ライフサイエンスコーパス: transcriptional initiation

1 ors bound at target promoters and stimulates transcriptional initiation.

2 ltiple enzymatic activities are required for transcriptional initiation.

3 an increase in HBP1 mRNA stability, but not transcriptional initiation.

4 H3K4 trimethylation, a mark associated with transcriptional initiation.

5 c promoters is key to accurate and efficient transcriptional initiation.

6 impair recruitment of RNA polymerase II and transcriptional initiation.

7 ory element 0.1 kb upstream from the site of transcriptional initiation.

8 genes influence the location and kinetics of transcriptional initiation.

9 manner, consistent with a role in promoting transcriptional initiation.

10 precedes nuc-1 remodeling and, subsequently, transcriptional initiation.

11 ized within 412 nucleotides from the site of transcriptional initiation.

12 f these operons is regulated at the level of transcriptional initiation.

13 ted to transcriptional interference and even transcriptional initiation.

14 ns potential promoter elements essential for transcriptional initiation.

15 that amplify the hormone signal and mediate transcriptional initiation.

16 the promoters of ribosomal protein genes for transcriptional initiation.

17 xpression is due to a defect at the level of transcriptional initiation.

18 le for TBP dimerization in the regulation of transcriptional initiation.

19 H4 within the reporter gene, and a block to transcriptional initiation.

20 ates with that mediating activated levels of transcriptional initiation.

21 , suggesting that it acts via improvement of transcriptional initiation.

22 iated abortive transcripts may down-regulate transcriptional initiation.

23 s or transcription factors lead to increased transcriptional initiation.

24 the RNA polymerase-sigma(54) complex during transcriptional initiation.

25 the inverse correlation seen at the site of transcriptional initiation.

26 kb transcript levels at a step subsequent to transcriptional initiation.

27 F dependence early in the process leading to transcriptional initiation.

28 IID dependency and become SAGA dependent for transcriptional initiation.

29 re was a TPA-induced increase in the rate of transcriptional initiation.

30 nderstanding of the physical biochemistry of transcriptional initiation.

31 tion at other SAGA-dependent genes and hence transcriptional initiation.

32 t observed in constructs lacking the zone of transcriptional initiation.

33 PIC) at the core promoter and, consequently, transcriptional initiation.

34 sion in CD4+ T cells is mainly controlled at transcriptional initiation.

35 ana BZR1-BAM isoforms (BAM7 and BAM8) during transcriptional initiation.

36 of the RNA polymerase II-mediated PIC before transcriptional initiation.

37 These results support the role of Rad14p in transcriptional initiation.

38 II phosphorylated at a site associated with transcriptional initiation.

39 tes the recruitment of the TFIID complex for transcriptional initiation.

40 alternative polyadenylation and alternative transcriptional initiation.

41 to poise quiescent genes for activation and transcriptional initiation.

42 istone mark is confined to the regulation of transcriptional initiation.

43 its promoter complexes, and the mechanism of transcriptional initiation.

44 icate that ExsA facilitates an early step in transcriptional initiation.

45 diated H3K4 methylation in the regulation of transcriptional initiation.

46 x act with this H3K36 HMT to prevent ectopic transcriptional initiation.

47 licing factor, controls MLL complex-mediated transcriptional initiation.

48 bryonic stem (ES) cells to prevent incorrect transcriptional initiation.

49 riptional coactivators that are required for transcriptional initiation after xenobiotic or hypoxic c

50 The positioning of transcriptional initiation agrees with our current under

51 nositol 3-kinase (PI3K) pathway operating on transcriptional initiation and a Raf-1-mitogen-activated

52 nucleotides upstream from the start site of transcriptional initiation and an Sp1 site located 83 nu

53 ry evolution, such that variants influencing transcriptional initiation and decay have opposite effec

54 t arise through the use of a unique site for transcriptional initiation and differential splicing.

55 FIIIC specifies an orientation of TFIIIB for transcriptional initiation and directs integration to th

56 isms of RNA polymerase II (RNA Pol II)-based transcriptional initiation and discuss the ways in which

57 SUPT16H or SSRP1 protein affects both HIV-1 transcriptional initiation and elongation and spontaneou

58 The transition between transcriptional initiation and elongation by RNA polymer

59 likely by interaction with components of the transcriptional initiation and elongation complexes duri

60 nome-wide analysis of the transition between transcriptional initiation and elongation in Escherichia

61 rent chromatin states coordinately influence transcriptional initiation and elongation rates and that

62 tightly regulated activator that stimulates transcriptional initiation and elongation using differen

63 ntegral role in regulating RNAPII occupancy, transcriptional initiation and elongation, and alternati

64 on by regulation of chromatin configuration, transcriptional initiation and elongation, and localizat

65 eorganizes nucleosomes and functions in both transcriptional initiation and elongation.

66 of RNA polymerase II, facilitating efficient transcriptional initiation and elongation.

67 of RelB during differentiation by increased transcriptional initiation and elongation.

68 ntrolled by PKCbetaII-mediated regulation of transcriptional initiation and elongation.

69 l dynamics predicted a tight coordination of transcriptional initiation and elongation.

70 n heat shock factor 1 (HSF1) stimulates both transcriptional initiation and elongation.

71 created to include or exclude the regions of transcriptional initiation and elongation.

72 or redistribution causes momentous swings in transcriptional initiation and elongation.

73 ll survival upon osmostress by acting during transcriptional initiation and elongation.

74 putative coactivator proteins implicated in transcriptional initiation and elongation.

75 ational modification, which is essential for transcriptional initiation and elongation.

76 and contains regulatory elements needed for transcriptional initiation and elongation.

77 ection, suggesting their requirement in both transcriptional initiation and elongation.

78 ng an unexpectedly significant delay between transcriptional initiation and mature mRNA production ea

79 effect of Snail on RKIP was on the level of transcriptional initiation and mediated by a proximal E-

80 We report here that alternative transcriptional initiation and mRNA splicing give rise t

81 egion stem-loop (RSL), has a small effect on transcriptional initiation and no effect on RNA polymera

82 letion of the R region had a small effect on transcriptional initiation and no effect on RNA polymera

83 d development was delayed despite normal Sry transcriptional initiation and overexpression.

84 upstream of genes, suggesting modulation of transcriptional initiation and polymerase-coupled spread

85 ' gene segment was used to identify sites of transcriptional initiation and promoter activity by RNas

86 tes Tax-dependent transcription by promoting transcriptional initiation and reinitiation.

87 some of the nucleotide elements involved in transcriptional initiation and sigma factor selection in

88 to other aspects of mRNA metabolism, such as transcriptional initiation and splicing, systematic info

89 Mechanistic analysis of transcriptional initiation and termination by RNA polyme

90 Positional effects of the transcriptional initiation and termination signals in th

91 uman PGE(2) EP2 receptor subtype, identified transcriptional initiation and termination sites in two

92 complexes that render chromatin insoluble at transcriptional initiation and termination sites.

93 e biological regulatory processes, including transcriptional initiation and termination, and the euka

94 The promoter activity of this zone of transcriptional initiation and the influence of gene seg

95 led that a nucleosome is positioned over the transcriptional initiation and the Sp1/3 binding sites.

96 lide (TPL), an XPB/TFIIH inhibitor, to block transcriptional initiation and then measured Pol II occu

97 ed region, suggesting an alternative site of transcriptional initiation and transcription through the

98 ter level in a region near the start site of transcriptional initiation and was independent of histon

99 y for viral replication and stimulates viral transcriptional initiation and/or elongation.

100 promoter DNA to form a complex required for transcriptional initiation, and many transcriptional reg

101 Deficient transcriptional initiation, and not elongation, is the m

102 lsE production is controlled at the level of transcriptional initiation, and regions of 5' DNA involv

103 tant sequence-based signals marking sites of transcriptional initiation at a large class of typical p

104 hat yFACT and Set2 oppose one another during transcriptional initiation at a step involving DNA bindi

105 s "active repression" complex, MerR prevents transcriptional initiation at merTPCAD until Hg(II) is a

106 Taken together, these results indicate that transcriptional initiation at the flhDC promoter by QseB

107 To understand how transcriptional initiation at these promoters is coordin

108 transcription complex assembly (and, hence, transcriptional initiation) at the promoter in vivo.

109 gistic effect on formation of PIC (and hence transcriptional initiation) at the promoter, revealing a

110 that Sus1p promotes PIC formation (and hence transcriptional initiation) at the SAGA-regulated genes

111 s, were potentially based on the increase of transcriptional initiation, both in TAR-dependent and -i

112 tile regulatory agents, influencing not only transcriptional initiation but also elongation, splicing

113 berrant heterochromatin is incompatible with transcriptional initiation but does not inhibit elongati

114 ation of the circadian system has focused on transcriptional initiation, but it is now apparent that

115 calized to specific sequences, as it is with transcriptional initiation, but rather associates with t

116 Transcriptional initiation by a sigma factor responsible

117 ing protein (TBP) plays an important role in transcriptional initiation by all three nuclear RNA poly

118 ked RNA cannot be generated through aberrant transcriptional initiation by E. coli RNA polymerase in

119 indings expose a striking similarity between transcriptional initiation by pol II, pol III and bacter

120 in both organisms but is not as critical for transcriptional initiation by RpoS(Bb) as it is for RpoS

121 and also distorts the merO DNA to facilitate transcriptional initiation by sigma70 RNA polymerase.

122 se factors work with co-activators to direct transcriptional initiation by the RNA polymerase II appa

123 Moreover, the rate of transcriptional initiation can be determined for mRNAs w

124 TATA-binding protein (TBP) is a key step in transcriptional initiation complex assembly on TATA-box-

125 1 and SREBP-1c and disrupted assembly of the transcriptional initiation complex on the SREBP-1c promo

126 site suggested that MAP kinases regulate the transcriptional initiation complex.

127 characterization of the entire mitochondrial transcriptional initiation complex.

128 n studied most extensively in the context of transcriptional initiation control, cooperativity from o

129 hese results provide a mechanistic basis for transcriptional initiation directed by YY1 in the absenc

130 the Mediator protein complex that regulates transcriptional initiation during development.

131 trate that regulatory complexes that mediate transcriptional initiation (e.g., p220(NPAT)) and 3'-end

132 and its regulation working at the levels of transcriptional initiation, elongation and degradation.

133 zed here the role of Mdm30p in regulation of transcriptional initiation, elongation, mRNA processing,

134 ngation factor TFIIS, Med25 also facilitates transcriptional initiation-elongation coupling.

135 lar concentrations, dCA reduces Tat-mediated transcriptional initiation/elongation from the viral pro

136 In these offspring, we mapped transcription, transcriptional initiation, enhancer activity, non-methy

137 SpOtx(beta) mRNAs resulted from two separate transcriptional initiation events, and these transcripts

138 Nhp6b demonstrate that Nhp6 is required for transcriptional initiation fidelity of some but not all

139 protein in Saccharomyces cerevisiae restores transcriptional initiation fidelity to this highly purif

140 ks canonical TATA and CAAT boxes but directs transcriptional initiation from a single site.

141 is GC-rich and lacks a TATA box but directs transcriptional initiation from a single site.

142 the leader RNA switching are the results of transcriptional initiation from the 9-nt site.

143 ions to lacZ reporters, we demonstrated that transcriptional initiation from the ARE1 promoter is sig

144 to be the only polymerase capable of correct transcriptional initiation from the HTLV-1 promoter.

145 e enhancer regions also result in a shift in transcriptional initiation from the P2 promoter to P1 th

146 Furthermore, normal transcriptional initiation from the Pmga P1 start site a

147 Transcriptional initiation from two different promoters

148 tain chromatin structure and prevent cryptic transcriptional initiation from within transcribed regio

149 n mRNA stability, protein synthesis, and new transcriptional initiation, have been studied to determi

150 in addition to its various functions during transcriptional initiation, Hog1 behaves as a transcript

151 n assays, we demonstrate that Mta stimulates transcriptional initiation in 293 cells.

152 vivo correlate with chromatin remodeling and transcriptional initiation in activated T-cells.

153 nd our prior analysis to the common model of transcriptional initiation in bacteria in terms of two p

154 phosphorylation had no additional effect on transcriptional initiation in crude extracts.

155 There is also evidence for deficient transcriptional initiation in FRDA, but its relationship

156 ome analysis revealed a severe deficiency of transcriptional initiation in FRDA.

157 ssion of MDR1 mRNA is regulated by increased transcriptional initiation in HL60/VCR cells.

158 erexpression as a marker indicating aberrant transcriptional initiation in leukemia.

159 Methylation is associated with repression of transcriptional initiation in plants and animals, and is

160 The regulation of transcriptional initiation in the human genome is a crit

161 ence for transcriptional control elements or transcriptional initiation in the intergenic GPR40-GPR41

162 the promoters of ribosomal protein genes for transcriptional initiation in vivo.

163 the TFIID-dependent promoter for productive transcriptional initiation in vivo.

164 Prf1 cis-regulatory regions correlated with transcriptional initiation (increased recruitment of RNA

165 D::lacZ fusion strain, we now show that pilD transcriptional initiation increases progressively as L.

166 Transcriptional initiation invariably involves the trans

167 dies indicate that steroid receptor-mediated transcriptional initiation is a cyclical process involvi

168 est that the repeated helical opening due to transcriptional initiation is a significant contributor

169 Transcriptional initiation is activated by the T4 gene 4

170 tion of Sus1p in promoting PIC formation and transcriptional initiation is not mediated via its role

171 A crucial step in eukaryotic transcriptional initiation is recognition of the promote

172 Indeed, deficient transcriptional initiation is the predominant cause of t

173 Although YY1 is not sufficient for transcriptional initiation, it is a required component o

174 with an active role in a subsequent step of transcriptional initiation leading to promoter opening.

175 A mutation that diminished transcriptional initiation led to twofold reductions in

176 ound hormone receptors and components of the transcriptional initiation machinery, including TATA-bin

177 omoter activity by interfering with the host transcriptional initiation machinery, potentially result

178 C2 targets are generally associated with the transcriptional initiation marker H3K4me3, but the signi

179 o gene transcription and that recruitment of transcriptional initiation markers also correlated with

180 the existence of a TAF1 (TFIID)-independent transcriptional initiation mechanism that may be used by

181 mplex displays two activities in redirecting transcriptional initiation of an S. pombe rDNA gene prom

182 Increased transcriptional initiation of c-myc induced by the short

183 class 2 flagellar gene, may be aiding in the transcriptional initiation of class 1 genes (flhDC) in E

184 Basal level transcriptional initiation of fission yeast ribosomal RN

185 Transcriptional initiation of mouse Cyp2s1 was found to

186 Transcriptional initiation of PbhuR mapped within the rh

187 elineate the molecular mechanisms underlying transcriptional initiation of rod-specific genes, we cha

188 In contrast, transcriptional initiation of Runx1 in nonpeptidergic no

189 lysine (K) acetyltransferase (KAT) promotes transcriptional initiation of TATA-binding protein (TBP)

190 nucleosome acetyltransferase of H4) promotes transcriptional initiation of TFIID (a complex of TBP an

191 ted that dimethylsulfoxide and HMBA enhanced transcriptional initiation of the reporter and p21/WAF1/

192 To better understand the mechanisms of transcriptional initiation of the X gene, we set out to

193 egulatory particle in controlling eukaryotic transcriptional initiation or activation independently o

194 ue to absolute blocks at the level of either transcriptional initiation or elongation but rather rela

195 thesis represents a critical juncture in the transcriptional initiation pathway when EC formation is

196 3' end formation, and appearance of aberrant transcriptional initiation products.

197 n was accompanied by coordinate increases in transcriptional initiation rate and gene promoter activi

198 e elements act cooperatively to increase the transcriptional initiation rate approximately 100-fold i

199 e occupancy is inversely proportional to the transcriptional initiation rate at the promoter.

200 omoter derivatives suggests that the maximal transcriptional initiation rate in yeast cells is one mR

201 V) produced a time-dependent increase in the transcriptional initiation rate of the IL-8 gene.

202 occupancy of cis-regulatory target sites to transcriptional initiation rate, and thence to RNA and p

203 l p50 and p52 homodimers at sites within the transcriptional initiation region of HIV-1 provides for

204 DHPLC and identified a point mutation at the transcriptional initiation site (-1C-->A) with a carrier

205 l nuclear protein binding at the Bf upstream transcriptional initiation site (UIS).

206 ous Giant to repress when bound close to the transcriptional initiation site and found that Giant eff

207 Definition of the transcriptional initiation site and sequence analysis sh

208 oter within the first 223 bp upstream of the transcriptional initiation site and the possible presenc

209 ts using mouse liver mRNA indicate one major transcriptional initiation site and three minor sites.

210 this operon 226 base pairs downstream of the transcriptional initiation site between the attenuator a

211 We determined the transcriptional initiation site by primer extension.

212 A transcriptional initiation site in exon 1b (P1b) was pri

213 the substitution of C with A at the beta2GPI transcriptional initiation site is a causative mutation

214 The primary transcriptional initiation site is located 213 bp upstre

215 The transcriptional initiation site is located 22 nucleotide

216 The transcriptional initiation site of norA was unchanged in

217 ing of a stably positioned nucleosome at the transcriptional initiation site of ORF50 is a regulatory

218 The transcriptional initiation site of the ilvGMEDA operon i

219 pha (RXRalpha), is specifically bound at the transcriptional initiation site of the major late promot

220 oximately 85 base pairs (bp) upstream of the transcriptional initiation site served as the minimal DN

221 of the MAP kinase-responsive element to the transcriptional initiation site suggested that MAP kinas

222 immediately upstream from the most upstream transcriptional initiation site that led to increased tr

223 A transcriptional initiation site was detected 260 bp 5' o

224 The transcriptional initiation site was determined to be 636

225 The transcriptional initiation site was identified by 5' RAC

226 The transcriptional initiation site was identified by RNase

227 CAAT boxes immediately upstream of the major transcriptional initiation site, although CAAT boxes wer

228 d at approximately 860 bases upstream of the transcriptional initiation site, and it contains a typic

229 nce was found 24 bp upstream from the second transcriptional initiation site, and two inverted CCAAT

230 between -927 to -1181, upstream of the major transcriptional initiation site, followed by positive el

231 A transcriptional initiation site, located an appropriate

232 -acting domains: within 6 kb surrounding the transcriptional initiation site, separate sequences were

233 However, in the region upstream of the transcriptional initiation site, the cryptdin 4 gene con

234 tion of nucleotides -68/-316 relative to the transcriptional initiation site.

235 sites lie within very close proximity to the transcriptional initiation site.

236 present both upstream and downstream of the transcriptional initiation site.

237 found approximately 300 nucleotides from the transcriptional initiation site.

238 lude a PU.1 binding site upstream of the P1b transcriptional initiation site.

239 h sequence was identified flanking the major transcriptional initiation site.

240 -RACE independently identified the identical transcriptional initiation site.

241 are centered at -18 and -36 relative to the transcriptional initiation site.

242 factor-dependent footprint downstream of the transcriptional initiation site.

243 nalysis employing T. pallidum RNA revealed a transcriptional initiation site.

244 ) located 1.7 kb upstream of the presumptive transcriptional initiation site.

245 ment or the entire 1.7 kb fragment 5' of the transcriptional initiation site.

246 ivator protein)-binding site proximal to the transcriptional initiation site; both SRC-1 and c-Jun we

247 of 5' ends of rpoE mRNA identified five new transcriptional initiation sites (P1 to P5) located dist

248 ces at least eight transcripts by using four transcriptional initiation sites (TIS; resulting in thre

249 nit and found that the promoter has multiple transcriptional initiation sites and lacks a TATA box.

250 protection assays were used to identify two transcriptional initiation sites for algR within the alg

251 Distinct transcriptional initiation sites for CD45 were demonstra

252 Multiple putative transcriptional initiation sites for this gene were iden

253 The presence of multiple transcriptional initiation sites is a typical feature of

254 SNP clusters were over-represented near the transcriptional initiation sites of immune response gene

255 extension and RNase protection analyses, two transcriptional initiation sites were identified 59 and

256 sity in endothelial cells results from three transcriptional initiation sites within exon 1.

257 rimer extension identified multiple putative transcriptional initiation sites, including several site

258 segment, which encompasses hypothetical srp transcriptional initiation sites, is relatively less con

259 Two transcriptional initiation sites, spaced 35 nucleotides

260 nd RNase protection methods showed two major transcriptional initiation sites.

261 found 19 and 42 bp upstream from the second transcriptional initiation sites.

262 ures into our EM maps results in a model for transcriptional initiation that strongly correlates with

263 evealing a role for JARID1d in regulation of transcriptional initiation through H3K4 demethylation.

264 Thus, the transition from transcriptional initiation to elongation is highly varia

265 fidaxomicin was added at different stages of transcriptional initiation to identify the blocked step.

266 A 3'-terminal CCCA (3'-CCCA) directs transcriptional initiation to opposite the underlined C;

267 ciferase reporter gene, could confer correct transcriptional initiation to the reporter and could con

268 The rate-limiting step in transcriptional initiation typically is opening the prom

269 a fast inducible yeast gene, GAL1, following transcriptional initiation via histone H3 Lys(56) acetyl

270 Quantitative analysis of transcriptional initiation via metabolic labeling of nas

271 irectly measured by quantitative analysis of transcriptional initiation via metabolic labeling of new

272 n assay and RACE analysis, the major site of transcriptional initiation was identified at -56 nt.

273 The zone of transcriptional initiation was part of a larger GC-rich

274 orticoid receptor (GR) as a model factor for transcriptional initiation, we classified chromatin stru

275 Nucleosomes regulate transcriptional initiation when positioned in the promot

276 one of which is PI3K-dependent operating on transcriptional initiation, whereas the other is mitogen

277 Here we determine the sites of FGFR4 transcriptional initiation which show a pattern characte

278 sting a nearly global positive regulation of transcriptional initiation with transcriptional pausing.

279 brain total RNA indicated multiple sites of transcriptional initiation within a approximately 70-nt

280 G methylation functions to suppress spurious transcriptional initiation within infrequently transcrib