the herpesvirus pro

213 carcinoma translocated-1) and the C-terminal transcriptional activation domain of the Notch coactivat

214 enzoyl-L-phenylalanine (pBpa) throughout the transcriptional activation domain of the prototypical eu

215 This protein interacted mainly with the transcriptional activation domain of the SRF protein and

216 acetylated survivin binds to the N-terminal transcriptional activation domain of the STAT3 dimer and

217 he tetracycline repressor of E. coli and the transcriptional activation domain of the VP16 protein of

218 iochemical assays have shown that the potent transcriptional activation domain of VP16 can associate

219 P16 residues lying near the carboxy-terminal transcriptional activation domain of VP16 in associating

220 full length Hex to two copies of the minimal transcriptional activation domain of VP16 together with

221 The transcriptional activation domain of WT1 is subject to r

222 In this study we localized the transcriptional activation domain of Xlim-1 to its carbo

223 of PML bodies by Z requires a portion of the transcriptional activation domain of Z but not the DNA-b

224 We map the transcriptional activation domain of ZLD to a central re

225 omains both interacted specifically with the transcriptional activation domain of Zta in an electroph

226 ted the previously described DNA binding and transcriptional activation domains of both Pit-1 and TR

227 ER-alpha36; the predicted protein lacks both transcriptional activation domains of hER-alpha66 but re

228 ate have been shown to affect DNA binding or transcriptional activation domains of MITF and act as do

229 id residues that exhibited homology with the transcriptional activation domains of several translocat

230 tion primarily by masking and inhibiting the transcriptional activation domains of the recruiting pro

231 (TGF-beta) activation and is mediated by the transcriptional activation domains of the Smad proteins.

232 ntains a limited region of homology with the transcriptional activation domains of three other genes

233 We have identified the transcriptional activation domains of Upc2p and Ecm22p a

234 Mutants in the transcriptional activation domain or DNA-binding domain

235 ric polypeptide composed of XSOX3 and a VP16 transcriptional activation domain or morpholino-induced

236 orm of MEF2C containing the Herpesvirus VP16 transcriptional activation domain partially bypasses the

237 atment caused a shift in the position of the transcriptional activation domain relative to the DNA bi

238 terminal phosphorylation sites or C-terminal transcriptional activation domain, restores positive sel

239 sion of a truncated form of CBF2 lacking its transcriptional activation domain resulted in a cold-sti

240 ession of a gene with Mcm1 fused to a strong transcriptional activation domain resulted in increased

241 Transcriptional activation domains share little sequence

242 ever, chromatin remodeling that depends on a transcriptional activation domain shows a considerable,

243 One class of transcriptional activation domains stimulates the concer

244 ve truncation or loss of the C-terminal BRCT transcriptional activation domain, suggesting that trans

245 y protein (IEP) lacking the essential acidic transcriptional activation domain (TAD) and serine-rich

246 ic cancer development in mice expressing p53 transcriptional activation domain (TAD) mutants.

247 Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the

248 the KIX domain of CBP/p300, and second, the transcriptional activation domain (TAD) of RelA binds to

249 ient mice, mice lacking the conserved Notch1 transcriptional activation domain (TAD) show attenuated

250 the following highly conserved regions: the transcriptional activation domain (TAD), MDM2 binding si

251 The COOH terminus of the STATs acts as a transcriptional activation domain (TAD).

252 ption and that this region contains a strong transcriptional activation domain (TAD).

253 r, IE62, contains a potent N-terminal acidic transcriptional activation domain (TAD).

254 The ability of transcriptional activation domains (TADs) to signal ubiq

255 oteins, including two experimentally defined transcriptional activation domains (TADs), fused to the

256 (amino acids 190-257), and assembly of their transcriptional activation domains (TADs).

257 Each of these factors contain a transcriptional activation domain that is activated by p

258 CBP was found to contain a signal-regulated transcriptional activation domain that is controlled by

259 yc that oppositely regulate its stability: a transcriptional activation domain that promotes Myc dest

260 FHY3 and FAR1 have separable DNA binding and transcriptional activation domains that are highly conse

261 Among the transcriptional activation domains that can stimulate vi

262 sent a novel class of cofactors recruited by transcriptional activation domains that function in dive

263 These data indicate that, in addition to the transcriptional activation domain, the p53 proline-rich

264 man and bovine PROP1 proteins contain potent transcriptional activation domains, the amino termini an

265 ncodes a large protein with a defined acidic transcriptional activation domain; this protein does not

266 on factor by recruiting multiple copies of a transcriptional activation domain to a nuclease-deficien

267 tiple gRNAs can direct dCas9 fused to a VP64 transcriptional activation domain to increase expression

268 othesize that this region merely tethers the transcriptional activation domain to the cytoplasmic mem

269 ins to characterize the ability of different transcriptional activation domains to stimulate transcri

270 atalytically inactive Cpf1 nuclease fused to transcriptional activation domains to tune the expressio

271 zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the n

272 cDNA, or truncated mPax6Delta286 lacking the transcriptional activation domain was inserted into a te

273 ; aa, 1-683) that lacks tyrosine 699 and the transcriptional activation domain was introduced into Ba

274 ative Pitx2 isoforms in which the C-terminal transcriptional activation domain was replaced by the re

275 activity because of mutations in the acidic transcriptional activation domain was restored by additi

276 To identify independently functional transcriptional activation domains, we developed a heter

277 in tandem with specific features of the HSF1 transcriptional activation domains, we first used deleti

278 ed to different oligomerization motifs and a transcriptional activation domain were analyzed for olig

279 Candidate proteins fused to a transcriptional activation domain were tested for the ab

280 EBPepsilon isoforms, p32 and p30, possessing transcriptional activation domains were coexpressed in m

281 The transcriptional activation domains were separated by ami

282 ntrast, the position and interactions of the transcriptional activation domains were similar througho

283 s of USF-1 and -2 lacking the DNA binding or transcriptional activation domains were unable to stimul

284 These ZFPs, when fused to either VP16 or p65 transcriptional activation domains, were able to activat

285 observed that FoxA2 induces Arx through its transcriptional activation domain whereas Nkx2.2, induce

286 CHOP is found to contain a transcriptional activation domain which is inducible by

287 It provides a transcriptional activation domain which, unlike Oct-1, a

288 epresent a prokaryotic version of the acidic transcriptional activation domain, which heretofore has

289 identified at the amino-terminus of BRCA2 a transcriptional activation domain whose importance is hi

290 ependent association and disassociation of a transcriptional activation domain with a promoter.

291 f Ets domain proteins, contains a C-terminal transcriptional activation domain with multiple copies o

292 acterization of two evolutionarily conserved transcriptional Activation Domains within the GATA-4/5/6

293 We found that EAF2 and EAF1 both contain transcriptional activation domains within this region.