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1 on was induced using a novel dead Cas9-VP160 transcriptional activator.
2 vide evidence that it may also function as a transcriptional activator.
3 s and acted evidently as a high hierarchical transcriptional activator.
4 n 3 (STAT3), a previously unidentified EDNRB transcriptional activator.
5 rs, ARF34 (AUXIN RESPONSE FACTOR 34) acts as transcriptional activator.
6 asm and the nucleus, where it functions as a transcriptional activator.
7 pment and differentiation, is a DPE-specific transcriptional activator.
8 neural patterning activities by acting as a transcriptional activator.
9 says suggested that PtrMYB152 functions as a transcriptional activator.
10 of TAFs in directing genomic occupancy of a transcriptional activator.
11 ional repressor of mitogenic pathways into a transcriptional activator.
12 that FUS3 acts primarily or exclusively as a transcriptional activator.
13 ain containing a basic leucine zipper (bZIP) transcriptional activator.
14 Saccharomyces cerevisiae using a dCas9-based transcriptional activator.
15 machinery and we demonstrate Psi is a potent transcriptional activator.
16 One of these genes, mga2, is a putative transcriptional activator.
17 ous genes using engineered CRISPR/Cas9-based transcriptional activators.
18 udies of a subgroup of ARFs that function as transcriptional activators.
19 distal enhancers by specific complements of transcriptional activators.
20 0) and TCP22 proteins act as LWD-interacting transcriptional activators.
21 interconnected cascades of signal-responsive transcriptional activators.
22 d mCdx4) are also preferential core promoter transcriptional activators.
23 d levels, balancing the inductive effects of transcriptional activators.
24 INPs by repressing genes encoding neuroblast transcriptional activators.
25 Shh and that Eya1/Six1 together regulate Gli transcriptional activators.
26 ation domain contained within the CRY2-fused transcriptional activators.
27 silent even in the presence of trans-acting transcriptional activators.
28 d NRF-1 transcription factors and TALE-based transcriptional activators.
29 e and does not belong to any known family of transcriptional activators.
30 , and yet, they synergized with conventional transcriptional activators.
31 RNA), which abrogates the function of CRISPR-transcriptional activators.
32 discovery of new cellular binding targets of transcriptional activators.
33 ide morphological cues that regulate certain transcriptional activators.
34 A (PrfA), a member of the Crp/Fnr family of transcriptional activators.
37 ression and cytokine promoter binding of the transcriptional activators activating transcription fact
39 virus) encode an AL2 protein that is both a transcriptional activator and a silencing suppressor.
40 responses, including induction of the fixK2 transcriptional activator and genes that are part of the
41 s fused to either a fluorescent protein or a transcriptional activator and is destabilized by mutatio
43 ys on B cells indicated that FOXP1 acts as a transcriptional activator and repressor of genes involve
44 bium japonicum Irr is a conditionally stable transcriptional activator and repressor that accumulates
46 al activity of GLI1, a Hedgehog (Hh) pathway transcriptional activator and self-renewal agonist, and
48 lecular analyses showed that GRHL2 acts as a transcriptional activator and strongly associates with h
49 s suggests that Prdm1a is required both as a transcriptional activator and transcriptional repressor
50 uited to gene promoters by sequence-specific transcriptional activators and by chromatin modification
52 subsets of the immune system, by controlling transcriptional activators and downstream cytokines, to
53 pectively regulate Zeb1, a repressor of Gnrh transcriptional activators and Gnrh itself, and Cebpb, a
54 promotes gene expression by both activating transcriptional activators and inactivating transcriptio
55 is minimal Cas9 to rationally design compact transcriptional activators and inducible nucleases, to f
57 n used with great variation to formulate the transcriptional activators and repressors of the clock.
58 ectors, which target phytohormone receptors, transcriptional activators and repressors, and other com
59 and Twist2 coordinate the regulation of both transcriptional activators and repressors, thereby media
62 hat repression acts in a dominant fashion on transcriptional activators and that the activity state o
63 ctions between basic helix-loop-helix (bHLH) transcriptional activators and the transcriptional repre
64 ke protein-1 (BMAL1) heterodimer acts as the transcriptional activator, and Cryptochrome (CRY) and Pe
65 large E1A (L-E1A) protein is a prototypical transcriptional activator, and it functions through the
66 of the bZIP (basic zipper) family of dimeric transcriptional activators, and its overexpression has b
67 acetylation enhances the search kinetics of transcriptional activators, and later the acetylation ac
68 e proteolysis of Fra and Fra's function as a transcriptional activator are required for its ability t
69 ssing recombinases, reporters, and inducible transcriptional activators are key for many genetic stud
70 ess is encoded by many binding sites for the transcriptional activator Arrowhead and that, during evo
71 at selective deletion of the circadian clock transcriptional activator aryl hydrocarbon receptor nucl
72 ent paradox of RNA-mediated stabilization of transcriptional activators at enhancers with a repressiv
73 ationally dynamic domain that complexes with transcriptional activators at two discrete binding sites
74 romoter association of the stress-responsive transcriptional activator Atf1 at the sites of transcrip
76 f the sigma(54) family must be acted on by a transcriptional activator before DNA opening and initiat
77 y the scaffold protein Axin, targets the key transcriptional activator beta-catenin for proteolysis.
79 l shutdown, nucleosome invasion, and reduced transcriptional activator binding required chromatin rem
80 the recycling of RNAP, delta functions as a transcriptional activator by binding to an A-rich sequen
81 V nuclear antigen 2 (EBNA2) both function as transcriptional activators by virtue of their interactio
84 r farnesoid X receptor (FXR) and the fasting transcriptional activator cAMP response element-binding
85 , we examined the role of CALMODULIN-BINDING TRANSCRIPTIONAL ACTIVATORs (CAMTAs) in RSRE induction.
86 The new studies with Zap1 highlight how a transcriptional activator can facilitate decreased prote
87 ermore, without the PIPTC, the Cat8 and Sip4 transcriptional activators cannot be efficiently recruit
88 otein CII from bacteriophage 186 is a potent transcriptional activator, capable of mediating at least
89 domain fusion proteins to serve as chimeric transcriptional activators challenge use of this approac
90 transcriptional feedback loop featuring the transcriptional activators circadian locomotor output cy
91 k loops, which balance the activities of the transcriptional activators CLOCK (circadian locomotor ou
92 or composed of a feedback loop that involves transcriptional activators CLOCK and BMAL1, and represso
93 epresses expression of the gene encoding the transcriptional activator, CLOCK (CLK), and may also aff
94 tical role in the formation and stability of transcriptional activator-coactivator complexes, perhaps
95 s effect through inducing c-Jun to bind to a transcriptional activator complex consisting of beta-cat
96 set of lytic viral proteins assembles into a transcriptional activator complex to induce expression o
99 yte differentiation by inhibiting RBPJ/MAML1 transcriptional activator complexes at NOTCH target DNA.
100 ) signaling, together with broadly expressed transcriptional activators, concurrently activates the g
101 H3K27me3 levels, while it switches EZH2 to a transcriptional activator, conferring higher proliferati
103 are antagonized by three different types of transcriptional activators: CREB/ATF-type Atf1, C(2)H(2)
104 nserved lncRNA, increases the association of transcriptional activators (DLX homeodomain proteins) wi
105 , which may provide effective treatments for transcriptional activator-driven malignancies and diseas
106 o repressed c-Myc transcription by targeting transcriptional activator E2f1 and coactivator Tfdp2, as
107 e used to study the contribution of the T3SS transcriptional activator ExsA to epithelial traversal.
110 r for Snai2, the somatic form functions as a transcriptional activator for Jarid2, Aebp2 and Snai2.
113 ach evolved strain has a point mutation in a transcriptional activator for xylose catabolic operons,
117 A-binding domain found in the LuxR family of transcriptional activators, functions as an essential ma
118 nsgenic method in combination with the yeast transcriptional activator gal4 protein/upstream activati
120 s a multi-zinc finger protein that binds the transcriptional activator GATA4 and modulates GATA4-medi
121 show that Brachyury functions primarily as a transcriptional activator genome-wide and that an unexpe
122 TCH/SMO causes an increase in the downstream transcriptional activator GLI1 and a decrease in the GLI
123 These data demonstrate that Cas9-derived transcriptional activators have the potential to be used
124 terestingly, although phosphorylation of the transcriptional activator Hcm1 on its N-terminus promote
127 cids were shown to require the invasion gene transcriptional activator hilD and to function independe
129 In ES cells, they are predicted to act as transcriptional activator hubs and might be under SetDB1
131 we show that an interaction between the RPG transcriptional activator Ifh1 and the rRNA processing f
132 h small inhibitory RNA showed that p107 is a transcriptional activator in prostate cancer cells.
133 S (MuDPIT) analysis, we can trap the PPIs of transcriptional activators in a cellular setting and ide
134 enome-wide effects of TALE- and CRISPR-based transcriptional activators in human cells using ChIP-seq
135 after associating with the core loops of the transcriptional activators in their ATP state and that t
137 presets chromatin before the recruitment of transcriptional activators including DREF that triggers
138 sts, we report here variants of the Q-system transcriptional activator, including QF2, for driving st
139 and demonstrate that TBX5, long considered a transcriptional activator, interacts biochemically and g
140 the effect is dependent upon EDS1 and PAD4, transcriptional activators involved in the pathogen resp
141 the yeast Saccharomyces cerevisiae, the Zap1 transcriptional activator is a central player in this pr
142 domain of BAM8 shows that its function as a transcriptional activator is independent of catalysis bu
143 uman ILC2 cells in a manner dependent on the transcriptional activator ISGF3 that led to altered cyto
144 ese effects are coordinated, in part, by the transcriptional activator Kruppel-like factor-6 (Klf6).
145 y, we compared the protein levels of a MAO A-transcriptional activator, Kruppel-like factor 11 (KLF11
146 f these syntelogs in the context of positive transcriptional activators may help guide attempts to al
148 ucible factors (HIFs), a family of essential transcriptional activators mediating the metazoan hypoxi
149 Using embryonic stem cell lines lacking the transcriptional activator MOZ and the polycomb-family re
150 men development and acting downstream of the transcriptional activator MS1 (MALE STERILITY 1), which
151 up-regulation of the smooth muscle-specific transcriptional activator myocardin at mRNA and protein
155 n lowers expression levels of the osteoclast transcriptional activator nuclear factor of activated T
156 r-activated receptor coactivator 1alpha, the transcriptional activators nuclear respiratory factor 1
157 mily member and p63 isoform, DeltaNp63, is a transcriptional activator of a cofactor critical for miR
158 of AtrA, which was initially described as a transcriptional activator of actinorhodin biosynthesis i
160 tor gamma coactivator 1alpha (PGC-1alpha), a transcriptional activator of ALAS1, to affect hepatic he
161 y and ChIP, KLF6 was established as a direct transcriptional activator of ATG7 and BECLIN1, but was d
163 s with published sites for SREBP-2, a master transcriptional activator of cholesterol biosynthesis.
168 ation and cellular invasion and was a direct transcriptional activator of genes that regulate CSC sel
169 sponsive element-binding protein (ChREBP), a transcriptional activator of glycolytic and lipogenic ge
170 ome proliferator-activated receptor alpha, a transcriptional activator of HMGCS2, is similarly down-r
177 a PAX3-MAML3 fusion protein that is a potent transcriptional activator of PAX3 response elements.
178 anistic studies demonstrated that MYSM1 is a transcriptional activator of Pax5, the repressors of pla
184 expression of constitutively active Sre1, a transcriptional activator of Tf2 elements, also alleviat
186 li RclR (formerly YkgD) is a redox-regulated transcriptional activator of the AraC family, whose high
187 ung-directed gene transfer of TFEB, a master transcriptional activator of the autophagolysosomal syst
188 g a dominant-negative mutant of NF-YA, a key transcriptional activator of the Ccnb1 promoter, increas
190 ves pheromone-induced degradation of Tec1, a transcriptional activator of the cyclin CLN1, because Te
191 emonstrate that Erg binds to and serves as a transcriptional activator of the G-protein-coupled recep
193 educed by genetically deleting Gli2, a major transcriptional activator of the Hedgehog pathway, or by
195 ent with preferential translation of ATF4, a transcriptional activator of the integrated stress respo
196 elective genetic ablation of RelA (p65), the transcriptional activator of the NF-kappaB pathway, reta
197 istems of vrs3 suggested that VRS3 acts as a transcriptional activator of the row-type genes VRS1 (Hv
198 omponent of E-cadherin junctions and as a co-transcriptional activator of the Wnt/beta-catenin signal
199 cytes IkappaBzeta was identified as a direct transcriptional activator of TNFalpha/IL-17A-inducible p
200 g the UCP1 promoter, we identify Zfp516 as a transcriptional activator of UCP1 as well as PGC1alpha,
202 FL) in which CLOCK and BMAL1 proteins act as transcriptional activators of Cryptochrome and Period ge
203 epeat Binding Factors (CBFs) are DNA-binding transcriptional activators of gene pathways imparting fr
205 anthomonas species are DNA-sequence-specific transcriptional activators of host susceptibility genes
207 on FIL lines suggested that YABs function as transcriptional activators of JA-triggered responses.
209 R gamma coactivator 1 alpha (PGC1alpha), key transcriptional activators of mitochondrial biogenesis a
210 and UC-514321 both directly target STAT3/5, transcriptional activators of TET1, and thus repress TET
211 hese results suggest that ERRs are important transcriptional activators of the glycolytic pathway and
213 M promoter and a reduction in the binding of transcriptional activators of the NF-kappaB pathway.
214 int-c confirmed that all three genes act as transcriptional activators of VRS1 and quantitative vari
216 is a zinc finger protein that functions as a transcriptional activator or repressor and participates
217 ant arginine methyltransferase, can act as a transcriptional activator or repressor by modifying a di
222 Furthermore, Hth/Exd act in concert with the transcriptional activators Orthodenticle (Otd) and Spalt
224 have also shown that these TFs act either as transcriptional activators (OsPCF2, OsNIN-like4) or repr
226 a, which promotes histone methylation or the transcriptional activator, p65, which promotes histone a
228 Here we describe a mechanism whereby the transcriptional activator PhoP elicits expression of dis
229 of the LLO-encoding gene (hly) requires the transcriptional activator PrfA, and both hly and prfA ge
230 Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of c
231 rome and de novo mutations in PURA, encoding transcriptional activator protein Pur-alpha, within the
233 lore the roles of the ATPase site in an AAA+ transcriptional activator protein, the phage shock prote
235 y of sigma subunits require the action of a 'transcriptional activator' protein to open the promoter
237 en receptor variant (ERT2) fused to the GAL4 transcriptional activator rapidly and robustly activates
238 that Arx plays a role as a context dependent transcriptional activator, rather than a primary inducer
242 ntify a bromodomain protein that serves as a transcriptional activator required to coordinate express
244 essors (for example, the NCoR/SMRT complex), transcriptional activators, RNA, chromatin remodellers,
246 tivation from latency is the replication and transcriptional activator (RTA) encoded by the gene Orf5
249 gether with co-analysis of engagement of the transcriptional activator Sox2, indicate that repressors
250 se SYN1 promoters contains cis-sites for the transcriptional activator Sp1 in close proximity to REST
252 hat ZNF143, the human homolog of the Xenopus transcriptional activator STAF, specifically binds to th
253 t gene transcription, despite the downstream transcriptional activator STAT1 being activated and boun
254 proteasomal degradation of the IFN-regulated transcriptional activator STAT2 from humans, but not mic
255 d binding sites for growth hormone-regulated transcriptional activators (STAT5, hepatocyte nuclear fa
257 ccharomyces cerevisiae, we tested whether co-transcriptional activator Sub1, recently identified as a
259 myelination require the serial expression of transcriptional activators, such as Sox10, Oct6 (also ca
260 We define the conserved sigma(54)-dependent transcriptional activator TacA as a global regulator in
262 ors, we discovered that PQM-1 is the elusive transcriptional activator that directly controls develop
265 es showed that this gene, denoted chlR, is a transcriptional activator that is essential for transcri
267 he gabTD operon and its own gene (GabR) is a transcriptional activator that regulates transcription o
271 ption factor binding data identified several transcriptional activators that bind promoters with diff
273 iferator-activated receptor alpha, which are transcriptional activators that mediate the fasting resp
274 sponse regulators (RRs): the type-B RR (RRB) transcriptional activators that promote the expression o
275 of PRDM13 in repressing the activity of bHLH transcriptional activators that together are required to
276 ich the UPS affects transcription centers on transcriptional activators, the function of which can be
279 We hypothesized that recruitment of a strong transcriptional activator to an enhancer would be suffic
280 ted in oral tumorigenesis and can serve as a transcriptional activator to drive podoplanin expression
281 ivation (CRISPRa) to synthetically recruit a transcriptional activator to sites across large genomic
282 te multiple DNA breaks or to target multiple transcriptional activators to a single promoter for syne
285 anscriptional repressor, but converts into a transcriptional activator upon activation of the canonic
286 that the noncanonical function of EZH2 as a transcriptional activator upregulates a set of genes inv
287 KLF1 and related family members function as transcriptional activators via recruitment of co-activat
288 dCas9) fused with four tandem repeats of the transcriptional activator VP16 (VP64) could be used for
291 assay showed that AtC3H14 also function as a transcriptional activator, which is consistent with the
292 ncy program is controlled by the EBNA2 viral transcriptional activator, which targets promoters via R
293 level is low because, we show, the relevant transcriptional activators, which work from regulatory s
295 ned unclear how beta-catenin's function as a transcriptional activator with TCF1 influences mESC fate
298 ippo pathway leads to phosphorylation of the transcriptional activator yes-associated protein 1 (YAP1
299 genome activation are currently unknown, the transcriptional activator Zelda (ZLD) has been shown to
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