ライフサイエンスコーパス: transcriptional response

1 n the gene context, contribute to modulating transcriptional response.

2 ed similarly to ATFS-1 and induces a similar transcriptional response.

3 ith an important role for FIH in the hypoxic transcriptional response.

4 ckground could provoke an entirely different transcriptional response.

5 and effectively suppresses the innate immune transcriptional response.

6 atory state and gave rise to a new, specific transcriptional response.

7 )Ebf1(+/-) pro-B cells were reflected in the transcriptional response.

8 at the levels of biosynthesis, transport and transcriptional response.

9 modification and coordinating the downstream transcriptional response.

10 on at E2f target genes and amplifies the E2f transcriptional response.

11 and related mycobacteria, and studied their transcriptional response.

12 rmational change that in turn brings about a transcriptional response.

13 almost completely erased estrogen-regulated transcriptional response.

14 ment changes and as mediators of the correct transcriptional response.

15 trates that all injuries start with a common transcriptional response.

16 he architecture of the nucleus modulates the transcriptional response.

17 nist-specific mutually exclusive dichotomous transcriptional response.

18 orrhagic fever to better understand the host transcriptional response.

19 ess response networks by specifying adaptive transcriptional responses.

20 OXF1, suggesting cross-regulation to enhance transcriptional responses.

21 whereas PCs respond to IFNs with distinctive transcriptional responses.

22 ancer cell lines by supporting oncogenic RAS transcriptional responses.

23 r activity, including both morphological and transcriptional responses.

24 level, less is known about bat IFN-mediated transcriptional responses.

25 about the functional complexes driving auxin transcriptional responses.

26 y on chromatin, and subsequent IRF3-mediated transcriptional responses.

27 t signaling pathways and eliciting different transcriptional responses.

28 inate their activities to facilitate diverse transcriptional responses.

29 GR binding site affinity to hormone-induced transcriptional responses.

30 ndent stem cell differentiation activity and transcriptional responses.

31 JAZ family allows fine-tuning of JA-mediated transcriptional responses.

32 gnal to induce hyphae that is independent of transcriptional responses.

33 VEPH1 expression suppressed TGF-beta-induced transcriptional responses.

34 chanisms in addition to its well-established transcriptional responses.

35 as an important regulator of hypoxia-induced transcriptional responses.

36 uct, which traffics to the nucleus to effect transcriptional responses.

37 multiple pathway activities and adjust their transcriptional responses accordingly.

38 ry neurons but was essential for appropriate transcriptional responses after injury, with Calca and T

39 Short-term transcriptional responses after transfer to Suc revealed

40 -specific biological processes in the sepsis transcriptional response: although both species upregula

41 Exposure to PBO and DEF resulted in a broad transcriptional response and about one third of the diff

42 t loss of HMGNs dampens the magnitude of the transcriptional response and alters the pattern of gene

43 ons leads to a decreased HIF-1alpha mediated transcriptional response and correlates with a reduction

44 r findings offer a new window into the Notch transcriptional response and demonstrate the importance

45 eptor, diminished the glucocorticoid-induced transcriptional response and increased glucocorticoid re

46 ibers, but not Matrigel, trigger a conserved transcriptional response and subsequent motility switch

47 Transcriptional response and target gene activation were

48 tween these metabolic modes requires a rapid transcriptional response and this is orchestrated by Sur

49 ablish the method, we reveal highly specific transcriptional responses and altered RNA processing in

50 basophils have cell- and activation-specific transcriptional responses and suggest that context-speci

51 community composition, the RSV-induced host transcriptional response, and clinical disease severity.

52 ata can disentangle key aspects of a complex transcriptional response, and it provides new insights i

53 ion restart through the checkpoint-dependent transcriptional response, and more specifically, through

54 assays to search for STAT1 phosphorylation, transcriptional response, and target gene expression wer

55 of their involvement in the immediate-early transcriptional response, and their wider functional sig

56 ed TGFbeta-stimulated Smad2 phosphorylation, transcriptional responses, and cell migration.

57 Thus, R-loops resulting from the E2 transcriptional response are a significant source of DNA

58 he Hippo signaling pathway, and YAP1-induced transcriptional responses are essential in cancer cell p

59 gnaling could mediate significant downstream transcriptional responses, as we show that acetylation o

60 capitulate chromatin modification states and transcriptional responses associated with colonization.

61 A and DDG and their mixtures induce multiple transcriptional responses at environmentally relevant co

62 st plant root exudates resulted in different transcriptional response between species.

63 eatures that might explain the difference in transcriptional response between subclasses is the local

64 involves a number of signaling pathways and transcriptional responses between both partners.

65 SC2 and p53 and that the activation of a p53 transcriptional response by AICAR was due to an activati

66 phorylation, which then triggered downstream transcriptional responses by coactivating SREBP-1, which

67 monstrate that PML promotes TNFalpha-induced transcriptional responses by promoting NF-kappaB activit

68 trate the unexpected speed at which a global transcriptional response can occur.

69 Finally, we detail how these transcriptional responses can be exploited to construct

70 In vivo, SPOP mutation results in a transcriptional response consistent with BRCA1 inactivat

71 NA repair factors with the regulation of the transcriptional response controlling dNTP production and

72 dered the master regulator of stress-induced transcriptional responses, controls the expression of cy

73 The Host Transcriptional Response DataBase (HoTResDB), allows vis

74 is with nitric oxide we found that the rapid transcriptional responses, detectable within minutes of

75 activated by type I IFNs to ensure that its transcriptional response did not evoke an aberrant ampli

76 With time, the transcriptional response diverges increasingly between o

77 e there are much data to support the role of transcriptional responses downstream of pattern recognit

78 (ADP-ribose) polymerase-1 (PARP-1)-dependent transcriptional responses downstream of the innate immun

79 irst study to globally assess the human skin transcriptional response during early Lyme disease.

80 r ATF3 as a key regulator of the acinar cell transcriptional response during injury and may provide a

81 ic processes that affect the fidelity of the transcriptional response during the activation of B cell

82 tedly to regulate tissue- and stage-specific transcriptional responses during development.

83 d yet the vast majority of investigations of transcriptional responses during developmental transitio

84 uum, the characterization of the bacterium's transcriptional responses during the infection cycle, an

85 However, despite highly similar transcriptional responses, each IEG exhibits dramaticall

86 AA and 2i induce differential transcriptional responses, each leading to the activatio

87 Injury-specific transcriptional responses emerged 30 hr after injury, in

88 induces a HIF2alpha-associated hypoxia-like transcriptional response followed by an increase in neur

89 ealed that Pal-GATA and Tandem-GATA generate transcriptional responses from GATA1 target genes distin

90 n at divergent regulatory elements and prime transcriptional responses genome-wide.Heat Shock Factor

91 downstream coactivators that coordinate the transcriptional response have not been fully illustrated

92 While similar transcriptional responses have been described in mammals

93 We show that KT and SD elicit common transcriptional responses implicating distinct elements

94 led that trisomy 21 activates the interferon transcriptional response in fibroblast and lymphoblastoi

95 Here we investigate the Notch transcriptional response in germline stem cells using si

96 Here, we demonstrate that the MAPK transcriptional response in human cells is funneled thro

97 use of PRO-seq to characterize the immediate transcriptional response in human cells to celastrol, a

98 s revealed that Pb induces an NRF2-dependent transcriptional response in neural stem cells and identi

99 Here we show that the transcriptional response in neurons is exquisitely sensi

100 Our results demonstrate that the transcriptional response in neurons to environmental sti

101 duction, leading to part of the SA-dependent transcriptional response in plant cells.

102 we show that 30% [CO2] triggered a profound transcriptional response in rice leaves, including a cha

103 the donor ESX-1 apparatus amplifies the esx4 transcriptional response in the recipient.

104 c expression of NANOG inhibits GLI1-mediated transcriptional responses in a dose-dependent fashion.

105 Importantly, GCs activated HIF transcriptional responses in a zebrafish mutant line har

106 na RNA-sequencing to investigate genome-wide transcriptional responses in an acaricide resistant stra

107 al haemoglobin, which leads to lower hypoxic transcriptional responses in blood mononuclear cells but

108 udy, we have comprehensively profiled global transcriptional responses in crowns of field-grown sprin

109 We compared activity-dependent transcriptional responses in developing human stem cell-

110 he Illumina platform to compare the range of transcriptional responses in leaf primordia of G. avella

111 brane are important regulators of downstream transcriptional responses in reactive glia.

112 an leverage metagenomic data to characterize transcriptional responses in uncultivated bacteria.

113 translational repression, (ii) mount various transcriptional responses, including innate immunity, an

114 scription factors that appear to drive these transcriptional responses, including members of the E2F

115 3BP1 to activate PKR and other innate immune transcriptional responses indicates that G3BP1 is an ant

116 chemical and genetic blockage mimicked these transcriptional responses, indicating that sterol deplet

117 First, both E9591 and LMT elicited a transcriptional response indicative of iron imbalance, c

118 We identified signatures of tissue-specific transcriptional responses indicative of tropism in the c

119 The concomitant transcriptional response involves up-regulation of the t

120 In larger eukaryotes, the stress-induced transcriptional response is mediated by a family of heat

121 However, the overall CpG-induced transcriptional response is muted in NOD cDCs.

122 The initial transcriptional response is relatively homogeneous among

123 The NF-kappaB transcriptional response is tightly regulated by a numbe

124 orphogen regulate SMO to promote switch-like transcriptional responses is a central unsolved issue.

125 ut how SHP senses the BA signal for feedback transcriptional responses is not clearly understood.

126 proteins within mitochondria, cells employ a transcriptional response known as the mitochondrial unfo

127 els trigger a coordinated intercompartmental transcriptional response manifested in the suppression o

128 drial unfolded protein response (UPR(mt)), a transcriptional response mediated by the transcription f

129 eals that IFN-beta selectively restricts the transcriptional responses mediated by both the TLRs and

130 Activation of cellular transcriptional responses, mediated by hypoxia-inducible

131 This transcriptional response occurred in two major waves, on

132 The transcriptional response of 38 (out of 204) candidate ge

133 Here, we assessed the transcriptional response of a primary 3D airway model ac

134 The transcriptional response of AM roots under K(+) deficien

135 Here, we systematically integrate the transcriptional response of B-ALL to GCs with a next-gen

136 ES cells, the presence of NANOG reduces the transcriptional response of cells to HH.

137 We have examined the CNS transcriptional response of Locusta migratoria manilensi

138 We used RNA-seq to characterize the hepatic transcriptional response of mature male brown trout expo

139 We found that age and sex affected the transcriptional response of most immune-related genes, w

140 over transcription factors that regulate the transcriptional response of oncogenic KRAS in pancreatic

141 An alternative possibility is that the transcriptional response of oncogenic transcription fact

142 s of African versus European ancestry on the transcriptional response of primary macrophages to live

143 we characterized, using RNA sequencing, the transcriptional response of primary monocytes from Afric

144 emperature-dependent growth, we compared the transcriptional response of primary mouse airway epithel

145 ptome sequencing (mRNA-seq), we profiled the transcriptional response of Pteropus vampyrus bat kidney

146 To study the transcriptional response of stem cells to HH signaling,

147 in accordance with the previously described transcriptional response of the esx-3 locus to these met

148 This study therefore characterized the transcriptional response of the filamentous fungus Asper

149 Instead, Zn simulated the transcriptional response of typical Fe-regulated genes,

150 The transcriptional responses of amoA, hao, nirK, and norB w

151 Contextualization of specific transcriptional responses of Arabidopsis within the stre

152 mammalian cells, and we reveal the distinct transcriptional responses of embryonic stem cells and mo

153 We compared the temporal transcriptional responses of human dendritic cells (DC)

154 the North Pacific Subtropical Gyre, and the transcriptional responses of phytoplankton functional gr

155 singly, these data suggest that the earliest transcriptional responses often involve promoters genera

156 tcome of vaccination experiments on mice and transcriptional responses on M. tuberculosis RESULTS: Va

157 ic CD8(+) T-cell responses, early interferon transcriptional responses, or myeloid antigen-presenting

158 hway perturbation state but instead identify transcriptional response orthologs across a set of train

159 Transcriptional responses partially reproduced in vivo s

160 Overall, our findings are consistent with transcriptional responses participating mostly in late-s

161 a simplified representation of the cellular transcriptional response pathways to abiotic stress, whi

162 Glucocorticoid (GC) and hypoxic transcriptional responses play a central role in tissue

163 Deletion of the cpxR transcriptional response regulator derepresses hlyA expr

164 systems consisting of a sensor kinase and a transcriptional response regulator to detect environment

165 m, protein synthesis, transport/binding, and transcriptional/response regulators.

166 anisms controlling stage- or tissue-specific transcriptional responses remain elusive.

167 sms of pausing including its dynamics during transcriptional responses remain to be fully understood.

168 We find that long term modulation of the transcriptional responses requires continued NODAL/Activ

169 Pathway-level analysis of this transcriptional response revealed key biological pathway

170 wed different routes led to the same overall transcriptional response seen in previously reported EBO

171 Activity-dependent transcriptional responses shape cortical function.

172 Hence, c-Jun-mediated transcriptional responses support starvation-induced aut

173 in Arabidopsis is characterized by a strong transcriptional response systemically induced in the fol

174 Armet protein into tobacco leaves induced a transcriptional response that included pathogen-responsi

175 ion of FPS also triggered an iron-deficiency transcriptional response that is consistent with the iro

176 oxidase-induced redox signaling initiates a transcriptional response that protects the cell and orga

177 flowing blood to stimulate cytoskeletal and transcriptional responses that form a highly efficient v

178 Non-neuronal cells showed clear transcriptional responses that may regulate experience-d

179 cal link between neuronal activation and the transcriptional responses that occur during memory forma

180 We have therefore named this common transcriptional response the intracellular pathogen resp

181 Gs are linked to activation of innate immune transcriptional responses through NF-kappaB and JNK.

182 ry networks are intrinsically limited by the transcriptional response time, which may restrict a cell

183 Here we characterized genetic effects on the transcriptional response to 50 treatments in five cell t

184 modifies the baseline and long-term hepatic transcriptional response to a high-fat diet (HFD).

185 particle formation, we demonstrate that the transcriptional response to a high-fat meal is associate

186 Application of MULCCH to mammalian transcriptional response to a panel of influenza viruses

187 other plants, the clade-specific features in transcriptional response to abiotic stress were detected

188 ial restoration of cilium numbers and in the transcriptional response to activation of the Shh pathwa

189 l conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulat

190 es in circulating immune cells-the conserved transcriptional response to adversity (CTRA).

191 and up-regulation of the leukocyte conserved transcriptional response to adversity (CTRA).

192 n health and a need to examine the conserved transcriptional response to adversity alongside other pr

193 d provide further evidence for the conserved transcriptional response to adversity as a marker of bio

194 related to increased expression of conserved transcriptional response to adversity genes and distinct

195 ne expression program known as the conserved transcriptional response to adversity.

196 RNA-Seq demonstrated that the transcriptional response to ATR-deficient proliferation

197 Here, we blocked the transcriptional response to auxin within specific tissue

198 study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the

199 t these cells show a previously unrecognized transcriptional response to caloric excess by reducing P

200 t cell wall integrity MAPK Slt2 mediates the transcriptional response to cell wall alterations throug

201 This transcriptional response to cholestatic liver injury lik

202 in vitro approaches to characterize the SOS transcriptional response to DNA damage in the Patescibac

203 novel target in beta-cells that coordinates transcriptional response to elevated glucose levels.

204 Genes with a transcriptional response to environmental perturbations

205 be more important than cis regulation in the transcriptional response to environmental perturbations.

206 m cells (hPSCs) to study the dynamics of the transcriptional response to exogenous activation of the

207 ulin resistance and prevents the appropriate transcriptional response to feeding.

208 ession; however, mechanisms that mediate the transcriptional response to fluctuating levels of zinc h

209 We evaluated the transcriptional response to genistein in Ishikawa cells

210 Indeed, the transcriptional response to genotoxic stress is enhanced

211 nge enhancer elements modulate the immediate transcriptional response to GR activation in human blood

212 Here we show that the genome-wide transcriptional response to heat shock in mammals is rap

213 Our results suggest that the plant organ transcriptional response to high salinity is regulated b

214 e inhibitor is a better mimic of the overall transcriptional response to hypoxia than the selective P

215 factor (HIF) is the master regulator of the transcriptional response to hypoxia; however, little is

216 These findings are based on analysis of the transcriptional response to infection by the intracellul

217 The transcriptional response to infection in Brachypodium wa

218 In this study, we measured the host transcriptional response to infection in multiple DENV t

219 viously unappreciated role in regulating the transcriptional response to infection, even in nonprolif

220 Little is known about the host transcriptional response to infection.

221 gene expression, play a central role in the transcriptional response to L. pneumophila METHODS: We i

222 We established that a chloroplast transcriptional response to light intensity was mediated

223 The transcriptional response to light varies with the develo

224 We also investigated the transcriptional response to mitochondrial damage by gene

225 Analysis of the host transcriptional response to Mucorales reveals platelet-d

226 l mechanism of muscular dystrophy: a blunted transcriptional response to muscle loading resulting in

227 at Pax5 and Ebf1 collaborate to modulate the transcriptional response to Notch signaling.

228 ize the regulatory mechanisms underlying the transcriptional response to oncogenic KRAS and provide a

229 ma (PDAC), but the mechanisms underlying the transcriptional response to oncogenic KRAS are still not

230 Nrf2 regulates the transcriptional response to oxidative stress.

231 Analysis of the transcriptional response to pdcA mutation indicates that

232 These studies reveal a dynamic transcriptional response to perturbation of sink demand

233 ss this question, we investigated the global transcriptional response to perturbations in O-GlcNAcyla

234 4A2 and NR4A3 are components of a downstream transcriptional response to PKA activation in the neutro

235 Ps) have recently been shown to also control transcriptional response to secreted Wnt signaling molec

236 For instance, conservation of the transcriptional response to sepsis in mouse models and h

237 ecreased, and we observed a reduction in the transcriptional response to Shh pathway activation.

238 on of interleukin-11 (IL-11) is the dominant transcriptional response to TGFbeta1 exposure and requir

239 mediates sensing of nutrients and controls a transcriptional response to the host nutritional status.

240 ntensity was mediated by SIG5; a chloroplast transcriptional response to the relative proportions of

241 ulates is associated with an altered cardiac transcriptional response to transverse aortic constricti

242 Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-Is)

243 large collection of datasets measuring host transcriptional response to various pathogens.

244 High-throughput screening of the host transcriptional response to various viral infections pro

245 The transcriptional response to Wnt signalling depends on ad

246 in oxygen tension and have evolved adaptive transcriptional responses to a low-oxygen environment.

247 3 function intact, switches TGF-beta-induced transcriptional responses to a prometastatic state.

248 However, RT-specific transcriptional responses to AM symbiosis were quantitat

249 ation and for determining the sensitivity of transcriptional responses to amino acid stress.

250 In contrast, transcriptional responses to ATIV boost were more homoge

251 uced IL-6, IL-1beta, CXCL1, CXCL2 and CXCL10 transcriptional responses to bacteria, and increased sus

252 promoter::reporter constructs suggested that transcriptional responses to changes in light intensity

253 gene pairs is species specific, the initial transcriptional responses to cold appear to be more cons

254 maize, the promoters of genes with conserved transcriptional responses to cold tend to contain more m

255 gnaling pathways, we characterized immediate transcriptional responses to either single- or multiple

256 d type and macroclimate had broad impacts on transcriptional responses to environmental fluctuations,

257 of the cis-regulatory code of plant spatial transcriptional responses to environmental stress.

258 effector proteins modulate a variety of host transcriptional responses to facilitate bacterial growth

259 ce of physical contact and of characteristic transcriptional responses to fungal signals.

260 We observed transcriptional responses to growth- and branching-inhib

261 widely studied, but there are few studies of transcriptional responses to hours of hypoxia in vivo, e

262 HIF-1alpha mediates key transcriptional responses to hypoxia, and promotes STS m

263 PI3K-Akt but not HIF were enriched in early transcriptional responses to hypoxia.

264 ains within eleven binned genomes had strong transcriptional responses to increased EET rates, with o

265 ics with data about host genetics and global transcriptional responses to infection allows for compre

266 nd NRF1 transcription factors in determining transcriptional responses to ischemia.

267 AM colonization induced specific transcriptional responses to K(+) deprivation that seem

268 ars, endomesoderm segregation arises through transcriptional responses to levels of nbeta-catenin act

269 ce, Yap1 nuclear exclusion, and beta-catenin transcriptional responses to mechanical strain required

270 urther insight into the natural variation of transcriptional responses to mild drought in a specific

271 report in Nature that primates evolved novel transcriptional responses to neuronal activity, includin

272 pendent antioxidant defences, and exhibit no transcriptional responses to Nrf2 activators, or to abla

273 he use of human neuronal systems for probing transcriptional responses to physiological stimuli or in

274 The aim of this study was to define transcriptional responses to PKA activation and to delin

275 We identified significant and divergent transcriptional responses to stimulation in each of the

276 enhancers is dynamically regulated to shape transcriptional responses to TCR signaling.

277 antly between diatoms, resulting in opposite transcriptional responses to the same environment.

278 Compared with transcriptional responses to TIV vaccination previously

279 feed-forward mechanism turns poor peak-like transcriptional responses to TNF-alpha into progressive

280 The priming of chromatin enabled robust transcriptional responses to weak upstream signals.

281 Furthermore, transcriptional responses triggered by ATAF1 largely ove

282 ilized next generation sequencing to examine transcriptional responses triggered by virus and dsRNA a

283 Unlike TGF-beta-induced Smad2/3 transcriptional responses underlying mitochondrial fragm

284 To profile the B-cell transcriptional responses underlying the activation of t

285 rio symbiosis, and more generally inform the transcriptional responses underlying the activities of m

286 However, how pyruvate controls the transcriptional responses underlying the metabolic switc

287 letion of HOS2 resulted in changes of esa1's transcriptional response upon damage.

288 Despite the overall selectivity of the net transcriptional response, vasopressin treatment was asso

289 ossi, we observed a key difference: a strong transcriptional response was only detected in the monocy

290 In accordance with transcriptional responses, we found persistent degradati

291 lopmental responses, fungal colonization and transcriptional responses were monitored in two independ

292 RNA sequencing showed that 8.5% of TNF-alpha transcriptional responses were TonEBP-dependent and iden

293 cis-regulatory element function during acute transcriptional responses, where primary DNA sequence an

294 ting DNA methylation marks into a downstream transcriptional response, which has implications for bot

295 robe Bacteroides caccae and LGG results in a transcriptional response, which is distinct from that of

296 protein in mammalian cells elicits a robust transcriptional response, which is distinct from the HSR

297 cogenic activities of E2f result in distinct transcriptional responses, which could be exploited to t

298 Stress triggers complex transcriptional responses, which include both gene activ

299 ulatory mechanisms underlying these temporal transcriptional responses, with a focus on the dynamic b

300 everal previously undescribed and unexpected transcriptional responses within the early stages of thi