ライフサイエンスコーパス: transcriptional repression

1 (miRNAs) to identify mRNAs targeted for post-transcriptional repression.

2 ts of VAL1, acting through epigenetic and/or transcriptional repression.

3 mechanism based on DNA methylation-mediated transcriptional repression.

4 richia coli can be co-opted for programmable transcriptional repression.

5 ification, which is strongly associated with transcriptional repression.

6 showed that these mutations compromise REST transcriptional repression.

7 he IL-2 promoter permissive to Foxp3-induced transcriptional repression.

8 lar, Xrn1 catalytic activity is required for transcriptional repression.

9 specific gene loci, which is associated with transcriptional repression.

10 use of an alteration of PcG protein-mediated transcriptional repression.

11 repressors and release of MYC proteins from transcriptional repression.

12 acetylation of lysine 9/14 of histone 3 and transcriptional repression.

13 yoR interacts directly with Gata4 to mediate transcriptional repression.

14 encing machinery that it recruits to enforce transcriptional repression.

15 er of the genome is thought to contribute to transcriptional repression.

16 ing of the mechanisms underlying AR-mediated transcriptional repression.

17 ers at HML and HMR, the critical targets for transcriptional repression.

18 2A, a chromatin modification associated with transcriptional repression.

19 Ankrd1 deletion additionally relieved MMP10 transcriptional repression.

20 ulatory loop, whereas Jmjd2c assists PRC2 in transcriptional repression.

21 ome, macroH2A1 was thought to play a role in transcriptional repression.

22 ins are dominant targets of EWS/FLI-mediated transcriptional repression.

23 ization, interactions with co-regulators and transcriptional repression.

24 tified as a direct target of Snail1-mediated transcriptional repression.

25 the prepupal stage by increasing the rate of transcriptional repression.

26 ne 3 lysine 27 (H3K27), a mark important for transcriptional repression.

27 ment provides a link between DSB repairs and transcriptional repression.

28 nsformation ex vivo, presumably by enhancing transcriptional repression.

29 ers of the SRC-1 interactome responsible for transcriptional repression.

30 7 (H3K27me3), a modification associated with transcriptional repression.

31 f WT1 target genes to elicit BASP1-dependent transcriptional repression.

32 ed for recruiting the co-repressor CtBP1 and transcriptional repression.

33 other sites throughout the genome to effect transcriptional repression.

34 s, protein kinase pathways, DNA binding, and transcriptional repression.

35 b group (PcG) complexes such as PRC1 mediate transcriptional repression.

36 n the methylation of the SAMHD1 promoter and transcriptional repression.

37 tems in which ERK induces genes by relief of transcriptional repression.

38 oter, epigenetic changes that correlate with transcriptional repression.

39 Histone deacetylation occurred after transcriptional repression.

40 proteins and causes chromatin compaction and transcriptional repression.

41 me sliding activity of Fun30 and its role in transcriptional repression.

42 and release of a tail fragment that mediates transcriptional repression.

43 ethyl-CG dinucleotides is not sufficient for transcriptional repression.

44 thylation varies with genomic context beyond transcriptional repression.

45 r Ago-2: one in pre-mRNA splicing and one in transcriptional repression.

46 ressive Complex 2 (PRC2) and associated with transcriptional repression.

47 ongly with the Gadd45a promoter and mediates transcriptional repression.

48 e promoters of these genes, leading to their transcriptional repression.

49 nes, leading to H3K4me2 demethylation and to transcriptional repression.

50 protein is not sufficient to establish such transcriptional repression.

51 DNA methylation is associated with transcriptional repression.

52 that regulate stem cell differentiation via transcriptional repression.

53 on of transcription, usually associated with transcriptional repression.

54 enetic signal for chromatin condensation and transcriptional repression.

55 n and recognition required for XIST-mediated transcriptional repression.

56 n, resulting in condensed chromatin and gene transcriptional repression.

57 assembly, resulting in decreased H3K4me3 and transcriptional repression.

58 s and other transcription factors leading to transcriptional repression.

59 ssociated with host-antiviral resistance and transcriptional repression.

60 requirement of MDM4 to promote p53-mediated transcriptional repression.

61 V selectively degrades IFI16, thus relieving transcriptional repression.

62 s N-CoR binding at NHR4, displays attenuated transcriptional repression ability and decreased cellula

63 rdinately functions as a master regulator of transcriptional repression, activation, and oncogenesis

64 ct histone signatures including two modes of transcriptional repression, active repression (hypoacety

65 nt ternary complex is required for the known transcriptional repression activities mediated by UBC9 a

66 tion factor Sharp-1 is required for its full transcriptional repression activity and function as an i

67 nged protein half life and exhibited reduced transcriptional repression activity compared to wild-typ

68 ependent epigenetic environment promotes the transcriptional repression activity of c-Myc for gene-sp

69 BASP1 interacts with WT1 and mediates WT1's transcriptional repression activity.

70 not exhibit previously described long-range transcriptional repression activity.

71 determined by in vivo promoter occupancy and transcriptional repression activity.

72 lves concomitant loss of KLF-4-HDAC-mediated transcriptional repression and active recruitment of SAF

73 ion of mutant and endogenous ETV6, decreased transcriptional repression and altered megakaryocyte mat

74 Salt stress triggers a simultaneous transcriptional repression and aquaporin internalization

75 These data suggest that PIP transcriptional repression and channel internalization a

76 analyses of mutant alleles that separate the transcriptional repression and clustering functions of S

77 control gene expression using mechanisms of transcriptional repression and derepression.

78 comb RING finger homologs that are linked to transcriptional repression and developmental gene regula

79 e possibility that the functions of ino80 in transcriptional repression and developmental timing are

80 on in the male germline and are required for transcriptional repression and for physical interaction

81 f action facilitates rapid switching between transcriptional repression and gene activation through t

82 repressive complex 2 (PRC2) mainly mediates transcriptional repression and has essential roles in va

83 ly, HOTAIR is a direct target of ER-mediated transcriptional repression and is thus restored upon the

84 regulating genes, and reveals a link between transcriptional repression and mitophagy, which is also

85 effects on NNMT were caused by PAX3-mediated transcriptional repression and overexpression of NNMT bl

86 rst time how Hha and H-NS interact to direct transcriptional repression and reveal that a positively

87 , a conserved eukaryotic protein involved in transcriptional repression and splicing in animals.

88 al C-terminal domain, which is necessary for transcriptional repression and sufficient for toxin neut

89 ed with enhancers, transcription initiation, transcriptional repression, and others.

90 This relationship explains why transcriptional repression appears to occur via protein

91 Here we present a modular transcriptional repression architecture based on cluster

92 er repressed mRNAs and the mechanism of post-transcriptional repression are currently unknown.

93 d molecular basis underlying SFMBT1-mediated transcriptional repression are poorly elucidated.

94 anscriptional activation) and negative (i.e. transcriptional repression) arms of the circadian regula

95 This connection involves transcriptional repression as previously shown, but also

96 ring roles for SF1 in pre-mRNA retention and transcriptional repression, as well as in splicing, futu

97 e repressor complex architecture maintaining transcriptional repression at theSUC2gene.

98 For its role in transcriptional repression, BCL11A was found to interact

99 ontains domains for self-multimerization and transcriptional repression, both of which have been prop

100 transcriptional corepressor that potentiates transcriptional repression by B cell leukemia/lymphoma 6

101 cent transcription, we find that HDACI cause transcriptional repression by blocking RNA polymerase II

102 ementary to the associated piRNA and induces transcriptional repression by establishing a repressive

103 hese findings highlight a novel mechanism of transcriptional repression by HNF6 and demonstrate how o

104 ls in dispersed MCL cells were due to direct transcriptional repression by hypoxia-induced factor 1al

105 ith reduced gene expression, consistent with transcriptional repression by KLF6.

106 is then down-regulated, in part through post-transcriptional repression by microRNAs, to allow normal

107 As Sin3b is also required for transcriptional repression by Mxd-Max complexes, our res

108 ell appreciated, physiological importance of transcriptional repression by NF-kappaB in cancer has re

109 hat is likely to have broad implications for transcriptional repression by orphan nuclear receptors.

110 system that exhibits CG methylation-specific transcriptional repression by purified human MeCP2.

111 n PPARgamma is abundant, PPARgamma abrogated transcriptional repression by Sp1 at the Atgl promoter a

112 ing a novel role for this variant histone in transcriptional repression by the dREAM complex.

113 ells as a quantitative phenotypic readout of transcriptional repression by the dREAM complex.

114 Transcriptional repression by uSTAT5 reflects restricted

115 ingly, epigenetic analyses indicate that the transcriptional repression caused by the ATF-SKD is not

116 epressor prohibitin is part of the WT1-BASP1 transcriptional repression complex.

117 y cognate corepressor proteins into specific transcriptional repression complexes that target HDAC ac

118 form the catalytic subunit of several large transcriptional repression complexes.

119 s) for targeting nuclease-dead Cas9-mediated transcriptional repression (CRISPRi) and activation (CRI

120 r the methyl-CpG binding domain (MBD) or the transcriptional repression domain (TRD).

121 s Wdr68 for craniofacial development, that a transcriptional repression domain fusion, MadFlagWdr68,

122 ys a novel and important role in stabilizing transcriptional repression during C. elegans sex determi

123 prisingly, very low levels of PTMs linked to transcriptional repression even at silent HBV promoters.

124 For archaea currently no tools for transcriptional repression exist.

125 Inactivating mutations in the transcriptional repression factor Capicua (CIC) occur in

126 f its promoter by OsGATA12, which suggests a transcriptional repression function for a GATA transcrip

127 colleagues describe an NF-kappaB independent transcriptional repression function for SUMOylated Ikapp

128 FoxM1b also possesses transcriptional repression function.

129 factor b1 (Safb1), primarily associated with transcriptional repression, functions as a positive regu

130 These modifications are heavily involved in transcriptional repression, gene regulation, development

131 Although their mechanism of transcriptional repression has been well studied for ove

132 ponents of this complex and the mechanism of transcriptional repression have not been characterized.

133 ns of Rap1 to telomere length regulation and transcriptional repression have yielded significant mech

134 Lack of TF binding leads to reversible transcriptional repression imposed by nucleosomal compac

135 ng, alter subcellular localization, decrease transcriptional repression in a dominant-negative fashio

136 e repurposed AsCpf1 and LbCpf1 for efficient transcriptional repression in Arabidopsis, and demonstra

137 get genes suggested that SRC-1 also mediates transcriptional repression in breast cancer cells.

138 11 interaction with p107 was associated with transcriptional repression in cells with low MAGE-A11 an

139 We consistently observe transcriptional repression in proximity to DSBs.

140 this, we observe no evidence for persistent transcriptional repression in response to a multi-day co

141 zinc homeostasis and showed that it mediates transcriptional repression in response to zinc.

142 rules that determine gRNA effectiveness for transcriptional repression in Saccharomyces cerevisiae.

143 ell imaging to detect and track nuclear RNAi transcriptional repression in single living human cells.

144 s FBXL3 separately regulates the duration of transcriptional repression in the nucleus.

145 ents led to a repressed epigenetic state and transcriptional repression in the ventricular zone.

146 CCL8, as a direct target of Blimp1-mediated transcriptional repression in these cells.

147 ght to primarily regulate gene expression by transcriptional repression, in this study, we discover t

148 Transcriptional repression includes the 5-Htr2a serotoni

149 promoters in a CG context is associated with transcriptional repression, including at genes silenced

150 for most of the Fur regulon, Fur binding and transcriptional repression increase under anaerobic cond

151 echanism mediating pathogenesis is excessive transcriptional repression induced by the expanded ATXN-

152 Transcriptional repression involves a class of proteins

153 ry, these studies suggest that E2F8-mediated transcriptional repression is a critical tumor suppresso

154 Transcriptional repression is a pervasive feature of ani

155 xin (FXN) protein and evidence suggests that transcriptional repression is caused by an R-loop that f

156 stone modification typically associated with transcriptional repression-is more enriched at the promo

157 d with increased gene promoter levels of the transcriptional repression mark H3K27me3 (histone 3 lysi

158 H3 at lysine 9 (H3K9), which is generally a transcriptional repression mark, is demethylated by H3K9

159 to decreased H3K27 trimethylation, a histone transcriptional repression mark.

160 regulation of Sirt1 function that results in transcriptional repression may be the cause of various s

161 the sequence and functional contribution of transcriptional repression mechanisms at high temporal r

162 owever, the biological significance of these transcriptional repression mechanisms remains unclear.

163 In this study, I found that RNF4 antagonizes transcriptional repression mediated by DNA methylation.

164 on of these cell cycle genes by antagonizing transcriptional repression mediated by p53.

165 Here we show that transcriptional repression, mediated by the zinc-finger

166 r studies indicate that equivalent levels of transcriptional repression occur by direct interaction o

167 in the SCN stays near the population mean if transcriptional repression occurs via protein sequestrat

168 own synthesis in stromal cells by signaling transcriptional repression of 15-PGDH elucidates long so

169 Mechanistically, we noticed transcriptional repression of 5-LO by proto-oncogene c-M

170 roto-oncogene c-Myb in TAMs induced a stable transcriptional repression of 5-LO.

171 cells are largely the result of a permanent transcriptional repression of a certain set of genes in

172 utagenesis studies suggest that the observed transcriptional repression of AChE is mediated by the E1

173 Furthermore, we demonstrated that transcriptional repression of AFP gene by ZBTB20 was liv

174 tion and expression of customized sgRNAs for transcriptional repression of any gene of interest.

175 , that is early down-regulated and induces a transcriptional repression of ATZ expression.

176 ancy in the CLV1 clade is in fact due to the transcriptional repression of BAM genes by CLV1 signalin

177 These include regulation of telomere length, transcriptional repression of both telomere-proximal gen

178 s (EMT) in cancer metastasis, acting through transcriptional repression of CDH1 (encoding E-cadherin)

179 Fs act as tumor suppressors, most likely via transcriptional repression of cell cycle genes in respon

180 E2F-mediated transcriptional repression of cell cycle-dependent gene

181 esis was mediated, at least in part, by post-transcriptional repression of Cp110, a centriolar protei

182 IL-10-induced transcriptional repression of CXCL8 and TNFA genes consi

183 e H3 lysine 27 trimethylation (H3K27me3) and transcriptional repression of differentiation genes.

184 Transcriptional repression of Dnmt1 by REMOTE-control wa

185 romatin remodeling protein INO80 facilitates transcriptional repression of ecdysone-regulated genes d

186 normal higher-order chromatin structure and transcriptional repression of environmental stress respo

187 Snai1-mediated transcriptional repression of epithelial genes depends o

188 LSD1 to chromatin, demethylation of H3K4me2, transcriptional repression of epithelial markers, and in

189 activity, while the HDAC4 mutation increased transcriptional repression of ESRRA.

190 ggested that DMRT1 controls pluripotency via transcriptional repression of Esrrb, Nr5a2/Lrh1, and Sox

191 enetic epistasis experiments show that MECP2 transcriptional repression of Evf2 and Dlx5, but not Dlx

192 ed binding of Dax1 to Sf1 to further enhance transcriptional repression of FAdE.

193 peats in intron 1 of the FXN gene leading to transcriptional repression of frataxin expression.

194 for mammalian development and implicated in transcriptional repression of genes and transposons.

195 dysregulation of innate immune responses and transcriptional repression of genes associated with memo

196 s an epigenetic modification involved in the transcriptional repression of genes controlling a variet

197 emia is partly because of its role in direct transcriptional repression of genes that limit the self-

198 ic and oncosuppressor effects rely on direct transcriptional repression of Gli1 and Gli2 effectors of

199 , we identify a novel B-lymphoid program for transcriptional repression of glucose and energy supply.

200 HCT116 colon cancer cells and NME2-mediated transcriptional repression of hTERT in these cells.

201 n with chemotherapies relieves ATF2-mediated transcriptional repression of IFNbeta1, resulting in imp

202 data indicate a novel role of PARP-1 in the transcriptional repression of integrated retroviruses.

203 cell expansion and effector function through transcriptional repression of Irf4.

204 nd function of CD8(+) T cells through direct transcriptional repression of Irf4.

205 nsducer and activator of transcription 5 and transcriptional repression of its negative regulators.

206 Thus G9a has a dominant function in transcriptional repression of K(+) channels and in acute

207 The transcriptional repression of key genes, induced by TCF1

208 s cardiomyocyte oxygen consumption by direct transcriptional repression of lipid metabolising genes.

209 ve to the c-MYC-uninduced livers, indicating transcriptional repression of miR-122 in c-MYC-overexpre

210 NF-kappaB is the downstream pathway for the transcriptional repression of MMP-3 in CAFs.

211 indicate that G9a contributes critically to transcriptional repression of MORs in primary sensory ne

212 umour (Brat) and Pumilio (Pum)-mediated post-transcriptional repression of mRNAs, including that enco

213 en phenotypes were caused by the direct post-transcriptional repression of multiple Notch pathway pro

214 exerts an impact on chromatin structure and transcriptional repression of muscle gene expression thr

215 I-BET151 causes transcriptional repression of MYC and MYC-dependent prog

216 Thus, we predict defective transcriptional repression of MYC by the Hfp orthologue,

217 duction of the smooth muscle lineage through transcriptional repression of Myocardin.

218 Therefore, transcriptional repression of Nestin by p53 restricts ce

219 reprogramming is accompanied by a transient transcriptional repression of Netrin-1 mediated by an Mb

220 stained in hepatic cells, largely because of transcriptional repression of nicotinamide phosphoribosy

221 muscle cell fusion correlates well with the transcriptional repression of Npnt, Itgb1D and Cav3, gen

222 ranscriptional regulatory complex and causes transcriptional repression of oncogenes MYC and CCND1.

223 deprivation of an essential nutrient induces transcriptional repression of organellar biogenesis invo

224 ctivates transcription factors, highlighting transcriptional repression of other transcription factor

225 es restricted to the optic cup by reciprocal transcriptional repression of pax6 and pax2 However, it

226 s suggest that the release of DISC1-mediated transcriptional repression of PDE4D9 acts as feedback in

227 e of Polycomb repressive complex 2, mediates transcriptional repression of prodifferentiation genes i

228 hways and transcription factors that mediate transcriptional repression of Rag.

229 DSBs induced in pre-B cells signal rapid transcriptional repression of Rag1 and Rag2, causing dow

230 phosphorylated and inhibited FOXO1-dependent transcriptional repression of rhotekin 2 (RTKN2), an oxy

231 es (such as Jurkat and Sup-T1), resulting in transcriptional repression of SAMHD1.

232 This regulation requires transcriptional repression of SIRT4, the mitochondrial-l

233 While SMAR1-dependent transcriptional repression of Slug by direct recruitment

234 Together, these data demonstrate that transcriptional repression of soma-specific genes by PRC

235 inase c-Abl increases HDAC2 levels, inducing transcriptional repression of synaptic genes.

236 regulation of gamma-glutamyltransferases and transcriptional repression of system xc(-) cystine and g

237 Cs by way of two distinct mechanisms, direct transcriptional repression of target fibrogenic genes an

238 Transcriptional repression of target genes is dependent

239 that participates in Polycomb group-mediated transcriptional repression of target genes such as the f

240 (TGF)-beta signaling through Notch-mediated transcriptional repression of TGF-beta pathway genes.

241 Dose-dependent transcriptional repression of the AR by MM45 has been de

242 CDC25A cooperates with previously described transcriptional repression of the CDC25A promoter and pr

243 during mouse heart development in the direct transcriptional repression of the fast-twitch skeletal m

244 the triplet-repeat sequence (GAA.TTC) cause transcriptional repression of the Frataxin gene (FXN) le

245 We determined that Myc-mediated transcriptional repression of the miR-15 and let-7 famil

246 ks cell cycle exit via methylation-dependent transcriptional repression of the MyoD target genes p21(

247 In mice, transcriptional repression of the paternal X-chromosome

248 osis requires STAT and Wg and is mediated by transcriptional repression of the pro-apoptotic gene rea

249 ial sugar utilization has been attributed to transcriptional repression of the secondary metabolic pa

250 rthermore, the introduced methylation causes transcriptional repression of the targeted genes.

251 erlying the tumorigenesis of KSHV is through transcriptional repression of the tumor suppressor gene

252 e endogenous, noncoding RNAs capable of post-transcriptional repression of their mRNA targets.

253 KLF11 binding resulted in transcriptional repression of these genes.

254 e miR-183-96-182 cluster promoter to inhibit transcriptional repression of this cluster by ZEB1, sugg

255 providing insight into a novel strategy for transcriptional repression of this gene by small molecul

256 of primary B lymphocytes resulted in global transcriptional repression of TSGs through engagement of

257 iated prostate cancer (PCa) cells via direct transcriptional repression of Twist1 and CD44.

258 e mechanism by which yeaG acts, involves the transcriptional repression of two toxin/antitoxin module

259 FOXO1-mediated transcriptional repression of UBE3A was sufficient to st

260 Transcriptional repression of ubiquitin B (UBB) is a can

261 ing factors of VEGF have been described, the transcriptional repression of VEGF remains much less und

262 Myc activation results in the transcriptional repression of Wnt antagonists through th

263 A higher abundance of Hsp90 causes increased transcriptional repression on RAD53 in a dose-dependent

264 G-quadruplex sequence showed dose-dependent transcriptional repression only when the AR promoter G-q

265 atory functions enables stable and efficient transcriptional repression or activation in human and ye

266 s-acting factor ZF6-DB without the intrinsic transcriptional repression properties of the canonical E

267 fish Tcf7l1 paralogs there is a limit to the transcriptional repression provided during early CM spec

268 to underlying molecular mechanism(s) through transcriptional repression regulation.

269 rve as a platform for understanding how post-transcriptional repression restricts interpretation of B

270 le genes, promoter occupancy correlated with transcriptional repression, resulting in differential le

271 During transcriptional repression, retrogenes are depleted of p

272 ping is involved in chromatin remodeling and transcriptional repression, revealing a mechanism by whi

273 Hence, high resolution mapping of transcriptional repression reveals complex and interdepe

274 hylation (H3K9me2), which is associated with transcriptional repression, specifically to the Cdk5 loc

275 a herpesviral RNA endonuclease induces host transcriptional repression that is mediated through the

276 repressive complex 2 (PRC2), plays a role in transcriptional repression through histone H3 Lys-27 tri

277 repressive complex 2 (PRC2) participates in transcriptional repression through methylation of histon

278 Polycomb Group (PcG) proteins maintain transcriptional repression throughout development, mostl

279 cause human CAKUT by interference with TBX18 transcriptional repression, thus implicating ureter smoo

280 Here we show that an epigenetic mechanism of transcriptional repression times the initiation of femal

281 slational levels, including RNA polymerases, transcriptional repression, translational activation, an

282 RNA genes are strongly associated with their transcriptional repression upon miR-494 overexpression,

283 routes are inhibited, but the mechanisms of transcriptional repression upon sugar sensing have remai

284 lysine residues on histone tails, promoting transcriptional repression via condensation of chromatin

285 be a mechanism whereby EZH2 directs IKKalpha transcriptional repression via H3K27 histone methylation

286 ion by binding to its promoter and mediating transcriptional repression via histone deacetylases.

287 v and ELBA proteins are competent to mediate transcriptional repression via Insv consensus sequences

288 Chaf1a reinforces transcriptional repression via its interaction with memb

289 reduced PRMT5 expression leads to cyclin D1 transcriptional repression via loss of TP53K372 methylat

290 This IFN-beta-mediated transcriptional repression was independent of the effect

291 Because protein sumoylation can promote transcriptional repression, we hypothesized that LMP1-in

292 have found to be required for ATXN1-induced transcriptional repression, we tested whether geneticall

293 7me3), an epigenetic modification that marks transcriptional repression, were changed in miR combo-tr

294 palindromes throughout the genome to mediate transcriptional repression, whereas Bsg25A and Elba2 het

295 xp1 directly mediated TGF-beta-induced c-Jun transcriptional repression, which abrogated T cell activ

296 mental retardation, X-linked (ATRX)-mediated transcriptional repression, which indicates that PML-NB/

297 eby antagonizing full-length SON function in transcriptional repression while not impairing full-leng

298 acterized cis-elements known to mediate REST transcriptional repression, while cell imaging studies c

299 The presence of R alleviated IK-1-mediated transcriptional repression, with IK-1 then cooperating w

300 Strongylocentrotus purpuratus exhibit broad transcriptional repression, yet enrichment for a set of