ライフサイエンスコーパス: transcytosis

1 n, "cytonemes", filopodia, "argosomes", and "transcytosis".

2 ion of the BBB via an endocytotic mechanism (transcytosis).

3 ic cleft to afferent synapses (transsynaptic transcytosis).

4 rates of transcellular vesicular transport (transcytosis).

5 barrier by virtue of tight junctions and low transcytosis.

6 the regulation of IgE synthesis and allergen transcytosis.

7 icant reduction in EBV apical to basolateral transcytosis.

8 st virus replication inside cells during IgA transcytosis.

9 factors that regulate apical-to-basolateral transcytosis.

10 nctions or suppressing endothelial vesicular transcytosis.

11 rant endosomes, and defective exocytosis and transcytosis.

12 receptor-mediated endocytosis and subsequent transcytosis.

13 intestinal barrier through receptor-mediated transcytosis.

14 ulation of virus significantly reduced HIV-1 transcytosis.

15 of HIV-1 and assess antiviral Ab blockade of transcytosis.

16 ssue M cells were defective in microparticle transcytosis.

17 protein Caveolin-1 and promoting endothelial transcytosis.

18 cal to the basolateral surface via vesicular transcytosis.

19 o the apical surface of epithelial cells via transcytosis.

20 in a reproducible decrease in FcRn-mediated transcytosis.

21 after mannose 6-phosphate receptor-mediated transcytosis.

22 e axonal transport, which is consistent with transcytosis.

23 a caveolin-1 and increased caveolae-mediated transcytosis.

24 no cross inhibition of membrane binding and transcytosis.

25 constituents, which are trafficked there by transcytosis.

26 apical recycling, and basolateral-to-apical transcytosis.

27 es its apical localization in MDCK cells via transcytosis.

28 tive sorting with a partner protein, and (c) transcytosis.

29 terminals, thus demonstrating transsynaptic transcytosis.

30 plicated in regulating basolateral to apical transcytosis.

31 through cytonemes, filopodia, argosomes, or transcytosis.

32 s and transendothelial albumin transport via transcytosis.

33 etheless allows for a cycle of bidirectional transcytosis.

34 licating these proteins in the regulation of transcytosis.

35 essed their effects on basolateral-to-apical transcytosis.

36 not essential for the process of binding and transcytosis.

37 um toxin displayed both specific binding and transcytosis.

38 helial BCA-1 expression may be consequent to transcytosis.

39 and binding induces a signal that stimulates transcytosis.

40 of GTP-locked rab3b inhibits dIgA-stimulated transcytosis.

41 horylated nephrin, and 4) attenuated albumin transcytosis.

42 recognized native SEB and also inhibited SEB transcytosis.

43 n vivo with the involvement of FcRn-mediated transcytosis.

44 ssociation of caveolin-1 with E. coli during transcytosis.

45 rparts, because of their specialized role in transcytosis.

46 olgi system before anterograde transport and transcytosis.

47 from lysosomal degradation and promotes LDL transcytosis.

48 able to neutralize HIV-1 and to block viral transcytosis.

49 lar permeability via mainly caveolar protein transcytosis.

50 etention by shedding surface Tf during their transcytosis.

51 ins the ability to move from cell-to-cell by transcytosis.

52 impacts the capacity for TfR to mediate BBB transcytosis.

53 plicated as the "receptor" mediating albumin transcytosis.

54 ross the cell to the basolateral membrane by transcytosis.

55 port the first microtubule motor involved in transcytosis.

56 Albumin transcytosis, a determinant of transendothelial permeabi

57 This transcytosis accounted for approximately 10% of total al

58 onstrated a similar 20-fold enhanced rate of transcytosis across an in vitro BBB model compared with

59 via CAM-mediated endocytosis, trafficked by transcytosis across cell monolayers without disrupting t

60 Chemokine transcytosis across endothelial cells and presentation o

61 gG1, 2F5 IgA2 more efficiently blocked HIV-1 transcytosis across epithelial cells and CD4(+) cell inf

62 tion, prechallenge sera to enhance SIVmac251 transcytosis across epithelial cells was associated with

63 ostchallenge rectal secretions inhibited SIV transcytosis across epithelial cells.

64 CAM to lysosomes, yet prominent and specific transcytosis across epithelial monolayers.

65 d gp340 as an important facilitator of HIV-1 transcytosis across genital tract tissue.

66 bnAb, denoted VRC01-LS, displayed increased transcytosis across human FcRn-expressing cellular monol

67 We report an approach to study insulin transcytosis across individual, primary human adipose mi

68 this may occur because generally inefficient transcytosis across intact mucosal surfaces could be enh

69 erichia coli (EHEC) require toxin uptake and transcytosis across intestinal epithelial cells.

70 from milk to blood by apical-to-basolateral transcytosis across intestinal epithelial cells.

71 23D7 and 25A4 did, however, reduce ricin transcytosis across MDCK II cell monolayers, possibly by

72 omplexes were cleared from brain to blood by transcytosis across the BBB via the neonatal Fc receptor

73 Receptor-mediated transcytosis across the blood-brain barrier (BBB) may be

74 eins and tissue remodeling subsequent to its transcytosis across the endothelial barrier.

75 ot polymeric IgM, 2F5 Abs also blocked HIV-1 transcytosis across the epithelium and, importantly, acr

76 lant lectin or a luteovirus coat protein for transcytosis across the gut epithelium, or via entomopat

77 ach the ocular surface via receptor-mediated transcytosis across the lacrimal gland (LG), which produ

78 ta brain capillary binding, endocytosis, and transcytosis across the mouse blood-brain barrier are su

79 below the mucosal epithelium, or through HIV transcytosis across the mucosal epithelium of a noninfec

80 tibody titers, this pattern suggested virion transcytosis across the surface.

81 dileucine residues conferring apical-lateral transcytosis act through a clathrin-dependent process an

82 r repeated rectal challenges had lower serum transcytosis activity than did 19 animals who subsequent

83 ver, the inefficient transport suggests that transcytosis alone would not engender a significant ther

84 ached to carrier molecules, through cells by transcytosis, along cell extensions, or in released memb

85 iga toxin macropinocytosis and transcellular transcytosis alters current ideas concerning mechanisms

86 required for caveolae formation and caveolar transcytosis and (ii) as a tonic inhibitor of eNOS activ

87 Thus, PICALM regulates Abeta BBB transcytosis and clearance, which has implications for A

88 Rab5 and Rab11, leading to Abeta endothelial transcytosis and clearance.

89 tly coupled to both increased (125)I-albumin transcytosis and decreased transendothelial electric res

90 r, a conserved protein complex that mediates transcytosis and endosome-to-Golgi protein trafficking,

91 rmation in CNS endothelial cells to suppress transcytosis and ensure BBB integrity.

92 e first evidence of vesicle-mediated insulin transcytosis and highlights that its initial uptake is c

93 In villus explants, IgG-virion transcytosis and macrophage uptake were blocked with try

94 We investigated whether transcytosis and paracellular leakage are co-regulated.

95 Our findings indicate that transcytosis and paracellular permeability are co-regula

96 cells and demonstrated that it functions in transcytosis and recycling of IgG.

97 ent pathways to the axon have been proposed: transcytosis and selective retrieval/retention.

98 gain insight into the mechanisms regulating transcytosis and the pathophysiology of cholestasis, we

99 of hypothetical mechanisms, such as "planar transcytosis" and "restricted extracellular diffusion."

100 ations, which function in cell signaling, in transcytosis, and in regulating cellular cholesterol hom

101 lls functioned in endocytosis, bidirectional transcytosis, and recycling of chicken FcY/IgY.

102 ctin during neutrophil rolling; in chemokine transcytosis; and by binding and presenting chemokines a

103 New features of transcytosis are elucidated, including transport involvi

104 tructural determinants governing binding and transcytosis are found in this fragment.

105 , the mechanisms of albumin reabsorption and transcytosis are undergoing intense study.

106 Our results reveal regulated transcytosis as an unexpected mode of Trk trafficking th

107 ansendothelial transport of NOA reflects its transcytosis as well as its exit from the microcirculati

108 ature vessel leakage occurs entirely through transcytosis, as specialized tight junctions are functio

109 ry by the in vitro Madin Darby Canine Kidney transcytosis assay, for pIgR-mediated transport through

110 In a transcytosis assay, human IgE or IgE-derived immune comp

111 We show in transcytosis assays that CD23a, but not CD23b, acts as a

112 use of HIV-infected cells in epithelial cell transcytosis assays, and cell-associated infection of mu

113 ular "hitchhiking" through receptor-mediated transcytosis at the blood-brain barrier is a CNS drug de

114 se findings underscore the potential role of transcytosis blockade in the prevention of HIV-1 transmi

115 ly more potent than dimeric IgA in effecting transcytosis blockade.

116 d heparan sulfate moieties in mediating this transcytosis but add gp340 as an important facilitator o

117 cal-to-basolateral and basolateral-to-apical transcytosis, but not recycling, suggesting the use of d

118 ponent of the RE, Rab11a, is dispensable for transcytosis, but regulates recycling to the basolateral

119 Inhibiting transcytosis by dynamin blockade increased paracellular

120 The combined data indicated that the transcytosis by GLUT1 and GLUT3 was a pathway of MAN-LIP

121 athway facilitates reabsorption and mediates transcytosis by its pH-dependent binding affinity in end

122 Rapid sequential transcytosis can occur to the alveolar air space via epi

123 gly induced, whereas pIgR expression and IgA-transcytosis capacity were decreased in cultures from su

124 However, BDL impaired transcytosis, causing (1) accumulation of the pIgA-R, ra

125 he extent to which receptor-mediated reverse transcytosis clears mAb from the brain is unknown.

126 heir differences in adherence, invasion, and transcytosis efficiencies.

127 us applied to the apical surface, indicating transcytosis efficiency was constant (r(2) = 0.9846; p <

128 can occur between (paracellular) or through (transcytosis) endothelial cells, yet little is known abo

129 Transcytosis experiments performed using human polymeric

130 in-mediated internalization pathway, such as transcytosis, for the entry of ASGP-R.ASOR complexes int

131 a reversal of IgG transport with predominant transcytosis from an apical-to-basolateral direction, wh

132 recognizes the Fc domain of IgG and mediates transcytosis from maternal to fetal circulation.

133 apical BBM complexes with megalin during its transcytosis from the BLM.

134 le-dependent redirection of beta(1) integrin transcytosis from the leading edge of migrating cells th

135 cursors was not CD137-dependent, full M cell transcytosis function required expression of CD137 by ra

136 Therefore, the temporal regulation of transcytosis governs the development of a functional BRB

137 Receptor mediated transcytosis harnessing the cellular uptake and transpor

138 n unusually low rate of vesicular transport (transcytosis) has been identified as one of the two uniq

139 tant mice with elevated or reduced levels of transcytosis have delayed or precocious sealing of the B

140 s to be a prerequisite for FcRn-mediated IgG transcytosis; IgG transcytosis was demonstrated in vivo

141 : (i) the toxin itself undergoes binding and transcytosis; (ii) an auxiliary protein, HA35, transport

142 oss epithelial barriers by receptor-mediated transcytosis in adult animals.

143 ortmannin disrupts basolateral recycling and transcytosis in both directions, but only minimally redu

144 IgG movement nonspecifically by constitutive transcytosis in caveolae.

145 of BBB function that may act by suppressing transcytosis in CNS endothelial cells.

146 obese mice impaired endothelial cell insulin transcytosis in culture and in vivo.

147 ligation (BDL) impairs basolateral-to-apical transcytosis in hepatocytes, causing accumulation of tra

148 lergens, our study implies CD23-mediated IgE transcytosis in human airway epithelial cells may play a

149 c increase in CNS-endothelial-cell vesicular transcytosis in Mfsd2a(-/-) mice, without obvious tight-

150 ns are anterogradely trafficked to axons via transcytosis in sympathetic neurons.

151 ffic from apical to basolateral membranes by transcytosis in the absence of toxin binding but only if

152 endocytosis and degradation and fluid-phase transcytosis in the apical-to-basal direction.

153 generated to determine the roles of ColA in transcytosis in vitro and virulence in hamsters.

154 accine-induced antibody capable of enhancing transcytosis in vitro via FcRn may play a role in determ

155 SEB and SEA showed comparable dose-dependent transcytosis in vitro, while toxic shock syndrome toxin

156 fficacy; (ii) caveolae can mediate selective transcytosis in vivo; and (iii) targeting caveolae may p

157 tion of adaptive mucosal immunity is antigen transcytosis, in which luminal antigens are transported

158 Blockade of transcytosis induced a rapid increase in paracellular le

159 ediated viral inhibition (ADCVI) in sera and transcytosis inhibition in rectal secretions.

160 secretions was significantly correlated with transcytosis inhibition.

161 ted, at least in part, by ADCVI activity and transcytosis inhibition.

162 Vb tail, which is dominant negative towards transcytosis, inhibits lumenal accumulation.

163 Both planar transcytosis initiated by Dynamin-mediated endocytosis a

164 ment of a functional BRB, and suppression of transcytosis is a principal contributor for functional b

165 owever, it is not known how this low rate of transcytosis is achieved.

166 Transcytosis is also essential for establishing and main

167 s as infectious particles, the efficiency of transcytosis is extremely poor (less than 0.02% of the i

168 in barrier (BBB) by "molecular Trojan horse" transcytosis is feasible, we synthesized several transpo

169 A functional barrier forms only when transcytosis is gradually suppressed during development.

170 Endosome transport by transcytosis is the primary mechanism by which proteins

171 IgR, Streptococcus pneumoniae can co-opt the transcytosis machinery and gain entry into airway epithe

172 ons could cross the epithelial barrier via a transcytosis mechanism.

173 d by a relatively nonspecific pinocytosis or transcytosis mechanism.

174 he axonal compartment, suggesting a possible transcytosis model for the dendritic targeting of neurot

175 specialised features (e.g. receptor-mediated transcytosis) need to be maximally expressed.

176 rotein followed by an i.p. boost resulted in transcytosis-neutralizing serum IgG and mucosal IgA resp

177 n mediates basal recycling and bidirectional transcytosis of albumin and uniquely determines the phys

178 A, but not filamin B, reduced the uptake and transcytosis of albumin by approximately 35 and 60%, res

179 r and pharmacologic approaches, we inhibited transcytosis of albumin in primary human microvascular e

180 ical actin, caused a significant increase in transcytosis of albumin in vitro and in an ex vivo whole

181 , efflux pump activity and receptor-mediated transcytosis of angiopep-2.

182 Our results suggest that pIgR-mediated transcytosis of antagonistic antibodies in dIgA format c

183 The role of CD23 isoforms in transcytosis of antigen and IgE-antigen complexes was as

184 , but not loss of ankyrin binding, prevented transcytosis of apically mis-sorted E-cadherin to the la

185 tricted mobility at the lateral membrane and transcytosis of apically mis-sorted protein to the later

186 We found that transcytosis of both cell-free and cell-associated virus

187 Transcytosis of both IgE and the IC was further verified

188 nd IgG from lysosomal degradation, abolished transcytosis of both types of transgenic albumin and IgG

189 egradation; this process allows apical-basal transcytosis of bound peptides.

190 Transcytosis of brain microvascular endothelial cells (B

191 human endocervical tissue can support direct transcytosis of cell-free virus from the apical to basol

192 ny diseases and explored for endocytosis and transcytosis of drug delivery systems.

193 olayer to IL-4 stimulation also enhanced the transcytosis of either human IgE or the IC.

194 We used a two-chamber system to study transcytosis of Enterococcus faecalis across monolayers

195 These events were associated with decreased transcytosis of Evans blue and increased transendothelia

196 found in the follicle-associated epithelium, transcytosis of fluorescent latex beads was evaluated wi

197 EPCR-mediated endocytosis may facilitate the transcytosis of FVIIa and its clearance from the circula

198 -1 gp41 envelope protein, which mediates the transcytosis of HIV-1 across the mucosal epithelia.

199 ize biological parameters of epithelial cell transcytosis of HIV-1 and assess antiviral Ab blockade o

200 endocytotic uptake and microtubule-dependent transcytosis of HIV-1.

201 Consistent with the epithelial transcytosis of HIV-IgA immune complexes, the colocaliza

202 GBS entry into host cells and transcytosis of host cells may occur by distinct mechani

203 uman FcRn were used to study the binding and transcytosis of IgE in the form of IgG anti-IgE/IgE ICs.

204 for factors necessary for the bidirectional transcytosis of IgG by the Fcgamma receptor FcRn.

205 se defects were physiologically relevant, as transcytosis of IgG was disrupted, lipid absorption was

206 e; however, little is known about the actual transcytosis of insulin and how this occurs in the relev

207 Transcytosis of KSI was confirmed in vivo by confocal an

208 play a proatherogenic role by promoting the transcytosis of LDL-cholesterol particles from the blood

209 ient cellular delivery and the potential for transcytosis of ligands across tight endothelia, includi

210 and polarized Caco-2 cells, the adhesion and transcytosis of M-like cells, the intracellular survival

211 gE in CB sera is the result of FcRn-mediated transcytosis of maternal-derived IgG anti-IgE/IgE ICs.

212 tention through ankyrin-G and apical-lateral transcytosis of mis-localized protein through clathrin.

213 ing to ICAM-1 could drive endocytosis and/or transcytosis of model cargo in different cell types.

214 permeability is mediated by (i) the caveolar transcytosis of molecules across endothelial cells and (

215 Thus, transcytosis of MPO by caveolae induced by its charge-de

216 Moreover, transcytosis of MPO, occurring independently of leukocyt

217 it allows for a single epitope blocking the transcytosis of multiple SE.

218 he conserved 10-amino-acid peptide inhibited transcytosis of multiple staphylococcal enterotoxins, SE

219 e kinase HCK regulates apical-to-basolateral transcytosis of non-opsonized and SIgA-opsonized particl

220 ts that Amn/Cubn is required for endocytosis/transcytosis of one or more ligands in the VE during gas

221 We show that TPKTSVT promotes transcytosis of phage into the embryo and blocks the tra

222 eport that this mutation reduces the rate of transcytosis of pIgR and pIgA, and seemingly the rate of

223 Ang II enhances the endocytosis and transcytosis of plasma albumin by podocytes, which may e

224 Whereas papillae are highly dependent on transcytosis of premade material, little is known about

225 fy the domain of the protein involved in the transcytosis of SE.

226 Transcytosis of SIgA-CD71 complexes and intestinal perme

227 t regimen of mucosal antibodies that inhibit transcytosis of SIV across an intact epithelial cell lay

228 Interestingly, no changes in transcytosis of the glycophosphatidylinositol-anchored p

229 the sorting of acid hydrolases to lysosomes, transcytosis of the polymeric immunoglobulin receptor, W

230 Similarly, both ethanol and TSA impaired transcytosis of the single-spanning apical resident amin

231 activate HCK-dependent apical-to-basolateral transcytosis of these particles.

232 h factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons, a

233 rthermore, opsonization enhances M-like-cell transcytosis of V. cholerae strains.

234 llular diffusion, to cell-based dispersal by transcytosis or cytonemes.

235 " receptors internalize Abeta or promote its transcytosis out of the brain, whereas "bad" receptors b

236 fusion of FC5 with Fc increased the rate of transcytosis (Papp) across brain endothelial monolayer b

237 very of CD98hc as a robust receptor-mediated transcytosis pathway for antibody delivery to the brain

238 stration in mice through a receptor-mediated transcytosis pathway.

239 be transported mainly via the intracellular transcytosis pathway.

240 s while discriminating between recycling and transcytosis pathways polarized in their direction of tr

241 the normal function of apical recycling and transcytosis pathways.

242 pithelial cells by (i) apical to basolateral transcytosis, potentially contributing to initial EBV pe

243 s VEGF and mPEG crossed the RPE monolayer by transcytosis, predominantly in the apical-to-basal direc

244 R interactions upon acidification during the transcytosis process to allow release of the nanoparticl

245 of vascular cell adhesion molecule-1 and the transcytosis protein Caveolin-1 and promoting endothelia

246 The efficiency of HIV-1 transcytosis ranged between 0.05 and 1.21%, depending on

247 sely, the number of endothelial caveolae and transcytosis rate increase as early as 6 hr after stroke

248 s associated with an increase in endothelial transcytosis rather than a loss of tight junctions.

249 Leptin crosses the blood-brain barrier by transcytosis rather than undergoing intracellular degrad

250 Insulin transcytosis required dynamin but was unaffected by cave

251 This active transcytosis requires normal caveolin-1 expression.

252 membrane mobility or loss of apical-lateral transcytosis result in partial mis-sorting of E-cadherin

253 Receptor mediated transcytosis (RMT) is a common mechanism used by protein

254 ansport systems, including receptor-mediated transcytosis (RMT).

255 ve exocytosis component of the transcellular transcytosis route.

256 Some transcytosis-selected peptides map to the same 402-410 p

257 Importantly, the transcytosis specific activity (percent inhibition/total

258 ficantly reduced the efficiency of IgE or IC transcytosis, suggesting a specific receptor-mediated tr

259 ot correlate with raft depletion or impaired transcytosis, suggesting other factors contribute to api

260 t protein through the pIgR-specific cellular transcytosis system.

261 ow that LRP-1 is associated with endothelial transcytosis that does not involve acidification of carg

262 lity that limited passage of cell-free HIV-1 transcytosis through an intact genital epithelium occurs

263 half-life from minutes to days and mediates transcytosis through binding to the neonatal Fc receptor

264 Thus, during its transcytosis through epithelial cells, HIV-specific IgA

265 , DeltacolA mutant displayed much-attenuated transcytosis through HEK293 and HUVEC monolayers, and le

266 interacting protein 2 (Rab11-FIP2) regulates transcytosis through its interactions with Rab11a and my

267 ion in invasion did not significantly affect transcytosis through M-like cells at early time points.

268 V-1 attachment, they enhance viral entry and transcytosis through PGECs.

269 These data suggest that during transcytosis through pIgR-positive cells, exposure to PD

270 stinct from those conferring cell-free virus transcytosis through the genital epithelium.

271 e cell to the basolateral plasma membrane by transcytosis, thus breeching the intestinal barrier.

272 ECM-abutting cell surface and initiating its transcytosis to an apical membrane initiation site for l

273 specialized tight junctions and low rates of transcytosis to limit the flux of substances between blo

274 that endothelial DARC facilitates chemokine transcytosis to promote neutrophil recruitment.

275 transient pool of the protein that undergoes transcytosis to the apical membrane.

276 After transcytosis to the apical surface, the extracellular, l

277 he basolateral surface stimulates subsequent transcytosis to the apical surface.

278 normal leaky vasculature for tumor access, a transcytosis transport pathway that is regulated by neur

279 axons via an endocytosis-dependent pathway (transcytosis), traversing somatodendritic endosomes.

280 sported across the BBB via receptor-mediated transcytosis using the brain-penetrant peptide Angiopep-

281 thelial cells and participate in endothelial transcytosis, vascular permeability, vasomotor tone cont

282 Transcytosis via caveolae is critical for maintaining va

283 ure, CRP suppressed endothelial cell insulin transcytosis via FcgammaRIIB activation and eNOS antagon

284 trans-Golgi network and the other half from transcytosis via the basolateral membrane in MDCK cells.

285 e we use electron tomography to make jejunal transcytosis visible directly in space and time, develop

286 d epithelial cells showed that FcRn-mediated transcytosis was blocked by the Fc fragment of IgG, but

287 Transcytosis was carried out by exposing sera and SIVmac

288 site for FcRn-mediated IgG transcytosis; IgG transcytosis was demonstrated in vivo by translocation o

289 Transcytosis was energy dependent, and it was blocked by

290 Caveolar protein transcytosis was found to have a prevailing role in over

291 This redirection in beta(1) integrin transcytosis was inhibited by depolymerization of microt

292 Significantly higher viral transcytosis was observed in the presence of MPA.

293 Instead, insulin transcytosis was significantly inhibited by the clathrin

294 Apical to basolateral EBV transcytosis was substantially reduced by amiloride, an

295 In contrast, basolateral to apical EBV transcytosis was substantially reduced by nystatin, an i

296 ic infection, and (ii) basolateral to apical transcytosis, which may enable EBV secretion into saliva

297 Finally, we documented extensive albumin transcytosis with vesicular and tubular delivery to and

298 In summary, we provide evidence of a transcytosis within the kidney tubular system that prote

299 Rab25 regulate a sorting step that specifies transcytosis without affecting recycling.

300 in biliary and mucosal secretions, constant transcytosis would render the exposed cells more suscept