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1 nking impaired Wnt signaling with hepatocyte transdifferentiation.
2 nerate HCs via both proliferation and direct transdifferentiation.
3 gh a Notch-dependent process of plasmatocyte transdifferentiation.
4 ived by both mitotic regeneration and direct transdifferentiation.
5 e activation of these genes can drive sexual transdifferentiation.
6 ues the inhibitory effect of YAP on squamous transdifferentiation.
7 unction postnatally as a barrier to cellular transdifferentiation.
8 ressively resistant to Dlx2-induced neuronal transdifferentiation.
9 is remarkably stable and resists direct cell transdifferentiation.
10 hat mechanism DMRT1 prevents from triggering transdifferentiation.
11 romote adipogenesis in preadipocytes, in HSC transdifferentiation.
12 nk between iPS cell reprogramming and B-cell transdifferentiation.
13 genes potentially involved in neuroendocrine transdifferentiation.
14 on or called iPSC transcription factor-based transdifferentiation.
15 pithelial cells (BHPrEs) promotes urothelial transdifferentiation.
16 st glycoprotein M6a, undergo myofibroblastic transdifferentiation.
17 nt, direct reprogramming to pluripotency and transdifferentiation.
18 n HSCs to determine if metabolism influenced transdifferentiation.
19 cineurin, which itself induced myofibroblast transdifferentiation.
20 tly described) glioblastoma-endothelial cell transdifferentiation.
21 r beta (TGF-beta) and angiotensin II-induced transdifferentiation.
22 ression of lineage master regulators induces transdifferentiation.
23 may not be required to potentiate pancreatic transdifferentiation.
24 rx in beta cells, causing beta-to-alpha-cell transdifferentiation.
25 modified to serve as a general platform for transdifferentiation.
26 tone deacetylase-4 is accumulated during HSC transdifferentiation.
27 mors arose from adenocarcinoma cells through transdifferentiation.
28 be limited by poor cell survival and lack of transdifferentiation.
29 ly because of loss of surface markers during transdifferentiation.
30 nerate either via proliferation or by direct transdifferentiation.
31 and cyp2e1, suggesting direct acinar-hepatic transdifferentiation.
32 hange of cell fate into neural retina called transdifferentiation.
33 RG1 significantly enhanced the efficiency of transdifferentiation.
34 ic regulation of PPARgamma and myofibroblast transdifferentiation.
35 P=0.02), indicating endothelial-mesenchymal transdifferentiation.
36 -) MSFs are able to undergo endothelial-like transdifferentiation.
37 ugh vascular mimicry (VM) and/or endothelial transdifferentiation.
38 nt for AR, often through neuroendocrine (NE) transdifferentiation.
39 king the nitrosylation site almost abrogated transdifferentiation.
40 OS-generated nitric oxide (NO) might enhance transdifferentiation.
41 sylation of RING1A is critical for effective transdifferentiation.
42 per cell type to another, a process known as transdifferentiation.
43 establishes a model for Notch regulation of transdifferentiation.
44 can develop drug resistance through squamous transdifferentiation.
45 meeting a conservative definition of direct transdifferentiation.
46 icts the transcription factors used in known transdifferentiations.
47 age, mutant disc cells displayed chondrocyte transdifferentiation, accompanied by strong expression o
48 terminally differentiated, remain plastic to transdifferentiation across germ layer lineage boundarie
49 tellate cells (HSCs) undergo myofibroblastic transdifferentiation (activation) to participate in live
50 nar-to-ductal and beta-cell-to-acinar/ductal transdifferentiation also contributed to the expansion o
52 (in BJ fibroblasts) of iNOS nearly abolished transdifferentiation, an effect that could be reversed b
53 y, these tumors exhibited characteristics of transdifferentiation and acquired expression of histiocy
55 actor (TGF)-beta is a potent inducer of both transdifferentiation and contraction, which are regarded
57 w concept of iPSC transcription factor-based transdifferentiation and discuss its application in gene
58 ited transforming growth factor-beta-induced transdifferentiation and fibrotic signaling in WT BM-FPC
59 a/Arf is a potent barrier to direct neuronal transdifferentiation and further suggest that this locus
60 In contrast, deletion of Brn3b leads to RGC transdifferentiation and loss, axon defects in the eye a
61 ify Rev-erbalpha as a novel regulator of HSC transdifferentiation and offers exciting new insights on
62 ure, and it interfered with ATII-to-ATI cell transdifferentiation and organoid formation, which were
63 kappaB (NF-kappaB) induces mesenchymal (MES) transdifferentiation and radioresistance in glioma stem
66 matic cells and its requirement in newt lens transdifferentiation and suggest that transdifferentiati
67 ivo evidence for smooth muscle-to-macrophage transdifferentiation and supports an important role of S
68 vascular regeneration, with its emphasis on 'Transdifferentiation and Tissue Plasticity in Cardiovasc
69 1 activity and gene expression abrogated GSC transdifferentiation and vascularization in vitro, and i
70 sure to FR, with cell cycle arrest, neuronal transdifferentiation, and concomitant up-regulation of t
71 broblasts proliferate, undergo myofibroblast transdifferentiation, and deposit large amounts of extra
73 ossible implications of GBM-endothelial cell transdifferentiation; and vasoformative responses, inclu
74 dings including iPS reprogramming and direct transdifferentiation as well as gene editing have gradua
75 romoted Smad2 phosphorylation and fibroblast transdifferentiation, as evidenced by increased smooth m
79 ncentrations (<20 ng/mL) and differentiation/transdifferentiation at higher concentrations (>50 ng/mL
80 progenitors or FSCs reveal no transfating or transdifferentiation between these lineages in the regen
81 ate ECM accumulation and modulate fibroblast transdifferentiation; both are critical events in advers
82 cell proliferation or by acinar-to-beta-cell transdifferentiation, but rather is due to the aggregati
83 ndent acquisition may involve neuroendocrine transdifferentiation, but there is little knowledge abou
84 trated to induce fibroblast-to-myofibroblast transdifferentiation by activation of p38 mitogen-activa
86 l of potency of these iMSCs and assess their transdifferentiation capacities into functional odontobl
88 Hep3B and HepG2, induced primary mouse HSCs transdifferentiation, characterized by profibrotic prope
90 ion of new hematopoietic differentiation and transdifferentiation data to foster our understanding of
91 order to bypass inducing pluripotent stage, transdifferentiation/direct conversion technologies have
92 LPCs and pluripotent stem cells, findings of transdifferentiation, disease-specific considerations fo
93 is responsible for myocyte-to-Purkinje fiber transdifferentiation during avian heart development.
94 nate immunity may play a fundamental role in transdifferentiation during wound healing and regenerati
96 that the efficiency of a naturally occurring transdifferentiation event in Caenorhabditis elegans is
97 e epithelial-mesenchymal transition (EMT), a transdifferentiation event that is frequently seen in ad
102 nd enhanced cell proliferation and triggered transdifferentiation from acinar, centroacinar and islet
104 r adult stem cells via differentiation or by transdifferentiation from other cell types with the aid
106 podocytes onto Bowman's capsule, rather than transdifferentiation from PECs to parietal podocytes.
107 man's capsule via the vascular stalk; direct transdifferentiation from PECs to podocytes was not obse
112 nique referred to as direct reprogramming or transdifferentiation has proven to be a rapid, robust, a
114 EndoMT), a newly recognized type of cellular transdifferentiation, has emerged as another possible so
115 em cell biology and direct reprogramming, or transdifferentiation, have produced powerful new tools t
116 t lens transdifferentiation and suggest that transdifferentiation in newts might share common strateg
117 support for the concept that neuroendocrine transdifferentiation in prostate cancer cell populations
118 n melanoma, treatment-induced neuroendocrine transdifferentiation in prostate cancer, and sarcomas, w
119 s epithelial cell growth and differentiation/transdifferentiation in the capsular bags, indicating th
120 inhibition in FSGS mice increased RFP(+)CoRL transdifferentiation in the IGC to phenotypes, consisten
124 s a developmental barrier to direct neuronal transdifferentiation induced by transcription factor ove
127 generation and expansion of alpha-cells for transdifferentiation into beta-cells and the treatment o
128 ication and proliferation, and in hepatocyte transdifferentiation into cholangiocytes during liver re
130 cluding the first-in-field model of complete transdifferentiation into lethal neuroendocrine prostate
134 RBP-Jkappa in forming beta-cells led to the transdifferentiation into the other endocrine cells type
135 induced pluripotent stem cells, facilitated transdifferentiation into trophoblast stem cells, and im
138 The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue regen
139 ult SMCs can transdifferentiate and that SMC transdifferentiation is an important process driving vas
140 Immunofluorescence showed that myofibroblast transdifferentiation is attenuated and appearance of fib
142 e predicted miRNA target genes confirmed the transdifferentiation is closely related to neuronal diff
145 eta cell conversion was not, suggesting that transdifferentiation is not mediated by glucagon/GLP-1 c
146 r, these data indicate that hepatocyte to BE transdifferentiation is regulated by HGF and EGF recepto
148 dramatic change in phenotype associated with transdifferentiation is underpinned by a global change i
149 or inhibitor-1 (PAI-1), PDGF-B (PDGF-B), the transdifferentiation marker fibroblast-specific protein-
151 Recent reports have proposed an alternative transdifferentiation method in which fibroblasts are dir
152 thereby allowing the execution of hepatocyte transdifferentiation; moreover, they highlight HOTAIR as
153 vidence of pregranulosa cell-to-Sertoli cell transdifferentiation near birth, following a severe decl
155 tures, supporting histological evidence that transdifferentiation occurs adjacent to the vasculature.
156 OXA1 cooperate with PPAR activation to drive transdifferentiation of a basal bladder cancer cells to
157 rculating glucocorticoid therefore promote a transdifferentiation of adult exocrine pancreas into hep
158 suggest that neogenesis from duct cells and transdifferentiation of alpha-cells are potential contri
160 r binding protein-alpha (C/EBPalpha) induces transdifferentiation of B cells into macrophages at high
161 d Ballon and colleagues describe the in vivo transdifferentiation of B lymphocytes by KSHV-encoded vi
163 lastic phenotype might arise in part through transdifferentiation of chief cells as opposed to expans
164 es indicate that SPEM evolves through either transdifferentiation of chief cells or activation of a b
167 vein clearing is caused by pathogen-induced transdifferentiation of chloroplast-containing bundle sh
168 ver, the loss of wild-type Braf also induces transdifferentiation of club cells, which leads to the r
169 he transcription factor C/EBPalpha induced a transdifferentiation of committed lymphoid precursors in
170 Xenopus had been described as one involving transdifferentiation of cornea epithelial cells (i.e., o
172 aling can be activated in SCs but not impede transdifferentiation of denervated SCs to regeneration-p
173 thelial mesenchymal cells may emerge through transdifferentiation of endothelial cells (ECs) into myo
175 ial-mesenchymal transition (EMT), defined as transdifferentiation of epithelial cells into mesenchyma
176 specification, might be sufficient to induce transdifferentiation of fibroblasts into ECs (induced EC
177 ducing signals, has been reported to trigger transdifferentiation of fibroblasts into other cell type
178 shown that innate immunity is necessary for transdifferentiation of fibroblasts to endothelial cells
179 however, it failed to rescue TGFbeta-driven transdifferentiation of fibroblasts to myofibroblasts in
181 transforming growth factor (TGF)B1-dependent transdifferentiation of foreskin and tongue, but not gin
182 he estrogen receptor represses Sox9 to block transdifferentiation of granulosa cells into Sertoli-lik
183 sume an immature replicating cell phenotype; transdifferentiation of hematopoietic stem cells into ca
184 rtebrate embryos, HSCs arise from the unique transdifferentiation of hemogenic endothelium comprising
185 etabeta (PDGF-betabeta) are hallmarks of the transdifferentiation of hepatic stellate cells (HSC).
189 ells (HSCs), but the mechanisms that control transdifferentiation of HSCs are poorly understood.
192 Overall, we describe a method for achieving transdifferentiation of human dermal fibroblasts into in
194 ockdown studies, we found that the effective transdifferentiation of human fibroblasts to ECs require
195 ent, markedly increase the efficiency in the transdifferentiation of human fibroblasts to iDA neurons
198 In conclusion, chronic inflammation induces transdifferentiation of intestinal mucosal microvascular
199 TGF-beta-Slug-EMT signaling reactivated the transdifferentiation of keratinocytes, reviving their mi
200 tively, our findings demonstrate the de novo transdifferentiation of lung ADC to SCC in mice and prov
201 Here we provide in vivo evidence showing the transdifferentiation of lung cancer from ADC to SCC in m
202 the mammalian gonad and even guards against transdifferentiation of male cells into female cells in
203 F acts redundantly with ThPOK to prevent the transdifferentiation of mature CD4(+) T cells into CD8(+
207 e stromal microenvironment, and induction of transdifferentiation of monocytes into endothelial cells
208 of stem or precursor cell populations or the transdifferentiation of more plentiful mature cell popul
210 Here we define the minimal requirements for transdifferentiation of mouse mesoderm to cardiac myocyt
211 ion of damaged nerves, acting to control the transdifferentiation of myelin and Remak Schwann cells t
212 ion, resistance to apoptosis, and subsequent transdifferentiation of PAH-PASMCs into osteoblast-like
216 tabilized TbetaRII and potentiated TGF-beta1 transdifferentiation of pericytes into myofibroblasts in
217 ost impressive examples of such a process is transdifferentiation of pigmented epithelial cells (PECs
219 the tumor microenvironment, TGF-beta induces transdifferentiation of quiescent pericytes and related
220 s both necessary and sufficient for neuronal transdifferentiation of RPE cells and reveal an essentia
222 , improvements in ex-vivo expansion of HSCs, transdifferentiation of somatic cells into hematopoietic
223 guing parallels to recent reports of induced transdifferentiation of specific cell types in the adult
224 uired for hair cell survival, as well as for transdifferentiation of support cells into hair cells du
225 ls begins by 12 h post-ablation and involves transdifferentiation of support cells rather than asymme
226 e t-butyl ester failed to promote the direct transdifferentiation of supporting cells into hair cells
228 r cells were derived via direct (nonmitotic) transdifferentiation of supporting cells: new hair cells
233 Because microRNAs (miRs) are involved in the transdifferentiation of vascular smooth muscle cells int
234 st that reinitiation of cambial activity and transdifferentiation of xylem parenchyma cells results i
235 production of fate-specific cells by in vivo transdifferentiation offers a targeted method for tissue
236 and characterize the efficiency of cellular transdifferentiation on a genome-wide scale can be appli
237 on factors used in iPSC generation to induce transdifferentiation or called iPSC transcription factor
239 presenting biomolecular events, such as cell transdifferentiation or the presence of an amplicon.
240 ls, represent intermediates during Treg/Th17 transdifferentiation, or constitute a distinct cell line
241 hes might include stem cell differentiation, transdifferentiation, or expansion of cadaver islets or
243 ined from mouse fibroblasts by OSKM-induced 'transdifferentiation' pass through a transient pluripote
245 taining, we detected c-kit (a marker of cell transdifferentiation) positive ductal cells co-expressin
246 tributors to fibrotic lesions because of the transdifferentiation potential of these cells into myofi
248 tem cells (HSCs) are generated via a natural transdifferentiation process known as endothelial to hem
249 ation of agents that selectively inhibit the transdifferentiation process leading to the formation of
251 thelial-to-mesenchymal transition (EMT) is a transdifferentiation process that converts epithelial ce
252 inted out CD25 as a key molecule during this transdifferentiation process, however molecules that all
257 mal transition (EMT), a reversible embryonic transdifferentiation program that allows partial or comp
259 thelial to mesenchymal transitions (EMT) are transdifferentiation programs that are required for tiss
260 roblasts that exhibit impaired myofibroblast transdifferentiation, reduced migratory potential, and s
263 cancer development, stem cell induction and transdifferentiation requires the modulation of multiple
264 rea by paracrine activity rather than active transdifferentiation, resulting into cardioprotection as
265 issue-specific cell types via a conventional transdifferentiation strategy typically uses overexpress
266 5 expression during alveolar epithelial cell transdifferentiation, suggesting that HDAC inhibitors ma
267 ulation of cell state through the process of transdifferentiation suggests that environmental cues ma
271 m cell and induced fibroblast-to-neuron (iN) transdifferentiation technologies has revolutionized our
274 active strategy for regenerative medicine is transdifferentiation-the direct conversion of one somati
275 as cell-fate specification, cell death, and transdifferentiation throughout post-embryonic developme
276 e tested if pancreatic metaplasia represents transdifferentiation to a biliary phenotype and what eff
277 ia (ADM), a reprogramming event that induces transdifferentiation to a ductlike phenotype and, in the
278 me painting of labelled donor cells revealed transdifferentiation to a myocyte fate in the absence of
279 s during atrial-to-ventricular cardiomyocyte transdifferentiation to define intermediate cardiac repr
281 Here we conferred fusogenic activity without transdifferentiation to multiple non-muscle cell types a
282 investigated its potential role in adipocyte transdifferentiation to myofibroblast in dermal fibrosis
283 gested that the FIZZ1 induction of adipocyte transdifferentiation to myofibroblast might be a key pat
284 ced homing of BM-FPCs to the heart and their transdifferentiation to myofibroblasts and thus attenuat
285 suggest that IL10 inhibits BM-FPC homing and transdifferentiation to myofibroblasts in pressure-overl
286 growth factor (TGF)-beta1 induces fibroblast transdifferentiation to myofibroblasts, a process that r
287 ext at key target genes is determinative for transdifferentiation to neurons and likely other cell ty
289 Recent studies revealed a new paradigm of transdifferentiation: using transcription factors used i
290 ly differentiated cell type into another (or transdifferentiation) usually requires the forced expres
293 by increasing CoRL number, migration, and/or transdifferentiation, we administered tamoxifen to Ren1c
294 ransition significantly accelerates squamous transdifferentiation, whereas constitutive YAP activatio
295 Pharmacological Lox inhibition promotes the transdifferentiation, whereas ectopic Lox expression sig
297 1(Deltabeta)) caused beta-to-delta-like cell transdifferentiation, which was delayed until postnatal
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