ライフサイエンスコーパス: transcriptional elongation

1 n downstream from SALL4 TSS influences SALL4 transcriptional elongation.

2 an H3K4me3 gradient important for productive transcriptional elongation.

3 -cells), as well as potential effects on HIV transcriptional elongation.

4 esolve DNA double-stranded breaks or promote transcriptional elongation.

5 atin reader present in complexes stimulating transcriptional elongation.

6 ghly conserved non-coding RNA that regulates transcriptional elongation.

7 BRD4, and ELL coincides with termination of transcriptional elongation.

8 oint mutation in the IKBKAP gene involved in transcriptional elongation.

9 in (CTD) repeats of RNA polymerase II during transcriptional elongation.

10 acilitate the assembling process by stalling transcriptional elongation.

11 e or more factors involved in the process of transcriptional elongation.

12 presented here suggest an additional role in transcriptional elongation.

13 n elongation factor-b, leading to a block in transcriptional elongation.

14 tive elongation factors to stimulate general transcriptional elongation.

15 work links histone methylation by Set2 with transcriptional elongation.

16 essive chromatin structure is restored after transcriptional elongation.

17 arge complex and determine the inhibition of transcriptional elongation.

18 the coactivator function in regulating HIV-1 transcriptional elongation.

19 domain (CTD) of RNA polymerase II to promote transcriptional elongation.

20 hat is required for normal initiation and/or transcriptional elongation.

21 RNA polymerase II and is required for normal transcriptional elongation.

22 pears to be a result of selective control of transcriptional elongation.

23 L1 expression is primarily due to inadequate transcriptional elongation.

24 at 6-AU sensitivity results from a defect in transcriptional elongation.

25 locking the transition from preinitiation to transcriptional elongation.

26 of RNA polymerase II, permitting productive transcriptional elongation.

27 logous to mammalian Cdk9, which functions in transcriptional elongation.

28 in both positively and negatively regulating transcriptional elongation.

29 r 5 phosphorylation of RNA polymerase II and transcriptional elongation.

30 hromatin reassembly enhances the fidelity of transcriptional elongation.

31 ers of the Paf1 complex, which also promotes transcriptional elongation.

32 omoter association and subsequent effects on transcriptional elongation.

33 -containing heptapeptide repeat and inhibits transcriptional elongation.

34 P-TEFb), to target gene promoters, enhancing transcriptional elongation.

35 the RNA polymerase II complex and stimulates transcriptional elongation.

36 at the CCR4-NOT complex also plays a role in transcriptional elongation.

37 nduced latency reversal by suppressing HIV-1 transcriptional elongation.

38 5-242 allele are factors involved in slowing transcriptional elongation.

39 e presented, implying a role for Bur1 during transcriptional elongation.

40 seful tool to identify factors important for transcriptional elongation.

41 ance of Spt16 in the absence of San1 impairs transcriptional elongation.

42 t system for studying DRB-sensitive steps of transcriptional elongation.

43 nd temperature stress releases the brakes on transcriptional elongation.

44 of the mechanisms used by HSF1 to facilitate transcriptional elongation.

45 vator protein, Tat, is a potent activator of transcriptional elongation.

46 ntified blocked Tat-dependent stimulation of transcriptional elongation.

47 to RNA comparable with inchworming models of transcriptional elongation.

48 ne clusters, supporting the role for RfaH in transcriptional elongation.

49 anscription by antagonizing elongin-enhanced transcriptional elongation.

50 IG-I, producing their enhanced expression by transcriptional elongation.

51 confirming that DDR signalling results from transcriptional elongation.

52 nhancer function and architectural models of transcriptional elongation.

53 tion initiation independent of its effect on transcriptional elongation.

54 lated action mechanism of eRNAs during early transcriptional elongation.

55 elongation factor b (P-TEFb) and facilitated transcriptional elongation.

56 mosome segregation, protein homeostasis, and transcriptional elongation.

57 ns across eukaryotes that are independent of transcriptional elongation.

58 sequence of the active GAL1 gene, and hence transcriptional elongation.

59 ukaemia (ELL) protein, as a key regulator of transcriptional elongation.

60 acting mechanism by which sequence modulates transcriptional elongation.

61 d H3K27 (H3K27me2), and proteins involved in transcriptional elongation.

62 tion by demethylating H3K27me3 and promoting transcriptional elongation.

63 nd results in suppression of hPAF1C-mediated transcriptional elongation.

64 lysine 120 (H2Bub) is associated with active transcriptional elongation.

65 pre-mRNA splicing by chromatin structure and transcriptional elongation.

66 m each burst of transcription by stimulating transcriptional elongation.

67 In contrast, a mutation that diminished transcriptional elongation abolished induction of full-l

68 Fusion with MLL preserves the transcriptional elongation activity of ELL but relocaliz

69 ncentration of ELL and EAF1 in CBs links the transcriptional elongation activity of ELL to the RNA pr

70 Factors regulating the transcriptional elongation activity of RNA polymerase II

71 , an activity that is required for efficient transcriptional elongation and 3' RNA processing.

72 fusion proteins in leukemia induce aberrant transcriptional elongation and associated chromatin pert

73 d zebrafish; Spt5 may provide a link between transcriptional elongation and cell fate.

74 role for these proteins in the regulation of transcriptional elongation and coordinated histone methy

75 ates for Bur1/Bur2, thus linking its role to transcriptional elongation and demonstrating a potential

76 usly unrecognized role of WHSC1, which links transcriptional elongation and H3.3 deposition into acti

77 S10 and H2Av phosphorylation is required for transcriptional elongation and heat shock-induced chroma

78 e Paf1 complex (PAF1C), which is involved in transcriptional elongation and histone modifications.

79 is directed to excellent existing reviews on transcriptional elongation and HIV transcription.

80 omain of RNA Pol II and stimulated efficient transcriptional elongation and HIV-1 expression in the a

81 ptualization of nucleosome remodeling during transcriptional elongation and in the development of his

82 We conclude that hHpr1/p84/Thoc1 regulates transcriptional elongation and may participate in a prot

83 uction of PRGs is controlled at the level of transcriptional elongation and mRNA processing, through

84 Although these proteins control transcriptional elongation and perhaps modulate the effe

85 iption/export) complex that is important for transcriptional elongation and recruitment of mRNA expor

86 or of viral gene expression required for HIV transcriptional elongation and replication.

87 subsequently respond to the effect of Tat on transcriptional elongation and represents a novel intera

88 racted P-TEFb, thereby mobilizing downstream transcriptional elongation and splicing machineries.

89 nt introns, likely reflecting a link between transcriptional elongation and splicing.

90 partner cyclin T1 are involved in regulating transcriptional elongation and tat-activation.

91 Transcriptional elongation and termination by RNA polyme

92 ctive genes and influence, in opposing ways, transcriptional elongation and termination.

93 h these mRNA processing reactions throughout transcriptional elongation and termination.

94 ssion of sec2(ts) is not a result of reduced transcriptional elongation and that Elp1p physically ass

95 lation is normally associated with efficient transcriptional elongation and the recruitment of pre-mR

96 in C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination.

97 se data suggest a model whereby Hmt1 affects transcriptional elongation and, as a result, influences

98 o the histone 3 tail, play an active role in transcriptional elongation, and colocalize with genes th

99 coordinates nucleosome dis- and re-assembly, transcriptional elongation, and mRNA processing.

100 phosphorylated in a pattern consistent with transcriptional elongation, and only minimal levels of i

101 hibit characteristics of genes controlled by transcriptional elongation, and the SEC-P-TEFb complex i

102 initiation, leucine-specific tRNA regulates transcriptional elongation, and unknown factors differen

103 ith a model in which Tat-mediated effects on transcriptional elongation are mediated in part by the a

104 Bacterial regulators of transcriptional elongation are versatile units for build

105 lts in 2-fold higher ubH2B, and 2-fold lower transcriptional elongation at IRF1.

106 ells along the monocytic pathway by blocking transcriptional elongation at the first exon/intron bord

107 for the negative and positive regulation of transcriptional elongation at the HIV-1 promoter.

108 ts identify a new component of regulation in transcriptional elongation based on CK2-dependent tyrosi

109 polymerase to promoters or physically block transcriptional elongation, but at genes that it strongl

110 These results suggest transcriptional elongation, but not initiation, is block

111 that are potentially involved in regulating transcriptional elongation, but the mechanisms of action

112 that bacterial RNAP pauses frequently during transcriptional elongation, but the relationship of thes

113 ibility that genes are commonly regulated by transcriptional elongation, but this remains largely unt

114 (HIV-1) gene expression Tat stimulates HIV-1 transcriptional elongation by increasing the processivit

115 mple, HIV-1 encodes a protein that regulates transcriptional elongation by interacting with a cellula

116 istributed mobile element, the inhibition of transcriptional elongation by L1 might profoundly affect

117 ection, Tat acts at least in part to control transcriptional elongation by overcoming premature trans

118 a Cdk9-cyclin T1 heterodimer that stimulates transcriptional elongation by phosphorylating RNA polyme

119 mer, stimulates general and disease-specific transcriptional elongation by phosphorylating RNA polyme

120 P-TEFb positively regulates transcriptional elongation by phosphorylating the C-term

121 and is instead involved in the regulation of transcriptional elongation by phosphorylating the carbox

122 Cyclin-dependent kinase 12 (CDK12) promotes transcriptional elongation by phosphorylation of the RNA

123 II (Pol II) binding to the tim promoter and transcriptional elongation by Pol II that is constitutiv

124 gest that KIS-L facilitates an early step in transcriptional elongation by Pol II.

125 on that has been demonstrated to function in transcriptional elongation by recruiting the Rpd3S histo

126 Tat may stimulate transcriptional elongation by recruitment of a complex c

127 human immunodeficiency virus type 1 (HIV-1) transcriptional elongation by recruitment of carboxyl-te

128 human immunodeficiency virus type 1 (HIV-1) transcriptional elongation by recruitment of the human t

129 Our results suggest control of transcriptional elongation by repressors contributes to

130 drugs have been implicated in the process of transcriptional elongation by RNA polymerase (Pol) II, b

131 or a direct role of AF4 in the regulation of transcriptional elongation by RNA polymerase II (Pol II)

132 ween these factors, chromatin structure, and transcriptional elongation by RNA polymerase II (pol II)

133 Biochemical experiments indicate that transcriptional elongation by RNA polymerase II (Pol II)

134 Transcriptional elongation by RNA polymerase II (Pol II)

135 ycT1, CycT2, or CycK and Cdk9 and stimulates transcriptional elongation by RNA polymerase II (RNAPII)

136 Transcriptional elongation by RNA polymerase II (RNAPII)

137 ates viral gene expression through promoting transcriptional elongation by RNA polymerase II (RNAPII)

138 Transcriptional elongation by RNA polymerase II (RNAPII)

139 Transcriptional elongation by RNA polymerase II has been

140 ature linking the key biochemical process of transcriptional elongation by RNA polymerase II to histo

141 IM 1 and 2, is involved in the inhibition of transcriptional elongation by RNA polymerase II.

142 SPT5 and its binding partner SPT4 regulate transcriptional elongation by RNA polymerase II.

143 m-level resolution, which we used to monitor transcriptional elongation by single molecules of Escher

144 nd cyclin T1, is also critical in regulating transcriptional elongation by SPT4 and SPT5.

145 scriptional inhibition and the activation of transcriptional elongation by the human immunodeficiency

146 and trimethylation, histone acetylation, and transcriptional elongation can occur.

147 factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) sta

148 These results indicate the existence of a transcriptional elongation checkpoint that is associated

149 with a preponderance of factors that impact transcriptional elongation compared with initiation, in

150 ls, the Rtf1 and Paf1 components of the Paf1 transcriptional elongation complex are important for rec

151 ved decreased binding and recruitment of the transcriptional elongation complex containing cyclin dep

152 ecruited Super Elongation Complex (SEC), the transcriptional elongation complex essential for HIV-1 l

153 y for RNA polymerases I, II, and III, pol II transcriptional elongation complexes, and a variety of c

154 Transcriptional elongation control by RNA polymerase II

155 In addition, transcriptional elongation-coupled DDR signalling involv

156 d show that this correlates with a defect in transcriptional elongation-coupled histone acetylation.

157 chromatin immunoprecipitation evidence for a transcriptional elongation defect in which RNA polymeras

158 Depletion of hHpr1/p84/Thoc1 causes transcriptional elongation defects and associated cellul

159 ycophenolic acid sensitivities, hallmarks of transcriptional elongation defects.

160 plicing factors function directly to promote transcriptional elongation, demonstrating that transcrip

161 roles in different cellular pathways such as transcriptional elongation, differentiation and apoptosi

162 e H2B de-ubiquitylation and further controls transcriptional elongation, DNA repair and replication v

163 istone H2B ubiquitylation is associated with transcriptional elongation, DNA repair and replication.

164 S syndrome and CdLS caused by disturbance of transcriptional elongation due to alterations in genome-

165 MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development.

166 e introduces a chemical kinetic model of the transcriptional elongation dynamics of RNA polymerase.

167 ssor protein down-regulates transcription by transcriptional elongation enhanced by antagonizing elon

168 ciently tight to allow strong attenuation of transcriptional elongation, even at operators located ma

169 36 trimethylation (H3K36me3) associated with transcriptional elongation, even when highly transcribed

170 ramatically in the requirements for positive transcriptional elongation factor (P-TEF) b activity.

171 l elongation factors, including the positive transcriptional elongation factor (P-TEFb), the bromodom

172 ociation of RelA with the activated positive transcriptional elongation factor (PTEF-b) complex prote

173 Spt6 is a transcriptional elongation factor and histone chaperone

174 By recruiting the positive transcriptional elongation factor b (P-TEFb) to paused R

175 Human positive transcriptional elongation factor b (P-TEFb), consisting

176 The positive transcriptional elongation factor b (P-TEFb), consisting

177 vents during initiation and P-TEFb (positive transcriptional elongation factor b) events during elong

178 ne activation might include recruitment of a transcriptional elongation factor by ubiquitinated activ

179 te myeloid leukemias fuses the gene encoding transcriptional elongation factor ELL to the MLL gene wi

180 of a chimeric protein that fuses MLL to the transcriptional elongation factor ELL.

181 ains casein kinase 2 (CK2) and the chromatin transcriptional elongation factor FACT (a heterodimer of

182 of CDK9 and a cyclin T subunit, is a global transcriptional elongation factor important for most RNA

183 presses KIT mRNA expression through positive transcriptional elongation factor inhibition and decreas

184 ich has two open reading frames encoding the transcriptional elongation factor M2-1 and the putative

185 The RNA polymerase II transcriptional elongation factor P-TEFb (cyclin-depende

186 Amt-87 works by activating the human transcriptional elongation factor P-TEFb, a CDK9-cyclin

187 on of GATA-1 with components of the positive transcriptional elongation factor P-TEFb, a complex cont

188 ene containing a bromo-adjacent homology and transcriptional elongation factor S-II domain, which we

189 The human transcriptional elongation factor SII or Trascription El

190 nse mutation (W049) in the gene encoding the transcriptional elongation factor Spt5 (reviewed in ) wh

191 ELL is an RNA Polymerase II (Pol II) transcriptional elongation factor that interacts with th

192 ranscriptional initiation, Hog1 behaves as a transcriptional elongation factor that is selective for

193 A homolog of the transcriptional elongation factor, GreA, was identified

194 tracellular signal regulated kinase/positive transcriptional elongation factor-b and NF-kappaB.

195 ntial third biological function of p53: as a transcriptional elongation factor.

196 nism that is distinct from its function as a transcriptional elongation factor.

197 innate response requires the recruitment of transcriptional elongation factors to rapidly induce inn

198 mplexes that also contain RNA polymerase II, transcriptional elongation factors, and general pre-mRNA

199 Here we identify multiple transcriptional elongation factors, including ELL2, TFII

200 ncing its interactions with coactivators and transcriptional elongation factors.

201 rentiation of KG1 by an early enhancement of transcriptional elongation, followed by an increase in t

202 r Tat resulting in Tat-mediated increases in transcriptional elongation from the HIV long terminal re

203 imulated both basal and tat-induced in vitro transcriptional elongation from the HIV-1 LTR.

204 The transactivator protein Tat stimulates transcriptional elongation from the HIV-1 LTR.

205 Tat and other cellular factors to stimulate transcriptional elongation from the viral long terminal

206 cation that is involved in regulating P-TEFb transcriptional elongation function.

207 hHSF1 residues responsible for activation of transcriptional elongation has the most severe effect on

208 CDK9/cyclin T) to suppress RNA polymerase II transcriptional elongation in a process that specificall

209 or Spt4, Spt5, and Spt6 in the regulation of transcriptional elongation in both yeast and humans.

210 We examine the role of transcriptional elongation in control of IRF3-dependent

211 not required for chromatin decondensation or transcriptional elongation in Drosophila.

212 translational initiation into regulators of transcriptional elongation in Escherichia coli.

213 regulation of c-myb mRNA and increased c-myb transcriptional elongation in HMBA-induced MEL cells.

214 NA 3'-end processing in chicken cells and in transcriptional elongation in human cells.

215 lation occurs through a conditional block to transcriptional elongation in intron I.

216 tivation of downstream inflammatory genes by transcriptional elongation in RSV infection.

217 eaks and DDR signalling in the mechanisms of transcriptional elongation in stimulus-inducible genes i

218 Transcriptional elongation in the C. elegans germline th

219 we analyze the domains of SPT5 that regulate transcriptional elongation in the presence of either DRB

220 Here, we designed a specific assay for transcriptional elongation in vivo that involves an arti

221 r-associated pausing and of Spt5 and Spt6 in transcriptional elongation in vivo.

222 ting the factors that regulate RNA decay and transcriptional elongation in vivo.

223 nduced pausing represents a major barrier to transcriptional elongation in vivo.

224 yeast or inhibition of CK2 activity impairs transcriptional elongation in yeast as well as in mammal

225 ymerase II and was thought to have a role in transcriptional elongation in yeast.

226 RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of th

227 Promoter-proximal pausing during transcriptional elongation is an important way of regula

228 ngly suggests that developmentally regulated transcriptional elongation is central to the process of

229 Transcriptional elongation is critical for gene expressi

230 The ability of Tat to stimulate transcriptional elongation is dependent on its binding t

231 dent manner, and domains are maintained when transcriptional elongation is inhibited.

232 hese results suggest that an optimal rate of transcriptional elongation is required for normal cotran

233 Tat stimulation of HIV-1 transcriptional elongation is species-specific and is be

234 equently reduces the engagement of Pol II in transcriptional elongation, leading to promoter-proximal

235 lers, general transcription factors, and the transcriptional elongation machinery are primarily invol

236 Genome-wide maps of the transcriptional elongation mark H3K36me3 were generated

237 suggest that the ability of Tat to increase transcriptional elongation may be due to its ability to

238 The effects of Tat on transcriptional elongation may be mediated by its abilit

239 methylation at lysine 4, in conjunction with transcriptional elongation, may function in a negative f

240 is necessary for licensing Pol II to enter a transcriptional elongation mode.

241 HPR1 loss compromises transcriptional elongation, nuclear RNA export, and geno

242 Activation of transcriptional elongation occurs following the recruitm

243 rease in our understanding of how productive transcriptional elongation occurs.

244 ic pattern of Ubx expression by facilitating transcriptional elongation of bxd ncRNAs, which represse

245 omide exerts these effects by inhibiting the transcriptional elongation of genes that are required fo

246 gation Complex (SEC) that strongly activates transcriptional elongation of HIV-1 and cellular genes.

247 To stimulate transcriptional elongation of HIV-1 genes, the transacti

248 Thus, transcriptional elongation of HSV IE genes is a key limi

249 The transcriptional elongation of human immunodeficiency vir

250 yptic intragenic transcription, and inhibits transcriptional elongation of KDM5B target genes.

251 Transcriptional elongation of most eukaryotic genes by R

252 is dependent on the p38 MAPK, which promotes transcriptional elongation of p21 by RNA Pol II.

253 ining protein 4 (BRD4) stimulates productive transcriptional elongation of pluripotency genes by diss

254 P-TEFb promotes transcriptional elongation of RNA polymerase II by using

255 ubunit, distinct P-TEFb species regulate the transcriptional elongation of specific genes that play c

256 utilizes TFIIS.h to selectively promote the transcriptional elongation of the bax gene, upsurging ce

257 ed downstream of PKCepsilon to derepress the transcriptional elongation of the c-myc gene.

258 ion of the tumor suppressor Rb, derepressess transcriptional elongation of the c-myc oncogene, and pr

259 merase II, the transactivator Tat stimulates transcriptional elongation of the human immunodeficiency

260 nscriptional activation domains to stimulate transcriptional elongation on the hsp70 gene in vitro.

261 cal studies have identified major players of transcriptional elongation, our understanding of the imp

262 evisiae COMPASS complex, is regulated by the transcriptional elongation Paf1-Rtf1 and histone ubiquit

263 NusA is a key regulator of bacterial transcriptional elongation, pausing, termination and ant

264 target region, consistent with an effect on transcriptional elongation/pausing.

265 The inhibition of transcriptional elongation plays an important role in ge

266 mt1 is recruited during the beginning of the transcriptional elongation process.

267 A polymerase II (RNAPII) postrecruitment and transcriptional elongation processes, is required for BR

268 ly promotes cell cycle arrest but also halts transcriptional elongation, promotes apoptosis, induces

269 ification that is involved in regulating its transcriptional elongation properties in response to vir

270 osphorylation and function in modulating its transcriptional elongation properties.

271 hyperacetylation leads to an increased local transcriptional elongation rate and decreased inclusion

272 modifications and subsequent changes in the transcriptional elongation rate and exon skipping.

273 Inhibition of transcriptional elongation resulted in the loss of SNAPC

274 ity, was efficiently abrogated by a block to transcriptional elongation, resulting in decreased c-myc

275 onent of TREX, and loss of Hpr1p compromises transcriptional elongation, RNA export, and genome stabi

276 complex that can specifically interfere with transcriptional elongation, RNA polymerase binding, or t

277 A frequently used schematic model of transcriptional elongation shows an RNA polymerase molec

278 stribution of Pol II, proteins important for transcriptional elongation (Spt5, Spt16), or RNA process

279 diated transcriptional activation involves a transcriptional elongation step, like HIV Tat, and const

280 n, genes involved in histone acetylation and transcriptional elongation, such as TRRAP and BRD4, were

281 ation complex (SEC), a critical regulator of transcriptional elongation, suggesting that aberrant con

282 Here we report a new layer of regulation in transcriptional elongation that is conserved from yeast

283 hat is essential for Tat activation of HIV-1 transcriptional elongation, the CAK kinase associated wi

284 nt understanding of the relationship between transcriptional elongation through a chromatin template

285 uired for effective Pol II pause release and transcriptional elongation through a novel mechanism inv

286 ally minor c-myc promoter, P1, and increased transcriptional elongation through inherent pause sites

287 P-TEFb) (CDK9/cyclin T (CycT)) promotes mRNA transcriptional elongation through phosphorylation of el

288 replication and activates RNA polymerase II transcriptional elongation through the association with

289 Here we show that blockade of transcriptional elongation through the mouse T cell rece

290 ivity in facilitating Pol II's engagement in transcriptional elongation, thus deciphering a novel reg

291 the wake of elongating RNA polymerase II and transcriptional elongation, thus revealing novel regulat

292 been proposed that the MSL complex regulates transcriptional elongation to control dosage compensatio

293 e ASRs and suggest that these ASRs allow the transcriptional elongation to proceed through the silenc

294 e-9 (CDK9; a kinase necessary for triggering transcriptional elongation) to promoters of NF-kappaB-de

295 that enhances the engagement of Pol II into transcriptional elongation) to the coding sequence of an

296 homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the elev

297 mal level of Spt16 is required for efficient transcriptional elongation, which is maintained by San1

298 ratus with a novel two-bead assay to monitor transcriptional elongation with near-base-pair precision

299 Hence, assembly of TREX physically couples transcriptional elongation with RNA processing factors.

300 Suggestive of a role in transcriptional elongation, Yta7 localized to the ORFs o