ライフサイエンスコーパス: transcriptional network

1 ession (although they couple functionally to transcriptional networks).

2 on or whether it triggers a broadly targeted transcriptional network.

3 AX variants converge to modulate the MAX-MYC transcriptional network.

4 of canalization and gene regulation in this transcriptional network.

5 egulated processes orchestrated by a complex transcriptional network.

6 d provides a resource for exploring the E2Fa transcriptional network.

7 rentiation program orchestrated by the Gata3 transcriptional network.

8 rlapped with downregulation of the HNF-1beta transcriptional network.

9 e systems have been integrated into a common transcriptional network.

10 f LHX1 and a largely separable VIP-dependent transcriptional network.

11 y to dampen the metabolic stress-induced UPR transcriptional network.

12 t conditions and that may act as hubs in the transcriptional network.

13 MT-mediated disruption of a lineage-specific transcriptional network.

14 tic matrix stiffness inhibited the HNF4alpha transcriptional network.

15 PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks.

16 ell pluripotency is governed by OCT4-centric transcriptional networks.

17 guide this process by controlling downstream transcriptional networks.

18 ganisms that did not co-evolve its regulated transcriptional networks.

19 ases are associated with the deregulation of transcriptional networks.

20 on the temporal and spatial dynamics of the transcriptional networks.

21 an underlying dysregulation of SOXF-mediated transcriptional networks.

22 rly because of the importance of QS in major transcriptional networks.

23 ave striking effects on integrated ceRNA and transcriptional networks.

24 med a cross-species comparison of glomerular transcriptional networks.

25 ochromes (PHYs) and modulation of downstream transcriptional networks.

26 t 3,5-diiodothyronine (T2) can also regulate transcriptional networks.

27 les in governing metabolic and developmental transcriptional networks.

28 tion factors (crisprTFs) to globally perturb transcriptional networks.

29 ssion also counteracts aging changes in gene transcriptional networks.

30 to improved modelling and prediction of post-transcriptional networks.

31 ugh the activation or repression of distinct transcriptional networks.

32 s an important genetic model for elucidating transcriptional networks.

33 INCR is a newly identified player in the MYC transcriptional network able to control the expression o

34 l antiangiogenesis and disruption of the p53 transcriptional network abolished the antiangiogenic act

35 data present a powerful resource for mapping transcriptional networks across eukaryotes.

36 The transcriptional network acting downstream of LIF, WNT an

37 mental signals in complex but poorly defined transcriptional networks, allowing trees to produce wood

38 us far, the extent to which genital and limb transcriptional networks also share cis-regulatory eleme

39 ystem, underscoring the power of genome-wide transcriptional-network analyses.

40 Transcriptional network analysis on these cells identifi

41 research into genetic algorithms, genetics, transcriptional network analysis, and genomics.

42 some of its target genes, modulating the p53 transcriptional network and contributing to apoptosis in

43 We also construct a simple synthetic transcriptional network and demonstrate using experiment

44 omprehensive insight on early human germline transcriptional network and epigenetic reprogramming tha

45 ion between p53 and autophagy through a vast transcriptional network and indicate that autophagy cont

46 This p53-centric transcriptional network and its associated phenotype wer

47 loss and long-term responses to remodel the transcriptional network and physiological and developmen

48 g is a central part of the core pluripotency transcriptional network and plays a critical role in emb

49 an primordial germ cells, revealing a unique transcriptional network and progressive and conserved gl

50 that impacts multiple components of the Th1 transcriptional network and provide further insight into

51 s, establishing a link between the proneural transcriptional network and the subtype-specific deletio

52 Changes in transcriptional networks and chromatin state lie at the

53 sults reveal how the cell cycle orchestrates transcriptional networks and epigenetic modifiers to ins

54 ransients for understanding morphogen-driven transcriptional networks and indicates that gene express

55 PRi-based approach can be applied to dissect transcriptional networks and interpret the contributions

56 grative network biology approach to identify transcriptional networks and key driver genes that regul

57 identified guide RNAs (gRNAs) that modulate transcriptional networks and protect cells from alpha-sy

58 proteome, largely accomplished by remodeling transcriptional networks and protein degradation.

59 ight recent progress in our understanding of transcriptional networks and proteolysis that illustrate

60 These receptors activate transcriptional networks and signaling cascades controll

61 changes in TF binding intensity in mammalian transcriptional networks and suggest that some TF-depend

62 de insights into the complex interplay of NR transcriptional networks and their contribution to the d

63 en delivered by XgDeltaavrHah1 By perturbing transcriptional networks and/or modifying the plant cell

64 immune cell subsets, activation of specific transcriptional networks, and upregulation of immune che

65 Transcriptional networks are reconfigured by changes in

66 Pluripotent-specific transcriptional networks are sequentially reactivated as

67 vascular expansion and define the FOXO1-MYC transcriptional network as a novel metabolic checkpoint

68 In order to define the transcriptional network associated with oxidative stress

69 plant transcription factor in modulating the transcriptional network associated with plant immunity.

70 ession and have been shown to fine-tune gene transcriptional networks because single miRNAs can targe

71 offers a basis for discovering the potential transcriptional network behind one of the most abundant

72 nd will serve as a basis for discovering the transcriptional network behind one of the most abundant

73 une cells, searching for gene expression and transcriptional networks belonging to specific cellular

74 tor-binding sites shed light on differential transcriptional networks between subgroups, whereas incr

75 Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements

76 onstrated that ERG and ETV1 control a common transcriptional network but largely in an opposing fashi

77 GATA-1, SCL, and Klf1 form an erythroid core transcriptional network by co-occupying >300 genes.

78 In mouse embryonic stem cells (mESCs), the transcriptional network can be divided into three functi

79 amatically improve the efficiency with which transcriptional networks can be analyzed, making genomic

80 In addition to biochemical gradients and transcriptional networks, cell behavior is regulated by

81 lengthening of telomeres (ALT) and aberrant transcriptional networks centering on mitochondrial biol

82 tor GLK1, a key regulator of a light-induced transcriptional network central to photomorphogenesis.

83 ignaling, and the activity of cell-intrinsic transcriptional networks change dynamically during patte

84 Bacterial transcriptional networks consist of hundreds of transcri

85 The TH17 transcriptional network consists of two self-reinforcing

86 shared human-mouse cross-species glomerular transcriptional networks containing 143 (Human-DBA STZ),

87 extracellular signals and dynamic control of transcriptional networks contribute to the correct spati

88 redox reaction inhibits the MEF2C-PGC1alpha transcriptional network, contributing to mitochondrial d

89 Transcriptional networks control the differentiation of

90 tudy provides comprehensive profiling of the transcriptional network controlled by C/EBPepsilon durin

91 tributable to disruption of a BPDCN-specific transcriptional network controlled by TCF4-dependent sup

92 ctively, our work provides insights into the transcriptional networks controlled by WT1 and identifie

93 these genes are linked functionally and the transcriptional networks controlling hair cell induction

94 lly mapped key regulators, bioprocesses, and transcriptional networks controlling lung maturation, pr

95 le we have considerable understanding of the transcriptional networks controlling mammalian cell diff

96 accessibility data allowed us to reconstruct transcriptional networks controlling photoreceptor diffe

97 n cereals will enable to further unravel the transcriptional networks controlling this important yiel

98 eproductive structures require Cu, and which transcriptional networks coordinate Cu delivery to repro

99 n parallel with cognitive processes, a novel transcriptional network coordinating brain structural or

100 1alpha co-activator that regulates the HIF-1 transcriptional network, crucial for cancer development.

101 icant progress has been made in defining the transcriptional networks directly regulated by PIFs, as

102 geted and effective gene product in the core transcriptional network downstream from the growth facto

103 tions of LHX1, we mapped the VIP-independent transcriptional network downstream of LHX1 and a largely

104 Further, TCP4 modulates the common transcriptional network downstream to auxin-BR signaling

105 Identifying the underlying transcriptional network driving these changes, and how t

106 his suggests that AGL22 uniquely regulates a transcriptional network during drought stress, linking c

107 a mechanism would permit the fine-tuning of transcriptional networks during differentiation.

108 xymethylated DNA is associated with specific transcriptional networks during heart development and fa

109 ophila and now also vertebrates suggest that transcriptional network dynamics are central to the gene

110 lineage segregation, miR-337-3p controls the transcriptional network dynamics of developing hepatocyt

111 otation of the genome and expand our view of transcriptional network dynamics.

112 olecular and genetic studies have revealed a transcriptional network encompassing a group of wood-ass

113 We performed an integrated analysis of transcriptional network evolution by examining mRNA expr

114 Strikingly, we found that transcriptional networks evolve at a common rate across

115 ation changes occur within 10 d, whereas the transcriptional network evolves over 2 months to resembl

116 The Mll-dependent transcriptional network extends well beyond the previous

117 ays puberty by impairing the transition of a transcriptional network from an immature repressive epig

118 esis that FKBP1b also can protect downstream transcriptional networks from aging-induced dysregulatio

119 R), that acts as a dominant negative of SND1 transcriptional network genes in Populus trichocarpa.

120 Thus, we identify ATF5 as a member of the transcriptional network governing pancreatic beta-cell s

121 proach provides a foundation for elucidating transcriptional networks guiding the development of the

122 This transcriptional network has significant overlap with the

123 ure of experimental information on bacterial transcriptional networks have prevented their systematic

124 ising direct link between two major cellular transcriptional networks, highlighting a previously unre

125 d KDM6A mutations, upregulation of the TP63N transcriptional network, hypermethylation of pancreatic

126 r cell including the rapid mobilization of a transcriptional network implicated in accelerated growth

127 indings identify alterations in a regulatory transcriptional network in adipocytes involving the dysr

128 particular, we identified an AP-1 regulated transcriptional network in dlPFC neurons associated with

129 r the repressive branch of the sugar sensing transcriptional network in Drosophila.

130 chanism that represses the core pluripotency transcriptional network in ESCs, allowing ESCs to transi

131 Here we elucidate a temperature-responsive transcriptional network in H. capsulatum, which switches

132 y and characterize part of the Mll-dependent transcriptional network in hematopoietic stem cells with

133 results reveal novel roles for PBX1 and its transcriptional network in mDAn development and PD, open

134 ings reveal that a large part of the complex transcriptional network in metastasis can be controlled

135 y Eya1 and Six1 as key components of the Shh transcriptional network in normal development and in onc

136 ish the landscape of SE-associated oncogenic transcriptional network in NPC, which can be exploited f

137 omprehensive analysis of the genome-wide WT1 transcriptional network in podocytes in vivo using chrom

138 d regulation of the primary, PIF3-controlled transcriptional network in response to initial light exp

139 and malignant lymphoid cells reveals a novel transcriptional network in transformed lymphoid cells ex

140 in testis cell types originate from modified transcriptional network in undifferentiated spermatogoni

141 nd that lncRNA knockdown can perturb complex transcriptional networks in a cell type-specific manner.

142 pression programs and temporal regulation of transcriptional networks in a mammalian genome.

143 t-A-iTreg cells dampened crucial TH2-skewing transcriptional networks in DCs.

144 cyte development and viability; however, WT1 transcriptional networks in podocytes remain elusive.

145 -throughput sequencing to analyze global p53 transcriptional networks in primary mouse embryo fibrobl

146 a systems biology approach to identify host transcriptional networks in such cells and study the con

147 While the role of transcriptional networks in these processes is increasin

148 on of flavonoid decorating enzymes and their transcriptional networks in various plant species.

149 data we define a comprehensive human breast transcriptional network, including a set of myoepithelia

150 gene expression profiling characterized the transcriptional networks induced in tolerogenic DCs by A

151 The proposed pipeline for transcriptional network inference and comparison is high

152 Starting from chemical-specific transcriptional networks inferred from these data, we sh

153 To this end, we characterized the transcriptional network initiated by the type-B ARABIDOP

154 and survival, and implicated that the c-Myc transcriptional network is deregulated following JMJD1A

155 egulation of T-cell factors so that a T-cell transcriptional network is maintained.

156 GRACE can improve our understanding of how a transcriptional network is re-wired in cancer.

157 we also show that the identified TCF7L2-ISL1 transcriptional network is regulated in a genotype-depen

158 ed in DRA ommatidia, the role of Hth in this transcriptional network is uncharacterized.

159 The regulation of cell-specific transcriptional networks is accomplished by an epigeneti

160 ombines the activity of a morphogen with the transcriptional network it controls.

161 o express a regulatory gene participating in transcriptional networks leading to photoreceptor genesi

162 Our data support the hypothesis that a transcriptional network may exist among key TFs in the m

163 that target both the MAPK pathway and Mist1 transcriptional networks may show promising efficacy in

164 differentiation, these poorly characterized transcriptional networks may underlie the etiology and b

165 ggesting differential signaling pathways and transcriptional network mechanisms that lead to the acti

166 unctions in part by inhibiting the HNF4alpha transcriptional network mediated through the Rho/Rho-ass

167 choice implying that etv2 participates in a transcriptional network mediating developmental plastici

168 pulation-specific gene regulation as well as transcriptional network modification.

169 Collectively, our data suggest that the transcriptional networks modulated by FOXO1 in VMH neuro

170 This activity results in blocking the core transcriptional network necessary for endoderm specifica

171 regulatory factor 4 (IRF4) is central to the transcriptional network of activated B-cell-like diffuse

172 In addition, Eomes activates a transcriptional network of core regulators of endodermal

173 master switch regulating the expression of a transcriptional network of genes integral to autophagy a

174 While the transcriptional network of human embryonic stem cells (h

175 Thus, we position Tshz1 in the transcriptional network of maturing beta-cells and sugge

176 However, the mode of action and transcriptional network of nuclear AURKA in BCSCs remain

177 TF mutant library provides key insights into transcriptional networks of basidiomycetous fungi and hu

178 critical roles for the identified miRNAs in transcriptional networks of the developing human brain a

179 e network function, here we deconvoluted the transcriptional networks on the same datasets using ARAC

180 Transcriptional networks orchestrate complex development

181 tiation was defined more subtly by nonrandom transcriptional network organization, with roles in thes

182 Reverse engineering of transcriptional networks plays a key role in the underst

183 We show that, when coupled to a downstream transcriptional network, pre-steady-state measurement of

184 vertebrate neural tube, a morphogen-induced transcriptional network produces multiple molecularly di

185 y signaling pathways and a core pluripotency transcriptional network (PTN) comprising Nanog, Oct4, an

186 are responsive to chromosomal stress and the transcriptional network regulated by p53.

187 Genome-wide analysis of the transcriptional network regulated by RAO2/ANAC017 under

188 c chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2, acting via m

189 Using a genomics approach, we identified the transcriptional networks regulated by Foxp1 in the devel

190 lysis of The Cancer Genome Atlas to identify transcriptional networks regulated by TAp63 and DeltaNp6

191 Transcriptional networks, regulated by extracellular sig

192 The transcriptional network regulating antibody-secreting ce

193 Combined, these findings define a novel transcriptional network regulating oncogenic EGFR signal

194 However, the WT1-dependent transcriptional network regulating podocyte development

195 Elucidation of the transcriptional networks regulating HC fate determinatio

196 surfactant proteins, lipid transporters, and transcriptional networks regulating their expression has

197 Here, we show that PBX1 controls a novel transcriptional network required for mDAn specification

198 ese findings reveal the presence of a robust transcriptional network required to produce functional M

199 ncing, we have identified a TCF7L2-regulated transcriptional network responsible for its effect on in

200 However, the transcriptional networks responsible for controlling the

201 Transcriptional networks revealed that the dominant phot

202 ental origins of LCs, reports addressing the transcriptional network ruling their differentiation rem

203 The generation of rewired transcriptional networks, selection for specific phenoty

204 ditionally, identification of protumorigenic transcriptional networks specific to RB loss that were v

205 ese findings reveal an environment-dependent transcriptional network specifying microglia-specific pr

206 necrosis factor therapy effects on specific transcriptional networks, suggesting that enhanced TSP-1

207 d is therefore critical for establishing the transcriptional network that controls GC B cell and plas

208 result, great progress in understanding the transcriptional network that controls photoreceptor spec

209 ng sets of target genes generate the complex transcriptional network that controls the Plasmodium lif

210 ene regulation in the chambers, the complete transcriptional network that controls these patterns rem

211 found to modulate the expression of a large transcriptional network that cooperates with androgen re

212 VttR(A) and VttR(B) act as part of a complex transcriptional network that coordinates virulence gene

213 3 is a key component of a highly coordinated transcriptional network that determines the balance of i

214 sclerotome are specified appropriately, the transcriptional network that drives early chondrogenesis

215 Our findings delineate a post-transcriptional network that governs breast cancer metas

216 of disease, delineation of the AR-dependent transcriptional network that governs disease progression

217 r with genetic perturbations, this reveals a transcriptional network that integrates opposing retinoi

218 em cells (mESCs) relies on the activity of a transcriptional network that is fuelled by the activity

219 growth to defense but rather by a conserved transcriptional network that is hardwired to attenuate g

220 inal function, but little is known about the transcriptional network that maintains these cells in th

221 have been extensively studied, the upstream transcriptional network that modulates their levels and

222 a novel role for Mef2c/d in coordinating the transcriptional network that promotes early B-cell devel

223 We reverse-engineered a transcriptional network that provides a mechanistic basi

224 cription factors positioned at the apex of a transcriptional network that regulates a diversity of do

225 ude that BCL11A is a critical component of a transcriptional network that regulates B cell fate by co

226 ude that BCL11A is a critical component of a transcriptional network that regulates B cell fate by co

227 d earlier studies, we present a model of the transcriptional network that regulates early steps of su

228 ndings reveal a novel role of HNF-1beta in a transcriptional network that regulates intrarenal choles

229 These results uncover an important transcriptional network that regulates metabolism, oxida

230 Little is known about the transcriptional network that regulates PD duplication.

231 nt of the DRA-specific factor Hth alters the transcriptional network that regulates Rhodopsin express

232 ctor independence 1 (Gfi-1) is a part of the transcriptional network that regulates the development o

233 ic physiology, but little is known about the transcriptional network that regulates their development

234 ring 26S proteasome capacity, we defined the transcriptional network that responds to this stress in

235 this work, we describe the structure of the transcriptional network that specifies the white and opa

236 nase, and by the activation of an intestinal transcriptional network that upregulates delta-9 fatty a

237 , many essential components of the beta cell transcriptional network that were down-regulated in the

238 xpression analysis was conducted to identify transcriptional networks that are responsive to the cons

239 ysis of the extrinsic signals and downstream transcriptional networks that assign cell fates in the c

240 We explored the transcriptional networks that CHD8 regulates in neural p

241 t of an organism would facilitate mapping of transcriptional networks that control cell-fate decision

242 rful new tools to study the functionality of transcriptional networks that control developmental proc

243 The mechanisms of root iron uptake and the transcriptional networks that control root-level regulat

244 Our study reveals novel transcriptional networks that control stress susceptibil

245 provide novel insight on the nonoverlapping transcriptional networks that control the differentiatio

246 nes is known, little is understood about the transcriptional networks that coordinate their expressio

247 regulator of the stem cell state by inducing transcriptional networks that drive pluripotency.

248 Many of the transcriptional networks that drive reprogramming of a s

249 Identification of the transcriptional networks that ensure the proper specific

250 every cell is maintained by highly specific transcriptional networks that establish a coherent molec

251 a set of conserved organizing principles and transcriptional networks that govern PR subtype differen

252 Transcriptional networks that govern secretory cell spec

253 A-PKcs functions as a selective modulator of transcriptional networks that induce cell migration, inv

254 Focusing on transcriptional networks that induce peroxisomes biogene

255 Second, gradients initiate transcriptional networks that integrate broadly distribu

256 To identify brain transcriptional networks that may predispose an animal t

257 ent goal of molecular biology is to identify transcriptional networks that regulate cell differentiat

258 ivo several key drivers and their associated transcriptional networks that regulate depression suscep

259 understanding of the signaling pathways and transcriptional networks that regulate effector and memo

260 As PAX3 and PAX7 are part of transcriptional networks that regulate muscle stem cell

261 Studies of the transcriptional networks that regulate nuclear receptor-

262 sition of the ENS, little is known about the transcriptional networks that regulate the diversificati

263 me maps are critical for elucidating complex transcriptional networks that underlie growth, behavior,

264 To unravel the transcriptional networks that underlie the development o

265 programmed in vitro by forced changes to the transcriptional network, the most dramatic example of wh

266 However, the transcriptional network through which BZR1 regulates fru

267 s in inaccessible chromatin to establish new transcriptional networks throughout development and cell

268 loping vasculature, potentially linking this transcriptional network to diseases with compromised vas

269 We generated a transcriptional network to explore how transcription fac

270 tivation triggers the noncanonical NF-kappaB transcriptional network to induce genes identified in hu

271 side-by-side analysis of the response of the transcriptional network to perturbation sheds a new ligh

272 d environmental signals converge on a common transcriptional network to promote cell elongation.

273 dr5, Pask integrates signaling cues with the transcriptional network to regulate the differentiation

274 sms ranging from repressing genes in the p53 transcriptional network to regulating mRNA translation a

275 However, the response of the transcriptional network to RUNX1-ETO expression is devel

276 inhibitors modulated the RORgammat-dependent transcriptional network to varying extents and through d

277 ave evolved adaptive strategies that involve transcriptional networks to cope with and survive enviro

278 e their multifunctional nature to alter host transcriptional networks to elicit a diverse set of cell

279 ng pathways that trigger distinct downstream transcriptional networks to regulate the diversity of ne

280 nized into 11 modules, provided insight into transcriptional network topology as well as grouping gen

281 l benefit from improved understanding of the transcriptional network underlying cambial growth and wo

282 ator of lymphatic vessel development and the transcriptional network underlying lymphatic vascular re

283 und that ERVs have shaped the evolution of a transcriptional network underlying the interferon (IFN)

284 vealed that p53 is a master regulator of the transcriptional network underlying the proneural phenoty

285 The transcriptional network underlying this carefully script

286 have contributed to our understanding of the transcriptional networks underlying Arabidopsis root end

287 r target genes is essential for modeling the transcriptional networks underlying developmental proces

288 loyed in computational analyses to model the transcriptional networks underlying wood formation, incl

289 Reverse engineering of transcriptional networks using gene expression data enab

290 high-throughput and unbiased perturbation of transcriptional networks via randomized crisprTFs can re

291 3, 4, and 5, in relaying such signals to the transcriptional network, we compared the shade-responsiv

292 Species-specific transcriptional networks were generated and compared wit

293 5 at the center of a stoichiometry-sensitive transcriptional network, where it acts as a molecular sw

294 F4-aryl hydrocarbon receptor (AhR)-dependent transcriptional network, which generates suppressive hum

295 Metazoan development is regulated by transcriptional networks, which must respond to extracel

296 The human-mouse shared glomerular transcriptional networks will assist DN researchers in s

297 s of glucose-TOR signalling in unprecedented transcriptional networks wiring central metabolism and b

298 The genome-wide perturbation of transcriptional networks with CRISPR-Cas technology has

299 We also analyzed the transcriptional network within which these genetic eleme

300 quires changes to chromatin architecture and transcriptional networks, yet whether other regulatory e