ライフサイエンスコーパス: transduction

1 hannels and is crucial to modulate signaling transduction.

2 l transfer of virulence genes by generalized transduction.

3 y associations between metabolism and signal transduction.

4 bioenergetics, cell death, and Ca(2+) signal transduction.

5 ng strategies deployed for allosteric signal transduction.

6 e a combination of PKD1 and PKD2 for optimal transduction.

7 tum catch and in part by opsin activation of transduction.

8 defective primary cilia morphology or signal transduction.

9 n was stimulated as a response to adenoviral transduction.

10 y machine facilitating locomotion and signal transduction.

11 f B-cell proliferation, survival, and signal transduction.

12 ional transcriptional regulation, and signal transduction.

13 keletal derivatives in jaw support and sound transduction.

14 sensors, such as for optogenetics and force transduction.

15 new ideas were shared in the field of signal transduction.

16 st paradigms for the study of mechanosensory transduction.

17 ding the molecular mechanism of visual photo-transduction.

18 distal, PKD domain (PKD1) of AAVR to promote transduction.

19 nits, which are invariable and ensure signal transduction.

20 ulation of ion transport and ion-to-electron transduction.

21 ate communications, excitability, and signal transduction.

22 ght the impact of ROS localization on signal transduction.

23 ould function broadly within cellular signal transduction.

24 ughput data in the context of Mvarphi signal transduction.

25 ns to CD4(+) T cells through Jak-STAT signal transduction.

26 ng to other brain regions at one month after transduction.

27 additional overnight in vitro culture after transduction.

28 control of stomata aperture and light signal transduction.

29 9 vector as a non-invasive means of cochlear transduction.

30 g units to an electronic platform for signal transduction.

31 nal extension, which is important for signal transduction.

32 impairs endosomal trafficking and BCR signal transduction.

33 somal morphology, BCR expression, and signal transduction.

34 t requirement for AAV2 binding or functional transduction.

35 ein phosphorylation as a mechanism of signal transduction.

36 cytes and alteration of intracellular signal transduction.

37 vation loop yields precise control of signal transduction.

38 e all response regulators involved in signal transduction.

39 ection, spanning both labeled and label-free transductions.

40 fficacy of GT correlating with the levels of transduction achieved.

41 cascades are conserved mechanisms of signal transduction across eukaryotes.

42 Nevertheless, AAVs that provide efficient transduction across specific organs or cell populations

43 and can further our understanding of signal transduction across the plasma membrane.

44 iple lines of evidence have shown that force transduction across the TCR complex is involved during T

45 virulence, including nutrient uptake, signal transduction, adhesion, conjugation, sporulation, and ou

46 uid crystals likely enable long-range signal transduction along meiotic chromosomes and underlie the

47 negative regulatory mechanisms of olfactory transduction also play a role in setting the resting sen

48 ules in complex cellular networks for signal transduction and biological function.

49 d elongation, cell cycle progression, signal transduction and cell proliferation.

50 hemical basis of how they orchestrate signal transduction and control gene expression.

51 r activation with CD3 and CD28 Abs (CD3/28), transduction and culture alone, or after reconstitution

52 facilitated our understanding of the signal transduction and cytoskeletal pathways that govern cell

53 olved in primary metabolism including energy transduction and deoxynucleotide production catalyzed by

54 om parental serotypes for enhancement of AAV transduction and evasion of Nab recognition without incr

55 or methionine metabolism to influence signal transduction and gene expression in budding yeast.

56 even more potent than TB1 in promoting viral transduction and infection.

57 rced KLF4 expression blocked TGF-beta signal transduction and inhibited cell migration and invasion v

58 through both gp130 receptor-mediated signal transduction and interaction of vIL-6 with the ER membra

59 For optimal ion-to-electron transduction and potential stability, the p-doped ECPs w

60 Transduction and spike generation possessed complementar

61 ance-dependent gain control occurred at both transduction and spiking.

62 diversity is required for optimal TCR signal transduction and subsequent T cell maturation.

63 ly regulated endosomal traffic in TCR signal transduction and T cell activation leading to IL-2 produ

64 gnificance of the intrinsic speed of sensory transduction and the pattern of the peripheral coding of

65 nal afferent neurons are responsible for the transduction and transmission of noxious (painful) stimu

66 ctivators and the inhibitors of IL-17 signal transduction, and also the physiological implications of

67 ement of lincRNAs in stress response, signal transduction, and developmental processes.

68 on models of human DCs, gene profiling, gene transduction, and immunohistology were used to identify

69 es calcineurin-dependent hypertrophic signal transduction, and its knockdown repressed hypertrophy an

70 ty, inexpensive instrumentation, fast signal transduction, and low limit of detection (0.12 ppm) are

71 organization of the plasma membrane, signal transduction, and membrane trafficking.

72 ize all circuit sensing, computation, signal transduction, and output elements in the same self-assem

73 able toehold-mediated strand-exchange signal transduction, and standard pregnancy test strips.

74 re reviewed, and different methods of signal transduction are evaluated.

75 n of enzymes could be as important in signal transduction as its catalytic activity, which is an anti

76 Wg ligand and nuclear trans-synaptic signal transduction, as well as downstream misregulation of bot

77 n architecture that includes a STAND (signal transduction ATPases with numerous domains) family NTPas

78 such as pH and Ca(2+), the effectiveness of transduction between the gating ring and the pore domain

79 erization or control other aspects of signal transduction, but a lack of structural information has p

80 enless (SOS) plays a critical role in signal transduction by activating Ras.

81 38 residues whose mutation eliminated signal transduction by all ligands, providing a comprehensive a

82 ced Src activation and blocked the signaling transduction by integrin alphaV, inhibited migration sig

83 Signal transduction by receptor tyrosine kinases (RTKs) involve

84 sted the susceptibility of human EC cells to transduction by retroviral vectors derived from three di

85 utophagy does not terminate cytosolic signal transduction by TGFbeta.

86 and significantly increased the information transduction capacity of the pathway.

87 ell motility through a nonproteolytic signal transduction cascade involving activation and phosphoryl

88 The visual photo-transduction cascade is a prototypical G protein-coupled

89 We also show that dendritic transduction cascade members mGluR6 and TRPM1 appear in

90 a kinetic "damper" present in the olfactory transduction cascade of the mouse that slows down the re

91 oassay demonstrated initiation of the signal transduction cascade, after binding of all investigated

92 naptic NMDA-R-CaMKII-SynGap-Ras-BRaf-MEK-ERK transduction cascade.

93 These gases play a pivotal role in signal transduction cascades, leading to adaptive processes suc

94 number of experimental and in silico signal transduction case-studies, including the recent HPN-DREA

95 Caveolae are signal transduction centers, yet their subcellular distribution

96 This sensory transduction channel is expressed in hair cell stereocil

97 A glucose-sensitive signal transduction circuit involving the mTOR complex 1 (mTORC

98 ypes with each type expressing receptors and transduction components for a subset of taste qualities.

99 lear potential that drives mechanoelectrical transduction currents in outer hair cells and hence coch

100 al a core function for TRPA1 in noxious heat transduction, demonstrate its conservation from planaria

101 hat the well known high speed of GPCR signal transduction does not require preassembly between G prot

102 primary cilium, a key platform for HH signal transduction, does not correlate with HH signal promotio

103 To overcome such limitations, protein transduction domains (PTDs) have been used as protein ca

104 that coupling DO sequences with tumor-homing transduction domains can create a potentially valuable n

105 r stomatitis virus (VSV) pseudoparticles and transduction efficiencies were monitored in HAP1 and HAP

106 ssemble haploid capsids and study both their transduction efficiency and Nab escape activity.

107 ptors contribute significantly to AAV vector transduction efficiency and tropism.

108 To test this hypothesis, we investigated the transduction efficiency of 12 rAAV serotypes carrying an

109 mbarked on an extensive study to compare the transduction efficiency of IDLVs pseudotyped with differ

110 e can evade NAbs without compromising titer, transduction efficiency, or tissue tropism.

111 ion and depression, AMPARs are the main fast transduction elements at synapses and are critical for t

112 expression of taste receptor genes and taste transduction elements in cultured organoids.

113 es therefore represent a new family of viral transduction enhancers for potential use in gene therapy

114 MENT We describe a novel mechanism of signal transduction enriched in medium spiny neurons of striatu

115 c signal without the use of expensive signal transduction equipment and facilitates the immobilizatio

116 biogenesis, protein trafficking, and signal transduction, especially in viral-associated tumorigenes

117 Shc) family are typically involved in signal transduction events involving Ras/MAPK and PI3K/Akt path

118 Here we examined the signal transduction events that occur during TLR9-induced IRF7

119 Of note, rAAVrh.10 showed excellent muscle transduction following IP administration, highlighting i

120 tegration-defective lentiviral vector (IDLV) transduction for donor template delivery to mediate HDR

121 g conditions, resulting from impaired signal transduction from beta-adrenergic receptors to adenylate

122 serve as adapter molecules to mediate signal transduction from Tumor Necrosis Factor Receptor to down

123 tal dynamics, cell-cycle progression, signal transduction, gene expression, and apoptosis.

124 roteins (GO: 0007242) and Ras protein signal transduction (GO: 0007265), and contain active Ras.

125 Although force transduction has been extensively studied in the context

126 CR coupling and the high rate of Gi/o signal transduction have been hypothesized to be enabled by the

127 modules and different models for SHK signal transduction have been proposed.

128 nflammasome activation and subsequent signal transduction have emerged as an excellent example of how

129 Surface acoustic wave mediated transductions have been widely used in the sensors and a

130 erestingly, Rag 2(-/-) serum enhanced HAdV-5 transduction in a FX-independent manner in CHO-CAR and S

131 rception and initiation of subsequent signal transduction in Arabidopsis.

132 rom one enzyme to another facilitates signal transduction in biological systems providing for feed-fo

133 kinetics and spatial coordination of signal transduction in cells are vital for cell fate determinat

134 electronics, where they perform vital energy transduction in filters and power converters.

135 Seven constructs retained efficient transduction in HAP1-DeltaDAG1 cells yet poorly transduc

136 FX is dispensable for liver transduction in mice lacking IgM antibodies or complemen

137 , which have reported that TNF blocks signal transduction in response to IFNs.

138 ral mechanism presents a template for signal transduction in sensor histidine kinases.Sensor histidin

139 discovery of the molecular basis for signal transduction in the initiation of sporulation in Bacillu

140 Mechanoelectrical transduction in the inner ear is a biophysical process u

141 ter systemic administration, a 4-fold higher transduction in the liver was observed with haploid AAV2

142 Here, we studied the effects of P301L hTau transduction in the medial EC (MEC) of mice on tau phosp

143 nd suggest that altered regulation of signal transduction in the muscles within the spine may lead to

144 ion with FX-binding protein (X-bp) inhibited transduction in the presence of C57BL/6 serum, it had ne

145 LVs may be efficient tools for in utero cord transduction in therapeutic strategies such as for treat

146 eature to regulate transcription via mechano-transduction in this most active and dynamic region of t

147 FX-independent entry, we investigated HAdV-5 transduction in vitro in the presence of serum from immu

148 elected examples of atypical modes of signal transduction including inactivation of HK activity via h

149 s therapeutic approaches to treatment signal transduction inhibition.

150 nt studies have demonstrated that the signal transduction initiated by these sensors is sophisticated

151 r, fostering transphosphorylation and signal transduction into the cell.

152 rent that appears in mutants in which normal transduction is lost.

153 ng steps, suggesting that cholinergic signal transduction itself is not voltage-sensitive, but that d

154 y Structural data suggest that during signal transduction, large transitions of the beta8-beta9 loop

155 nd in endosomal compartments, (c) TCR signal transduction leading to T cell activation, and (d) TCR d

156 d pharmaceutical interventions at the signal transduction level is still far from complete.

157 ry system seems to be to allow the olfactory transduction machinery to work at a precisely regulated

158 inflammation or blocking inflammatory signal transduction may prevent cancer development.

159 ty and pH, upon addition of adulterants as a transduction mechanism for detecting milk adulteration.

160 a is responsible for tension bearing and the transduction mechanism in the stereocilia and for melano

161 ATP-binding site are important in the signal transduction mechanism of AfGcHK.

162 employing an artificial transmembrane signal transduction mechanism.

163 quid samples, according to the corresponding transduction mechanism.

164 nctional chemical sensors, in which multiple transduction mechanisms are applied to the same sensing

165 likely do these employing different stimulus transduction mechanisms to sense the diverse chemicals o

166 oresonators with new functionalities, unique transduction mechanisms, and in some cases, unparalleled

167 n, we investigated the intramolecular signal transduction mechanisms.

168 ic processes but can also function as signal transduction mediators.

169 functions related to signal recognition and transduction, metabolism, transport and catabolism.

170 ynamics of PNC migration under various force-transduction models, including the pushing or pulling of

171 legic (SMAD) proteins are a family of signal transduction molecules in transforming growth factor bet

172 They primarily function as signal transduction molecules that regulate different pathways

173 Signal transduction networks allow eukaryotic cells to make dec

174 The nature of signal transduction networks in the regulation of cell contract

175 ings can be used to decompose natural signal transduction networks into modules, and at the same time

176 mRNAs, lncRNAs and miRNAs on cellular signal transduction networks.

177 shows how these metrics depend on the signal transduction noise level.

178 abnormal conditions, and in the presence of transduction noise uncertainty.

179 genes are involved in signal perception and transduction not only during MTI but also upon damage-as

180 um, it had negligible effect on the enhanced transduction observed in the presence of Rag 2(-/-) or N

181 by conjugation and the efficiency with which transduction occurs.

182 eered from HCV-seronegative donor T cells by transduction of a lentiviral vector expressing HCV-speci

183 from all three mouse strains enhanced HAdV-5 transduction of A549 cells.

184 ere, we show, for the first time, successful transduction of all inner hair cells and the majority of

185 iled structural dynamic understanding of the transduction of ATP energy to the work of substrate tran

186 om this library were then used for the batch transduction of bone marrow-derived mesenchymal stromal

187 Transduction of CD4(+) T cells with BIV Vif blocked HIV-

188 ve conductive surfaces for the detection and transduction of cell-extracellular matrix recognition ev

189 GPB, or GPC via lentiviral short hairpin RNA transduction of erythroid progenitor cells, with global

190 Transduction of fibroblasts with a lentivirus encoding t

191 ubunit is classically involved in the signal transduction of G protein-coupled receptors (GPCRs) at t

192 Transduction of HAdV-5 KO1 and HAdV-5/F35 (CAR binding d

193 ed receptor-related protein required for the transduction of Hedgehog (HH).

194 yped lentivirus resulted in almost exclusive transduction of hepatocytes allowing analysis of hepatoc

195 een these two electrodes provides electrical transduction of HSA binding to the virus-PEDOT film.

196 ull-length dystrophin open-reading frame for transduction of human muscle derived cells.

197 The transduction of human primary T cells with the equivalen

198 mistry, as it measures the efficiency of the transduction of light energy into chemical energy.

199 of CP-CML, BC-CML, and AML generated by the transduction of mouse BM with fusion cDNAs derived from

200 Ex vivo transduction of mouse organotypic explants identified An

201 mitters enable broadband quantum storage and transduction of photonic qubits, with applications in hi

202 Here we show that efficient transduction of PUMA in FLS can be achieved by conjugati

203 ors located in the inner ear that enable the transduction of sound, motion, and gravity into neuronal

204 Intriguingly, transduction of the artificial transcription factor PSD9

205 Rag 2(-/-) serum also enhanced transduction of the FX binding-deficient HAdV-5HVR5*HVR7

206 llowed by the short and clinically validated transduction of these cells with a therapeutic lentivira

207 consistent with a role for Vax1 in mediating transduction of this pathway.

208 essential cellular receptor required for the transduction of vectors derived from multiple AAV seroty

209 s in vitro and in vivo require ETS1-mediated transduction of VEGF signaling to release paused RNAPII.

210 TCF7 retroviral transduction opposes GZMB expression and the formation o

211 s of proteins, such as in metabolism, signal transduction or immunity.

212 which binds to a crucial site in the agonist transduction pathway and causes conformational changes t

213 haracterise a multi-step phosphorelay signal transduction pathway consisting of TcsA, TcrA, FsrR, Rpo

214 the phosphoinositide 3-kinase (PI3K) signal transduction pathway contribute to the hypothalamic regu

215 icating that targeting a specific D2R signal transduction pathway could allow for more precise modula

216 s as a key control element in the allosteric transduction pathway for potentiating betaEST and dFBr.

217 Notch signaling is a ubiquitous signal transduction pathway found in most if not all metazoan c

218 a2+/CaM as a limiting resource in the signal transduction pathway owing to its low abundance relative

219 part of an operon encoding the VieSAB signal transduction pathway that is nearly silent in V. cholera

220 hoinositide 3-kinase/protein kinase B signal transduction pathway, and that can be overcome by miR-7

221 ese genes to investigate the c-di-GMP signal transduction pathway.

222 ing those involved in the phytochrome signal transduction pathway.

223 ough a hitherto unknown communication signal transduction pathway.

224 lysis reveals that the 'plant hormone signal transduction' pathway is enhanced during pollen-pistil i

225 ance signaling molecules that control signal transduction pathways and are necessary for cellular hom

226 ole of the ERM proteins in regulating signal transduction pathways and suggests that modulation of mo

227 Ras is at the hub of signal transduction pathways controlling cell proliferation and

228 However, the signal transduction pathways culminating in the biological cons

229 in vivo the requirement of different signal transduction pathways emanating from KIT for tumorigenes

230 s or complement, suggesting that alternative transduction pathways exist.

231 ery from pneumonia, and modulation of signal transduction pathways that have been linked to prion pro

232 Targeting signal transduction pathways which promote therapy resistance a

233 cross-talk among the external milieu, signal transduction pathways, and transcription factors that di

234 hylation is an important modulator of signal transduction pathways, but methyltransferases themselves

235 d crucial pathways, including several signal transduction pathways, hormone response, oxidative respo

236 rnalization and activation of several signal transduction pathways, such as phosphoinositide 3-kinase

237 n regulating protein stability and signaling transduction pathways.

238 act indirectly via receptor-mediated signal transduction pathways.

239 d carcinoma and describe the involved signal transduction pathways.

240 s as a mediator of cross-talk between signal transduction pathways.

241 trafficking, and the organization of signal transduction pathways.

242 Epr3 is integrated into the symbiosis signal transduction pathways.

243 a cells and for the study of involved signal transduction pathways.

244 -IL-1beta, generally via NF-kappaB-dependent transduction pathways; and the assembly and activation o

245 ta suggest that IP administration emphasizes transduction patterns that are different from previously

246 from metabolic, gene regulatory, and signal transduction perspectives.

247 res (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes

248 ated, such as the active force gain, mechano-transduction properties, and membrane RC time constant.

249 t "redoxosomes," contribute to proper signal transduction.Protein-tyrosine phosphatases (PTPs) are th

250 zed to track the expression of photoreceptor transduction proteins and ribbon and synaptic markers in

251 of a proper complement of dendritic tips and transduction proteins in rod bipolar cells.

252 dendritic tips, as well as the expression of transduction proteins within dendrites.

253 transduced in an apex-to-base gradient, with transduction reaching 96% in the apical turn.

254 modulating metabolic and inflammatory signal transduction reactions.

255 n DCs and PCs that did not influence sensory transduction, receptor-current-driving-voltage, low-mid-

256 ganelles contain proteins that enable signal transduction, regulation of morphology and trafficking,

257 limited effect on G protein-mediated signal transduction, removal of positive charge from this resid

258 ugation is simple, can be done on the day of transduction, requires minimal time, has low reagent cos

259 Furthermore, SNAI2 transduction rescues metastasis suppression by miR-452.

260 e design principles orchestrating the signal transduction roles of the Hha protein family.

261 toward the membrane is coupled to an energy transduction step that could thermodynamically drive pro

262 and intercellular processes including signal transduction, subcellular localization, and regulation o

263 s for this unprecedented mechanism of signal transduction suggests new modalities for the treatment o

264 Recent work on conjugation and transduction suggests that transfer by these mechanisms

265 egulated by the VanSARA two-component signal transduction system.

266 integrate to provide a rapid oxygen sensing transduction system.

267 n is often regulated by two-component signal transduction systems (TCSTs).

268 Bacterial signal transduction systems commonly use receiver (REC) domains

269 use electrochemical, optical, and mass-based transduction systems in cancer biomarker detection.

270 e to these signals through complex signaling transduction systems.

271 verall procedure from T-cell isolation to RV transduction takes 2 d, and enrichment of activated T ce

272 f metal-oxide nanofibers and electrochemical transduction techniques, resulting in label-free zeptomo

273 n, all of the haploid viruses induced higher transduction than their parental AAV vectors (2- to 9-fo

274 e present a novel method for magnetic energy transduction that utilizes ferromagnetic islands (FIs) o

275 ein-tyrosine phosphatase oxidation in signal transduction, the cell biological details of reactive ox

276 Indeed, after transduction, the NK cell line NK-92 became TCR positive

277 Another was a recalibration of energy transduction through apparent reductions in mitochondria

278 ctivin binding site, hence preventing signal transduction through either ActRII.

279 l systems that initiate transmembrane signal transduction through molecular binding events is a criti

280 xample, cell-fate decision-making and signal transduction, through multiple layers of regulation invo

281 hat minimize excitation-contraction coupling transduction times.

282 One group of likely candidates for signal transduction to the circadian clock are the PHYTOCHROME

283 Agonist binding leads to rapid signal transduction via an allosteric mechanism, where global p

284 Signal transduction via calcium ions (Ca2+) represents a fundam

285 ER)-localized vIL-6, which can induce signal transduction via the gp130 signaling receptor, activatin

286 Sonic hedgehog (Shh) signal transduction was downregulated in the mutant forebrain,

287 tly, the differential pulse anodic stripping transduction was realized to be approximately four-fold

288 arget of rapamycin complex 1 (mTORC1) signal transduction was unleashed, and this coincided with live

289 At week 1 post-transduction, we found that reprogrammed CMs expressed n

290 'ribosomal subunit' and 'phosphorelay signal transduction', were overrepresented in Namikonga at thes

291 neuronal morphologies as early as day 3 post-transduction while still retaining a CM gene expression

292 hner relation and occurred primarily at odor transduction, while variance-dependent gain control occu

293 ein-9 (Cas9) technology, simultaneously with transduction with a cancer-reactive receptor of choice.

294 2 association with CAV1 was evident, whereas transduction with a dominant negative CAV1 mutated at ty

295 Finally, transduction with a pan-cancer-reactive gammadelta TCR u

296 ked by SHANK3-edited ES cells and rescued by transduction with a Shank3 expression construct.

297 In addition, after transduction with DNA encoding wild-type CAV1 into SECs

298 ame this obstacle through in vivo adenoviral transduction with matrix-targeted photoactivatable GFP a

299 are versatile regulators of platelet signal transduction, with functions beyond inhibiting ITAM-medi

300 rs primarily by conjugation or bacteriophage transduction, with the latter traditionally being percei